메뉴 건너뛰기




Volumn 21, Issue 20, 2015, Pages 2698-2712

Overcoming the skin permeation barrier: Challenges and opportunities

Author keywords

Active methods; Chemical penetration enhancers; Lipid nanoparticles; Microneedles; Passive methods; Permeation enhancement; Transdermal delivery

Indexed keywords

ALCOHOL; CERAMIDE; DRUG VEHICLE; LIPOSOME; NANOCARRIER; PENETRATION ENHANCING AGENT; POLYMER; SOLID LIPID NANOPARTICLE; TERPENE DERIVATIVE; DRUG;

EID: 84930883529     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150428124053     Document Type: Article
Times cited : (56)

References (139)
  • 1
    • 33645286192 scopus 로고    scopus 로고
    • Dermal and transdermal drug delivery systems: Current and future prospects
    • Brown MB, Martin GP, Jones SA, Akomeah FK. Dermal and transdermal drug delivery systems: current and future prospects. Drug Deliv 2006; 13: 175-87
    • (2006) Drug Deliv , vol.13 , pp. 175-187
    • Brown, M.B.1    Martin, G.P.2    Jones, S.A.3    Akomeah, F.K.4
  • 2
    • 84886034541 scopus 로고    scopus 로고
    • Transdermal and Topical Drug Delivery Today
    • John Wiley Sons Inc
    • Watkinson AC. Transdermal and Topical Drug Delivery Today. In: ed., Transdermal and Topical Drug Delivery. John Wiley Sons Inc 2011; pp: 357-66
    • (2011) Transdermal and Topical Drug Delivery , pp. 357-366
    • Watkinson, A.C.1
  • 3
    • 84885970506 scopus 로고    scopus 로고
    • Skin Structure, Function, and Permeation
    • John Wiley Sons Inc
    • Benson HAE. Skin Structure, Function, and Permeation. In: ed., Transdermal and Topical Drug Delivery. John Wiley Sons Inc 2011; pp: 1-22
    • (2011) Transdermal and Topical Drug Delivery , pp. 1-22
    • Benson, H.1
  • 4
    • 78049345788 scopus 로고    scopus 로고
    • Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery
    • Desai P, Patlolla RR, Singh M. Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery. Mol Membr Biol 2010; 27: 247-59
    • (2010) Mol Membr Biol , vol.27 , pp. 247-259
    • Desai, P.1    Patlolla, R.R.2    Singh, M.3
  • 5
    • 24344448276 scopus 로고    scopus 로고
    • Stratum corneum defensive functions: An integrated view
    • Elias PM. Stratum corneum defensive functions: an integrated view. J Invest Dermatol 2005; 125: 183-200
    • (2005) J Invest Dermatol , vol.125 , pp. 183-200
    • Elias, P.M.1
  • 6
    • 34748850100 scopus 로고    scopus 로고
    • The skin barrier as an innate immune element
    • Elias PM. The skin barrier as an innate immune element. Semin Immunopathol 2007; 29: 3-14
    • (2007) Semin Immunopathol , vol.29 , pp. 3-14
    • Elias, P.M.1
  • 10
    • 84867838466 scopus 로고    scopus 로고
    • Approaches for breaking the barriers of drug permeation through transdermal drug delivery
    • Alexander A, Dwivedi S, Ajazuddin, et al. Approaches for breaking the barriers of drug permeation through transdermal drug delivery. J Control Release 2012; 164: 26-40
    • (2012) J Control Release , vol.164 , pp. 26-40
    • Alexander, A.1    Dwivedi, Ajazuddin, S.2
  • 12
    • 0042121374 scopus 로고    scopus 로고
    • Barrier function of the skin: "la raison d'etre" of the epidermis
    • Madison KC. Barrier function of the skin: "la raison d'etre" of the epidermis. J Invest Dermatol 2003; 121: 231-41
    • (2003) J Invest Dermatol , vol.121 , pp. 231-241
    • Madison, K.C.1
  • 13
    • 65549141532 scopus 로고    scopus 로고
    • Structure and function of skin, hair and nails
    • Lai-Cheong JE, McGrath JA. Structure and function of skin, hair and nails. Medicine 2009; 37: 223-226
    • (2009) Medicine , vol.37 , pp. 223-226
    • Lai-Cheong, J.E.1    McGrath, J.A.2
  • 14
    • 79953198946 scopus 로고    scopus 로고
    • Nanoparticles and microparticles for skin drug delivery
    • Prow TW, Grice JE, Lin LL, et al. Nanoparticles and microparticles for skin drug delivery. Adv Drug Deliv Rev 2011; 63: 470-91
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 470-491
    • Prow, T.W.1    Grice, J.E.2    Lin, L.L.3
  • 15
    • 12344301866 scopus 로고    scopus 로고
    • Epidermal differentiation: The role of proteases and their inhibitors
    • Zeeuwen PLJM. Epidermal differentiation: The role of proteases and their inhibitors. Eur J Cell Biol 2004; 83: 761-73
    • (2004) Eur J Cell Biol , vol.83 , pp. 761-773
    • Zeeuwen, P.1
  • 16
    • 26444570089 scopus 로고    scopus 로고
    • Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity
    • Hachem JP, Man MQ, Crumrine D, et al. Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol 2005; 125: 510-20
    • (2005) J Invest Dermatol , vol.125 , pp. 510-520
    • Hachem, J.P.1    Man, M.Q.2    Crumrine, D.3
  • 17
    • 0036852419 scopus 로고    scopus 로고
    • New insights into skin structure: Scratching the surface
    • Menon GK. New insights into skin structure: scratching the surface. Adv Drug Deliv Rev 2002; 54, (Suppl): S3-17
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. S3-S17
    • Menon, G.K.1
  • 18
    • 0036511049 scopus 로고    scopus 로고
    • Recent progress in studies on Merkel cell biology
    • Tachibana T, Nawa T. Recent progress in studies on Merkel cell biology. Anat Sci Int 2002; 77: 26-33
    • (2002) Anat Sci Int , vol.77 , pp. 26-33
    • Tachibana, T.1    Nawa, T.2
  • 19
    • 0023949069 scopus 로고
    • The epidermal permeability barrier
    • Landmann L. The epidermal permeability barrier. Anat Embryol 1988; 178: 1-13
    • (1988) Anat Embryol , vol.178 , pp. 1-13
    • Landmann, L.1
  • 20
    • 0027183540 scopus 로고
    • Purification and preliminary characterization of stratum corneum chymotryptic enzyme: A proteinase that may be involved in desquamation
    • Egelrud T. Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation. J Invest Dermatol 1993; 101: 200-4
    • (1993) J Invest Dermatol , vol.101 , pp. 200-204
    • Egelrud, T.1
  • 21
    • 0020608231 scopus 로고
    • Epidermal lipids, barrier function, and desquamation
    • Elias PM. Epidermal lipids, barrier function, and desquamation. J Invest Dermatol 1983; 80: 44s-9
    • (1983) J Invest Dermatol , vol.80 , pp. 44s-49s
    • Elias, P.M.1
  • 22
    • 0033620472 scopus 로고    scopus 로고
    • Bricks and mortar of the epidermal barrier
    • Nemes Z, Steinert PM. Bricks and mortar of the epidermal barrier. Exp Mol Med 1999; 31: 5-19
    • (1999) Exp Mol Med , vol.31 , pp. 5-19
    • Nemes, Z.1    Steinert, P.M.2
  • 23
    • 34047122673 scopus 로고    scopus 로고
    • Structure and function of the epidermal barrier
    • Wickett RR, Visscher MO. Structure and function of the epidermal barrier. Am J Infect Control 2006; 34: S98-110
    • (2006) Am J Infect Control , vol.34 , pp. S98-S110
    • Wickett, R.R.1    Visscher, M.O.2
  • 24
    • 0029131753 scopus 로고
    • Lipids are covalently attached to rigid corneocyte protein envelopes existing predominantly as beta- sheets: A solid-state nuclear magnetic resonance study
    • Lazo ND, Meine JG, Downing DT. Lipids are covalently attached to rigid corneocyte protein envelopes existing predominantly as beta- sheets: a solid-state nuclear magnetic resonance study. J Invest Dermatol 1995; 105: 296-300
    • (1995) J Invest Dermatol , vol.105 , pp. 296-300
    • Lazo, N.D.1    Meine, J.G.2    Downing, D.T.3
  • 25
    • 0034081229 scopus 로고    scopus 로고
    • Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function
    • Behne M, Uchida Y, Seki T, de Montellano PO, Elias PM, Holleran WM. Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. J Invest Dermatol 2000; 114: 185-92
    • (2000) J Invest Dermatol , vol.114 , pp. 185-192
    • Behne, M.1    Uchida, Y.2    Seki, T.3    De Montellano, P.O.4    Elias, P.M.5    Holleran, W.M.6
  • 27
    • 50949109754 scopus 로고    scopus 로고
    • Characterization of overall ceramide species in human stratum corneum
    • Masukawa Y, Narita H, Shimizu E, et al. Characterization of overall ceramide species in human stratum corneum. J Lipid Res 2008; 49: 1466-76
    • (2008) J Lipid Res , vol.49 , pp. 1466-1476
    • Masukawa, Y.1    Narita, H.2    Shimizu, E.3
  • 28
    • 84859757836 scopus 로고    scopus 로고
    • Influence of skin type, race, sex, and anatomic location on epidermal barrier function
    • Darlenski R, Fluhr JW. Influence of skin type, race, sex, and anatomic location on epidermal barrier function. Clin Dermatol 2012; 30: 269-73
    • (2012) Clin Dermatol , vol.30 , pp. 269-273
    • Darlenski, R.1    Fluhr, J.W.2
  • 29
    • 33645893177 scopus 로고    scopus 로고
    • Study of human stratum corneum and extracted lipids by thermomicroscopy and DSC
    • Silva CL, Nunes SCC, Eusébio MES, Sousa JJS, Pais AACC. Study of human stratum corneum and extracted lipids by thermomicroscopy and DSC. Chem Phys Lipids 2006; 140: 36-47
    • (2006) Chem Phys Lipids , vol.140 , pp. 36-47
    • Silva, C.L.1    Nunes, S.2    Eusébio, M.3    Sousa, J.4    Pais, A.5
  • 31
    • 0031879094 scopus 로고    scopus 로고
    • Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum
    • Sato J, Denda M, Nakanishi J, Nomura J, Koyama J. Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum. J Invest Dermatol 1998; 111: 189-93
    • (1998) J Invest Dermatol , vol.111 , pp. 189-193
    • Sato, J.1    Denda, M.2    Nakanishi, J.3    Nomura, J.4    Koyama, J.5
  • 32
    • 0031672087 scopus 로고    scopus 로고
    • A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction
    • Norlen L, Nicander I, Lundsjo A, Cronholm T, Forslind B. A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction. Arch Dermatol Res 1998; 290: 508-16
    • (1998) Arch Dermatol Res , vol.290 , pp. 508-516
    • Norlen, L.1    Nicander, I.2    Lundsjo, A.3    Cronholm, T.4    Forslind, B.5
  • 34
    • 0034778702 scopus 로고    scopus 로고
    • Skin barrier structure and function: The single gel phase model
    • Norlen L. Skin barrier structure and function: the single gel phase model. J Invest Dermatol 2001; 117: 830-6
    • (2001) J Invest Dermatol , vol.117 , pp. 830-836
    • Norlen, L.1
  • 36
    • 33646563138 scopus 로고    scopus 로고
    • Overcoming the stratum corneum: The modulation of skin penetration
    • Trommer H, Neubert RHH. Overcoming the stratum corneum: the modulation of skin penetration. Skin Pharmacol Physiol 2006; 19: 106-21
    • (2006) Skin Pharmacol Physiol , vol.19 , pp. 106-121
    • Trommer, H.1    Neubert, R.2
  • 37
    • 0034902043 scopus 로고    scopus 로고
    • Novel mechanisms and devices to enable successful transdermal drug delivery
    • Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 2001; 14: 101-14
    • (2001) Eur J Pharm Sci , vol.14 , pp. 101-114
    • Barry, B.W.1
  • 40
  • 41
    • 0036380418 scopus 로고    scopus 로고
    • Influence of age on the wrinkling capacities of skin
    • Batisse D, Bazin R, Baldeweck T. Influence of age on the wrinkling capacities of skin. Skin Res Technol 2002; 8: 148-54
    • (2002) Skin Res Technol , vol.8 , pp. 148-154
    • Batisse, D.1    Bazin, R.2    Baldeweck, T.3
  • 42
    • 0024953967 scopus 로고
    • The effect of aging on percutaneous absorption in man
    • Roskos K, Maibach H, Guy R. The effect of aging on percutaneous absorption in man. J Pharmacokinetics Biopharm 1989; 17: 617-30
    • (1989) J Pharmacokinetics Biopharm , vol.17 , pp. 617-630
    • Roskos, K.1    Maibach, H.2    Guy, R.3
  • 43
    • 0035013520 scopus 로고    scopus 로고
    • Skin barrier, hydration, and pH of the skin of infants under 2 years of age
    • Giusti F, Martella A, Bertoni L, Seidenari S. Skin barrier, hydration, and pH of the skin of infants under 2 years of age. Pediatric Dermatol 2001; 18: 93-6
    • (2001) Pediatric Dermatol , vol.18 , pp. 93-96
    • Giusti, F.1    Martella, A.2    Bertoni, L.3    Seidenari, S.4
  • 44
    • 0025115692 scopus 로고
    • Frictional properties of human skin: Relation to age, sex and anatomical region, stratum corneum hydration and transepidermal water loss
    • Cua AB, Wilhelm KP, Maibach HI. Frictional properties of human skin: relation to age, sex and anatomical region, stratum corneum hydration and transepidermal water loss. Br J Dermatol 1990; 123: 473-9
    • (1990) Br J Dermatol , vol.123 , pp. 473-479
    • Cua, A.B.1    Wilhelm, K.P.2    Maibach, H.I.3
  • 45
    • 0024594970 scopus 로고
    • Baseline transepidermal water loss (TEWL) as a prediction of susceptibility to sodium lauryl sulphate
    • Tupker RA, Coenraads PJ, Pinnagoda J, Nater JP. Baseline transepidermal water loss (TEWL) as a prediction of susceptibility to sodium lauryl sulphate. Contact Dermatitis 1989; 20: 265-9
    • (1989) Contact Dermatitis , vol.20 , pp. 265-269
    • Tupker, R.A.1    Coenraads, P.J.2    Pinnagoda, J.3    Nater, J.P.4
  • 46
    • 0026521395 scopus 로고
    • System functionality and physicochemical model of fentanyl transdermal system
    • Gupta SK, Southam M, Gale R, Hwang SS. System functionality and physicochemical model of fentanyl transdermal system. J Pain Symptom Management 1992; 7: S17-26
    • (1992) J Pain Symptom Management , vol.7 , pp. S17-S26
    • Gupta, S.K.1    Southam, M.2    Gale, R.3    Hwang, S.S.4
  • 48
    • 0034282141 scopus 로고    scopus 로고
    • Transdermal drug delivery: Overcoming the skin’s barrier function
    • Naik A, Kalia YN, Guy RH. Transdermal drug delivery: overcoming the skin’s barrier function. Pharm Sci Technol Today 2000; 3: 318-26
    • (2000) Pharm Sci Technol Today , vol.3 , pp. 318-326
    • Naik, A.1    Kalia, Y.N.2    Guy, R.H.3
  • 50
    • 84874943703 scopus 로고    scopus 로고
    • Co-encapsulating nanostructured lipid carriers for transdermal application: From experimental design to the molecular detail
    • Vitorino C, Almeida J, Gonçalves LM, Almeida AJ, Sousa JJ, Pais AACC. Co-encapsulating nanostructured lipid carriers for transdermal application: From experimental design to the molecular detail. J Control Release 2013; 167: 301-314
    • (2013) J Control Release , vol.167 , pp. 301-314
    • Vitorino, C.1    Almeida, J.2    Gonçalves, L.M.3    Almeida, A.J.4    Sousa, J.J.5    Pais, A.6
  • 52
    • 0030899727 scopus 로고    scopus 로고
    • The penetration of supersaturated solutions of piroxicam across silicone membranes and human skin in vitro
    • Pellett MA, Castellano S, Hadgraft J, Davis AF. The penetration of supersaturated solutions of piroxicam across silicone membranes and human skin in vitro. J Control Release 1997; 46: 205-14
    • (1997) J Control Release , vol.46 , pp. 205-214
    • Pellett, M.A.1    Castellano, S.2    Hadgraft, J.3    Davis, A.F.4
  • 53
    • 0031695851 scopus 로고    scopus 로고
    • Transdermal delivery of estradiol in postmenopausal women with a novel topical aerosol
    • Morgan TM, O'Sullivan HMM, Reed BL, Finnin BC. Transdermal delivery of estradiol in postmenopausal women with a novel topical aerosol. J Pharm Sci 1998; 87: 1226-8
    • (1998) J Pharm Sci , vol.87 , pp. 1226-1228
    • Morgan, T.M.1    O'sullivan, H.2    Reed, B.L.3    Finnin, B.C.4
  • 54
    • 0032956744 scopus 로고    scopus 로고
    • Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations
    • Marjukka Suhonen T, A. Bouwstra J, Urtti A. Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. J Control Release 1999; 59: 149-61
    • (1999) J Control Release , vol.59 , pp. 149-161
    • Marjukka Suhonen, T.1    Bouwstra, A.2    Urtti, A.3
  • 55
    • 0032472340 scopus 로고    scopus 로고
    • Transdermal delivery from eutectic systems: Enhanced permeation of a model drug, ibuprofen
    • Stott PW, Williams AC, Barry BW. Transdermal delivery from eutectic systems: enhanced permeation of a model drug, ibuprofen. J Control Release 1998; 50: 297-308
    • (1998) J Control Release , vol.50 , pp. 297-308
    • Stott, P.W.1    Williams, A.C.2    Barry, B.W.3
  • 56
    • 0032883241 scopus 로고    scopus 로고
    • Transdermal penetration enhancers: Applications, limitations, and potential
    • Finnin BC, Morgan TM. Transdermal penetration enhancers: Applications, limitations, and potential. J Pharm Sci 1999; 88: 955-8
    • (1999) J Pharm Sci , vol.88 , pp. 955-958
    • Finnin, B.C.1    Morgan, T.M.2
  • 57
    • 0025906898 scopus 로고
    • Lipid-Protein-Partitioning theory of skin penetration enhancement
    • Barry BW. Lipid-Protein-Partitioning theory of skin penetration enhancement. J Control Release 1991; 15: 237-48
    • (1991) J Control Release , vol.15 , pp. 237-248
    • Barry, B.W.1
  • 59
    • 0742270987 scopus 로고    scopus 로고
    • Breaching the skin's barrier to drugs
    • Barry BW. Breaching the skin's barrier to drugs. Nat Biotechnol 2004; 22: 165-7
    • (2004) Nat Biotechnol , vol.22 , pp. 165-167
    • Barry, B.W.1
  • 60
    • 78049386886 scopus 로고    scopus 로고
    • The effect of cationic gemini surfactants upon lipid membranes. An experimental and molecular dynamics simulation study
    • Almeida JAS, Marques EF, Jurado AS, Pais AACC. The effect of cationic gemini surfactants upon lipid membranes. An experimental and molecular dynamics simulation study. Phys Chem Chem Phys 2010; 12: 14462-76
    • (2010) Phys Chem Chem Phys , vol.12 , pp. 14462-14476
    • Almeida, J.1    Marques, E.F.2    Jurado, A.S.3    Pais, A.4
  • 61
    • 84888009099 scopus 로고    scopus 로고
    • Structure activity relationships in alkylammonium C12-gemini surfactants used as dermal permeation enhancers
    • Silva SC, Sousa JS, Marques E, Pais ACC, Michniak-Kohn B. Structure activity relationships in alkylammonium C12-gemini surfactants used as dermal permeation enhancers. AAPS J 2013; 15: 1119-27
    • (2013) AAPS J , vol.15 , pp. 1119-1127
    • Silva, S.C.1    Sousa, J.S.2    Marques, E.3    Pais, A.4    Michniak-Kohn, B.5
  • 62
    • 0025905320 scopus 로고
    • Evidence that oleic acid exists in a separate phase within stratum corneum lipids
    • Ongpipattanakul B, Burnette RR, Potts RO, Francoeur ML. Evidence that oleic acid exists in a separate phase within stratum corneum lipids. Pharm Res 1991; 8: 350-4
    • (1991) Pharm Res , vol.8 , pp. 350-354
    • Ongpipattanakul, B.1    Burnette, R.R.2    Potts, R.O.3    Francoeur, M.L.4
  • 63
    • 0033037654 scopus 로고    scopus 로고
    • Passive enhancement strategies in topical and transdermal drug delivery
    • Hadgraft J. Passive enhancement strategies in topical and transdermal drug delivery. Int J Pharm 1999; 184: 1-6
    • (1999) Int J Pharm , vol.184 , pp. 1-6
    • Hadgraft, J.1
  • 64
    • 85012373035 scopus 로고
    • Diffusion of univalent ions across the lamellae of swollen phospholipids
    • Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965; 13: 238-IN27
    • (1965) J Mol Biol , vol.13
    • Bangham, A.D.1    Standish, M.M.2    Watkins, J.C.3
  • 65
    • 0027533544 scopus 로고
    • Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential
    • Gregoriadis G, Florence AT. Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential. Drugs 1993; 45: 15-28
    • (1993) Drugs , vol.45 , pp. 15-28
    • Gregoriadis, G.1    Florence, A.T.2
  • 66
    • 58149325630 scopus 로고
    • Non-ionic surfactant vesicles (Niosomes): Physical and pharmaceutical chemistry
    • Uchegbu IF, Florence AT. Non-ionic surfactant vesicles (niosomes): Physical and pharmaceutical chemistry. Adv Colloid Interface Sci 1995; 58: 1-55
    • (1995) Adv Colloid Interface Sci , vol.58 , pp. 1-55
    • Uchegbu, I.F.1    Florence, A.T.2
  • 67
    • 0033996247 scopus 로고    scopus 로고
    • Ethosomes - novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties
    • Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 2000; 65: 403-18
    • (2000) J Control Release , vol.65 , pp. 403-418
    • Touitou, E.1    Dayan, N.2    Bergelson, L.3    Godin, B.4    Eliaz, M.5
  • 68
    • 0030470587 scopus 로고    scopus 로고
    • Transfersomes, liposomes and other lipid suspensions on the skin: Permeation enhancement, vesicle penetration, and transdermal drug delivery
    • Cevc G. Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery. Crit Rev Ther Drug Carrier Syst 1996; 13: 257-388
    • (1996) Crit Rev Ther Drug Carrier Syst , vol.13 , pp. 257-388
    • Cevc, G.1
  • 70
    • 0019309326 scopus 로고
    • Liposomes - a selective drug delivery system for the topical route of administration I. Lotion dosage form
    • Mezei M, Gulasekharam V. Liposomes - a selective drug delivery system for the topical route of administration I. Lotion dosage form. Life Sci 1980; 26: 1473-7
    • (1980) Life Sci , vol.26 , pp. 1473-1477
    • Mezei, M.1    Gulasekharam, V.2
  • 72
    • 0035479411 scopus 로고    scopus 로고
    • New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes
    • Cevc G, Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochimica et Biophysica Acta (BBA) - Biomembranes 2001; 1514: 191-205
    • (2001) Biochimica Et Biophysica Acta (BBA) - Biomembranes , vol.1514 , pp. 191-205
    • Cevc, G.1    Blume, G.2
  • 73
    • 33846905467 scopus 로고    scopus 로고
    • Lipid vesicles for skin delivery of drugs: Reviewing three decades of research
    • Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM. Lipid vesicles for skin delivery of drugs: reviewing three decades of research. Int J Pharm 2007; 332: 1-16
    • (2007) Int J Pharm , vol.332 , pp. 1-16
    • Elsayed, M.1    Abdallah, O.Y.2    Naggar, V.F.3    Khalafallah, N.M.4
  • 74
    • 33750507126 scopus 로고    scopus 로고
    • Microemulsions as transdermal drug delivery vehicles
    • Kogan A, Garti N. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci 2006; 126: 369-85
    • (2006) Adv Colloid Interface Sci , vol.126 , pp. 369-385
    • Kogan, A.1    Garti, N.2
  • 76
    • 84930888328 scopus 로고
    • Medication vehicles made of solid lipid particles (Solid lipid nanospheres-SLN)
    • ed, (Fehlandtstrasse 3, Hamburg, D-20354, DE)
    • Lucks S, Müller R. Medication vehicles made of solid lipid particles (solid lipid nanospheres-SLN). In: ed., MEDAC Gesellschaft für klinische spezial präparate GmbH (Fehlandtstrasse 3, Hamburg, D-20354, DE) 1991
    • (1991) MEDAC Gesellschaft für Klinische Spezial präparate Gmbh
    • Lucks, S.1    Müller, R.2
  • 78
    • 85039894183 scopus 로고    scopus 로고
    • Lipid particles based on matrix comprising solid and liquid lipid, useful in diagnostics and for controlled release of active agents, especially pharmaceuticals
    • (2000)
  • 79
    • 57849099131 scopus 로고    scopus 로고
    • Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products
    • Pardeike J, Hommoss A, Müller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm 2009; 366: 170-84
    • (2009) Int J Pharm , vol.366 , pp. 170-184
    • Pardeike, J.1    Hommoss, A.2    Müller, R.H.3
  • 80
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002; 54: S131-55
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. S131-S155
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 81
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • Wissing SA, Kayser O, Müller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 2004; 56: 1257-1272
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1257-1272
    • Wissing, S.A.1    Kayser, O.2    Müller, R.H.3
  • 82
    • 33748353240 scopus 로고    scopus 로고
    • Nanocarriers: Promising Vehicle for Bioactive Drugs
    • Rawat M, Singh D, Saraf S, Saraf S. Nanocarriers: Promising Vehicle for Bioactive Drugs. Biol Pharm Bull 2006; 29: 1790-8
    • (2006) Biol Pharm Bull , vol.29 , pp. 1790-1798
    • Rawat, M.1    Singh, D.2    Saraf, S.3    Saraf, S.4
  • 84
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • Mehnert W, Mäder K. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 2001; 47: 165-96
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 85
    • 0037151496 scopus 로고    scopus 로고
    • Nanostructured lipid matrices for improved microencapsulation of drugs
    • Müller RH, Radtke M, Wissing SA. Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 2002; 242: 121-8
    • (2002) Int J Pharm , vol.242 , pp. 121-128
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 86
    • 34250893864 scopus 로고    scopus 로고
    • Cetyl palmitate-based NLC for topical delivery of Coenzyme Q10 - Development, physicochemical characterization and in vitro release studies
    • Teeranachaideekul V, Souto EB, Junyaprasert VB, Müller RH. Cetyl palmitate-based NLC for topical delivery of Coenzyme Q10 - Development, physicochemical characterization and in vitro release studies. Eur J Pharm Biopharm 2007; 67: 141-8
    • (2007) Eur J Pharm Biopharm , vol.67 , pp. 141-148
    • Teeranachaideekul, V.1    Souto, E.B.2    Junyaprasert, V.B.3    Müller, R.H.4
  • 87
    • 57349171371 scopus 로고    scopus 로고
    • Lipid nanoparticles with a solid matrix (SLN®, NLC®, LDC®) for oral drug delivery
    • Muchow M, Maincent P, Müller RH. Lipid nanoparticles with a solid matrix (SLN®, NLC®, LDC®) for oral drug delivery. Drug Develop Ind Pharm 2008; 34: 1394-405
    • (2008) Drug Develop Ind Pharm , vol.34 , pp. 1394-1405
    • Muchow, M.1    Maincent, P.2    Müller, R.H.3
  • 88
    • 79956102907 scopus 로고    scopus 로고
    • SLN and NLC): Present state of development and industrial applications. Curr Drug Discov Technol
    • Müller RH, Shegokar R, Keck CM. 20 Years of Lipid Nanoparticles (SLN and NLC): Present state of development and industrial applications. Curr Drug Discov Technol 2011
    • (2011) 20 Years of Lipid Nanoparticles
    • Müller, R.H.1    Shegokar, R.2    Keck, C.M.3
  • 89
    • 1542611547 scopus 로고    scopus 로고
    • Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles
    • Venkateswarlu V, Manjunath K. Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J Control Release 2004; 95: 627-38
    • (2004) J Control Release , vol.95 , pp. 627-638
    • Venkateswarlu, V.1    Manjunath, K.2
  • 90
    • 0031960962 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery - Drug release and release mechanism
    • zur Mühlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery - Drug release and release mechanism. Eur J Pharm Biopharm 1998; 45: 149-55
    • (1998) Eur J Pharm Biopharm , vol.45 , pp. 149-155
    • Zur Mühlen, A.1    Schwarz, C.2    Mehnert, W.3
  • 91
    • 2442712381 scopus 로고    scopus 로고
    • Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
    • Souto EB, Wissing SA, Barbosa CM, Müller RH. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm 2004; 278: 71-7
    • (2004) Int J Pharm , vol.278 , pp. 71-77
    • Souto, E.B.1    Wissing, S.A.2    Barbosa, C.M.3    Müller, R.H.4
  • 92
    • 0030949023 scopus 로고    scopus 로고
    • Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant
    • Müller RH, Rühl D, Runge S, Schulze-Forster K, Mehnert W. Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant. Pharm Res 1997; 14: 458-62
    • (1997) Pharm Res , vol.14 , pp. 458-462
    • Müller, R.H.1    Rühl, D.2    Runge, S.3    Schulze-Forster, K.4    Mehnert, W.5
  • 93
    • 34547913813 scopus 로고    scopus 로고
    • Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles
    • Wong HL, Bendayan R, Rauth AM, Li Y, Wu XY. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev 2007; 59: 491-504
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 491-504
    • Wong, H.L.1    Bendayan, R.2    Rauth, A.M.3    Li, Y.4    Wu, X.Y.5
  • 94
    • 56749105731 scopus 로고    scopus 로고
    • Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: In vitro and in vivo characteristics
    • Bhaskar K, Mohan CK, Lingam M, et al. Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics. Drug Develop Ind Pharm 2009; 35: 98-113
    • (2009) Drug Develop Ind Pharm , vol.35 , pp. 98-113
    • Bhaskar, K.1    Mohan, C.K.2    Lingam, M.3
  • 95
    • 36148968932 scopus 로고    scopus 로고
    • Nanostructured lipid carrier (NLC) based gel of celecoxib
    • Joshi M, Patravale V. Nanostructured lipid carrier (NLC) based gel of celecoxib. Int J Pharm 2008; 346: 124-32
    • (2008) Int J Pharm , vol.346 , pp. 124-132
    • Joshi, M.1    Patravale, V.2
  • 96
    • 75749149383 scopus 로고    scopus 로고
    • Chitosantripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability
    • Hasanovic A, Zehl M, Reznicek G, Valenta C. Chitosantripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability. J Pharm Pharmacol 2009; 61: 1609-16
    • (2009) J Pharm Pharmacol , vol.61 , pp. 1609-1616
    • Hasanovic, A.1    Zehl, M.2    Reznicek, G.3    Valenta, C.4
  • 97
    • 67650064830 scopus 로고    scopus 로고
    • Investigation of polylactic acid (PLA) nanoparticles as drug delivery systems for local dermatotherapy
    • Rancan F, Papakostas D, Hadam S, et al. Investigation of polylactic acid (PLA) nanoparticles as drug delivery systems for local dermatotherapy. Pharm Res 2009; 26: 2027-36
    • (2009) Pharm Res , vol.26 , pp. 2027-2036
    • Rancan, F.1    Papakostas, D.2    Hadam, S.3
  • 98
    • 78349312540 scopus 로고    scopus 로고
    • Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles
    • Zhang W, Gao J, Zhu Q, et al. Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles. Int J Pharm 2010; 402: 205-12
    • (2010) Int J Pharm , vol.402 , pp. 205-212
    • Zhang, W.1    Gao, J.2    Zhu, Q.3
  • 99
    • 33947499733 scopus 로고    scopus 로고
    • Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers
    • Yiyun C, Na M, Tongwen X, et al. Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers. J Pharm Sci 2007; 96: 595-602
    • (2007) J Pharm Sci , vol.96 , pp. 595-602
    • Yiyun, C.1    Na, M.2    Tongwen, X.3
  • 100
    • 78649319195 scopus 로고    scopus 로고
    • Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design
    • Murthy SN, Sammeta SM, Bowers C. Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design. J Control Release 2010; 148: 197-203
    • (2010) J Control Release , vol.148 , pp. 197-203
    • Murthy, S.N.1    Sammeta, S.M.2    Bowers, C.3
  • 101
    • 1542358753 scopus 로고    scopus 로고
    • Transdermal drug delivery with a pressure wave
    • Doukas AG, Kollias N. Transdermal drug delivery with a pressure wave. Adv Drug Deliv Rev 2004; 56: 559-79
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 559-579
    • Doukas, A.G.1    Kollias, N.2
  • 102
    • 84874929996 scopus 로고    scopus 로고
    • Stratum corneum permeabilization with photoacoustic waves generated by piezophotonic materials
    • Sá GFF, Serpa C, Arnaut LG. Stratum corneum permeabilization with photoacoustic waves generated by piezophotonic materials. J Control Release 2013; 167: 290-300
    • (2013) J Control Release , vol.167 , pp. 290-300
    • Sá, G.1    Serpa, C.2    Arnaut, L.G.3
  • 103
    • 55649101168 scopus 로고    scopus 로고
    • Micro-scale devices for transdermal drug delivery
    • Arora A, Prausnitz MR, Mitragotri S. Micro-scale devices for transdermal drug delivery. Int J Pharm 2008; 364: 227-36
    • (2008) Int J Pharm , vol.364 , pp. 227-236
    • Arora, A.1    Prausnitz, M.R.2    Mitragotri, S.3
  • 106
    • 84858159621 scopus 로고    scopus 로고
    • A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl
    • Silva SMC, Hu L, Sousa JJS, Pais AACC, Michniak-Kohn BB. A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl. Eur J Pharm Biopharm 2012; 80: 663-73
    • (2012) Eur J Pharm Biopharm , vol.80 , pp. 663-673
    • Silva, S.1    Hu, L.2    Sousa, J.3    Pais, A.4    Michniak-Kohn, B.B.5
  • 107
    • 1542328820 scopus 로고    scopus 로고
    • Skin electroporation for transdermal and topical delivery
    • Denet A-R, Vanbever R, Préat V. Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev 2004; 56: 659-74
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 659-674
    • Denet, A.-R.1    Vanbever, R.2    Préat, V.3
  • 108
    • 44149105335 scopus 로고    scopus 로고
    • Low-frequency sonophoresis: Current status and future prospects
    • Ogura M, Paliwal S, Mitragotri S. Low-frequency sonophoresis: Current status and future prospects. Adv Drug Deliv Rev 2008; 60: 1218-23
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1218-1223
    • Ogura, M.1    Paliwal, S.2    Mitragotri, S.3
  • 109
    • 0037130568 scopus 로고    scopus 로고
    • Sonicated transdermal drug transport
    • Joshi A, Raje J. Sonicated transdermal drug transport. J Control Release 2002; 83: 13-22
    • (2002) J Control Release , vol.83 , pp. 13-22
    • Joshi, A.1    Raje, J.2
  • 110
    • 34249896035 scopus 로고    scopus 로고
    • Perspectives on transdermal ultrasound mediated drug delivery
    • Smith NB. Perspectives on transdermal ultrasound mediated drug delivery. Int J Nanomed 2007; 2: 585-94
    • (2007) Int J Nanomed , vol.2 , pp. 585-594
    • Smith, N.B.1
  • 111
    • 48249100198 scopus 로고    scopus 로고
    • Delivering drugs by the transdermal route: Review and comment
    • Tanner T, Marks R. Delivering drugs by the transdermal route: review and comment. Skin Res Technol 2008; 14: 249-60
    • (2008) Skin Res Technol , vol.14 , pp. 249-260
    • Tanner, T.1    Marks, R.2
  • 112
    • 84862675560 scopus 로고    scopus 로고
    • Microneedle technologies for (Trans)dermal drug and vaccine delivery
    • van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release 2012; 161: 645-55
    • (2012) J Control Release , vol.161 , pp. 645-655
    • Van Der Maaden, K.1    Jiskoot, W.2    Bouwstra, J.3
  • 113
    • 84864575139 scopus 로고    scopus 로고
    • The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin
    • Liu S, Jin MN, Quan YS, et al. The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin. J Control Release 2012; 161: 933-41
    • (2012) J Control Release , vol.161 , pp. 933-941
    • Liu, S.1    Jin, M.N.2    Quan, Y.S.3
  • 114
    • 53549130424 scopus 로고    scopus 로고
    • Proteins and peptides: Strategies for delivery to and across the skin
    • Benson HAE, Namjoshi S. Proteins and peptides: Strategies for delivery to and across the skin. J Pharm Sci 2008; 97: 3591-610
    • (2008) J Pharm Sci , vol.97 , pp. 3591-3610
    • Benson, H.1    Namjoshi, S.2
  • 117
    • 78649319195 scopus 로고    scopus 로고
    • Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design
    • Murthy SN, Sammeta SM, Bowers C. Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design. J Control Release 2010; 148: 197-203
    • (2010) J Control Release , vol.148 , pp. 197-203
    • Murthy, S.N.1    Sammeta, S.M.2    Bowers, C.3
  • 118
    • 79961161684 scopus 로고    scopus 로고
    • Magnetophoresis in combination with chemical enhancers for transdermal drug delivery
    • Sammeta SM, Repka MA, Narasimha Murthy S. Magnetophoresis in combination with chemical enhancers for transdermal drug delivery. Drug Dev Ind Pharm 2011; 37: 1076-82
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 1076-1082
    • Sammeta, S.M.1    Repka, M.A.2    Narasimha Murthy, S.3
  • 119
    • 0041342090 scopus 로고    scopus 로고
    • Ultrastructural evidence of stratum corneum permeabilization induced by photomechanical waves
    • Menon GK, Kollias N, Doukas AG. Ultrastructural evidence of stratum corneum permeabilization induced by photomechanical waves. J Invest Dermatol 2003; 121: 104-9
    • (2003) J Invest Dermatol , vol.121 , pp. 104-109
    • Menon, G.K.1    Kollias, N.2    Doukas, A.G.3
  • 120
    • 0033337173 scopus 로고    scopus 로고
    • Laser-generated stress waves and their effects on the cell membrane. Selected topics in quantum electronics
    • Lee S, Doukas A. Laser-generated stress waves and their effects on the cell membrane. Selected topics in quantum electronics. IEEE J 1999; 5: 997-1003
    • (1999) IEEE J , vol.5 , pp. 997-1003
    • Lee, S.1    Doukas, A.2
  • 121
    • 84897860758 scopus 로고    scopus 로고
    • Lasers as an approach for promoting drug delivery via skin
    • Lin CH, Aljuffali IA, Fang JY. Lasers as an approach for promoting drug delivery via skin. Expert Opin Drug Deliv 2014; 11: 599-614
    • (2014) Expert Opin Drug Deliv , vol.11 , pp. 599-614
    • Lin, C.H.1    Aljuffali, I.A.2    Fang, J.Y.3
  • 122
    • 3042515268 scopus 로고    scopus 로고
    • The effect of pretreatment with terpenes on transdermal iontophoretic delivery of arginine vasopressin
    • Nair VB, Panchagnula R. The effect of pretreatment with terpenes on transdermal iontophoretic delivery of arginine vasopressin. Il Farmaco 2004; 59: 575-81
    • (2004) Il Farmaco , vol.59 , pp. 575-581
    • Nair, V.B.1    Panchagnula, R.2
  • 123
    • 53949108970 scopus 로고    scopus 로고
    • Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate
    • Liu W, Hu M, Liu W, Xue C, Xu H, Yang X. Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate. Int J Pharm 2008; 364: 135-41
    • (2008) Int J Pharm , vol.364 , pp. 135-141
    • Liu, W.1    Hu, M.2    Liu, W.3    Xue, C.4    Xu, H.5    Yang, X.6
  • 124
    • 1242293732 scopus 로고    scopus 로고
    • Mechanism of the synergic effects of calcium chloride and electroporation on the in vitro enhanced skin permeation of drugs
    • Tokudome Y, Sugibayashi K. Mechanism of the synergic effects of calcium chloride and electroporation on the in vitro enhanced skin permeation of drugs. J Control Release 2004; 95: 267-74
    • (2004) J Control Release , vol.95 , pp. 267-274
    • Tokudome, Y.1    Sugibayashi, K.2
  • 125
    • 77953364279 scopus 로고    scopus 로고
    • Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with fullthickness and split-thickness pig and human skin
    • Seto JE, Polat BE, Lopez RFV, Blankschtein D, Langer R. Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: comparative in vitro studies with fullthickness and split-thickness pig and human skin. J Control Release 2010; 145: 26-32
    • (2010) J Control Release , vol.145 , pp. 26-32
    • Seto, J.E.1    Polat, B.E.2    Lopez, R.3    Blankschtein, D.4    Langer, R.5
  • 126
    • 84855830076 scopus 로고    scopus 로고
    • Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management. Nanomed: Nanotechnol
    • Qin G, Gao Y, Wu Y, et al. Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management. Nanomed: Nanotechnol, Biol Med 2012; 8: 221-227
    • (2012) Biol Med , vol.8 , pp. 221-227
    • Qin, G.1    Gao, Y.2    Wu, Y.3
  • 127
    • 77149175967 scopus 로고    scopus 로고
    • Sonophoretic enhanced microneedles array (SEMA)—Improving the efficiency of transdermal drug delivery
    • Chen B, Wei J, Iliescu C. Sonophoretic enhanced microneedles array (SEMA)—Improving the efficiency of transdermal drug delivery. Sens Actuat B: Chem 2010; 145: 54-60
    • (2010) Sens Actuat B: Chem , vol.145 , pp. 54-60
    • Chen, B.1    Wei, J.2    Iliescu, C.3
  • 128
    • 31544458945 scopus 로고    scopus 로고
    • Painless electroporation with a new needle-free microelectrode array to enhance transdermal drug delivery
    • Wong T-W, Chen C-H, Huang C-C, Lin C-D, Hui S-W. Painless electroporation with a new needle-free microelectrode array to enhance transdermal drug delivery. J Control Release 2006; 110: 557-65
    • (2006) J Control Release , vol.110 , pp. 557-565
    • Wong, T.-W.1    Chen, C.-H.2    Huang, C.-C.3    Lin, C.-D.4    Hui, S.-W.5
  • 129
    • 33750488402 scopus 로고    scopus 로고
    • Effect of electroporation and pH on the iontophoretic transdermal delivery of human insulin
    • Tokumoto S, Higo N, Sugibayashi K. Effect of electroporation and pH on the iontophoretic transdermal delivery of human insulin. Int J Pharm 2006; 326: 13-9
    • (2006) Int J Pharm , vol.326 , pp. 13-19
    • Tokumoto, S.1    Higo, N.2    Sugibayashi, K.3
  • 130
    • 4544275025 scopus 로고    scopus 로고
    • Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles
    • Muller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol 2004; 113: 151-70
    • (2004) J Biotechnol , vol.113 , pp. 151-170
    • Muller, R.H.1    Keck, C.M.2
  • 131
    • 17344391922 scopus 로고    scopus 로고
    • Vitamin A-loaded solid lipid nanoparticles for topical use: Drug release properties
    • Jenning V, Schäfer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release 2000; 66: 115-26
    • (2000) J Control Release , vol.66 , pp. 115-126
    • Jenning, V.1    Schäfer-Korting, M.2    Gohla, S.3
  • 133
    • 77952290634 scopus 로고    scopus 로고
    • Effect of lipid nanoparticles containing fatty alcohols having different chain length on the ex vivo skin permeability of Econazole nitrate
    • Sanna V, Caria G, Mariani A. Effect of lipid nanoparticles containing fatty alcohols having different chain length on the ex vivo skin permeability of Econazole nitrate. Powder Technol 2010; 201: 32-6
    • (2010) Powder Technol , vol.201 , pp. 32-36
    • Sanna, V.1    Caria, G.2    Mariani, A.3
  • 134
    • 84858858095 scopus 로고    scopus 로고
    • Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals
    • Puglia C, Bonina F. Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals. Expert Opin Drug Deliv 2012; 9: 429-441
    • (2012) Expert Opin Drug Deliv , vol.9 , pp. 429-441
    • Puglia, C.1    Bonina, F.2
  • 135
    • 17844373273 scopus 로고    scopus 로고
    • Transdermal drug delivery: Penetration enhancement techniques
    • Benson H. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Deliv 2005; 2: 23-33
    • (2005) Curr Drug Deliv , vol.2 , pp. 23-33
    • Benson, H.1
  • 136
    • 84887009174 scopus 로고    scopus 로고
    • Design of a dual nanostructured lipid carrier formulation based on physicochemical, rheological, and mechanical properties
    • Vitorino C, Alves L, Antunes F, Sousa J, Pais ACC. Design of a dual nanostructured lipid carrier formulation based on physicochemical, rheological, and mechanical properties. J Nanoparticle Res 2013; 15: 1-14
    • (2013) J Nanoparticle Res , vol.15 , pp. 1-14
    • Vitorino, C.1    Alves, L.2    Antunes, F.3    Sousa, J.4    Pais, A.5
  • 137
    • 84884176105 scopus 로고    scopus 로고
    • A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers
    • Vitorino C, Sousa JJ, Pais AACC. A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers. Analytical Methods 2013; 5: 5058-64
    • (2013) Analytical Methods , vol.5 , pp. 5058-5064
    • Vitorino, C.1    Sousa, J.J.2    Pais, A.3
  • 138
    • 1542358759 scopus 로고    scopus 로고
    • Microneedles for transdermal drug delivery
    • Prausnitz MR. Microneedles for transdermal drug delivery. Adv Drug Deliv Rev 2004; 56: 581-7
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 581-587
    • Prausnitz, M.R.1
  • 139
    • 84896389539 scopus 로고    scopus 로고
    • Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies
    • Vitorino C, Almeida A, Sousa J, et al. Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs. in vivo studies. Eur J Pharm Biopharm 2014; 86: 133-44.
    • (2014) Eur J Pharm Biopharm , vol.86 , pp. 133-144
    • Vitorino, C.1    Almeida, A.2    Sousa, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.