ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

Scientific Reports

Volumn 2, Issue , 2012, Pages

  Barcia, Carlos ^a   Ros, Carmen María ^a   Annese, Valentina ^a   Sauvage, María Angeles Carrillo De ^a   Ros Bernal, Francisco ^a   Gómez, Aurora ^a   Yuste, José Enrique ^a   Campuzano, Carmen María ^a   De Pablos, Vicente ^a   Fernandez Villalba, Emiliano ^a   Herrero, María Trinidad ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; DRUG DERIVATIVE; FASUDIL; PROTEIN CDC42; RHO KINASE; ROCK1 PROTEIN, MOUSE;

ACTIN FILAMENT; ANIMAL; ARTICLE; C57BL MOUSE; CELL SIZE; CHEMICALLY INDUCED DISORDER; DOPAMINERGIC NERVE CELL; DRUG ANTAGONISM; DRUG EFFECT; GOLGI COMPLEX; INTOXICATION; METABOLISM; MICROGLIA; MOUSE; PATHOLOGY; PHAGOCYTOSIS; PHYSIOLOGY;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ACTIN CYTOSKELETON; ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL SIZE; DOPAMINERGIC NEURONS; GOLGI APPARATUS; MICE; MICE, INBRED C57BL; MICROGLIA; MPTP POISONING; PHAGOCYTOSIS; RHO-ASSOCIATED KINASES;

EID: 84869154969     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00809     Document Type: Article

References (45)

1. Neumann, H., Kotter, M. R. & Franklin, R. J. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132, 288-295 (2009).
2. Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (New York, N.Y) 308, 1314-1318 (2005). (Pubitemid 40746128)
3. Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nature neuroscience 8, 752-758 (2005). (Pubitemid 43085841)
4. Koizumi, S. et al. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446, 1091-1095 (2007). (Pubitemid 46676051)
5. Inoue, K., Koizumi, S., Kataoka, A., Tozaki-Saitoh, H. & Tsuda, M. P2Y(6)-Evoked Microglial Phagocytosis. International review of neurobiology 85, 159-163 (2009).
6. Haynes, S. E. et al. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nature neuroscience 9, 1512-1519 (2006). (Pubitemid 44862659)
7. Fuhrmann, M. et al.Microglial Cx3cr1 knockout prevents neuron loss in amouse model of Alzheimer's disease. Nature neuroscience 13, 411-413 (2010).
8. Cardona, A. E. et al. Control of microglial neurotoxicity by the fractalkine receptor. Nature neuroscience 9, 917-924 (2006). (Pubitemid 43980506)
9. Fricker, M. et al. MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation. J Neurosci 32, 2657-2666 (2012).
10. Koenigsknecht-Talboo, J. & Landreth, G. E. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 25, 8240-8249 (2005). (Pubitemid 41292118)
11. Ueyama, T. et al. Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia. J Immunol 173, 4582-4589 (2004). (Pubitemid 39280691)
12. Majumdar, A. et al. Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Molecular biology of the cell 18, 1490-1496 (2007). (Pubitemid 46626644)
13. Peri, F. & Nusslein-Volhard, C. Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. Cell 133, 916-927 (2008). (Pubitemid 351707689)
14. Sierra, A. et al. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell stem cell 7, 483-495 (2010).
15. Welch, M. D. &Mullins, R. D. Cellular control of actin nucleation. Annual review of cell and developmental biology 18, 247-288 (2002). (Pubitemid 35387352)
16. Ridley, A. J. & Hall, A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399 (1992).
17. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. & Hall, A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410 (1992).
18. Kozma, R., Ahmed, S., Best, A. & Lim, L. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Molecular and cellular biology 15, 1942-1952 (1995).
19. Nobes, C. D. & Hall, A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62 (1995).
20. Etienne-Manneville, S. Cdc42-the centre of polarity. Journal of cell science 117, 1291-1300 (2004).
21. May, R. C. &Machesky, L. M. Phagocytosis and the actin cytoskeleton. Journal of cell science 114, 1061-1077 (2001). (Pubitemid 32288521)
22. Etienne-Manneville, S. & Hall, A. Rho GTPases in cell biology. Nature 420, 629-635 (2002). (Pubitemid 36764489)
23. Goodridge, H. S. et al. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature 472, 471-475 (2011).
24. Tremblay, M. E. et al. The Role of Microglia in the Healthy Brain. J Neurosci 31, 16064-16069 (2011).
25. McGeer, P. L., Itagaki, S., Boyes, B. E. & McGeer, E. G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38, 1285-1291 (1988).
26. Mueller, B. K., Mack, H. & Teusch, N. Rho kinase, a promising drug target for neurological disorders. Nature reviews 4, 387-398 (2005). (Pubitemid 40704122)
27. Shimizu, Y. et al. ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. The Journal of cell biology 168, 941-953 (2005). (Pubitemid 40397008)
28. Wilkinson, S., Paterson, H. F. & Marshall, C. J. Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nature cell biology 7, 255-261 (2005). (Pubitemid 40331126)
29. Kim, J. V.&Dustin, M. L. Innate response to focal necrotic injury inside the bloodbrain barrier. J Immunol 177, 5269-5277 (2006). (Pubitemid 44527599)
30. Galambos, R. A glia-neural theory of brain function. Proceedings of the National Academy of Sciences of the United States of America 47, 129-136 (1961).
31. Lin, H. H. et al. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. The Journal of experimental medicine 201, 1615-1625 (2005).
32. Neher, J. J. et al. Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J Immunol 186, 4973-4983 (2012).
33. McAllister, A. K. & van de Water, J. Breaking boundaries in neural-immune interactions. Neuron 64, 9-12 (2009).
34. Kokovay, E. & Cunningham, L. A. Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson's disease. Neurobiology of disease 19, 471-478 (2005). (Pubitemid 40968060)
35. Rodriguez, M. et al. Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease. Neurobiology of disease 28, 316-325 (2007). (Pubitemid 350116601)
36. Reale, M. et al. Peripheral cytokines profile in Parkinson's disease. Brain, behavior, and immunity 23, 55-63 (2009).
37. Hamza, T. H. et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nature genetics 42, 781-785 (2010).
38. Langston, J. W. et al. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine exposure. Annals of neurology 46, 598-605 (1999). (Pubitemid 29466438)
39. Barcia, C. et al. Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia 46, 402-409 (2004). (Pubitemid 38679198)
40. Hirsch, E. C. & Hunot, S. Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet neurology 8, 382-397 (2009).
41. Ouchi, Y. et al. Microglial activation and dopamine terminal loss in early Parkinson's disease. Annals of neurology 57, 168-175 (2005). (Pubitemid 40179853)
42. Gerhard, A. et al. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiology of disease 21, 404-412 (2006). (Pubitemid 43099863)
43. Paxinos, G.a.W., C & Franklin, K. B. J. The mouse brain in stereotaxic coordinates (Academic Press, New York, 2001).
44. Barcia, C. et al. IFN-gamma signaling, with the synergistic contribution of TNFalpha, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell death & disease 2, e142 (2011).
45. Gundersen, H. J. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. Journal of microscopy 143, 3-45 (1986).