Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity

Journal of Investigative Dermatology

Volumn 125, Issue 3, 2005, Pages 510-520

  Hachem, Jean Pierre ^a,b   Man, Mao Quiang ^a   Crumrine, Debra ^a   Uchida, Yoshikazu ^a   Brown, Barbara E ^a,c   Regiers, Vera ^b   Roseeuw, Diane ^b   Feingold, Kenneth R ^a   Elias, Peter M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Barrier function; Cohesion; Corneodesmosomes; Integrity; Serine protease; Serine protease inhibitors; Stratum corneum; Superbase; Transepidermal water loss

Indexed keywords

1,1,3,3 TETRAMETHYLGUANIDINE; CHYMOTRYPSIN; DESMOGLEIN 1; GLUCOSYLCERAMIDASE; LIPID; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; 1,1,3,3-TETRAMETHYLGUANIDINE; GUANIDINE DERIVATIVE; KALLIKREIN; KLK7 PROTEIN, MOUSE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; CORNEODESMOSOME; DESMOSOME; ENZYME BINDING; ENZYME SYNTHESIS; HOMEOSTASIS; LIPID ANALYSIS; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; OCCUPATIONAL ECZEMA; PRIORITY JOURNAL; STRATUM CORNEUM; ANIMAL; CATALYSIS; DRUG EFFECT; ENZYMOLOGY; EPIDERMIS; HAIRLESS MOUSE; HUMAN; LIPID METABOLISM; MALE; METABOLISM; PH;

ANIMALS; CATALYSIS; EPIDERMIS; GLUCOSYLCERAMIDASE; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; KALLIKREINS; LIPID METABOLISM; MALE; MICE; MICE, INBRED HRS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 26444570089     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23838.x     Document Type: Article

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