Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure

Circulation Research

Volumn 99, Issue 7, 2006, Pages 758-766

  Kang, Yu Ming ^a   Zhang, Zhi Hua ^a   Johnson, Ralph F ^a   Yu, Yang ^a   Beltz, Terry ^a   Johnson, Alan Kim ^a   Weiss, Robert M ^a,b   Felder, Robert B ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aldosterone; Congestive heart failure; Cyclooxygenase 2; Cytokines; Nervous system

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR; CYCLOOXYGENASE 2; CYTOKINE; DRINKING WATER; EPLERENONE; ETANERCEPT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; NORADRENALIN; PENTOXIFYLLINE; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR FRA 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN DEPTH STIMULATION; CEREBROSPINAL FLUID; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; CYTOKINE PRODUCTION; DRUG EFFECT; ECHOCARDIOGRAPHY; ENZYME BLOOD LEVEL; EXPERIMENTAL RAT; FOLLOW UP; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART RIGHT VENTRICLE; HYPOTHALAMUS; HYPOTHALAMUS FUNCTION; HYPOTHESIS; IMMUNOCYTOCHEMISTRY; ISCHEMIC HEART DISEASE; LUNG WEIGHT; MALE; NERVE CELL STIMULATION; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; SYSTEMIC THERAPY; THALAMUS MIDLINE NUCLEUS;

ANIMALS; CYTOKINES; DRUG SYNERGISM; ECHOCARDIOGRAPHY; HEART FAILURE, CONGESTIVE; HYPOTHALAMUS; IMMUNOGLOBULIN G; INFLAMMATION MEDIATORS; MALE; MYOCARDIAL ISCHEMIA; PERTUSSIS TOXIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MINERALOCORTICOID; RECEPTORS, TUMOR NECROSIS FACTOR; SPIRONOLACTONE;

EID: 33749354007     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000244092.95152.86     Document Type: Article

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