메뉴 건너뛰기




Volumn 9, Issue APR, 2015, Pages

Inflammation in Parkinson’s disease: Role of glucocorticoids

Author keywords

Glucocorticoid receptor; Microglia; Neurodegeneration; Neuroinflammation; Parkinson s disease (PD)

Indexed keywords

ALPHA SYNUCLEIN; CORTICOTROPIN; CORTISONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOPHILIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEUCINE RICH REPEAT KINASE 2; MINERALOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; RANTES; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84930508415     PISSN: 16625129     EISSN: 16625129     Source Type: Journal    
DOI: 10.3389/fnana.2015.00032     Document Type: Review
Times cited : (130)

References (126)
  • 1
    • 84940461152 scopus 로고    scopus 로고
    • Parkinson's disease and age: The obvious but largely unexplored link
    • [Epub ahead of print]
    • Abdullah, R., Basak, I., Patil, K. S., Alves, G., Larsen, J. P., and Møll, S. G. (2014). Parkinson's disease and age: the obvious but largely unexplored link. Exp. Gerontol. doi: 10. 1016/j. exger. 2014. 09. 014. [Epub ahead of print].
    • (2014) Exp. Gerontol
    • Abdullah, R.1    Basak, I.2    Patil, K.S.3    Alves, G.4    Larsen, J.P.5    Møll, S.G.6
  • 2
    • 84864770092 scopus 로고    scopus 로고
    • Association between Parkinson's disease and the HLA-DRB1 locus
    • Ahmed, I., Tamouza, R., Delord, M., Krishnamoorthy, R., Tzourio, C., Mulot, C., et al. (2012). Association between Parkinson's disease and the HLA-DRB1 locus. Mov. Disord. 27, 1104-1110. doi: 10. 1002/mds. 25035.
    • (2012) Mov. Disord , vol.27 , pp. 1104-1110
    • Ahmed, I.1    Tamouza, R.2    Delord, M.3    Krishnamoorthy, R.4    Tzourio, C.5    Mulot, C.6
  • 3
    • 84946916611 scopus 로고    scopus 로고
    • Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinsonism
    • Annese, V., Herrero, M. T., Di Pentima, M., Gomez, A., Lombardi, L., Ros, C. M., et al. (2015). Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinsonism. Brain Struct Funct. 220, 703-727. doi: 10. 1007/s00429-014-0718-8.
    • (2015) Brain Struct Funct , vol.220 , pp. 703-727
    • Annese, V.1    Herrero, M.T.2    Di Pentima, M.3    Gomez, A.4    Lombardi, L.5    Ros, C.M.6
  • 4
  • 5
    • 84869154969 scopus 로고    scopus 로고
    • ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo
    • Barcia, C., Ros, C. M., Annese, V., Carrillo-de Sauvage, M. A., Ros-Bernal, F., Gómez, A., et al. (2012). ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo. Sci. Rep. 2: 809. doi: 10. 1038/srep00809.
    • (2012) Sci. Rep , vol.2
    • Barcia, C.1    Ros, C.M.2    Annese, V.3    Carrillo-De Sauvage, M.A.4    Ros-Bernal, F.5    Gómez, A.6
  • 6
    • 79959977446 scopus 로고    scopus 로고
    • IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
    • Barcia, C., Ros, C. M., Annese, V., Gómez, A., Ros-Bernal, F., Aguado-Yera, D., et al. (2011). IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell Death Dis. 2: e142. doi: 10. 1038/cddis. 2011. 17.
    • (2011) Cell Death Dis , vol.2
    • Barcia, C.1    Ros, C.M.2    Annese, V.3    Gómez, A.4    Ros-Bernal, F.5    Aguado-Yera, D.6
  • 7
    • 2542455543 scopus 로고    scopus 로고
    • Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure
    • Barcia, C., Sánchez Bahillo, A., Fernández-Villalba, E., Bautista, V., Poza Y Poza, M., Fernández-Barreiro, A., et al. (2004). Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia 46, 402-409. doi: 10. 1002/glia. 20015.
    • (2004) Glia , vol.46 , pp. 402-409
    • Barcia, C.1    Sánchez Bahillo, A.2    Fernández-Villalba, E.3    Bautista, V.4    Poza, Y.5    Poza, M.6    Fernández-Barreiro, A.7
  • 8
    • 84893719111 scopus 로고    scopus 로고
    • Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem
    • Bardou, I., Kaercher, R. M., Brothers, H. M., Hopp, S. C., Royer, S., and Wenk, G. L. (2014). Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem. Neurobiol. Aging 35, 1065-1073. doi: 10. 1016/j. neurobiolaging. 2013. 11. 006.
    • (2014) Neurobiol. Aging , vol.35 , pp. 1065-1073
    • Bardou, I.1    Kaercher, R.M.2    Brothers, H.M.3    Hopp, S.C.4    Royer, S.5    Wenk, G.L.6
  • 9
    • 3042856300 scopus 로고    scopus 로고
    • Somatic and germline mosaicism in sporadic early-onset alzheimer's disease
    • Beck, J. A., Poulter, M., Campbell, T. A., Uphill, J. B., Adamson, G., Geddes, J. F., et al. (2004). Somatic and germline mosaicism in sporadic early-onset alzheimer's disease. Hum. Mol. Genet. 13, 1219-1224. doi: 10. 1093/hmg/ddh134.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 1219-1224
    • Beck, J.A.1    Poulter, M.2    Campbell, T.A.3    Uphill, J.B.4    Adamson, G.5    Geddes, J.F.6
  • 10
    • 47049117420 scopus 로고    scopus 로고
    • Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition
    • Beck, I. M., Vanden Berghe, W., Vermeulen, L., Bougarne, N., Vander Cruyssen, B., Haegeman, G., et al. (2008). Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. EMBO J. 27, 1682-1693. doi: 10. 1038/emboj. 2008. 95.
    • (2008) EMBO J , vol.27 , pp. 1682-1693
    • Beck, I.M.1    Vanden Berghe, W.2    Vermeulen, L.3    Bougarne, N.4    Vander Cruyssen, B.5    Haegeman, G.6
  • 11
    • 0025972572 scopus 로고
    • Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated Parkinson's disease
    • Bellomo, G., Santambrogio, L., Fiacconi, M., Scarponi, A. M., and Ciuffetti, G. (1991). Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated Parkinson's disease. J. Neurol. 238, 19-22. doi: 10. 1007/bf00319704.
    • (1991) J. Neurol , vol.238 , pp. 19-22
    • Bellomo, G.1    Santambrogio, L.2    Fiacconi, M.3    Scarponi, A.M.4    Ciuffetti, G.5
  • 12
    • 84898057951 scopus 로고    scopus 로고
    • Time to redefine PD? Introductory statement of the MDS task force on the definition of Parkinson's disease
    • Berg, D., Postuma, R. B., Bloem, B., Chan, P., Dubois, B., Gasser, T., et al. (2014). Time to redefine PD? Introductory statement of the MDS task force on the definition of Parkinson's disease. Mov. Disord. 29, 454-462. doi: 10. 1002/mds. 25844.
    • (2014) Mov. Disord , vol.29 , pp. 454-462
    • Berg, D.1    Postuma, R.B.2    Bloem, B.3    Chan, P.4    Dubois, B.5    Gasser, T.6
  • 13
    • 77950442119 scopus 로고    scopus 로고
    • TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in toll-like receptor-stimulated macrophages
    • Bhattacharyya, S., Ratajczak, C. K., Vogt, S. K., Kelley, C., Colonna, M., Schreiber, R. D., et al. (2010). TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in toll-like receptor-stimulated macrophages. Blood 115, 1921-1931. doi: 10. 1182/blood-2009-06-224782.
    • (2010) Blood , vol.115 , pp. 1921-1931
    • Bhattacharyya, S.1    Ratajczak, C.K.2    Vogt, S.K.3    Kelley, C.4    Colonna, M.5    Schreiber, R.D.6
  • 14
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block, M. L., Zecca, L., and Hong, J. S. (2007). Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69. doi: 10. 1038/nrn2038.
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 15
    • 33750377224 scopus 로고    scopus 로고
    • Pathology associated with sporadic Parkinson's disease-where does it end?
    • Braak, H., Müller, C. M., Rüb, U., Ackermann, H., Bratzke, H., de Vos, R. A., et al. (2006). Pathology associated with sporadic Parkinson's disease-where does it end? J. Neural Transm. Suppl. 70, 89-97. doi: 10. 1007/978-3-211-45295-0_15.
    • (2006) J. Neural Transm. Suppl , vol.70 , pp. 89-97
    • Braak, H.1    Müller, C.M.2    Rüb, U.3    Ackermann, H.4    Bratzke, H.5    de Vos, R.A.6
  • 16
    • 0038748401 scopus 로고    scopus 로고
    • Idiopathic Parkinson's disease: Possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
    • Braak, H., Rüb, U., Gai, W. P., and Del Tredici, K. (2003). Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J. Neural Transm. 110, 517-536. doi: 10. 1007/s00702-002-0808-2.
    • (2003) J. Neural Transm , vol.110 , pp. 517-536
    • Braak, H.1    Rüb, U.2    Gai, W.P.3    Del Tredici, K.4
  • 17
    • 84857536339 scopus 로고    scopus 로고
    • Nigral pathology and parkinsonian signs in elders without Parkinson disease
    • Buchman, A. S., Shulman, J. M., Nag, S., Leurgans, S. E., Arnold, S. E., Morris, M. C., et al. (2012). Nigral pathology and parkinsonian signs in elders without Parkinson disease. Ann. Neurol. 71, 258-266. doi: 10. 1002/ana. 22588.
    • (2012) Ann. Neurol , vol.71 , pp. 258-266
    • Buchman, A.S.1    Shulman, J.M.2    Nag, S.3    Leurgans, S.E.4    Arnold, S.E.5    Morris, M.C.6
  • 20
    • 84885426536 scopus 로고    scopus 로고
    • Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation
    • Carrillo-de Sauvage, M. A., Maatouk, L., Arnoux, I., Pasco, M., Sanz Diez, A., Delahaye, M., et al. (2013). Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation. Cell Death Differ. 20, 1546-1557. doi: 10. 1038/cdd. 2013. 108.
    • (2013) Cell Death Differ , vol.20 , pp. 1546-1557
    • Carrillo-De Sauvage, M.A.1    Maatouk, L.2    Arnoux, I.3    Pasco, M.4    Sanz Diez, A.5    Delahaye, M.6
  • 21
    • 0036077851 scopus 로고    scopus 로고
    • The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma
    • Castaño, A., Herrera, A. J., Cano, J., and Machado, A. (2002). The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma. J. Neurochem. 81, 150-157. doi: 10. 1046/j. 1471-4159. 2002. 00799. x.
    • (2002) J. Neurochem , vol.81 , pp. 150-157
    • Castaño, A.1    Herrera, A.J.2    Cano, J.3    Machado, A.4
  • 22
    • 84904106826 scopus 로고    scopus 로고
    • Evidence of inflammatory system involvement in Parkinson's disease
    • Chao, Y., Wong, S. C., and Tan, E. K. (2014). Evidence of inflammatory system involvement in Parkinson's disease. Biomed. Res. Int. 2014: 308654. doi: 10. 1155/2014/308654.
    • (2014) Biomed. Res. Int , vol.2014
    • Chao, Y.1    Wong, S.C.2    Tan, E.K.3
  • 23
    • 0031882472 scopus 로고    scopus 로고
    • Cortisol is higher in parkinsonism and associated with gait deficit
    • Charlett, A., Dobbs, R. J., Purkiss, A. G., Wright, D. J., Peterson, D. W., Weller, C., et al. (1998). Cortisol is higher in parkinsonism and associated with gait deficit. Acta Neurol. Scand. 97, 77-85. doi: 10. 1111/j. 1600-0404. 1998. tb00614. x.
    • (1998) Acta Neurol. Scand , vol.97 , pp. 77-85
    • Charlett, A.1    Dobbs, R.J.2    Purkiss, A.G.3    Wright, D.J.4    Peterson, D.W.5    Weller, C.6
  • 24
    • 84884535413 scopus 로고    scopus 로고
    • Nuclear receptors in inflammation control: Repression by GR and beyond
    • Chinenov, Y., Gupte, R., and Rogatsky, I. (2013). Nuclear receptors in inflammation control: repression by GR and beyond. Mol. Cell. Endocrinol. 380, 55-64. doi: 10. 1016/j. mce. 2013. 04. 006.
    • (2013) Mol. Cell. Endocrinol , vol.380 , pp. 55-64
    • Chinenov, Y.1    Gupte, R.2    Rogatsky, I.3
  • 26
    • 84894086893 scopus 로고    scopus 로고
    • Parkinson's disease: From genetics to clinical practice
    • Clarimón, J., and Kulisevsky, J. (2013). Parkinson's disease: from genetics to clinical practice. Curr. Genomics 14, 560-567. doi: 10. 2174/1389202914666131210212305.
    • (2013) Curr. Genomics , vol.14 , pp. 560-567
    • Clarimón, J.1    Kulisevsky, J.2
  • 27
    • 79957467314 scopus 로고    scopus 로고
    • Ageing as a primary risk factor for Parkinson's disease: Evidence from studies of non-human primates
    • Collier, T. J., Kanaan, N. M., and Kordower, J. H. (2011). Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nat. Rev. Neurosci. 12, 359-366. doi: 10. 1038/nrn3039.
    • (2011) Nat. Rev. Neurosci , vol.12 , pp. 359-366
    • Collier, T.J.1    Kanaan, N.M.2    Kordower, J.H.3
  • 28
    • 0041324898 scopus 로고    scopus 로고
    • The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: Molecular mechanisms for gene repression
    • De Bosscher, K., Vanden Berghe, W., and Haegeman, G. (2003). The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. Endocr. Rev. 24, 488-522. doi: 10. 1210/er. 2002-0006.
    • (2003) Endocr. Rev , vol.24 , pp. 488-522
    • De Bosscher, K.1    Vanden Berghe, W.2    Haegeman, G.3
  • 29
    • 84895814467 scopus 로고    scopus 로고
    • Dominance of the strongest: Inflammatory cytokines versus glucocorticoids
    • Dejager, L., Vandevyver, S., Petta, I., and Libert, C. (2014). Dominance of the strongest: inflammatory cytokines versus glucocorticoids. Cytokine Growth Factor Rev. 25, 21-33. doi: 10. 1016/j. cytogfr. 2013. 12. 006.
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 21-33
    • Dejager, L.1    Vandevyver, S.2    Petta, I.3    Libert, C.4
  • 30
    • 34447343326 scopus 로고    scopus 로고
    • A de novo SPAST mutation leading to somatic mosaicism is associated with a later age at onset in HSP
    • Depienne, C., Fedirko, E., Faucheux, J. M., Forlani, S., Bricka, B., Goizet, C., et al. (2007). A de novo SPAST mutation leading to somatic mosaicism is associated with a later age at onset in HSP. Neurogenetics 8, 231-233. doi: 10. 1007/s10048-007-0090-4.
    • (2007) Neurogenetics , vol.8 , pp. 231-233
    • Depienne, C.1    Fedirko, E.2    Faucheux, J.M.3    Forlani, S.4    Bricka, B.5    Goizet, C.6
  • 32
    • 0036920021 scopus 로고    scopus 로고
    • Stress-induced augmentation of immune function-the role of stress hormones, leukocyte trafficking and cytokines
    • Dhabhar, F. S. (2002). Stress-induced augmentation of immune function-the role of stress hormones, leukocyte trafficking and cytokines. Brain Behav. Immun. 16, 785-798. doi: 10. 1016/s0889-1591(02)00036-3.
    • (2002) Brain Behav. Immun , vol.16 , pp. 785-798
    • Dhabhar, F.S.1
  • 33
    • 0025081214 scopus 로고
    • Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element
    • Diamond, M. I., Miner, J. N., Yoshinaga, S. K., and Yamamoto, K. R. (1990). Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249, 1266-1272. doi: 10. 1126/science. 2119054.
    • (1990) Science , vol.249 , pp. 1266-1272
    • Diamond, M.I.1    Miner, J.N.2    Yoshinaga, S.K.3    Yamamoto, K.R.4
  • 35
    • 0033005112 scopus 로고    scopus 로고
    • Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism
    • Dobbs, R. J., Charlett, A., Purkiss, A. G., Dobbs, S. M., Weller, C., and Peterson, D. W. (1999). Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism. Acta Neurol. Scand. 100, 34-41. doi: 10. 1111/j. 1600-0404. 1999. tb00721. x.
    • (1999) Acta Neurol. Scand , vol.100 , pp. 34-41
    • Dobbs, R.J.1    Charlett, A.2    Purkiss, A.G.3    Dobbs, S.M.4    Weller, C.5    Peterson, D.W.6
  • 36
    • 4444289382 scopus 로고    scopus 로고
    • Negative glucocorticoid receptor response elements and their role in glucocorticoid action
    • Dostert, A., and Heinzel, T. (2004). Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr. Pharm. Des. 10, 2807-2816. doi: 10. 2174/1381612043383601.
    • (2004) Curr. Pharm. Des , vol.10 , pp. 2807-2816
    • Dostert, A.1    Heinzel, T.2
  • 37
    • 84938221814 scopus 로고    scopus 로고
    • Inflammation is genetically implicated in Parkinson's disease
    • [Epub ahead of print]
    • Dzamko, N., Geczy, C. L., and Halliday, G. M. (2014). Inflammation is genetically implicated in Parkinson's disease. Neuroscience doi: 10. 1016/j. neuroscience. 2014. 10. 028. [Epub ahead of print].
    • (2014) Neuroscience
    • Dzamko, N.1    Geczy, C.L.2    Halliday, G.M.3
  • 38
    • 1442329302 scopus 로고    scopus 로고
    • CYP2D6 polymorphism, pesticide exposure and Parkinson's disease
    • Elbaz, A., Levecque, C., Clavel, J., Vidal, J. S., Richard, F., Amouyel, P., et al. (2004). CYP2D6 polymorphism, pesticide exposure and Parkinson's disease. Ann. Neurol. 55, 430-434. doi: 10. 1002/ana. 20051.
    • (2004) Ann. Neurol , vol.55 , pp. 430-434
    • Elbaz, A.1    Levecque, C.2    Clavel, J.3    Vidal, J.S.4    Richard, F.5    Amouyel, P.6
  • 39
    • 0028125574 scopus 로고
    • A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons
    • Ericsson, A., Kovács, K. J., and Sawchenko, P. E. (1994). A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 14, 897-913.
    • (1994) J. Neurosci , vol.14 , pp. 897-913
    • Ericsson, A.1    Kovács, K.J.2    Sawchenko, P.E.3
  • 40
    • 82455206282 scopus 로고    scopus 로고
    • Increased intestinal permeability correlateswith sigmoidmucosa alpha-synuclein staining and endotoxin exposuremarkers in early Parkinson's disease
    • Forsyth, C. B., Shannon, K. M., Kordower, J. H., Voigt, R. M., Shaikh, M., Jaglin, J. A., et al. (2011). Increased intestinal permeability correlateswith sigmoidmucosa alpha-synuclein staining and endotoxin exposuremarkers in early Parkinson's disease. PLoS One 6: e28032. doi: 10. 1371/journal. pone. 0028032.
    • (2011) PLoS One , vol.6
    • Forsyth, C.B.1    Shannon, K.M.2    Kordower, J.H.3    Voigt, R.M.4    Shaikh, M.5    Jaglin, J.A.6
  • 41
    • 0036135774 scopus 로고    scopus 로고
    • Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
    • Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., et al. (2002). Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J. 16, 61-71. doi: 10. 1096/fj. 01-0245com.
    • (2002) FASEB J , vol.16 , pp. 61-71
    • Galon, J.1    Franchimont, D.2    Hiroi, N.3    Frey, G.4    Boettner, A.5    Ehrhart-Bornstein, M.6
  • 42
    • 36749015082 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    • Ghosh, A., Roy, A., Liu, X., Kordower, J. H., Mufson, E. J., Hartley, D. M., et al. (2007). Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U S A 104, 18754-18759. doi: 10. 1073/pnas. 0704908104.
    • (2007) Proc. Natl. Acad. Sci. U S A , vol.104 , pp. 18754-18759
    • Ghosh, A.1    Roy, A.2    Liu, X.3    Kordower, J.H.4    Mufson, E.J.5    Hartley, D.M.6
  • 43
    • 84858620880 scopus 로고    scopus 로고
    • Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
    • Gillardon, F., Schmid, R., and Draheim, H. (2012). Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity. Neuroscience208, 41-48. doi: 10. 1016/j. neuroscience. 2012. 02. 001.
    • (2012) Neuroscience , vol.208 , pp. 41-48
    • Gillardon, F.1    Schmid, R.2    Draheim, H.3
  • 45
    • 84904043213 scopus 로고    scopus 로고
    • Premotor and nonmotor features of Parkinson's disease
    • Goldman, J. G., and Postuma, R. (2014). Premotor and nonmotor features of Parkinson's disease. Curr. Opin. Neurol. 27, 434-441. doi: 10. 1097/WCO. 0000000000000112.
    • (2014) Curr. Opin. Neurol , vol.27 , pp. 434-441
    • Goldman, J.G.1    Postuma, R.2
  • 46
    • 0030021001 scopus 로고    scopus 로고
    • Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide
    • Goujon, E., Parnet, P., Layé, S., Combe, C., and Dantzer, R. (1996). Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Brain Res. Mol. Brain Res. 36, 53-62. doi: 10. 1016/0169-328x(95)00242-k.
    • (1996) Brain Res. Mol. Brain Res , vol.36 , pp. 53-62
    • Goujon, E.1    Parnet, P.2    Layé, S.3    Combe, C.4    Dantzer, R.5
  • 47
    • 34547872322 scopus 로고    scopus 로고
    • The glucocorticoid responses are shaped by molecular chaperones
    • Grad, I., and Picard, D. (2007). The glucocorticoid responses are shaped by molecular chaperones. Mol. Cell. Endocrinol. 275, 2-12. doi: 10. 1016/j. mce. 2007. 05. 018.
    • (2007) Mol. Cell. Endocrinol , vol.275 , pp. 2-12
    • Grad, I.1    Picard, D.2
  • 48
    • 79955527505 scopus 로고    scopus 로고
    • Rapid non-genomic effects of corticosteroids and their role in the central stress response
    • Groeneweg, F. L., Karst, H., de Kloet, E. R., and Joëls, M. (2011). Rapid non-genomic effects of corticosteroids and their role in the central stress response. J. Endocrinol. 209, 153-167. doi: 10. 1530/JOE-10-0472.
    • (2011) J. Endocrinol , vol.209 , pp. 153-167
    • Groeneweg, F.L.1    Karst, H.2    de Kloet, E.R.3    Joëls, M.4
  • 49
    • 79951499176 scopus 로고    scopus 로고
    • Glia: Initiators and progressors of pathology in Parkinson's disease
    • Halliday, G. M., and Stevens, C. H. (2011). Glia: initiators and progressors of pathology in Parkinson's disease. Mov. Disord. 26, 6-17. doi: 10. 1002/mds. 23455.
    • (2011) Mov. Disord , vol.26 , pp. 6-17
    • Halliday, G.M.1    Stevens, C.H.2
  • 50
    • 84878508881 scopus 로고    scopus 로고
    • MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation and dopaminergic neurodegeneration
    • Harms, A. S., Cao, S., Rowse, A. L., Thome, A. D., Li, X., Mangieri, L. R., et al. (2013). MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation and dopaminergic neurodegeneration. J. Neurosci. 33, 9592-9600. doi: 10. 1523/JNEUROSCI. 5610-12. 2013.
    • (2013) J. Neurosci , vol.33 , pp. 9592-9600
    • Harms, A.S.1    Cao, S.2    Rowse, A.L.3    Thome, A.D.4    Li, X.5    Mangieri, L.R.6
  • 51
    • 0030739052 scopus 로고    scopus 로고
    • Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: Ultradian secretory pulsatility and diurnal variation
    • Hartmann, A., Veldhuis, J. D., Deuschle, M., Standhardt, H., and Heuser, I. (1997). Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation. Neurobiol. Aging 18, 285-289. doi: 10. 1016/s0197-4580(97)80309-0.
    • (1997) Neurobiol. Aging , vol.18 , pp. 285-289
    • Hartmann, A.1    Veldhuis, J.D.2    Deuschle, M.3    Standhardt, H.4    Heuser, I.5
  • 52
    • 68649095434 scopus 로고    scopus 로고
    • Parkinson's disease: The dual hit theory revisited
    • Hawkes, C. H., Del Tredici, K., and Braak, H. (2009). Parkinson's disease: the dual hit theory revisited. Ann. N Y Acad. Sci. 1170, 615-622. doi: 10. 1111/j. 1749-6632. 2009. 04365. x.
    • (2009) Ann. N Y Acad. Sci , vol.1170 , pp. 615-622
    • Hawkes, C.H.1    Del Tredici, K.2    Braak, H.3
  • 54
    • 76549251874 scopus 로고
    • Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions
    • Hench, P. S., Kendall, E. C., Slocumb, C. H., and Polley, H. F. (1950). Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions. Arch. Intern. Med. (Chic). 85, 545-666. doi: 10. 1001/archinte. 1950. 00230100002001.
    • (1950) Arch. Intern. Med. (Chic) , vol.85 , pp. 545-666
    • Hench, P.S.1    Kendall, E.C.2    Slocumb, C.H.3    Polley, H.F.4
  • 55
    • 80655141577 scopus 로고    scopus 로고
    • Evidence for more than one Parkinson's disease-associated variant within the HLA region
    • Hill-Burns, E. M., Factor, S. A., Zabetian, C. P., Thomson, G., and Payami, H. (2011). Evidence for more than one Parkinson's disease-associated variant within the HLA region. PLoS One 6: e27109. doi: 10. 1371/journal. pone. 0027109.
    • (2011) PLoS One , vol.6
    • Hill-Burns, E.M.1    Factor, S.A.2    Zabetian, C.P.3    Thomson, G.4    Payami, H.5
  • 56
    • 68949100471 scopus 로고    scopus 로고
    • Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer's disease
    • Huang, C. W., Lui, C. C., Chang, W. N., Lu, C. H., Wang, Y. L., and Chang, C. C. (2009). Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer's disease. J. Clin. Neurosci. 16, 1283-1286. doi: 10. 1016/j. jocn. 2008. 12. 026.
    • (2009) J. Clin. Neurosci , vol.16 , pp. 1283-1286
    • Huang, C.W.1    Lui, C.C.2    Chang, W.N.3    Lu, C.H.4    Wang, Y.L.5    Chang, C.C.6
  • 57
    • 0343844458 scopus 로고    scopus 로고
    • Nitric oxide synthase and neuronal vulnerability in Parkinson's disease
    • Hunot, S., Boissière, F., Faucheux, B., Brugg, B., Mouatt-Prigent, A., Agid, Y., et al. (1996). Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 72, 355-363. doi: 10. 1016/0306-4522(95)00578-1.
    • (1996) Neuroscience , vol.72 , pp. 355-363
    • Hunot, S.1    Boissière, F.2    Faucheux, B.3    Brugg, B.4    Mouatt-Prigent, A.5    Agid, Y.6
  • 58
    • 84871529499 scopus 로고    scopus 로고
    • In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease
    • Iannaccone, S., Cerami, C., Alessio, M., Garibotto, V., Panzacchi, A., Olivieri, S., et al. (2013). In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease. Parkinsonism Relat. Disord. 19, 47-52. doi: 10. 1016/j. parkreldis. 2012. 07. 002.
    • (2013) Parkinsonism Relat. Disord , vol.19 , pp. 47-52
    • Iannaccone, S.1    Cerami, C.2    Alessio, M.3    Garibotto, V.4    Panzacchi, A.5    Olivieri, S.6
  • 59
    • 31344446119 scopus 로고    scopus 로고
    • Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression
    • Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., et al. (2006). Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J. Exp. Med. 203, 7-13. doi: 10. 1084/jem. 20050466.
    • (2006) J. Exp. Med , vol.203 , pp. 7-13
    • Ito, K.1    Yamamura, S.2    Essilfie-Quaye, S.3    Cosio, B.4    Ito, M.5    Barnes, P.J.6
  • 60
    • 21744440118 scopus 로고    scopus 로고
    • MPTP and SNpc DA neuronal vulnerability: Role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview
    • Jackson-Lewis, V., and Smeyne, R. J. (2005). MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview. Neurotox. Res. 7, 193-201. doi: 10. 1007/bf03036449.
    • (2005) Neurotox. Res , vol.7 , pp. 193-201
    • Jackson-Lewis, V.1    Smeyne, R.J.2
  • 61
    • 69549120391 scopus 로고    scopus 로고
    • Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration
    • Jang, H., Boltz, D., Sturm-Ramirez, K., Shepherd, K. R., Jiao, Y., Webster, R., et al. (2009). Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc. Natl. Acad. Sci. U S A106, 14063-14068. doi: 10. 1073/pnas. 0900096106.
    • (2009) Proc. Natl. Acad. Sci. U S A , vol.106 , pp. 14063-14068
    • Jang, H.1    Boltz, D.2    Sturm-Ramirez, K.3    Shepherd, K.R.4    Jiao, Y.5    Webster, R.6
  • 62
    • 51349096586 scopus 로고    scopus 로고
    • Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine exposure in monkeys
    • Kanaan, N. M., Kordower, J. H., and Collier, T. J. (2008). Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine exposure in monkeys. Glia 56, 1199-1214. doi: 10. 1002/glia. 20690.
    • (2008) Glia , vol.56 , pp. 1199-1214
    • Kanaan, N.M.1    Kordower, J.H.2    Collier, T.J.3
  • 63
    • 77951977811 scopus 로고    scopus 로고
    • Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys
    • Kanaan, N. M., Kordower, J. H., and Collier, T. J. (2010). Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiol. Aging 31, 937-952. doi: 10. 1016/j. neurobiolaging. 2008. 07. 006.
    • (2010) Neurobiol. Aging , vol.31 , pp. 937-952
    • Kanaan, N.M.1    Kordower, J.H.2    Collier, T.J.3
  • 64
    • 33749354007 scopus 로고    scopus 로고
    • Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure
    • Kang, Y. M., Zhang, Z. H., Johnson, R. F., Yu, Y., Beltz, T., Johnson, A. K., et al. (2006). Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure. Circ. Res. 99, 758-766. doi: 10. 1161/01. res. 0000244092. 95152. 86.
    • (2006) Circ. Res , vol.99 , pp. 758-766
    • Kang, Y.M.1    Zhang, Z.H.2    Johnson, R.F.3    Yu, Y.4    Beltz, T.5    Johnson, A.K.6
  • 65
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: Linking inflammation and immunity to cancer development and progression
    • Karin, M., and Greten, F. R. (2005). NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749-759. doi: 10. 1038/nri1703.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 66
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on toll-like receptors
    • Kawai, T., and Akira, S. (2010). The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat. Immunol. 11, 373-384. doi: 10. 1038/ni. 1863.
    • (2010) Nat. Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 67
    • 84873443346 scopus 로고    scopus 로고
    • Parkinson's disease: Evidence for environmental risk factors
    • Kieburtz, K., and Wunderle, K. B. (2013). Parkinson's disease: evidence for environmental risk factors. Mov. Disord. 28, 8-13. doi: 10. 1002/mds. 25150.
    • (2013) Mov. Disord , vol.28 , pp. 8-13
    • Kieburtz, K.1    Wunderle, K.B.2
  • 68
    • 84930507937 scopus 로고    scopus 로고
    • Hypothesis: Somatic mosaicism and parkinson disease
    • Kim, H. J., and Jeon, B. S. (2014). Hypothesis: somatic mosaicism and parkinson disease. Exp. Neurobiol. 23, 271-276. doi: 10. 5607/en. 2014. 23. 4. 271.
    • (2014) Exp. Neurobiol , vol.23 , pp. 271-276
    • Kim, H.J.1    Jeon, B.S.2
  • 69
    • 62949138967 scopus 로고    scopus 로고
    • Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity
    • Kino, T., Manoli, I., Kelkar, S., Wang, Y., Su, Y. A., and Chrousos, G. P. (2009). Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity. Biochem. Biophys. Res. Commun. 381, 671-675. doi: 10. 1016/j. bbrc. 2009. 02. 110.
    • (2009) Biochem. Biophys. Res. Commun , vol.381 , pp. 671-675
    • Kino, T.1    Manoli, I.2    Kelkar, S.3    Wang, Y.4    Su, Y.A.5    Chrousos, G.P.6
  • 71
    • 84859339977 scopus 로고    scopus 로고
    • Comprehensive research synopsis and systematic metaanalyses in Parkinson's disease genetics: The PDGene database
    • Lill, C. M., Roehr, J. T., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B. M., et al. (2012). Comprehensive research synopsis and systematic metaanalyses in Parkinson's disease genetics: the PDGene database. PLoS Genet. 8: e1002548. doi: 10. 1371/journal. pgen. 1002548.
    • (2012) PLoS Genet , vol.8
    • Lill, C.M.1    Roehr, J.T.2    McQueen, M.B.3    Kavvoura, F.K.4    Bagade, S.5    Schjeide, B.M.6
  • 72
    • 79959229744 scopus 로고    scopus 로고
    • Lipopolysaccaride animal models for Parkinson's disease
    • Liu, M., and Bing, G. (2011). Lipopolysaccaride animal models for Parkinson's disease. Parkinson Dis. 2011: 327089. doi: 10. 4061/2011/327089.
    • (2011) Parkinson Dis , vol.2011
    • Liu, M.1    Bing, G.2
  • 73
    • 79960981876 scopus 로고    scopus 로고
    • Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population
    • Liu, X., Cheng, R., Verbitsky, M., Kisselev, S., Browne, A., Mejia-Sanatana, H., et al. (2011). Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population. BMC Med. Genet. 12: 104. doi: 10. 1186/1471-2350-12-104.
    • (2011) BMC Med. Genet , vol.12
    • Liu, X.1    Cheng, R.2    Verbitsky, M.3    Kisselev, S.4    Browne, A.5    Mejia-Sanatana, H.6
  • 74
    • 84896793936 scopus 로고    scopus 로고
    • Comparable autoantibody serum levels against amyloid-and inflammation-associated proteins in Parkinson's disease patients and controls
    • Maetzler, W., Apel, A., Langkamp, M., Deuschle, C., Dilger, S. S., Stirnkorb, J. G., et al. (2014). Comparable autoantibody serum levels against amyloid-and inflammation-associated proteins in Parkinson's disease patients and controls. PLoS One 9: e88604. doi: 10. 1371/journal. pone. 0088604.
    • (2014) PLoS One , vol.9
    • Maetzler, W.1    Apel, A.2    Langkamp, M.3    Deuschle, C.4    Dilger, S.S.5    Stirnkorb, J.G.6
  • 75
    • 33645346751 scopus 로고    scopus 로고
    • Reduced Glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives
    • Matsubara, T., Funato, H., Kobayashi, A., Nobumoto, M., and Watanabe, Y. (2006). Reduced Glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives. Biol. Psychiatry 59, 689-695. doi: 10. 1016/j. biopsych. 2005. 09. 026.
    • (2006) Biol. Psychiatry , vol.59 , pp. 689-695
    • Matsubara, T.1    Funato, H.2    Kobayashi, A.3    Nobumoto, M.4    Watanabe, Y.5
  • 76
    • 34447629382 scopus 로고    scopus 로고
    • Physiology and neurobiology of stress and adaptation: Central role of the brain
    • McEwen, B. S. (2007). Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol. Rev. 87, 873-904. doi: 10. 1152/physrev. 00041. 2006.
    • (2007) Physiol. Rev , vol.87 , pp. 873-904
    • McEwen, B.S.1
  • 77
    • 47349093970 scopus 로고    scopus 로고
    • The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease
    • McGeer, P. L., and McGeer, E. G. (2008). The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease. Exp. Neurol. 212, 235-238. doi: 10. 1016/j. expneurol. 2008. 04. 008.
    • (2008) Exp. Neurol , vol.212 , pp. 235-238
    • McGeer, P.L.1    McGeer, E.G.2
  • 78
    • 84856632181 scopus 로고    scopus 로고
    • LRRK2 inhibition attenuates microglial inflammatory responses
    • Moehle, M. S., Webber, P. J., Tse, T., Sukar, N., Standaert, D. G., DeSilva, T. M., et al. (2012). LRRK2 inhibition attenuates microglial inflammatory responses. J. Neurosci. 32, 1602-1611. doi: 10. 1523/JNEUROSCI. 5601-11. 2012.
    • (2012) J. Neurosci , vol.32 , pp. 1602-1611
    • Moehle, M.S.1    Webber, P.J.2    Tse, T.3    Sukar, N.4    Standaert, D.G.5    DeSilva, T.M.6
  • 79
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi, M., Harada, M., Kondo, T., Riederer, P., Inagaki, H., Minami, M., et al. (1994). Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180, 147-150. doi: 10. 1016/0304-3940(94)90508-8.
    • (1994) Neurosci. Lett , vol.180 , pp. 147-150
    • Mogi, M.1    Harada, M.2    Kondo, T.3    Riederer, P.4    Inagaki, H.5    Minami, M.6
  • 80
    • 44149103168 scopus 로고    scopus 로고
    • Neuroinflammation and peripheral immune infiltration in Parkinson's disease: An autoimmune hypothesis
    • Monahan, A. J., Warren, M., and Carvey, P. M. (2008). Neuroinflammation and peripheral immune infiltration in Parkinson's disease: an autoimmune hypothesis. Cell Transplant. 17, 363-372. doi: 10. 3727/096368908784423328.
    • (2008) Cell Transplant , vol.17 , pp. 363-372
    • Monahan, A.J.1    Warren, M.2    Carvey, P.M.3
  • 81
    • 33847322535 scopus 로고    scopus 로고
    • Acute levodopa administration reduces cortisol release in patients with Parkinson's disease
    • Müller, T., Welnic, J., and Muhlack, S. (2007). Acute levodopa administration reduces cortisol release in patients with Parkinson's disease. J. Neural Transm. 114, 347-350. doi: 10. 1007/s00702-006-0552-0.
    • (2007) J. Neural Transm , vol.114 , pp. 347-350
    • Müller, T.1    Welnic, J.2    Muhlack, S.3
  • 82
    • 0037105511 scopus 로고    scopus 로고
    • Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: Role of glucocorticoids and CD14
    • Nadeau, S., and Rivest, S. (2002). Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. J. Immunol. 169, 3370-3381. doi: 10. 4049/jimmunol. 169. 6. 3370.
    • (2002) J. Immunol , vol.169 , pp. 3370-3381
    • Nadeau, S.1    Rivest, S.2
  • 83
    • 0038722154 scopus 로고    scopus 로고
    • Glucocorticoids play a fundamental role in protecting the brain during innate immune response
    • Nadeau, S., and Rivest, S. (2003). Glucocorticoids play a fundamental role in protecting the brain during innate immune response. J. Neurosci. 23, 5536-5544.
    • (2003) J. Neurosci , vol.23 , pp. 5536-5544
    • Nadeau, S.1    Rivest, S.2
  • 84
    • 84923445949 scopus 로고    scopus 로고
    • NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases
    • Nalls, M. A., Bras, J., Hernandez, D. G., Keller, M. F., Majounie, E., Renton, A. E., et al. (2015). NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiol. Aging 36, 1605. e7-1605. e12. doi: 10. 1016/j. neurobiolaging. 2014. 07. 028.
    • (2015) Neurobiol. Aging , vol.36 , pp. 1605.e7-1605.e12
    • Nalls, M.A.1    Bras, J.2    Hernandez, D.G.3    Keller, M.F.4    Majounie, E.5    Renton, A.E.6
  • 85
    • 84939599004 scopus 로고    scopus 로고
    • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
    • Nalls, M. A., Pankratz, N., Lill, C. M., Do, C. B., Hernandez, D. G., Saad, M., et al. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat. Genet. 46, 989-993. doi: 10. 1038/ng. 3043.
    • (2014) Nat. Genet , vol.46 , pp. 989-993
    • Nalls, M.A.1    Pankratz, N.2    Lill, C.M.3    Do, C.B.4    Hernandez, D.G.5    Saad, M.6
  • 86
    • 84897388280 scopus 로고    scopus 로고
    • Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain
    • Noh, H., Jeon, J., and Seo, H. (2014). Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain. Neurochem. Int. 69, 35-40. doi: 10. 1016/j. neuint. 2014. 02. 008.
    • (2014) Neurochem. Int , vol.69 , pp. 35-40
    • Noh, H.1    Jeon, J.2    Seo, H.3
  • 87
    • 84887016715 scopus 로고    scopus 로고
    • The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease
    • Oakley, R. H., and Cidlowski, J. A. (2013). The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. J. Allergy Clin. Immunol. 132, 1033-1044. doi: 10. 1016/j. jaci. 2013. 09. 007.
    • (2013) J. Allergy Clin. Immunol , vol.132 , pp. 1033-1044
    • Oakley, R.H.1    Cidlowski, J.A.2
  • 88
    • 0142122404 scopus 로고    scopus 로고
    • Peripheral and central proinflammatory cytokine response to a severe acute stressor
    • O'Connor, K. A., Johnson, J. D., Hansen, M. K., Wieseler Frank, J. L., Maksimova, E., Watkins, L. R., et al. (2003). Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Res. 991, 123-132. doi: 10. 1016/j. brainres. 2003. 08. 006.
    • (2003) Brain Res , vol.991 , pp. 123-132
    • O'Connor, K.A.1    Johnson, J.D.2    Hansen, M.K.3    Wieseler Frank, J.L.4    Maksimova, E.5    Watkins, L.R.6
  • 89
    • 27644531857 scopus 로고    scopus 로고
    • A possible role for humoral immunity in the pathogenesis of Parkinson's disease
    • Orr, C. F., Rowe, D. B., Mizuno, Y., Mori, H., and Halliday, G. M. (2005). A possible role for humoral immunity in the pathogenesis of Parkinson's disease. Brain 128(Pt. 11), 2665-2674. doi: 10. 1093/brain/awh625.
    • (2005) Brain , vol.128 , pp. 2665-2674
    • Orr, C.F.1    Rowe, D.B.2    Mizuno, Y.3    Mori, H.4    Halliday, G.M.5
  • 90
    • 13144258735 scopus 로고    scopus 로고
    • Microglial activation and dopamine terminal loss in early Parkinson's disease
    • Ouchi, Y., Yoshikawa, E., Sekine, Y., Futatsubashi, M., Kanno, T., Ogusu, T., et al. (2005). Microglial activation and dopamine terminal loss in early Parkinson's disease. Ann. Neurol. 57, 168-175. doi: 10. 1002/ana. 20338.
    • (2005) Ann. Neurol , vol.57 , pp. 168-175
    • Ouchi, Y.1    Yoshikawa, E.2    Sekine, Y.3    Futatsubashi, M.4    Kanno, T.5    Ogusu, T.6
  • 91
    • 9644302538 scopus 로고    scopus 로고
    • Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness
    • Perlman, W. R., Webster, M. J., Kleinman, J. E., and Weickert, C. S. (2004). Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness. Biol. Psychiatry 56, 844-852. doi: 10. 1016/j. biopsych. 2004. 09. 006.
    • (2004) Biol. Psychiatry , vol.56 , pp. 844-852
    • Perlman, W.R.1    Webster, M.J.2    Kleinman, J.E.3    Weickert, C.S.4
  • 92
    • 56449115830 scopus 로고    scopus 로고
    • Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability
    • Pieper, H. C., Evert, B. O., Kaut, O., Riederer, P. F., Waha, A., and Wüllner, U. (2008). Different methylation of the TNF-alpha promoter in cortex and substantia nigra: implications for selective neuronal vulnerability. Neurobiol. Dis. 32, 521-527. doi: 10. 1016/j. nbd. 2008. 09. 010.
    • (2008) Neurobiol. Dis , vol.32 , pp. 521-527
    • Pieper, H.C.1    Evert, B.O.2    Kaut, O.3    Riederer, P.F.4    Waha, A.5    Wüllner, U.6
  • 93
    • 84875257430 scopus 로고    scopus 로고
    • Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease
    • Pihlstrøm, L., Axelsson, G., Bjørnarå, K. A., Dizdar, N., Fardell, C., Forsgren, L., et al. (2013). Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease. Neurobiol. Aging 34, 1708. e7-1708. e13. doi: 10. 1016/j. neurobiolaging. 2012. 10. 019.
    • (2013) Neurobiol. Aging , vol.34 , pp. 1708.e7-1708.e13
    • Pihlstrøm, L.1    Axelsson, G.2    Bjørnarå, K.A.3    Dizdar, N.4    Fardell, C.5    Forsgren, L.6
  • 94
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela, A., and Esteller, M. (2010). Epigenetic modifications and human disease. Nat. Biotechnol. 28, 1057-1068. doi: 10. 1038/nbt. 1685.
    • (2010) Nat. Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 95
    • 46849088998 scopus 로고    scopus 로고
    • Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease
    • Pott Godoy, M. C., Tarelli, R., Ferrari, C. C., Sarchi, M. I., and Pitossi, F. J. (2008). Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain 131(Pt. 7), 1880-1894. doi: 10. 1093/brain/awn101.
    • (2008) Brain , vol.131 , pp. 1880-1894
    • Pott Godoy, M.C.1    Tarelli, R.2    Ferrari, C.C.3    Sarchi, M.I.4    Pitossi, F.J.5
  • 96
    • 84911423174 scopus 로고    scopus 로고
    • The prevalence of Parkinson's disease: A systematic review and meta-analysis
    • Pringsheim, T., Jette, N., Frolkis, A., and Steeves, T. D. (2014). The prevalence of Parkinson's disease: a systematic review and meta-analysis. Mov. Disord. 29, 1583-1590. doi: 10. 1002/mds. 25945.
    • (2014) Mov. Disord , vol.29 , pp. 1583-1590
    • Pringsheim, T.1    Jette, N.2    Frolkis, A.3    Steeves, T.D.4
  • 97
    • 84904422726 scopus 로고    scopus 로고
    • Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations
    • Proukakis, C., Shoaee, M., Morris, J., Brier, T., Kara, E., Sheerin, U. M., et al. (2014). Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations. Mov. Disord. 29, 1060-1064. doi: 10. 1002/mds. 25883.
    • (2014) Mov. Disord , vol.29 , pp. 1060-1064
    • Proukakis, C.1    Shoaee, M.2    Morris, J.3    Brier, T.4    Kara, E.5    Sheerin, U.M.6
  • 98
    • 0020321970 scopus 로고
    • 1918 influenza, encephalitis lethargica, parkinsonism
    • Ravenholt, R. T., and Foege, W. H. (1982). 1918 influenza, encephalitis lethargica, parkinsonism. Lancet 2, 860-864. doi: 10. 1016/s0140-6736(82)90820-0.
    • (1982) Lancet , vol.2 , pp. 860-864
    • Ravenholt, R.T.1    Foege, W.H.2
  • 99
    • 70450213422 scopus 로고    scopus 로고
    • Peripheral chemo-cytokine profiles in Alzheimer's and Parkinson's diseases
    • Reale, M., Greig, N. H., and Kamal, M. A. (2009a). Peripheral chemo-cytokine profiles in Alzheimer's and Parkinson's diseases. Mini. Rev. Med. Chem. 9, 1229-1241. doi: 10. 2174/138955709789055199.
    • (2009) Mini. Rev. Med. Chem , vol.9 , pp. 1229-1241
    • Reale, M.1    Greig, N.H.2    Kamal, M.A.3
  • 101
    • 84860813005 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: Evidence from observational studies
    • Rees, K., Stowe, R., Patel, S., Ives, N., Breen, K., Clarke, C. E., et al. (2011). Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies. Cochrane Database Syst. Rev. 9: CD008454. doi: 10. 1002/14651858. CD008454.
    • (2011) Cochrane Database Syst. Rev , vol.9
    • Rees, K.1    Stowe, R.2    Patel, S.3    Ives, N.4    Breen, K.5    Clarke, C.E.6
  • 102
    • 34547878870 scopus 로고
    • Chemistry of adrenal cortex hormones
    • Reichstein, T. (1951). Chemistry of adrenal cortex hormones. Bull. Schweiz. Akad. Med. Wiss. 7, 359-370.
    • (1951) Bull. Schweiz. Akad. Med. Wiss , vol.7 , pp. 359-370
    • Reichstein, T.1
  • 103
    • 79955599480 scopus 로고    scopus 로고
    • Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism
    • Ros-Bernal, F., Hunot, S., Herrero, M. T., Parnadeau, S., Corvol, J. C., Lu, L., et al. (2011). Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism. Proc. Natl. Acad. Sci. U S A 108, 6632-6637. doi: 10. 1073/pnas. 1017820108.
    • (2011) Proc. Natl. Acad. Sci. U S A , vol.108 , pp. 6632-6637
    • Ros-Bernal, F.1    Hunot, S.2    Herrero, M.T.3    Parnadeau, S.4    Corvol, J.C.5    Lu, L.6
  • 104
    • 0035813090 scopus 로고    scopus 로고
    • Coregulator codes of transcriptional regulation by nuclear receptors
    • Rosenfeld, M. G., and Glass, C. K. (2001). Coregulator codes of transcriptional regulation by nuclear receptors. J. Biol. Chem. 276, 36865-36868. doi: 10. 1074/jbc. r100041200.
    • (2001) J. Biol. Chem , vol.276 , pp. 36865-36868
    • Rosenfeld, M.G.1    Glass, C.K.2
  • 105
    • 84899138668 scopus 로고    scopus 로고
    • LRRK2 and neuroinflammation: Partners in crime in Parkinson's disease?
    • Russo, I., Bubacco, L., and Greggio, E. (2014). LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?. J. Neuroinflammation 11: 52. doi: 10. 1186/1742-2094-11-52.
    • (2014) J. Neuroinflammation , vol.11
    • Russo, I.1    Bubacco, L.2    Greggio, E.3
  • 106
    • 63049083734 scopus 로고    scopus 로고
    • A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • Saijo, K., Winner, B., Carson, C. T., Collier, J. G., Boyer, L., Rosenfeld, M. G., et al. (2009). A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137, 47-59. doi: 10. 1016/j. cell. 2009. 01. 038.
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo, K.1    Winner, B.2    Carson, C.T.3    Collier, J.G.4    Boyer, L.5    Rosenfeld, M.G.6
  • 107
    • 73549117185 scopus 로고    scopus 로고
    • Dual roles for perivascular macrophages in immune-to-brain signaling
    • Serrats, J., Schiltz, J. C., García-Bueno, B., van Rooijen, N., Reyes, T. M., and Sawchenko, P. E. (2010). Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron 65, 94-106. doi: 10. 1016/j. neuron. 2009. 11. 032.
    • (2010) Neuron , vol.65 , pp. 94-106
    • Serrats, J.1    Schiltz, J.C.2    García-Bueno, B.3    van Rooijen, N.4    Reyes, T.M.5    Sawchenko, P.E.6
  • 108
    • 84893922235 scopus 로고    scopus 로고
    • Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract
    • Sharkey, K. A., and Savidge, T. C. (2014). Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton. Neurosci. 181, 94-106. doi: 10. 1016/j. autneu. 2013. 12. 006.
    • (2014) Auton. Neurosci , vol.181 , pp. 94-106
    • Sharkey, K.A.1    Savidge, T.C.2
  • 109
    • 45549085016 scopus 로고    scopus 로고
    • Steroid hormone receptor expression and function in microglia
    • Sierra, A., Gottfried-Blackmore, A., Milner, T. A., McEwen, B. S., and Bulloch, K. (2008). Steroid hormone receptor expression and function in microglia. Glia 56, 659-674. doi: 10. 1002/glia. 20644.
    • (2008) Glia , vol.56 , pp. 659-674
    • Sierra, A.1    Gottfried-Blackmore, A.2    Milner, T.A.3    McEwen, B.S.4    Bulloch, K.5
  • 110
    • 34547288192 scopus 로고    scopus 로고
    • Periparturient cortisol, acute phase cytokine and acute phase protein profiles of gilts housed in groups or stalls during gestation
    • Sorrells, A. D., Eicher, S. D., Harris, M. J., Pajor, E. A., and Richert, B. T. (2007). Periparturient cortisol, acute phase cytokine and acute phase protein profiles of gilts housed in groups or stalls during gestation. J. Anim. Sci. 85, 1750-1757. doi: 10. 2527/jas. 2007-0025.
    • (2007) J. Anim. Sci , vol.85 , pp. 1750-1757
    • Sorrells, A.D.1    Eicher, S.D.2    Harris, M.J.3    Pajor, E.A.4    Richert, B.T.5
  • 112
    • 61849149792 scopus 로고    scopus 로고
    • Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases
    • Stolp, H. B., and Dziegielewska, K. M. (2009). Review: role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases. Neuropathol. Appl. Neurobiol. 35, 132-146. doi: 10. 1111/j. 1365-2990. 2008. 01005. x.
    • (2009) Neuropathol. Appl. Neurobiol , vol.35 , pp. 132-146
    • Stolp, H.B.1    Dziegielewska, K.M.2
  • 113
    • 0029839174 scopus 로고    scopus 로고
    • Evaluation of interleukins, ACTH, cortisol and prolactin concentrations in the blood of patients with parkinson's disease
    • Stypula, G., Kunert-Radek, J., Stepień, H., Zylińska, K., and Pawlikowski, M. (1996). Evaluation of interleukins, ACTH, cortisol and prolactin concentrations in the blood of patients with parkinson's disease. Neuroimmunomodulation 3, 131-134. doi: 10. 1159/000097237.
    • (1996) Neuroimmunomodulation , vol.3 , pp. 131-134
    • Stypula, G.1    Kunert-Radek, J.2    Stepień, H.3    Zylińska, K.4    Pawlikowski, M.5
  • 114
    • 84900017196 scopus 로고    scopus 로고
    • Immune responses in Parkinson's disease: Interplay between central and peripheral immune systems
    • Su, X., and Federoff, J. H. (2014). Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed. Res. Int. 2014: 275178. doi: 10. 1155/2014/275178.
    • (2014) Biomed. Res. Int , vol.2014
    • Su, X.1    Federoff, J.H.2
  • 115
    • 62549125971 scopus 로고    scopus 로고
    • Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration
    • Sugama, S., Takenouchi, T., Kitani, H., Fujita, M., and Hashimoto, M. (2009). Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration. J. Neuroimmunol. 208, 104-114. doi: 10. 1016/j. jneuroim. 2009. 01. 016.
    • (2009) J. Neuroimmunol , vol.208 , pp. 104-114
    • Sugama, S.1    Takenouchi, T.2    Kitani, H.3    Fujita, M.4    Hashimoto, M.5
  • 116
    • 79953871100 scopus 로고    scopus 로고
    • Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor
    • Surjit, M., Ganti, K. P., Mukherji, A., Ye, T., Hua, G., Metzger, D., et al. (2011). Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 145, 224-241. doi: 10. 1016/j. cell. 2011. 03. 027.
    • (2011) Cell , vol.145 , pp. 224-241
    • Surjit, M.1    Ganti, K.P.2    Mukherji, A.3    Ye, T.4    Hua, G.5    Metzger, D.6
  • 117
    • 84920520147 scopus 로고    scopus 로고
    • Correlation between serum RANTES levels and the severity of Parkinson's disease
    • Tang, P., Chong, L., Li, X., Liu, Y., Liu, P., Hou, C., et al. (2014). Correlation between serum RANTES levels and the severity of Parkinson's disease. Oxid. Med. Cell. Longev. 2014: 208408. doi: 10. 1155/2014/208408.
    • (2014) Oxid. Med. Cell. Longev , vol.2014
    • Tang, P.1    Chong, L.2    Li, X.3    Liu, Y.4    Liu, P.5    Hou, C.6
  • 118
    • 85047697344 scopus 로고    scopus 로고
    • Somatic mosaicism for a MECP2 mutation associated with classic Rett syndrome in a boy
    • Topçu, M., Akyerli, C., Sayi, A., Törüner, G. A., Koçoğlu, S. R., Climbis, M., et al. (2002). Somatic mosaicism for a MECP2 mutation associated with classic Rett syndrome in a boy. Eur. J. Hum. Genet. 10, 77-81. doi: 10. 1038/sj. ejhg. 5200745.
    • (2002) Eur. J. Hum. Genet , vol.10 , pp. 77-81
    • Topçu, M.1    Akyerli, C.2    Sayi, A.3    Törüner, G.A.4    Koçoğlu, S.R.5    Climbis, M.6
  • 119
    • 0024405530 scopus 로고
    • Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm
    • Veldhuis, J. D., Iranmanesh, A., Lizarralde, G., and Johnson, M. L. (1989). Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm. Am. J. Physiol. 257, E6-E14.
    • (1989) Am. J. Physiol , vol.257 , pp. E6-E14
    • Veldhuis, J.D.1    Iranmanesh, A.2    Lizarralde, G.3    Johnson, M.L.4
  • 120
    • 34250312421 scopus 로고    scopus 로고
    • Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease
    • Wahner, A. D., Sinsheimer, J. S., Bronstein, J. M., and Ritz, B. (2007). Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease. Neurology 64, 836-840. doi: 10. 1001/archneur. 64. 6. 836.
    • (2007) Neurology , vol.64 , pp. 836-840
    • Wahner, A.D.1    Sinsheimer, J.S.2    Bronstein, J.M.3    Ritz, B.4
  • 121
    • 0030662269 scopus 로고    scopus 로고
    • Neuropathology of autonomic nervous system in Parkinson's disease
    • Wakabayashi, K., and Takahashi, H. (1997). Neuropathology of autonomic nervous system in Parkinson's disease. Eur. Neurol. 38(Suppl. 2), 2-7. doi: 10. 1159/000113469.
    • (1997) Eur. Neurol , vol.38 , pp. 2-7
    • Wakabayashi, K.1    Takahashi, H.2
  • 122
    • 34347357758 scopus 로고    scopus 로고
    • Inflammation in Parkinson's diseases and other neurodegenerative diseases: Cause and therapeutic implications
    • Wilms, H., Zecca, L., Rosenstiel, P., Sievers, J., Deuschl, G., and Lucius, R. (2007). Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Curr. Pharm. Des. 13, 1925-1928. doi: 10. 2174/138161207780858429.
    • (2007) Curr. Pharm. Des , vol.13 , pp. 1925-1928
    • Wilms, H.1    Zecca, L.2    Rosenstiel, P.3    Sievers, J.4    Deuschl, G.5    Lucius, R.6
  • 123
    • 84890215976 scopus 로고    scopus 로고
    • Association of Parkinson disease with structural and regulatory variants in the HLA region
    • Wissemann, W. T., Hill-Burns, E. M., Zabetian, C. P., Factor, S. A., Patsopoulos, N., Hoglund, B., et al. (2013). Association of Parkinson disease with structural and regulatory variants in the HLA region. Am. J. Hum. Genet. 93, 984-993. doi: 10. 1016/j. ajhg. 2013. 10. 009.
    • (2013) Am. J. Hum. Genet , vol.93 , pp. 984-993
    • Wissemann, W.T.1    Hill-Burns, E.M.2    Zabetian, C.P.3    Factor, S.A.4    Patsopoulos, N.5    Hoglund, B.6
  • 124
    • 9644256061 scopus 로고    scopus 로고
    • Cortisol pulsatility and its role in stress regulation and health
    • Young, E. A., Abelson, J., and Lightman, S. L. (2004). Cortisol pulsatility and its role in stress regulation and health. Front. Neuroendocrinol. 25, 69-76. doi: 10. 1016/j. yfrne. 2004. 07. 001.
    • (2004) Front. Neuroendocrinol , vol.25 , pp. 69-76
    • Young, E.A.1    Abelson, J.2    Lightman, S.L.3
  • 125
    • 56749092171 scopus 로고    scopus 로고
    • Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans
    • Zarković, M., Ignjatović, S., Dajak, M., Cirić, J., Beleslin, B., Savić, S., et al. (2008). Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. Eur. J. Endocrinol. 159, 649-652. doi: 10. 1530/EJE-08-0544.
    • (2008) Eur. J. Endocrinol , vol.159 , pp. 649-652
    • Zarković, M.1    Ignjatović, S.2    Dajak, M.3    Cirić, J.4    Beleslin, B.5    Savić, S.6
  • 126
    • 18144399332 scopus 로고    scopus 로고
    • The human glucocorticoid receptor: One gene, multiple proteins and diverse responses
    • Zhou, J., and Cidlowski, J. A. (2005). The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70, 407-417. doi: 10. 1016/j. steroids. 2005. 02. 006.
    • (2005) Steroids , vol.70 , pp. 407-417
    • Zhou, J.1    Cidlowski, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.