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Volumn 2014, Issue , 2014, Pages

Immune responses in parkinson's disease: Interplay between central and peripheral immune systems

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL NERVOUS SYSTEM; CHRONIC INFLAMMATION; DISEASE COURSE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; NERVE DEGENERATION; PARKINSON DISEASE; PERIPHERAL NERVOUS SYSTEM; REVIEW; RISK FACTOR; IMMUNOLOGY; INFLAMMATION; PATHOPHYSIOLOGY;

EID: 84900017196     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/275178     Document Type: Review
Times cited : (76)

References (128)
  • 3
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • 2-s2.0-0141741347 10.1016/S0896-6273(03)00568-3
    • Dauer W., Przedborski S., Parkinson's disease: mechanisms and models. Neuron 2003 39 6 889 909 2-s2.0-0141741347 10.1016/S0896-6273(03)00568-3
    • (2003) Neuron , vol.39 , Issue.6 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 4
    • 45749107101 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease: Possible role of periodontal diseases
    • 2-s2.0-45749107101 10.1016/j.jalz.2007.08.004
    • Kamer A. R., Craig R. G., Dasanayake A. P., Brys M., Glodzik-Sobanska L., de Leon M. J., Inflammation and Alzheimer's disease: possible role of periodontal diseases. Alzheimer's and Dementia 2008 4 4 242 250 2-s2.0-45749107101 10.1016/j.jalz.2007.08.004
    • (2008) Alzheimer's and Dementia , vol.4 , Issue.4 , pp. 242-250
    • Kamer, A.R.1    Craig, R.G.2    Dasanayake, A.P.3    Brys, M.4    Glodzik-Sobanska, L.5    De Leon, M.J.6
  • 7
    • 84865112006 scopus 로고    scopus 로고
    • Oxidative stress and inflammation biomarkers in the blood of patients with Huntington's disease
    • Sanchez-Lopez F., Tasset I., Aguera E., Oxidative stress and inflammation biomarkers in the blood of patients with Huntington's disease. Neurological Research 2012 34 7 721 724
    • (2012) Neurological Research , vol.34 , Issue.7 , pp. 721-724
    • Sanchez-Lopez, F.1    Tasset, I.2    Aguera, E.3
  • 8
    • 84875951681 scopus 로고    scopus 로고
    • A critical role of astrocyte-mediated nuclear factor-kappaB-dependent inflammation in Huntington's disease
    • Hsiao H. Y., Chen Y. C., Chen H. M., Tu P. H., Chern Y., A critical role of astrocyte-mediated nuclear factor-kappaB-dependent inflammation in Huntington's disease. Human Molecular Genetics 2013 22 9 1826 1842
    • (2013) Human Molecular Genetics , vol.22 , Issue.9 , pp. 1826-1842
    • Hsiao, H.Y.1    Chen, Y.C.2    Chen, H.M.3    Tu, P.H.4    Chern, Y.5
  • 9
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • 2-s2.0-0023789193
    • McGeer P. L., Itagaki S., Boyes B. E., McGeer E. G., Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988 38 8 1285 1291 2-s2.0-0023789193
    • (1988) Neurology , vol.38 , Issue.8 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 10
    • 0029417080 scopus 로고
    • Interleukin-1 β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • 2-s2.0-0029417080 10.1016/0304-3940(95)12192-7
    • Blum-Degena D., Müller T., Kuhn W., Gerlach M., Przuntek H., Riederer P., Interleukin-1 β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neuroscience Letters 1995 202 1-2 17 20 2-s2.0-0029417080 10.1016/0304-3940(95) 12192-7
    • (1995) Neuroscience Letters , vol.202 , Issue.1-2 , pp. 17-20
    • Blum-Degena, D.1    Müller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 11
    • 0028171374 scopus 로고
    • Interleukin-1 β, interleukin-6, epidermal growth factor and transforming growth factor- α are elevated in the brain from parkinsonian patients
    • 2-s2.0-0028171374 10.1016/0304-3940(94)90508-8
    • Mogi M., Harada M., Kondob T., Riederer P., Inagaki H., Minami M., Nagatsu T., Interleukin-1 β interleukin-6, epidermal growth factor and transforming growth factor- α are elevated in the brain from parkinsonian patients. Neuroscience Letters 1994 180 2 147 150 2-s2.0-0028171374 10.1016/0304-3940(94)90508-8
    • (1994) Neuroscience Letters , vol.180 , Issue.2 , pp. 147-150
    • Mogi, M.1    Harada, M.2    Kondob, T.3    Riederer, P.4    Inagaki, H.5    Minami, M.6    Nagatsu, T.7
  • 12
    • 0028178281 scopus 로고
    • Tumor necrosis factor- α (TNF- α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
    • 2-s2.0-0028178281 10.1016/0304-3940(94)90746-3
    • Mogi M., Harada M., Riederer P., Narabayashi H., Fujita K., Nagatsu T., Tumor necrosis factor- α (TNF- α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neuroscience Letters 1994 165 1-2 208 210 2-s2.0-0028178281 10.1016/0304-3940(94)90746-3
    • (1994) Neuroscience Letters , vol.165 , Issue.1-2 , pp. 208-210
    • Mogi, M.1    Harada, M.2    Riederer, P.3    Narabayashi, H.4    Fujita, K.5    Nagatsu, T.6
  • 13
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 β, IL-2, IL-4, IL-6 and transforming growth factor- α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • 2-s2.0-0030582991 10.1016/0304-3940(96)12706-3
    • Mogi M., Harada M., Narabayashi H., Inagaki H., Minami M., Nagatsu T., Interleukin (IL)-1 β IL-2, IL-4, IL-6 and transforming growth factor- α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neuroscience Letters 1996 211 1 13 16 2-s2.0-0030582991 10.1016/0304-3940(96)12706-3
    • (1996) Neuroscience Letters , vol.211 , Issue.1 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 15
  • 16
    • 51449099473 scopus 로고    scopus 로고
    • Synuclein activates microglia in a model of Parkinson's disease
    • 2-s2.0-51449099473 10.1016/j.neurobiolaging.2007.04.006
    • Su X., Maguire-Zeiss K. A., Giuliano R., Prifti L., Venkatesh K., Federoff H. J., Synuclein activates microglia in a model of Parkinson's disease. Neurobiology of Aging 2008 29 11 1690 1701 2-s2.0-51449099473 10.1016/j.neurobiolaging.2007.04.006
    • (2008) Neurobiology of Aging , vol.29 , Issue.11 , pp. 1690-1701
    • Su, X.1    Maguire-Zeiss, K.A.2    Giuliano, R.3    Prifti, L.4    Venkatesh, K.5    Federoff, H.J.6
  • 17
    • 70349917814 scopus 로고    scopus 로고
    • Mutant α -synuclein overexpression mediates early proinflammatory activity
    • 2-s2.0-70349917814 10.1007/s12640-009-9053-x
    • Su X., Federoff H. J., Maguire-Zeiss K. A., Mutant α -synuclein overexpression mediates early proinflammatory activity. Neurotoxicity Research 2009 16 3 238 254 2-s2.0-70349917814 10.1007/s12640-009-9053-x
    • (2009) Neurotoxicity Research , vol.16 , Issue.3 , pp. 238-254
    • Su, X.1    Federoff, H.J.2    Maguire-Zeiss, K.A.3
  • 18
    • 0031881687 scopus 로고    scopus 로고
    • Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system
    • 2-s2.0-0031881687
    • Castaño A., Herrera A. J., Cano J., Machado A., Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system. Journal of Neurochemistry 1998 70 4 1584 1592 2-s2.0-0031881687
    • (1998) Journal of Neurochemistry , vol.70 , Issue.4 , pp. 1584-1592
    • Castaño, A.1    Herrera, A.J.2    Cano, J.3    Machado, A.4
  • 19
    • 0343844458 scopus 로고    scopus 로고
    • Nitric oxide synthase and neuronal vulnerability in Parkinson's disease
    • 2-s2.0-0343844458 10.1016/0306-4522(95)00578-1
    • Hunot S., Boissière F., Faucheux B., Brugg B., Mouatt-Prigent A., Agid Y., Hirsch E. C., Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 1996 72 2 355 363 2-s2.0-0343844458 10.1016/0306-4522(95)00578-1
    • (1996) Neuroscience , vol.72 , Issue.2 , pp. 355-363
    • Hunot, S.1    Boissière, F.2    Faucheux, B.3    Brugg, B.4    Mouatt-Prigent, A.5    Agid, Y.6    Hirsch, E.C.7
  • 20
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
    • 2-s2.0-0031715925
    • Hirsch E. C., Hunot S., Damier P., Faucheux B., Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Annals of Neurology 1998 44 3 S115 S120 2-s2.0-0031715925
    • (1998) Annals of Neurology , vol.44 , Issue.3
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 22
    • 0034023082 scopus 로고    scopus 로고
    • Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain
    • 2-s2.0-0034023082
    • Mogi M., Togari A., Kondo T., Mizuno Y., Komure O., Kuno S., Ichinose H., Nagatsu T., Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain. Journal of Neural Transmission 2000 107 3 335 341 2-s2.0-0034023082
    • (2000) Journal of Neural Transmission , vol.107 , Issue.3 , pp. 335-341
    • Mogi, M.1    Togari, A.2    Kondo, T.3    Mizuno, Y.4    Komure, O.5    Kuno, S.6    Ichinose, H.7    Nagatsu, T.8
  • 23
    • 20444441180 scopus 로고    scopus 로고
    • Interleukin-1 β exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures
    • 2-s2.0-20444441180 10.1111/j.1460-9568.2005.04067.x
    • Hailer N. P., Vogt C., Korf H.-W., Dehghani F., Interleukin-1 β exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures. European Journal of Neuroscience 2005 21 9 2347 2360 2-s2.0-20444441180 10.1111/j.1460-9568.2005.04067.x
    • (2005) European Journal of Neuroscience , vol.21 , Issue.9 , pp. 2347-2360
    • Hailer, N.P.1    Vogt, C.2    Korf, H.-W.3    Dehghani, F.4
  • 24
    • 22544484235 scopus 로고    scopus 로고
    • Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1 β signaling pathway
    • 2-s2.0-22544484235 10.1074/jbc.M503262200
    • Li C., Zienkiewicz J., Hawiger J., Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1 β signaling pathway. Journal of Biological Chemistry 2005 280 28 26152 26159 2-s2.0-22544484235 10.1074/jbc.M503262200
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.28 , pp. 26152-26159
    • Li, C.1    Zienkiewicz, J.2    Hawiger, J.3
  • 25
    • 0842277733 scopus 로고    scopus 로고
    • Inflammation and dopaminergic neuronal loss in Parkinson's disease: A complex matter
    • 2-s2.0-0842277733 10.1016/j.expneurol.2003.08.004
    • Hartmann A., Hunot S., Hirsch E. C., Inflammation and dopaminergic neuronal loss in Parkinson's disease: a complex matter. Experimental Neurology 2003 184 2 561 564 2-s2.0-0842277733 10.1016/j.expneurol.2003.08.004
    • (2003) Experimental Neurology , vol.184 , Issue.2 , pp. 561-564
    • Hartmann, A.1    Hunot, S.2    Hirsch, E.C.3
  • 26
    • 0033121299 scopus 로고    scopus 로고
    • Fc ε RII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor- α in glial cells
    • 2-s2.0-0033121299
    • Hunot S., Dugas N., Faucheux B., Hartmann A., Tardieu M., Debré P., Agid Y., Dugas B., Hirsch E. C., Fc ε RII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor- α in glial cells. Journal of Neuroscience 1999 19 9 3440 3447 2-s2.0-0033121299
    • (1999) Journal of Neuroscience , vol.19 , Issue.9 , pp. 3440-3447
    • Hunot, S.1    Dugas, N.2    Faucheux, B.3    Hartmann, A.4    Tardieu, M.5    Debré, P.6    Agid, Y.7    Dugas, B.8    Hirsch, E.C.9
  • 27
    • 0027178135 scopus 로고
    • Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
    • 2-s2.0-0027178135
    • Dawson V. L., Dawson T. M., Bartley D. A., Uhl G. R., Snyder S. H., Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. Journal of Neuroscience 1993 13 6 2651 2661 2-s2.0-0027178135
    • (1993) Journal of Neuroscience , vol.13 , Issue.6 , pp. 2651-2661
    • Dawson, V.L.1    Dawson, T.M.2    Bartley, D.A.3    Uhl, G.R.4    Snyder, S.H.5
  • 28
    • 0035805523 scopus 로고    scopus 로고
    • Death of a monopoly?
    • 2-s2.0-0035805523 10.1126/science.1060885
    • Hunot S., Flavell R. A., Death of a monopoly? Science 2001 292 5518 865 866 2-s2.0-0035805523 10.1126/science.1060885
    • (2001) Science , vol.292 , Issue.5518 , pp. 865-866
    • Hunot, S.1    Flavell, R.A.2
  • 29
    • 0043162103 scopus 로고    scopus 로고
    • Novel anti-inflammatory therapy for Parkinson's disease
    • 2-s2.0-0043162103 10.1016/S0165-6147(03)00176-7
    • Gao H.-M., Liu B., Zhang W., Hong J.-S., Novel anti-inflammatory therapy for Parkinson's disease. Trends in Pharmacological Sciences 2003 24 8 395 401 2-s2.0-0043162103 10.1016/S0165-6147(03)00176-7
    • (2003) Trends in Pharmacological Sciences , vol.24 , Issue.8 , pp. 395-401
    • Gao, H.-M.1    Liu, B.2    Zhang, W.3    Hong, J.-S.4
  • 30
    • 10644230914 scopus 로고    scopus 로고
    • Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: A death wish?
    • 2-s2.0-10644230914 10.1002/jnr.20346
    • Li Z., Jansen M., Ogburn K., Salvatierra L., Hunter L., Mathew S., Figueiredo-Pereira M. E., Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? Journal of Neuroscience Research 2004 78 6 824 836 2-s2.0-10644230914 10.1002/jnr.20346
    • (2004) Journal of Neuroscience Research , vol.78 , Issue.6 , pp. 824-836
    • Li, Z.1    Jansen, M.2    Ogburn, K.3    Salvatierra, L.4    Hunter, L.5    Mathew, S.6    Figueiredo-Pereira, M.E.7
  • 31
    • 0036499224 scopus 로고    scopus 로고
    • Prostaglandins as modulators of immunity
    • 2-s2.0-0036499224 10.1016/S1471-4906(01)02154-8
    • Harris S. G., Padilla J., Koumas L., Ray D., Phipps R. P., Prostaglandins as modulators of immunity. Trends in Immunology 2002 23 3 144 150 2-s2.0-0036499224 10.1016/S1471-4906(01)02154-8
    • (2002) Trends in Immunology , vol.23 , Issue.3 , pp. 144-150
    • Harris, S.G.1    Padilla, J.2    Koumas, L.3    Ray, D.4    Phipps, R.P.5
  • 32
    • 21744440118 scopus 로고    scopus 로고
    • MPTP and SNpc da neuronal vulnerability: Role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview
    • 2-s2.0-21744440118 10.1007/BF03036449
    • Jackson-Lewis V., Smeyne R. J., MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview. Neurotoxicity Research 2005 7 3 193 201 2-s2.0-21744440118 10.1007/BF03036449
    • (2005) Neurotoxicity Research , vol.7 , Issue.3 , pp. 193-201
    • Jackson-Lewis, V.1    Smeyne, R.J.2
  • 33
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • 2-s2.0-33845768784 10.1038/nrn2038
    • Block M. L., Zecca L., Hong J.-S., Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience 2007 8 1 57 69 2-s2.0-33845768784 10.1038/nrn2038
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 34
    • 0027352040 scopus 로고
    • Altered antigen expression of microglia in the aged rodent CNS
    • 2-s2.0-0027352040
    • Perry V. H., Matyszak M. K., Fearn S., Altered antigen expression of microglia in the aged rodent CNS. Glia 1993 7 1 60 67 2-s2.0-0027352040
    • (1993) Glia , vol.7 , Issue.1 , pp. 60-67
    • Perry, V.H.1    Matyszak, M.K.2    Fearn, S.3
  • 35
    • 0031960498 scopus 로고    scopus 로고
    • Microglial expression of MHC class II increases in normal aging of nonhuman primates
    • 2-s2.0-0031960498 10.1016/S0197-4580(97)00168-1
    • Sheffield L. G., Berman N. E. J., Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiology of Aging 1998 19 1 47 55 2-s2.0-0031960498 10.1016/S0197-4580(97)00168-1
    • (1998) Neurobiology of Aging , vol.19 , Issue.1 , pp. 47-55
    • Sheffield, L.G.1    Berman, N.E.J.2
  • 36
    • 33646006075 scopus 로고    scopus 로고
    • MRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
    • 2-s2.0-33646006075 10.1016/j.neurobiolaging.2005.03.013
    • Frank M. G., Barrientos R. M., Biedenkapp J. C., Rudy J. W., Watkins L. R., Maier S. F., mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiology of Aging 2006 27 5 717 722 2-s2.0-33646006075 10.1016/j.neurobiolaging.2005.03.013
    • (2006) Neurobiology of Aging , vol.27 , Issue.5 , pp. 717-722
    • Frank, M.G.1    Barrientos, R.M.2    Biedenkapp, J.C.3    Rudy, J.W.4    Watkins, L.R.5    Maier, S.F.6
  • 37
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • 2-s2.0-23444443814 10.1096/fj.05-3776fje
    • Godbout J. P., Chen J., Abraham J., Richwine A. F., Berg B. M., Kelley K. W., Johnson R. W., Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. The FASEB Journal 2005 19 10 1329 1331 2-s2.0-23444443814 10.1096/fj.05-3776fje
    • (2005) The FASEB Journal , vol.19 , Issue.10 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6    Johnson, R.W.7
  • 38
    • 26244433532 scopus 로고    scopus 로고
    • Macrosialin increases during normal brain aging are attenuated by caloric restriction
    • 2-s2.0-26244433532 10.1016/j.neulet.2005.07.058
    • Wong A. M., Patel N. V., Patel N. K., Wei M., Morgan T. E., De Beer M. C., De Villiers W. J. S., Finch C. E., Macrosialin increases during normal brain aging are attenuated by caloric restriction. Neuroscience Letters 2005 390 2 76 80 2-s2.0-26244433532 10.1016/j.neulet.2005.07.058
    • (2005) Neuroscience Letters , vol.390 , Issue.2 , pp. 76-80
    • Wong, A.M.1    Patel, N.V.2    Patel, N.K.3    Wei, M.4    Morgan, T.E.5    De Beer, M.C.6    De Villiers, W.J.S.7    Finch, C.E.8
  • 39
    • 34547749000 scopus 로고    scopus 로고
    • Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells
    • 2-s2.0-34547749000 10.1016/j.neurobiolaging.2006.07.022
    • Stichel C. C., Luebbert H., Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells. Neurobiology of Aging 2007 28 10 1507 1521 2-s2.0-34547749000 10.1016/j.neurobiolaging.2006.07.022
    • (2007) Neurobiology of Aging , vol.28 , Issue.10 , pp. 1507-1521
    • Stichel, C.C.1    Luebbert, H.2
  • 40
    • 34247471687 scopus 로고    scopus 로고
    • Innate immune receptor expression in normal brain aging
    • 2-s2.0-34247471687 10.1016/j.neuroscience.2007.01.004
    • Letiembre M., Hao W., Liu Y., Walter S., Mihaljevic I., Rivest S., Hartmann T., Fassbender K., Innate immune receptor expression in normal brain aging. Neuroscience 2007 146 1 248 254 2-s2.0-34247471687 10.1016/j. neuroscience.2007.01.004
    • (2007) Neuroscience , vol.146 , Issue.1 , pp. 248-254
    • Letiembre, M.1    Hao, W.2    Liu, Y.3    Walter, S.4    Mihaljevic, I.5    Rivest, S.6    Hartmann, T.7    Fassbender, K.8
  • 41
    • 33750480549 scopus 로고    scopus 로고
    • The age-related attenuation in long-term potentiation is associated with microglial activation
    • 2-s2.0-33750480549 10.1111/j.1471-4159.2006.04165.x
    • Griffin R., Nally R., Nolan Y., McCartney Y., Linden J., Lynch M. A., The age-related attenuation in long-term potentiation is associated with microglial activation. Journal of Neurochemistry 2006 99 4 1263 1272 2-s2.0-33750480549 10.1111/j.1471-4159.2006.04165.x
    • (2006) Journal of Neurochemistry , vol.99 , Issue.4 , pp. 1263-1272
    • Griffin, R.1    Nally, R.2    Nolan, Y.3    McCartney, Y.4    Linden, J.5    Lynch, M.A.6
  • 42
    • 81355132325 scopus 로고    scopus 로고
    • Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function
    • 2-s2.0-81355132325 10.1016/j.neurobiolaging.2010.05.008
    • Njie E. G., Boelen E., Stassen F. R., Steinbusch H. W. M., Borchelt D. R., Streit W. J., Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiology of Aging 2012 33 1 195.e1 195.e12 2-s2.0-81355132325 10.1016/j.neurobiolaging.2010.05.008
    • (2012) Neurobiology of Aging , vol.33 , Issue.1
    • Njie, E.G.1    Boelen, E.2    Stassen, F.R.3    Steinbusch, H.W.M.4    Borchelt, D.R.5    Streit, W.J.6
  • 43
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • 2-s2.0-38649119160 10.1016/j.bbi.2007.08.014
    • Chen J., Buchanan J. B., Sparkman N. L., Godbout J. P., Freund G. G., Johnson R. W., Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain, Behavior, and Immunity 2008 22 3 301 311 2-s2.0-38649119160 10.1016/j.bbi.2007.08.014
    • (2008) Brain, Behavior, and Immunity , vol.22 , Issue.3 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 44
    • 33644788171 scopus 로고    scopus 로고
    • Interaction between interferon γ and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation
    • 2-s2.0-33644788171 10.1111/j.1471-4159.2006.03664.x
    • Maher F. O., Clarke R. M., Kelly A., Nally R. E., Lynch M. A., Interaction between interferon γ and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation. Journal of Neurochemistry 2006 96 6 1560 1571 2-s2.0-33644788171 10.1111/j.1471-4159.2006.03664.x
    • (2006) Journal of Neurochemistry , vol.96 , Issue.6 , pp. 1560-1571
    • Maher, F.O.1    Clarke, R.M.2    Kelly, A.3    Nally, R.E.4    Lynch, M.A.5
  • 45
    • 0029087348 scopus 로고
    • Modulation of human microglial cell superoxide production by cytokines
    • 2-s2.0-0029087348
    • Chao C. C., Hu S., Peterson P. K., Modulation of human microglial cell superoxide production by cytokines. Journal of Leukocyte Biology 1995 58 1 65 70 2-s2.0-0029087348
    • (1995) Journal of Leukocyte Biology , vol.58 , Issue.1 , pp. 65-70
    • Chao, C.C.1    Hu, S.2    Peterson, P.K.3
  • 46
    • 0025244176 scopus 로고
    • Interferon- γ -induced priming for secretion of superoxide anion and tumor necrosis factor- α declines in macrophages from aged rats
    • 2-s2.0-0025244176
    • Davila D. R., Edwards C. K. III, Arkins S., Simon J., Kelley K. W., Interferon- γ -induced priming for secretion of superoxide anion and tumor necrosis factor- α declines in macrophages from aged rats. The FASEB Journal 1990 4 11 2906 2911 2-s2.0-0025244176
    • (1990) The FASEB Journal , vol.4 , Issue.11 , pp. 2906-2911
    • Davila, D.R.1    Edwards III, C.K.2    Arkins, S.3    Simon, J.4    Kelley, K.W.5
  • 47
    • 13644253039 scopus 로고    scopus 로고
    • Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat
    • 2-s2.0-13644253039 10.1016/j.neurobiolaging.2004.07.002
    • Maher F. O., Nolan Y., Lynch M. A., Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat. Neurobiology of Aging 2005 26 5 717 728 2-s2.0-13644253039 10.1016/j. neurobiolaging.2004.07.002
    • (2005) Neurobiology of Aging , vol.26 , Issue.5 , pp. 717-728
    • Maher, F.O.1    Nolan, Y.2    Lynch, M.A.3
  • 48
    • 0035720799 scopus 로고    scopus 로고
    • An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice
    • 2-s2.0-0035720799 10.1159/000049025
    • Ye S.-M., Johnson R. W., An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice. NeuroImmunoModulation 2001 9 4 183 192 2-s2.0-0035720799 10.1159/000049025
    • (2001) NeuroImmunoModulation , vol.9 , Issue.4 , pp. 183-192
    • Ye, S.-M.1    Johnson, R.W.2
  • 49
    • 0027169639 scopus 로고
    • GFAP mRNA increases with age in rat and human brain
    • 2-s2.0-0027169639 10.1016/0197-4580(93)90100-P
    • Nichols N. R., Day J. R., Laping N. J., Johnson S. A., Finch C. E., GFAP mRNA increases with age in rat and human brain. Neurobiology of Aging 1993 14 5 421 429 2-s2.0-0027169639 10.1016/0197-4580(93)90100-P
    • (1993) Neurobiology of Aging , vol.14 , Issue.5 , pp. 421-429
    • Nichols, N.R.1    Day, J.R.2    Laping, N.J.3    Johnson, S.A.4    Finch, C.E.5
  • 50
    • 0036144231 scopus 로고    scopus 로고
    • Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
    • 2-s2.0-0036144231 10.1002/jnr.10107
    • Cotrina M. L., Nedergaard M., Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. Journal of Neuroscience Research 2002 67 1 21 29 2-s2.0-0036144231 10.1002/jnr.10107
    • (2002) Journal of Neuroscience Research , vol.67 , Issue.1 , pp. 21-29
    • Cotrina, M.L.1    Nedergaard, M.2
  • 51
    • 0042360512 scopus 로고    scopus 로고
    • Analysis of gial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease
    • 2-s2.0-0042360512 10.1002/pmic.200300456
    • Porchet R., Probst A., Bouras C., Dráberová E., Dráber P., Riederer B. M., Analysis of gial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease. Proteomics 2003 3 8 1476 1485 2-s2.0-0042360512 10.1002/pmic.200300456
    • (2003) Proteomics , vol.3 , Issue.8 , pp. 1476-1485
    • Porchet, R.1    Probst, A.2    Bouras, C.3    Dráberová, E.4    Dráber, P.5    Riederer, B.M.6
  • 52
    • 7944223409 scopus 로고    scopus 로고
    • Astrocyte intermediate filaments in CNS pathologies and regeneration
    • 2-s2.0-7944223409 10.1002/path.1645
    • Pekny M., Pekna M., Astrocyte intermediate filaments in CNS pathologies and regeneration. Journal of Pathology 2004 204 4 428 437 2-s2.0-7944223409 10.1002/path.1645
    • (2004) Journal of Pathology , vol.204 , Issue.4 , pp. 428-437
    • Pekny, M.1    Pekna, M.2
  • 53
    • 37049017788 scopus 로고    scopus 로고
    • Modulation by astrocytes of microglial cell-mediated neuroinflammation: Effect on the activation of microglial signaling pathways
    • 2-s2.0-37049017788 10.1159/000110642
    • Tichauer J., Saud K., von Bernhardi R., Modulation by astrocytes of microglial cell-mediated neuroinflammation: effect on the activation of microglial signaling pathways. NeuroImmunoModulation 2007 14 3-4 168 174 2-s2.0-37049017788 10.1159/000110642
    • (2007) NeuroImmunoModulation , vol.14 , Issue.3-4 , pp. 168-174
    • Tichauer, J.1    Saud, K.2    Von Bernhardi, R.3
  • 54
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • 2-s2.0-29244463365 10.1038/nrn1824
    • Abbott N. J., Rönnbäck L., Hansson E., Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews Neuroscience 2006 7 1 41 53 2-s2.0-29244463365 10.1038/nrn1824
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 55
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • 2-s2.0-38149090292 10.1016/j.neuron.2008.01.003
    • Zlokovic B. V., The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008 57 2 178 201 2-s2.0-38149090292 10.1016/j.neuron.2008.01.003
    • (2008) Neuron , vol.57 , Issue.2 , pp. 178-201
    • Zlokovic, B.V.1
  • 56
    • 0032476641 scopus 로고    scopus 로고
    • Astrocyte expression of monocyte chemoattractant protein-1 is differentially regulated by transforming growth factor beta
    • 2-s2.0-0032476641 10.1016/S0165-5728(98)00183-0
    • Weiss J. M., Berman J. W., Astrocyte expression of monocyte chemoattractant protein-1 is differentially regulated by transforming growth factor beta. Journal of Neuroimmunology 1998 91 1-2 190 197 2-s2.0-0032476641 10.1016/S0165-5728(98)00183-0
    • (1998) Journal of Neuroimmunology , vol.91 , Issue.1-2 , pp. 190-197
    • Weiss, J.M.1    Berman, J.W.2
  • 57
    • 82155168545 scopus 로고    scopus 로고
    • The acute inflammatory response to intranigral α -synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation
    • 2-s2.0-82155168545 10.1186/1742-2094-8-166
    • Couch Y., Alvarez-Erviti L., Sibson N. R., Wood M. J. A., Anthony D. C., The acute inflammatory response to intranigral α -synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation. Journal of Neuroinflammation 2011 8, article 166 2-s2.0-82155168545 10.1186/1742-2094-8-166
    • (2011) Journal of Neuroinflammation , vol.8166
    • Couch, Y.1    Alvarez-Erviti, L.2    Sibson, N.R.3    Wood, M.J.A.4    Anthony, D.C.5
  • 58
    • 67650351515 scopus 로고    scopus 로고
    • Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells
    • 2-s2.0-67650351515 10.1021/pr9001614
    • Reynolds A. D., Stone D. K., Mosley R. L., Gendelman H. E., Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells. Journal of Proteome Research 2009 8 7 3497 3511 2-s2.0-67650351515 10.1021/pr9001614
    • (2009) Journal of Proteome Research , vol.8 , Issue.7 , pp. 3497-3511
    • Reynolds, A.D.1    Stone, D.K.2    Mosley, R.L.3    Gendelman, H.E.4
  • 59
    • 64249169415 scopus 로고    scopus 로고
    • Nitrated α -synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets
    • 2-s2.0-64249169415 10.4049/jimmunol.0803982
    • Reynolds A. D., Stone D. K., Mosley R. L., Gendelman H. E., Nitrated α -synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets. Journal of Immunology 2009 182 7 4137 4149 2-s2.0-64249169415 10.4049/jimmunol.0803982
    • (2009) Journal of Immunology , vol.182 , Issue.7 , pp. 4137-4149
    • Reynolds, A.D.1    Stone, D.K.2    Mosley, R.L.3    Gendelman, H.E.4
  • 60
    • 34247631275 scopus 로고    scopus 로고
    • Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
    • 2-s2.0-34247631275 10.1016/j.tins.2007.03.009
    • Sulzer D., Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends in Neurosciences 2007 30 5 244 250 2-s2.0-34247631275 10.1016/j.tins.2007.03.009
    • (2007) Trends in Neurosciences , vol.30 , Issue.5 , pp. 244-250
    • Sulzer, D.1
  • 61
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of α -synuclein and its aggregates
    • 2-s2.0-21344456506 10.1523/JNEUROSCI.0692-05.2005
    • Lee H.-J., Patel S., Lee S.-J., Intravesicular localization and exocytosis of α -synuclein and its aggregates. Journal of Neuroscience 2005 25 25 6016 6024 2-s2.0-21344456506 10.1523/JNEUROSCI.0692-05.2005
    • (2005) Journal of Neuroscience , vol.25 , Issue.25 , pp. 6016-6024
    • Lee, H.-J.1    Patel, S.2    Lee, S.-J.3
  • 62
    • 33846668868 scopus 로고    scopus 로고
    • Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α -synuclein
    • 2-s2.0-33846668868 10.1186/1742-2094-4-2
    • Jin J., Shie F.-S., Liu J., Wang Y., Davis J., Schantz A. M., Montine K. S., Montine T. J., Zhang J., Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α -synuclein. Journal of Neuroinflammation 2007 4, article 2 2-s2.0-33846668868 10.1186/1742-2094-4-2
    • (2007) Journal of Neuroinflammation , vol.42
    • Jin, J.1    Shie, F.-S.2    Liu, J.3    Wang, Y.4    Davis, J.5    Schantz, A.M.6    Montine, K.S.7    Montine, T.J.8    Zhang, J.9
  • 63
    • 76349085159 scopus 로고    scopus 로고
    • Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen
    • 2-s2.0-76349085159 10.1016/j.bbrc.2010.01.041
    • Maekawa T., Kubo M., Yokoyama I., Ohta E., Obata F., Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen. Biochemical and Biophysical Research Communications 2010 392 3 431 435 2-s2.0-76349085159 10.1016/j.bbrc.2010.01.041
    • (2010) Biochemical and Biophysical Research Communications , vol.392 , Issue.3 , pp. 431-435
    • Maekawa, T.1    Kubo, M.2    Yokoyama, I.3    Ohta, E.4    Obata, F.5
  • 65
    • 84858620880 scopus 로고    scopus 로고
    • Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
    • 2-s2.0-84858620880 10.1016/j.neuroscience.2012.02.001
    • Gillardon F., Schmid R., Draheim H., Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity. Neuroscience 2012 208 41 48 2-s2.0-84858620880 10.1016/j.neuroscience.2012.02. 001
    • (2012) Neuroscience , vol.208 , pp. 41-48
    • Gillardon, F.1    Schmid, R.2    Draheim, H.3
  • 66
    • 84893714532 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease
    • Lopez de Maturana R., Aguila J. C., Sousa A., Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease. Neurobiology of Aging 2014 35 5 1116 1124
    • (2014) Neurobiology of Aging , vol.35 , Issue.5 , pp. 1116-1124
    • Lopez De Maturana, R.1    Aguila, J.C.2    Sousa, A.3
  • 68
    • 84859499649 scopus 로고    scopus 로고
    • Impaired inflammatory responses in murine lrrk2-knockdown brain microglia
    • 2-s2.0-84859499649 10.1371/journal.pone.0034693 e34693
    • Kim B., Yang M.-S., Choi D., Kim J.-H., Kim H.-S., Seol W., Choi S., Jou I., Kim E.-Y., Joe E.-H., Impaired inflammatory responses in murine lrrk2-knockdown brain microglia. PLoS ONE 2012 7 4 2-s2.0-84859499649 10.1371/journal.pone.0034693 e34693
    • (2012) PLoS ONE , vol.7 , Issue.4
    • Kim, B.1    Yang, M.-S.2    Choi, D.3    Kim, J.-H.4    Kim, H.-S.5    Seol, W.6    Choi, S.7    Jou, I.8    Kim, E.-Y.9    Joe, E.-H.10
  • 71
    • 77958072667 scopus 로고    scopus 로고
    • PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease
    • 52ra73
    • Zheng B., Liao Z., Locascio J. J., PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease. Science Translational Medicine 2010 2 52 52ra73
    • (2010) Science Translational Medicine , vol.2 , Issue.52
    • Zheng, B.1    Liao, Z.2    Locascio, J.J.3
  • 75
    • 71749083139 scopus 로고    scopus 로고
    • Increased serum levels of soluble tumor necrosis factor- α receptor-1 in patients with Parkinson's disease
    • 2-s2.0-71749083139 10.1016/j.jneuroim.2009.08.001
    • Scalzo P., Kümmer A., Cardoso F., Teixeira A. L., Increased serum levels of soluble tumor necrosis factor- α receptor-1 in patients with Parkinson's disease. Journal of Neuroimmunology 2009 216 1-2 122 125 2-s2.0-71749083139 10.1016/j.jneuroim.2009.08.001
    • (2009) Journal of Neuroimmunology , vol.216 , Issue.1-2 , pp. 122-125
    • Scalzo, P.1    Kümmer, A.2    Cardoso, F.3    Teixeira, A.L.4
  • 77
    • 37549057265 scopus 로고    scopus 로고
    • Peripheral inflammatory biomarkers and risk of Parkinson's disease
    • 2-s2.0-37549057265 10.1093/aje/kwm260
    • Chen H., O'Reilly E. J., Schwarzschild M. A., Ascherio A., Peripheral inflammatory biomarkers and risk of Parkinson's disease. The American Journal of Epidemiology 2008 167 1 90 95 2-s2.0-37549057265 10.1093/aje/kwm260
    • (2008) The American Journal of Epidemiology , vol.167 , Issue.1 , pp. 90-95
    • Chen, H.1    O'Reilly, E.J.2    Schwarzschild, M.A.3    Ascherio, A.4
  • 79
    • 10744223160 scopus 로고    scopus 로고
    • Diagnostic staging of Parkinson's disease: Conceptual aspects
    • 2-s2.0-10744223160 10.1007/s00702-003-0102-y
    • Przuntek H., Müller T., Riederer P., Diagnostic staging of Parkinson's disease: conceptual aspects. Journal of Neural Transmission 2004 111 2 201 216 2-s2.0-10744223160 10.1007/s00702-003-0102-y
    • (2004) Journal of Neural Transmission , vol.111 , Issue.2 , pp. 201-216
    • Przuntek, H.1    Müller, T.2    Riederer, P.3
  • 80
    • 24344442953 scopus 로고    scopus 로고
    • Role of inflammation in gastrointestinal tract in aetiology and pathogenesis of idiopathic parkinsonism
    • 2-s2.0-24344442953 10.1016/j.femsim.2005.01.011
    • Weller C., Oxlade N., Dobbs S. M., Dobbs R. J., Charlett A., Bjarnason I. T., Role of inflammation in gastrointestinal tract in aetiology and pathogenesis of idiopathic parkinsonism. FEMS Immunology and Medical Microbiology 2005 44 2 129 135 2-s2.0-24344442953 10.1016/j.femsim.2005.01.011
    • (2005) FEMS Immunology and Medical Microbiology , vol.44 , Issue.2 , pp. 129-135
    • Weller, C.1    Oxlade, N.2    Dobbs, S.M.3    Dobbs, R.J.4    Charlett, A.5    Bjarnason, I.T.6
  • 81
    • 0034005171 scopus 로고    scopus 로고
    • Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson's disease
    • 2-s2.0-0034005171 10.1034/j.1600-0404.2000.101003159.x
    • Hasegawa Y., Inagaki T., Sawada M., Suzumura A., Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson's disease. Acta Neurologica Scandinavica 2000 101 3 159 164 2-s2.0-0034005171 10.1034/j.1600-0404.2000.101003159.x
    • (2000) Acta Neurologica Scandinavica , vol.101 , Issue.3 , pp. 159-164
    • Hasegawa, Y.1    Inagaki, T.2    Sawada, M.3    Suzumura, A.4
  • 83
    • 31544482391 scopus 로고    scopus 로고
    • Long-term survival of Parkinson's disease: A population-based study
    • 2-s2.0-31544482391 10.1007/s00415-005-0916-7
    • D'Amelio M., Ragonese P., Morgante L., Reggio A., Callari G., Salemi G., Savettieri G., Long-term survival of Parkinson's disease: a population-based study. Journal of Neurology 2006 253 1 33 37 2-s2.0-31544482391 10.1007/s00415-005-0916-7
    • (2006) Journal of Neurology , vol.253 , Issue.1 , pp. 33-37
    • D'Amelio, M.1    Ragonese, P.2    Morgante, L.3    Reggio, A.4    Callari, G.5    Salemi, G.6    Savettieri, G.7
  • 84
    • 33645559991 scopus 로고    scopus 로고
    • Inflammation and infection in Parkinson's disease
    • 2-s2.0-33645559991
    • Arai H., Furuya T., Mizuno Y., Mochizuki H., Inflammation and infection in Parkinson's disease. Histology and Histopathology 2006 21 4-6 673 678 2-s2.0-33645559991
    • (2006) Histology and Histopathology , vol.21 , Issue.4-6 , pp. 673-678
    • Arai, H.1    Furuya, T.2    Mizuno, Y.3    Mochizuki, H.4
  • 86
    • 68249145501 scopus 로고    scopus 로고
    • Innate and adaptive immunity for the pathobiology of Parkinson's disease
    • 2-s2.0-68249145501 10.1089/ars.2009.2460
    • Stone D. K., Reynolds A. D., Mosley R. L., Gendelman H. E., Innate and adaptive immunity for the pathobiology of Parkinson's disease. Antioxidants and Redox Signaling 2009 11 9 2151 2166 2-s2.0-68249145501 10.1089/ars.2009.2460
    • (2009) Antioxidants and Redox Signaling , vol.11 , Issue.9 , pp. 2151-2166
    • Stone, D.K.1    Reynolds, A.D.2    Mosley, R.L.3    Gendelman, H.E.4
  • 88
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: A target for neuroprotection?
    • 2-s2.0-62549133546 10.1016/S1474-4422(09)70062-6
    • Hirsch E. C., Hunot S., Neuroinflammation in Parkinson's disease: a target for neuroprotection? The Lancet Neurology 2009 8 4 382 397 2-s2.0-62549133546 10.1016/S1474-4422(09)70062-6
    • (2009) The Lancet Neurology , vol.8 , Issue.4 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 89
    • 4344691112 scopus 로고    scopus 로고
    • Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: A potential, new model of Parkinson's disease
    • 2-s2.0-4344691112
    • Carvey P. M., Chang Q., Lipton J. W., Ling Z., Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: a potential, new model of Parkinson's disease. Frontiers in Bioscience 2003 8 s826 s837 2-s2.0-4344691112
    • (2003) Frontiers in Bioscience , vol.8
    • Carvey, P.M.1    Chang, Q.2    Lipton, J.W.3    Ling, Z.4
  • 90
    • 0036460861 scopus 로고    scopus 로고
    • In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain
    • 2-s2.0-0036460861 10.1002/mds.10078
    • Ling Z., Gayle D. A., Ma S. Y., Lipton J. W., Tong C. W., Hong J.-S., Carvey P. M., In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Movement Disorders 2002 17 1 116 124 2-s2.0-0036460861 10.1002/mds.10078
    • (2002) Movement Disorders , vol.17 , Issue.1 , pp. 116-124
    • Ling, Z.1    Gayle, D.A.2    Ma, S.Y.3    Lipton, J.W.4    Tong, C.W.5    Hong, J.-S.6    Carvey, P.M.7
  • 91
    • 8644287610 scopus 로고    scopus 로고
    • Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally
    • 2-s2.0-8644287610 10.1016/j.expneurol.2004.08.006
    • Ling Z., Chang Q. A., Tong C. W., Leurgans S. E., Lipton J. W., Carvey P. M., Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally. Experimental Neurology 2004 190 2 373 383 2-s2.0-8644287610 10.1016/j.expneurol.2004.08.006
    • (2004) Experimental Neurology , vol.190 , Issue.2 , pp. 373-383
    • Ling, Z.1    Chang, Q.A.2    Tong, C.W.3    Leurgans, S.E.4    Lipton, J.W.5    Carvey, P.M.6
  • 92
    • 63249120288 scopus 로고    scopus 로고
    • Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson's disease
    • 2-s2.0-63249120288 10.1016/j.bbi.2009.01.018
    • Engler H., Doenlen R., Riether C., Engler A., Niemi M.-B., Besedovsky H. O., Rey A. D., Pacheco-López G., Feldon J., Schedlowski M., Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson's disease. Brain, Behavior, and Immunity 2009 23 4 518 526 2-s2.0-63249120288 10.1016/j.bbi.2009.01.018
    • (2009) Brain, Behavior, and Immunity , vol.23 , Issue.4 , pp. 518-526
    • Engler, H.1    Doenlen, R.2    Riether, C.3    Engler, A.4    Niemi, M.-B.5    Besedovsky, H.O.6    Rey, A.D.7    Pacheco-López, G.8    Feldon, J.9    Schedlowski, M.10
  • 94
    • 75749135592 scopus 로고    scopus 로고
    • A timeline for Parkinson's disease
    • 2-s2.0-75749135592 10.1016/j.parkreldis.2009.08.007
    • Hawkes C. H., Del Tredici K., Braak H., A timeline for Parkinson's disease. Parkinsonism and Related Disorders 2010 16 2 79 84 2-s2.0-75749135592 10.1016/j.parkreldis.2009.08.007
    • (2010) Parkinsonism and Related Disorders , vol.16 , Issue.2 , pp. 79-84
    • Hawkes, C.H.1    Del Tredici, K.2    Braak, H.3
  • 95
    • 78649686234 scopus 로고    scopus 로고
    • The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease
    • 2-s2.0-78649686234 10.1176/appi.psy.51.6.474
    • Menza M., Dobkin R. D., Marin H., Mark M. H., Gara M., Bienfait K., Dicke A., Kusnekov A., The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease. Psychosomatics 2010 51 6 474 479 2-s2.0-78649686234 10.1176/appi.psy.51.6.474
    • (2010) Psychosomatics , vol.51 , Issue.6 , pp. 474-479
    • Menza, M.1    Dobkin, R.D.2    Marin, H.3    Mark, M.H.4    Gara, M.5    Bienfait, K.6    Dicke, A.7    Kusnekov, A.8
  • 96
    • 33749241734 scopus 로고    scopus 로고
    • Who are we? Indigenous microbes and the ecology of human diseases
    • 2-s2.0-33749241734 10.1038/sj.embor.7400812
    • Blaser M. J., Who are we? Indigenous microbes and the ecology of human diseases. EMBO Reports 2006 7 10 956 960 2-s2.0-33749241734 10.1038/sj.embor. 7400812
    • (2006) EMBO Reports , vol.7 , Issue.10 , pp. 956-960
    • Blaser, M.J.1
  • 97
    • 84860896167 scopus 로고    scopus 로고
    • Treatment for Helicobacter pylori infection and risk of parkinson's disease in Denmark
    • 2-s2.0-84855764812 10.1111/j.1468-1331.2011.03643.x
    • Nielsen H. H., Qiu J., Friis S., Wermuth L., Ritz B., Treatment for Helicobacter pylori infection and risk of parkinson's disease in Denmark. European Journal of Neurology 2012 19 6 864 869 2-s2.0-84855764812 10.1111/j.1468-1331.2011.03643.x
    • (2012) European Journal of Neurology , vol.19 , Issue.6 , pp. 864-869
    • Nielsen, H.H.1    Qiu, J.2    Friis, S.3    Wermuth, L.4    Ritz, B.5
  • 98
    • 25444515150 scopus 로고    scopus 로고
    • Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic Parkinsonism. Part 2: Response of facets of clinical idiopathic Parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, placebo-controlled efficacy study
    • 2-s2.0-25444515150 10.1111/j.1523-5378.2005.00354.x
    • Bjarnason I. T., Charlett A., Dobbs R. J., Dobbs S. M., Ibrahim M. A. A., Kerwin R. W., Mahler R. F., Oxlade N. L., Peterson D. W., Plant J. M., Price A. B., Weller C., Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic Parkinsonism. Part 2: response of facets of clinical idiopathic Parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, placebo-controlled efficacy study. Helicobacter 2005 10 557 287 2-s2.0-25444515150 10.1111/j.1523-5378.2005.00354.x
    • (2005) Helicobacter , vol.10 , pp. 557-287
    • Bjarnason, I.T.1    Charlett, A.2    Dobbs, R.J.3    Dobbs, S.M.4    Ibrahim, M.A.A.5    Kerwin, R.W.6    Mahler, R.F.7    Oxlade, N.L.8    Peterson, D.W.9    Plant, J.M.10    Price, A.B.11    Weller, C.12
  • 99
    • 73349092154 scopus 로고    scopus 로고
    • Medical records documentation of constipation preceding Parkinson disease: A case-control study
    • 2-s2.0-73349092154 10.1212/WNL.0b013e3181c34af5
    • Savica R., Carlin J. M., Grossardt B. R., Bower J. H., Ahlskog J. E., Maraganore D. M., Bharucha A. E., Rocca W. A., Medical records documentation of constipation preceding Parkinson disease: a case-control study. Neurology 2009 73 21 1752 1758 2-s2.0-73349092154 10.1212/WNL.0b013e3181c34af5
    • (2009) Neurology , vol.73 , Issue.21 , pp. 1752-1758
    • Savica, R.1    Carlin, J.M.2    Grossardt, B.R.3    Bower, J.H.4    Ahlskog, J.E.5    Maraganore, D.M.6    Bharucha, A.E.7    Rocca, W.A.8
  • 100
    • 4644313269 scopus 로고    scopus 로고
    • Diabetes mellitus and progression of rigidity and gait disturbance in older persons
    • 2-s2.0-4644313269
    • Arvanitakis Z., Wilson R. S., Schneider J. A., Bienias J. L., Evans D. A., Bennett D. A., Diabetes mellitus and progression of rigidity and gait disturbance in older persons. Neurology 2004 63 6 996 1001 2-s2.0-4644313269
    • (2004) Neurology , vol.63 , Issue.6 , pp. 996-1001
    • Arvanitakis, Z.1    Wilson, R.S.2    Schneider, J.A.3    Bienias, J.L.4    Evans, D.A.5    Bennett, D.A.6
  • 101
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • 2-s2.0-33745861300 10.1172/JCI29069
    • Shoelson S. E., Lee J., Goldfine A. B., Inflammation and insulin resistance. Journal of Clinical Investigation 2006 116 7 1793 1801 2-s2.0-33745861300 10.1172/JCI29069
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 102
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, inflammation, and cardiovascular disease
    • 2-s2.0-19044393872 10.1161/01.RES.0000163635.62927.34
    • Berg A. H., Scherer P. E., Adipose tissue, inflammation, and cardiovascular disease. Circulation Research 2005 96 9 939 949 2-s2.0-19044393872 10.1161/01.RES.0000163635.62927.34
    • (2005) Circulation Research , vol.96 , Issue.9 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 104
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK- β and NF- B
    • 2-s2.0-14644427890 10.1038/nm1166
    • Cai D., Yuan M., Frantz D. F., Melendez P. A., Hansen L., Lee J., Shoelson S. E., Local and systemic insulin resistance resulting from hepatic activation of IKK- β and NF- B. Nature Medicine 2005 11 2 183 190 2-s2.0-14644427890 10.1038/nm1166
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 106
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • 2-s2.0-24944438230 10.1210/en.2004-1520
    • De Souza C. T., Araujo E. P., Bordin S., Ashimine R., Zollner R. L., Boschero A. C., Saad M. J. A., Velloso L. A., Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005 146 10 4192 4199 2-s2.0-24944438230 10.1210/en.2004-1520
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3    Ashimine, R.4    Zollner, R.L.5    Boschero, A.C.6    Saad, M.J.A.7    Velloso, L.A.8
  • 107
    • 0030028606 scopus 로고    scopus 로고
    • The expression of TNF α by human muscle: Relationship to insulin resistance
    • 2-s2.0-0030028606
    • Saghizadeh M., Ong J. M., Garvey W. T., Henry R. R., Kern P. A., The expression of TNF α by human muscle: relationship to insulin resistance. Journal of Clinical Investigation 1996 97 4 1111 1116 2-s2.0-0030028606
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.4 , pp. 1111-1116
    • Saghizadeh, M.1    Ong, J.M.2    Garvey, W.T.3    Henry, R.R.4    Kern, P.A.5
  • 108
    • 84865639699 scopus 로고    scopus 로고
    • Neuroinflammation and non-motor symptoms: The dark passenger of Parkinson's disease?
    • Barnum C. J., Tansey M. G., Neuroinflammation and non-motor symptoms: the dark passenger of Parkinson's disease? Current Neurology and Neuroscience Reports 2012 12 4 350 358
    • (2012) Current Neurology and Neuroscience Reports , vol.12 , Issue.4 , pp. 350-358
    • Barnum, C.J.1    Tansey, M.G.2
  • 109
    • 61849149792 scopus 로고    scopus 로고
    • Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases
    • 2-s2.0-61849149792 10.1111/j.1365-2990.2008.01005.x
    • Stolp H. B., Dziegielewska K. M., Review: role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases. Neuropathology and Applied Neurobiology 2009 35 2 132 146 2-s2.0-61849149792 10.1111/j.1365-2990.2008.01005.x
    • (2009) Neuropathology and Applied Neurobiology , vol.35 , Issue.2 , pp. 132-146
    • Stolp, H.B.1    Dziegielewska, K.M.2
  • 110
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • 2-s2.0-0037180778 10.1038/nature01321
    • Tracey K. J., The inflammatory reflex. Nature 2002 420 6917 853 859 2-s2.0-0037180778 10.1038/nature01321
    • (2002) Nature , vol.420 , Issue.6917 , pp. 853-859
    • Tracey, K.J.1
  • 112
    • 0033573451 scopus 로고    scopus 로고
    • An essential role of interleukin-1 β in mediating NF- B activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia
    • 2-s2.0-0033573451
    • Laflamme N., Lacroix S., Rivest S., An essential role of interleukin-1 β in mediating NF- B activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. Journal of Neuroscience 1999 19 24 10923 10930 2-s2.0-0033573451
    • (1999) Journal of Neuroscience , vol.19 , Issue.24 , pp. 10923-10930
    • Laflamme, N.1    Lacroix, S.2    Rivest, S.3
  • 113
    • 0026667651 scopus 로고
    • Role of the OVLT in the febrile response to circulating pyrogens
    • 2-s2.0-0026667651
    • Blatteis C. M., Role of the OVLT in the febrile response to circulating pyrogens. Progress in Brain Research 1992 91 409 412 2-s2.0-0026667651
    • (1992) Progress in Brain Research , vol.91 , pp. 409-412
    • Blatteis, C.M.1
  • 114
    • 61349193143 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1 β and anti-inflammatory IL-10 cytokines
    • 2-s2.0-61349193143 10.1016/j.bbi.2008.09.002
    • Henry C. J., Huang Y., Wynne A. M., Godbout J. P., Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1 β and anti-inflammatory IL-10 cytokines. Brain, Behavior, and Immunity 2009 23 3 309 317 2-s2.0-61349193143 10.1016/j.bbi.2008.09.002
    • (2009) Brain, Behavior, and Immunity , vol.23 , Issue.3 , pp. 309-317
    • Henry, C.J.1    Huang, Y.2    Wynne, A.M.3    Godbout, J.P.4
  • 115
    • 79955921784 scopus 로고    scopus 로고
    • Neuroinflammation and α -synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease
    • 2-s2.0-79955921784 10.1289/ehp.1003013
    • Gao H.-M., Zhang F., Zhou H., Kam W., Wilson B., Hong J.-S., Neuroinflammation and α -synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environmental Health Perspectives 2011 119 6 807 814 2-s2.0-79955921784 10.1289/ehp.1003013
    • (2011) Environmental Health Perspectives , vol.119 , Issue.6 , pp. 807-814
    • Gao, H.-M.1    Zhang, F.2    Zhou, H.3    Kam, W.4    Wilson, B.5    Hong, J.-S.6
  • 117
    • 78650132056 scopus 로고    scopus 로고
    • Prospects for minocycline neuroprotection
    • 2-s2.0-78650132056 10.1001/archneurol.2010.191
    • Plane J. M., Shen Y., Pleasure D. E., Deng W., Prospects for minocycline neuroprotection. Archives of Neurology 2010 67 12 1442 1448 2-s2.0-78650132056 10.1001/archneurol.2010.191
    • (2010) Archives of Neurology , vol.67 , Issue.12 , pp. 1442-1448
    • Plane, J.M.1    Shen, Y.2    Pleasure, D.E.3    Deng, W.4
  • 118
    • 33645894705 scopus 로고    scopus 로고
    • A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
    • 2-s2.0-33645894705 10.1212/01.wnl.0000201252.57661.e1
    • Ravina B., A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology 2006 66 5 664 671 2-s2.0-33645894705 10.1212/01.wnl.0000201252.57661.e1
    • (2006) Neurology , vol.66 , Issue.5 , pp. 664-671
    • Ravina, B.1
  • 119
    • 79959575659 scopus 로고    scopus 로고
    • Regulation of LRRK2 expression points to a functional role in human monocyte maturation
    • e21519 2-s2.0-84855737999
    • Thévenet J., Pescini Gobert R., Hooft van Huijsduijnen R., Wiessner C., Sagot Y. J., Regulation of LRRK2 expression points to a functional role in human monocyte maturation. PLoS ONE 2011 6 6 e21519 2-s2.0-84855737999
    • (2011) PLoS ONE , vol.6 , Issue.6
    • Thévenet, J.1    Pescini Gobert, R.2    Hooft Van Huijsduijnen, R.3    Wiessner, C.4    Sagot, Y.J.5
  • 121
    • 84861552733 scopus 로고    scopus 로고
    • LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
    • Hinkle K. M., Yue M., Behrouz B., LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Molecular Neurodegeneration 2012 7, article 25
    • (2012) Molecular Neurodegeneration , vol.725
    • Hinkle, K.M.1    Yue, M.2    Behrouz, B.3
  • 122
    • 77449139468 scopus 로고    scopus 로고
    • PGC-1 α activation as a therapeutic approach in mitochondrial disease
    • 2-s2.0-77449139468 10.1002/iub.261
    • Wenz T., PGC-1 α activation as a therapeutic approach in mitochondrial disease. IUBMB Life 2009 61 11 1051 1062 2-s2.0-77449139468 10.1002/iub.261
    • (2009) IUBMB Life , vol.61 , Issue.11 , pp. 1051-1062
    • Wenz, T.1
  • 124
    • 80455174540 scopus 로고    scopus 로고
    • Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1 α
    • 2-s2.0-80455174540 10.1371/journal.pone.0026989 e26989
    • Pardo R., Enguix N., Lasheras J., Feliu J. E., Kralli A., Villena J. A., Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1 α PLoS ONE 2011 6 11 2-s2.0-80455174540 10.1371/journal.pone.0026989 e26989
    • (2011) PLoS ONE , vol.6 , Issue.11
    • Pardo, R.1    Enguix, N.2    Lasheras, J.3    Feliu, J.E.4    Kralli, A.5    Villena, J.A.6
  • 125
    • 33845411854 scopus 로고    scopus 로고
    • Metformin increases the PGC-1 α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
    • 2-s2.0-33845411854 10.1152/japplphysiol.00255.2006
    • Suwa M., Egashira T., Nakano H., Sasaki H., Kumagai S., Metformin increases the PGC-1 α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo. Journal of Applied Physiology 2006 101 6 1685 1692 2-s2.0-33845411854 10.1152/japplphysiol.00255.2006
    • (2006) Journal of Applied Physiology , vol.101 , Issue.6 , pp. 1685-1692
    • Suwa, M.1    Egashira, T.2    Nakano, H.3    Sasaki, H.4    Kumagai, S.5
  • 126
    • 73649125823 scopus 로고    scopus 로고
    • Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1 α expression
    • 2-s2.0-73649125823 10.1074/jbc.M109.030130
    • Chowanadisai W., Bauerly K. A., Tchaparian E., Wong A., Cortopassi G. A., Rucker R. B., Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1 α expression. Journal of Biological Chemistry 2010 285 1 142 152 2-s2.0-73649125823 10.1074/jbc.M109.030130
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.1 , pp. 142-152
    • Chowanadisai, W.1    Bauerly, K.A.2    Tchaparian, E.3    Wong, A.4    Cortopassi, G.A.5    Rucker, R.B.6
  • 127
    • 58349095060 scopus 로고    scopus 로고
    • AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells
    • e3614 2-s2.0-58349095060
    • Irrcher I., Ljubicic V., Kirwan A. F., Hood D. A., AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells. PLoS ONE 2008 3 10 e3614 2-s2.0-58349095060
    • (2008) PLoS ONE , vol.3 , Issue.10
    • Irrcher, I.1    Ljubicic, V.2    Kirwan, A.F.3    Hood, D.A.4


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