Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling

PLoS Computational Biology

Volumn 11, Issue 5, 2015, Pages

  Dolan, David W P ^a,b   Zupanic, Anze ^b,c   Nelson, Glyn ^b   Hall, Philip ^b   Miwa, Satomi ^b   Kirkwood, Thomas B L ^b   Shanley, Daryl P ^b  

^a DURHAM UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL SIGNALING; DNA; IRRADIATION; JOINING; REPAIR; STOCHASTIC SYSTEMS;

CELL-FATE; CELLULAR SENESCENCE; CONTROL-CELL; DAMAGE REPAIR; DNA DAMAGE SIGNALLING; DNA DAMAGES; DOWN-STREAM; INTEGRATED MODELING; NONHOMOLOGOUS END JOINING; STOCHASTIC-MODELING;

STOCHASTIC MODELS;

ATM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NUTLIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE RELATED KINASE; PROTEIN KINASE C; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE G1 PHASE; CELL FATE; CONTROLLED STUDY; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; G1 PHASE CELL CYCLE CHECKPOINT; GAMMA IRRADIATION; HUMAN; HUMAN CELL; OSCILLATION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RADIATION DOSE FRACTIONATION; SIGNAL TRANSDUCTION; STEADY STATE; STOCHASTIC MODEL; BIOLOGICAL MODEL; BIOLOGY; CELL LINE; COMPUTER SIMULATION; MARKOV CHAIN; METABOLISM; RADIATION RESPONSE;

CELL AGING; CELL LINE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA END-JOINING REPAIR; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84930599374     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004246     Document Type: Article

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