Poly(ADP-Ribose) Polymerase-1 and DNA-Dependent Protein Kinase Have Equivalent Roles in Double Strand Break Repair Following Ionizing Radiation

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 5, 2009, Pages 1520-1527

  Mitchell, Jody ^a   Smith, Graeme C M ^b   Curtin, Nicola J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b KuDOS Pharmaceuticals   (United Kingdom)

Author keywords

DNA dependent protein kinase; double strand break repair; Ionizing radiation; Poly(ADP ribose) polymerase

Indexed keywords

CELLULAR RESPONSE; DNA DOUBLE STRAND BREAKS; DNA DSB; DNA-DEPENDENT PROTEIN KINASE; DOUBLE STRAND BREAK REPAIR; IN-CELL; IN-VITRO; NONHOMOLOGOUS END JOINING; POLY POLYMERASE; POLY(ADP-RIBOSE)-POLYMERASE 1 (PARP-1); RADIATION-INDUCED; SINGLE-STRAND BREAK REPAIRS;

BIOLOGICAL RADIATION EFFECTS; CATALYSTS; DNA; ENZYME KINETICS; ENZYMES; FREE RADICALS; IONIZING RADIATION; NUCLEIC ACIDS; OLIGONUCLEOTIDES; POLYMERS; RADIATION SHIELDING; RADIOACTIVITY; REPAIR;

GENES;

DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX; KU 0058684; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NU 7441; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME INACTIVATION; ENZYME KINETICS; GENE LOCUS; IMMUNOFLUORESCENCE; IN VITRO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CHROMONES; COMET ASSAY; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; ENZYME ACTIVATION; FIBROBLASTS; HISTONES; HUMANS; MICE; MORPHOLINES; OLIGONUCLEOTIDES; POLY(ADP-RIBOSE) POLYMERASES;

EID: 71649091348     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.07.1722     Document Type: Article

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