Glial reactivity, an early feature of diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 7, 2000, Pages 1971-1980

  Rungger Brändle, Elisabeth ^a   Dosso, André A ^a   Leuenberger, Peter M ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD RETINA BARRIER; BLOOD VESSEL PERMEABILITY; CELL DENSITY; CONTROLLED STUDY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; HYPERGLYCEMIA; MICROGLIA; MUELLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD-RETINAL BARRIER; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; CELL COUNT; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROSCOPY, CONFOCAL; NEUROGLIA; RATS; RATS, INBRED WKY; RETINAL VESSELS;

EID: 0034121302     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (79)

1. Garner A. Histopathology of diabetic retinopathy in man. Eye. 1993;7:250-253.
2. Di Leo MAS, Caputo S, Falsini B, et al Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes. Diabetes Care. 1992;15:620-625.
3. Dosso AA, Bonvin ER, Morel Y, Golay A, Assal JP, Leuenberger PM. Risk factors associated with contrast sensitivity loss in diabetic patients. Graefes Arch Clin Exp Ophthalmol. 1996;234:300-305.
4. Harris A, Arend O, Danis RP, Evans E, WolfS, Martin BJ. Hyperoxia improves contrast sensitivity in early diabetic retinopathy. Br J Ophthalmol. 1996;80:209-213
5. Hardy KJ, Lipton J, Foster DH, Scarpello JHB. Detection of colour vision abnormalities in uncomplicated type I diabetic patients with angiographically normal retinas. Br J Ophthalmol. 1992;76:461-464.
6. Hardy KJ, Scarpello JHB, Foster DH, Moreland JD. Effect of diabetes associated increases in lens optical density on colour vision discrimination in insulin dependent diabetes. Br J Ophthalmol. 1994;78:754-756.
7. Arden GB, Hamilton AMP, Wilson-Holt J, Ryan S, Yudkin JS, Kurtz A. Pattern electroreginograms become abnormal when background diabetic retinopathy deteriorates to a preproliferative stage: possible use as a screening test. Br J Ophthalmol. 1986;70: 330-335.
8. Karadeniz S, Kir N, Yilmaz MT, et al. Alteration of visual function in impaired glucose tolerance. Eur J Ophthalmol. 1996;6:59-62.
9. Dosso AA, Yenice-Ustun F, Sommerhalder J, Golay A, Morel Y, Leuenberger PM. Contrast sensitivity in obese dyslipidemic patients with insulin resistance. Arch Ophthalmol. 1998;116:1316-1320.
10. Tsacopoulos M, Magistretti PJ. Metabolic coupling between glia and neurons. J Neurosci. 1996;16:877-885.
11. Wiesinger H, Hamprecht B, Dringen R. Metabolic pathways for glucose in astrocytes. Glia. 1997;21:22-34.
12. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG. Energy on demand. Science. 1999;283:496-497.
13. Rothstein JD, Dykes-Hoberg M, Pardo CA, et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 1996;16: 675-686.
14. Westergaard N, Sonnewald U, Schousboe A. Metabolic trafficking between neurons and astrocytes: the glutamate/glutamine cycle revisited. Dev Neurosci. 1995;17:203-211.
15. Sonnewald U, Westergaard N, Schousboe A. Glutamate transport and metabolism in astrocytes Glia. 1997;21:56-63.
16. Gillies MC, Su T, Stayt J, Simpson JM, Naidoo D, Salonikas C. Effect of high glucose on permeability of retinal capillary endothelium in vitro. Invest Ophthalmol Vis Sci. 1997;38:635-642.
17. MacGregor LC, Matschinsky FM. Altered retinal metabolism in diabetes, II: measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers. J Biol Chem. 1986;261:4052-4058.
18. +-ATPase activity in the retina of streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci. 1996;37:1633-1641.
19. Ruderman NB, Williamson JR, Brownlee M. Glucose and diabetic vascular disease. FASEB J. 1992;6:2905-2914.
20. +-ATPase in diabetes: streptozotocin-induced and Zucker diabetic fatty rats. Curr Eye Res. 1993;12:1111-1121.
21. Kowluru R, Bitensky MW, Kowluru A, Dembo M, Keaton PA, Buican T. Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy. Proc Natl Acad Sci USA. 1989;86:3327-3331.
22. +-ATPase in the nervous system and kidney of the spontaneously diabetic BB/Wor rat. Biochim Biophys Acta. 1991;1118: 77-82.
23. Stojkovic T, Colin C, Le Saux F, Jacque C. Specific pattern of nitric oxide synthase expression in glial cells after hippocampal injury. Glia. 1998;22:329-337.
24. Giugliano D, Ceriello A, Paolisso G. Diabetes mellitus, hypertension, and cardiovascular disease: which role for oxidative stress? Metabolism. 1995;44:363-368.
25. Amaducci L, Forno KI, Eng LF. Glial fibrillary acidic protein in cryogenic lesions of the rat brain. Neurosci Lett. 1981;21:27-32.
26. Aquino DA, Chiu FC, Brosnan CF, Norton WT. Glial fibrillary acidic protein increases in the spinal cord of Lewis rats with acute experimental autoimmune encephalomyelitis. J Neurochem. 1988; 51:1085-1096.
27. Eddleston M, Mucke L. Molecular profile of reactive astrocytes: implication for their role in neurologic disease. Neuroscience. 1993;54:15-36.
28. Norton WT, Aquino DA, Hozumi I, Chiu F-C, Brosnan CF. Quantitative aspects of reactive gliosis: a review. Neurochem Res. 1992; 17:877-885.
29. Laping NJ, Teter B, Nichols NR, Rozovsky I, Finch CE. Glial fibrillary acidic protein: regulation by hormones, cytokines, and growth factors. Brain Pathol. 1994;1:259-275.
30. Ridet JL, Malhotra SK, Privat A, Gage FH. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 1997;20:570-577.
31. Tanihara H, Hangai M, Sawaguchi S, et al. Up-regulation of glial fibrillary acidic protein in the retina of primate eyes with experimental glaucoma. Arch Ophthalmol. 1997;115:752-756.
32. Erickson PA, Fisher SK, Guerin CJ, Anderson DH, Kaska DD. Glial fibrillary acidic protein increases in Müller cells after retinal detachment. Exp Eye Res. 1987;44:37-48.
33. Okada M, Matsumura M, Ogino N, Honda Y. Müller cells in detached human retina express glial fibrillary acidic protein and vimentin. Graefes Arch Clin Exp Ophthalmol. 1990;228:467-474.
34. Lewis GP, Guerin CJ, Anderson DH, Matsumoto B, Fisher SK. Rapid changes in the expression of glial cell proteins caused by experimental retinal detachment. Am J Ophthalmol. 1994;118:368-376.
35. Grosche J, Hartig W, Reichenbach A. Expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and Bcl-2 protooncogene protein by Müller (glial) cells in retinal light damage of rats. Neurosci Lett. 1995;185:119-122.
36. Bignami A, Dahl D. The radial glia of Müller in the rat retina and their response to injury: an immunofluorescence study with anti-bodies to the glial fibrillary acidic (GFA) protein. Exp Eye Res. 1979;28:63-69.
37. Humphrey MF, Moore SR. Microglial responses to focal lesions of the rabbit retina: correlation with neural and macroglial reactions. Glia. 1996;16:325-341.
38. Ekström P, Sanyal S, Narfström K, Chader GJ, van Veen T. Accumulation of glial fibrillary acidic protein in Müller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci. 1988;29:1363-1371.
39. Eisenfeld AJ, Bunt-Milam AH, Sarthy PV. Müller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina. Invest Ophthalmol Vis Sci. 1984;25:1321-1328.
40. Hammes H-P, Federoff HJ, Brownlee M. Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol Med. 1995;1:527-534.
41. Lieth E, Barber AJ, Xu B, et al. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Diabetes. 1998;47:815-820.
42. Mizutani M, Gerhardinger C, Lorenzi M. Müller cell changes in human diabetic retinopathy. Diabetes. 1998;47:445-449.
43. Chan-Ling T, Stone J. Degeneration of astrocytes in feline retinopathy of prematurity causes failure of the blood-retinal barrier. Invest Ophthalmol Vis Sci. 1992;33:2148-2159.
44. Medana IM, Chan-Ling T, Hunt NH. Redistribution and degeneration of retinal astrocytes in experimental murine cerebral malaria: relationship to disruption of the blood-retinal barrier. Glia. 1996; 16:51-64.
45. Rungger-Brändle E, Leuenberger PM. Senile retinal deficiencies in astrocytes and blood vessels. In: LaVail MM, Hollyfield JG, Anderson RE, eds. Degenerative Retinal Diseases. New York: Plenum Press; 1997:409-415.
46. Banati RB, Graeber MB. Surveillance, intervention and cytotoxicity: is there a protective role of microglia? Dev Neurosci. 1994;16:114-127.
47. Chan-Ling T, Neill AL, Hunt NH. Early microvascular changes in murine cerebral malaria detected in retinal wholemounts. Am J Pathol. 1992;140:1121-1130.
48. Rungger-Brändle E, Messerli JM, Niemeyer G, Eppenberger HM. Confocal microscopy and computer-assisted image reconstruction of astrocytes in the mammalian retina. Eur J Neurosci. 1993;5: 1093-1106.
49. Nelson WJ, Veshnock PJ. Dynamics of membrane-skeleton (fodrin) organization during development of polarity in Madin-Darby canine kidney epithelial cells. J Cell Biol. 1986;103:1751-1765.
50. Li G, Rungger-Brändle E, Just, I, Jonas J-C, Aktories K, Wollheim CB. Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets. Mol Biol Cell. 1994;5:199-1213.
51. Sachs L. Angewandte Statistik. 7th ed. New York: Springer; 1992.
52. Corbett JA, Tilton RG, Chang K, et al. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes. 1992;41:552-556.
53. Do Carmo A, Ramos P, Reis A, et al. Breakdown of the inner and outer blood retinal barrier in streptozotocin-induced diabetes. Exp Eye Res. 1998;67:569-575.
54. Kondo K, Makita T. Immunocytochemistry of apoptosis induced by bromodeoxyuridine in human leukemic HL-60 cells. Jpn J Cancer Res. 1997;88:44-48.
55. Chan-Ling T, Stone J. Factors determining the shape, spacing and distribution of astrocytes in the cat retina: the contact-spacing model of astrocyte interaction. J Comp Neurol. 1991;303:387-399.
56. Distler C, Dreher Z, Stone J. Contact spacing among astrocytes in the central nervous system: an hypothesis of their structural role. Glia. 1991;4:484-494.
57. Pugliese G, Tilton RG, Speedy A, et al. Effects of very mild versus overt diabetes on vascular haemodynamics and barrier function in rats. Diabetologia. 1989;32:845-857.
58. Kinukawa Y, Shimura M, Tamai M. Quantifying leukocyte dynamics and plugging in retinal microcirculation of streptozotocininduced diabetic rats. Curr Eye Res. 1999;18:49-55.
59. Morohoshi M, Fujisawa K, Uchimura I, Numano F. Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro. Diabetes. 1996;45:954-959.
60. Topp KS, Faddis BT, Vijayan VK. Trauma-induced proliferation of astrocytes in the brains of young and aged rats. Glia. 1989;2:201-211.
61. Cavanagh JB. The proliferation of astrocytes around a needle wound in the rat brain. J Anat. 1970;106:471-487.
62. Latov N, Nilaver G, Zimmerman EA, et al. Fibrillary astrocytes proliferate in response to brain injury. Dev Biol. 1979;72:381-384.
63. Miyake T, Hattori T, Fukuda M, Kitamura T, Fujita S. Quantitative studies on proliferative changes of reactive astrocytes in mouse cerebral cortex. Brain Res. 1988;451:133-138.
64. Miller RH, Abney ER, French-Constant C, et al. Is reactive gliosis a property of a distinct subpopulation of astrocytes? J Neurosci. 1986;6:22-29.
65. Yong VW, Kim MW, Kim SU. Human glial cells and growth factors. In: Kim SU, ed. Myelination and Demyelination: Implications for Multiple Sclerosis. New York: Plenum Press: 1989:29-48.
66. Lu SC, Bao Y, Huang Z-Z, Sarthy VP, Kannan R. Regulation of γ-glutamylcysteine synthetase subunit gene expression in retinal Müller cells by oxidative stress. Invest Ophthalmol Vis Sci. 1999; 40:1776-1782.
67. Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF. Proliferation of astrocytes in vitro in response to cytokines: a primary role for tumor necrosis factor. J Immunol. 1990;144:129-135.
68. Selmaj KW, Shafit-Zagardo B, Aquino DA, et al. Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J Neurochem. 1991;57:823-830.
69. Holländer H, Makarov F, Dreher Z, van Driel D, Chan-Ling T, Stone J. Structure of the macroglia of the retina: sharing and division of labour between astrocytes and Müller cells. J Comp Neurol. 1991; 313:587-603.
70. Newman EA. Sodium-bicarbonate cotransport in retinal astrocytes and Müller cells of the rat. Glia. 1999;26:302-308.
71. Rungger-Brändle E, Kolb H, Niemeyer G. Histochemical demonstration of glycogen in neurons of the cat retina. Invest Ophthalmol Vis Sci. 1996;37:702-715.
72. Spranger M, Fontana A. Activation of microglia: a dangerous interlude in immune function in the brain. Neuroscientist. 1996;2:293-299.
73. Giulian D, Johnson B, Krebs JF, George JK, Tapscott M. Microglial mitogens are produced in the developing and injured mammalian brain. J Cell Biol. 1991;112:323-333.
74. Liva SM, Kahn MA, Dopp JM, De Vellis J. Signal transduction pathways induced by GM-CSF in microglia: significance in the control of proliferation. Glia. 1999;26:344-352.
75. Thanos S, Mey J, Wild M. Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J Neurosci. 1993;13:455-466.
76. Chen ST, Hsu CY, Hogan EL, Halushka PV, Linet OI, Yatsu FM. Thromboxane, prostacyclin, and leukotrienes in cerebral ischemia. Neurology. 1986;36:466-471.
77. Lipton SA. Molecular mechanisms of trauma-induced neuronal degeneration. Curr Opin Neurol Neurosurg. 1993;6:588-596.
78. Lassmann H, Zimprich F, Rössler K, Vass K. Inflammation in the nervous system. Rev Neurol. 1991;147:763-781
79. Medana IM, Hunt NH, Chan-Ling T. Early activation of microglia in the pathogenesis of fatal murine cerebral malaria. Glia. 1997;19: 91-103