Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 86, Issue 2, 2014, Pages 133-144

  Vitorino, Carla ^a   Almeida, António ^b   Sousa, João ^a   Lamarche, Isabelle ^c,d   Gobin, Patrice ^c   Marchand, Sandrine ^c,d,e   Couet, William ^c,d,e   Olivier, Jean Christophe ^c,d   Pais, Alberto ^f  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c INSERM   (France)

^d UNIVERSITÉ DE POITIERS   (France)

^e POITIERS UNIVERSITY HOSPITAL   (France)

^f UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Microneedles; Nanostructured lipid carriers; Olanzapine; Permeation enhancers; Pharmacokinetics; Simvastatin; Transdermal delivery

Indexed keywords

ALCOHOL; CO ENCAPSULATING NANOSTRUCTURED LIPID CARRIER; LIMONENE; NANOCARRIER; OLANZAPINE; SIMVASTATIN; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; ADSORPTION KINETICS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFUSION; DISPERSION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG TRANSPORT; DYSLIPIDEMIA; EMULSION; EVAPORATION; GEL; HIGH PRESSURE HOMOGENIZATION; HUMAN; HUMAN CELL; HYPERBARISM; IN VITRO STUDY; IN VIVO STUDY; MALE; MATHEMATICAL MODEL; MAXIMUM PLASMA CONCENTRATION; NANOENCAPSULATION; NONHUMAN; PASSIVE TRANSPORT; RAT; SCHIZOPHRENIA; SKIN; STEADY STATE;

MICRONEEDLES; NANOSTRUCTURED LIPID CARRIERS; OLANZAPINE; PERMEATION ENHANCERS; PHARMACOKINETICS; SIMVASTATIN; TRANSDERMAL DELIVERY;

ADMINISTRATION, CUTANEOUS; ANIMALS; BENZODIAZEPINES; CHEMISTRY, PHARMACEUTICAL; CYCLOHEXENES; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; HUMANS; LIPIDS; MALE; NANOSTRUCTURES; PARTICLE SIZE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SKIN; SKIN ABSORPTION; SWINE; TERPENES;

EID: 84896389539     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.12.004     Document Type: Article

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