The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 933-941

  Liu, Shu ^a   Jin, Mei Na ^a   Quan, Ying Shu ^a,b   Kamiyama, Fumio ^b   Katsumi, Hidemasa ^a   Sakane, Toshiyasu ^a   Yamamoto, Akira ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b Higashikujo Kawanishi cho 32 ^*  (Japan)

Author keywords

Drug absorption; Hyaluronic acid; Insulin; Microneedle; Peptide delivery; Transdermal delivery

Indexed keywords

DRUG ABSORPTION; HYALURONIC ACIDS; MICRONEEDLES; PEPTIDE DELIVERY; TRANSDERMAL DELIVERY;

DERMATOLOGY; DISSOLUTION; FABRICATION; NEEDLES; ORGANIC ACIDS; PIERCING; SCANNING ELECTRON MICROSCOPY;

INSULIN;

HYALURONIC ACID; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; HUMIDITY; INSULIN BLOOD LEVEL; INSULIN TREATMENT; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SKIN WATER LOSS; TEMPERATURE; WETTABILITY;

ADMINISTRATION, CUTANEOUS; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DRUG DELIVERY SYSTEMS; HYALURONIC ACID; HYPOGLYCEMIC AGENTS; INSULIN; MALE; NEEDLES; RATS; RATS, WISTAR;

EID: 84864575139     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.030     Document Type: Article

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