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Volumn 156, Issue 6, 2015, Pages 2087-2102

Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CARNITINE PALMITOYLTRANSFERASE IA; FIBROBLAST GROWTH FACTOR 21; NARINGENIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; FIBROBLAST GROWTH FACTOR; FLAVANONE DERIVATIVE;

EID: 84930470246     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-2003     Document Type: Article
Times cited : (82)

References (61)
  • 1
  • 2
    • 46249093117 scopus 로고    scopus 로고
    • Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    • Adiels M, Olofsson SO, Taskinen MR, Boren J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28:1225-1236.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1225-1236
    • Adiels, M.1    Olofsson, S.O.2    Taskinen, M.R.3    Boren, J.4
  • 3
    • 40749137040 scopus 로고    scopus 로고
    • Fatty liver, insulin resistance, and dyslipidemia
    • Adiels M, Taskinen MR, Boren J. Fatty liver, insulin resistance, and dyslipidemia. Curr Diab Rep. 2008;8:60-64.
    • (2008) Curr Diab Rep , vol.8 , pp. 60-64
    • Adiels, M.1    Taskinen, M.R.2    Boren, J.3
  • 4
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009;120:1640-1645.
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 5
    • 20044368479 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein expression and apolipo-protein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes
    • Allister EM, Borradaile NM, Edwards JY, Huff MW. Inhibition of microsomal triglyceride transfer protein expression and apolipo-protein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes. Diabetes. 2005;54:1676-1683.
    • (2005) Diabetes , vol.54 , pp. 1676-1683
    • Allister, E.M.1    Borradaile, N.M.2    Edwards, J.Y.3    Huff, M.W.4
  • 6
    • 67049138804 scopus 로고    scopus 로고
    • Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor
    • Allister EM, Mulvihill EE, Barrett PH, Edwards JY, Carter LP, Huff MW. Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor. J Lipid Res. 2008;49:2218-2229.
    • (2008) J Lipid Res , vol.49 , pp. 2218-2229
    • Allister, E.M.1    Mulvihill, E.E.2    Barrett, P.H.3    Edwards, J.Y.4    Carter, L.P.5    Huff, M.W.6
  • 7
    • 0033043969 scopus 로고    scopus 로고
    • Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin
    • Borradaile NM, Carroll KK, Kurowska EM. Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin. Lipids. 1999;34:591-598.
    • (1999) Lipids , vol.34 , pp. 591-598
    • Borradaile, N.M.1    Carroll, K.K.2    Kurowska, E.M.3
  • 8
    • 0037432066 scopus 로고    scopus 로고
    • Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation
    • Borradaile NM, de Dreu LE, Barrett PH, Behrsin CD, Huff MW. Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry. 2003;42:1283-1291.
    • (2003) Biochemistry , vol.42 , pp. 1283-1291
    • Borradaile, N.M.1    De Dreu, L.E.2    Barrett, P.H.3    Behrsin, C.D.4    Huff, M.W.5
  • 9
    • 0036740573 scopus 로고    scopus 로고
    • Inhibition of hepatocyte apoB secretion by naringenin: Enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters
    • Borradaile NM, de Dreu LE, Barrett PH, Huff MW. Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters. J Lipid Res. 2002;43:1544-1554.
    • (2002) J Lipid Res , vol.43 , pp. 1544-1554
    • Borradaile, N.M.1    De Dreu, L.E.2    Barrett, P.H.3    Huff, M.W.4
  • 10
    • 0141643289 scopus 로고    scopus 로고
    • Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation
    • Borradaile NM, de Dreu LE, Huff MW. Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Diabetes. 2003;52:2554-2561.
    • (2003) Diabetes , vol.52 , pp. 2554-2561
    • Borradaile, N.M.1    De Dreu, L.E.2    Huff, M.W.3
  • 12
    • 70349651441 scopus 로고    scopus 로고
    • Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulin-emia in LDL receptor-null mice with diet-induced insulin resistance
    • Mulvihill EE, Allister EM, Sutherland BG, et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulin-emia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes. 2009;58:2198-2210.
    • (2009) Diabetes , vol.58 , pp. 2198-2210
    • Mulvihill, E.E.1    Allister, E.M.2    Sutherland, B.G.3
  • 13
    • 77950914240 scopus 로고    scopus 로고
    • Naringenin decreases progression of atherosclerosis by improving dyslipidemia in highfat-fed low-density lipoprotein receptor-null mice
    • Mulvihill EE, Assini JM, Sutherland BG, et al. Naringenin decreases progression of atherosclerosis by improving dyslipidemia in highfat-fed low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol. 2010;30:742-748.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 742-748
    • Mulvihill, E.E.1    Assini, J.M.2    Sutherland, B.G.3
  • 14
    • 84862299874 scopus 로고    scopus 로고
    • Protection from metabolic dysregulation, obesity, and atherosclerosis by citrus flavonoids: Activation of hepatic PGC1α-mediated fatty acid oxidation
    • Mulvihill EE, Huff MW. Protection from metabolic dysregulation, obesity, and atherosclerosis by citrus flavonoids: activation of hepatic PGC1α-mediated fatty acid oxidation. PPAR Res. 2012;2012:857142.
    • (2012) PPAR Res , vol.2012
    • Mulvihill, E.E.1    Huff, M.W.2
  • 15
    • 78851469588 scopus 로고    scopus 로고
    • Effect of resveratrol on fat mobilization
    • Baile CA, Yang JY, Rayalam S, et al. Effect of resveratrol on fat mobilization. Ann NY Acad Sci. 2011;1215:40-47.
    • (2011) Ann NY Acad Sci , vol.1215 , pp. 40-47
    • Baile, C.A.1    Yang, J.Y.2    Rayalam, S.3
  • 16
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, et al. Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5:415-425.
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3
  • 17
    • 48349127924 scopus 로고    scopus 로고
    • The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARα activation in man
    • Galman C, Lundasen T, Kharitonenkov A, et al. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARα activation in man. Cell Metab. 2008;8:169-174.
    • (2008) Cell Metab , vol.8 , pp. 169-174
    • Galman, C.1    Lundasen, T.2    Kharitonenkov, A.3
  • 18
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007;5:426-437.
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 21
    • 34247565954 scopus 로고    scopus 로고
    • Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
    • Goetz R, Beenken A, Ibrahimi OA, et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol. 2007;27:3417-3428.
    • (2007) Mol Cell Biol , vol.27 , pp. 3417-3428
    • Goetz, R.1    Beenken, A.2    Ibrahimi, O.A.3
  • 22
    • 39149091423 scopus 로고    scopus 로고
    • FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho
    • Kharitonenkov A, Dunbar JD, Bina HA, et al. FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho. J Cell Physiol. 2008;215:1-7.
    • (2008) J Cell Physiol , vol.215 , pp. 1-7
    • Kharitonenkov, A.1    Dunbar, J.D.2    Bina, H.A.3
  • 23
    • 34848869695 scopus 로고    scopus 로고
    • Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    • Kurosu H, Choi M, Ogawa Y, et al. 2007 Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 282:26687-26695.
    • (2007) J Biol Chem , vol.282 , pp. 26687-26695
    • Kurosu, H.1    Choi, M.2    Ogawa, Y.3
  • 24
    • 34249697012 scopus 로고    scopus 로고
    • βKlotho is required for metabolic activity of fibroblast growth factor 21
    • Ogawa Y, Kurosu H, Yamamoto M, et al. βKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci USA. 2007;104:7432-7437.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7432-7437
    • Ogawa, Y.1    Kurosu, H.2    Yamamoto, M.3
  • 25
    • 41649109108 scopus 로고    scopus 로고
    • βKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
    • Suzuki M, Uehara Y, Motomura-Matsuzaka K, et al. βKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol. 2008;22:1006-1014.
    • (2008) Mol Endocrinol , vol.22 , pp. 1006-1014
    • Suzuki, M.1    Uehara, Y.2    Motomura-Matsuzaka, K.3
  • 26
    • 76549112800 scopus 로고    scopus 로고
    • Relevant use of Klotho in FGF19 subfamily signaling system in vivo
    • Tomiyama K, Maeda R, Urakawa I, et al. Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc Natl Acad Sci USA. 2010;107:1666-1671.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1666-1671
    • Tomiyama, K.1    Maeda, R.2    Urakawa, I.3
  • 27
    • 57349098220 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 corrects obesity in mice
    • Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008;149:6018-6027.
    • (2008) Endocrinology , vol.149 , pp. 6018-6027
    • Coskun, T.1    Bina, H.A.2    Schneider, M.A.3
  • 28
    • 67649823642 scopus 로고    scopus 로고
    • FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    • Potthoff MJ, Inagaki T, Satapati S, et al. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA. 2009;106:10853-10858.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10853-10858
    • Potthoff, M.J.1    Inagaki, T.2    Satapati, S.3
  • 29
    • 79960726293 scopus 로고    scopus 로고
    • Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
    • Fisher FM, Estall JL, Adams AC, et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011;152:2996-3004.
    • (2011) Endocrinology , vol.152 , pp. 2996-3004
    • Fisher, F.M.1    Estall, J.L.2    Adams, A.C.3
  • 30
    • 79960844094 scopus 로고    scopus 로고
    • The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes
    • Zhang Y, Lei T, Huang JF, et al. The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes. Mol Cell Endocrinol. 2011;342:41-47.
    • (2011) Mol Cell Endocrinol , vol.342 , pp. 41-47
    • Zhang, Y.1    Lei, T.2    Huang, J.F.3
  • 31
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes. 2009;58:250-259.
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3
  • 32
    • 70350455732 scopus 로고    scopus 로고
    • Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models-association with liver and adipose tissue effects
    • Xu J, Stanislaus S, Chinookoswong N, et al. Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models-association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab. 2009;297:E1105-E1114.
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. E1105-E1114
    • Xu, J.1    Stanislaus, S.2    Chinookoswong, N.3
  • 33
    • 84865442538 scopus 로고    scopus 로고
    • Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
    • Veniant MM, Komorowski R, Chen P, et al. Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys. Endocrinology. 2012;153:4192-4203.
    • (2012) Endocrinology , vol.153 , pp. 4192-4203
    • Veniant, M.M.1    Komorowski, R.2    Chen, P.3
  • 35
    • 84881508008 scopus 로고    scopus 로고
    • The starvation hormone, fibroblast growth factor-21, extends life span in mice
    • Zhang Y, Xie Y, Berglund ED, et al. The starvation hormone, fibroblast growth factor-21, extends life span in mice. Elife. 2012;1:e00065.
    • (2012) Elife , vol.1
    • Zhang, Y.1    Xie, Y.2    Berglund, E.D.3
  • 36
  • 37
    • 70350093621 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice
    • Johnson CL, Weston JY, Chadi SA, et al. Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice. Gastroenterology. 2009;137:1795-1804.
    • (2009) Gastroenterology , vol.137 , pp. 1795-1804
    • Johnson, C.L.1    Weston, J.Y.2    Chadi, S.A.3
  • 38
    • 79959389136 scopus 로고    scopus 로고
    • Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance
    • Mulvihill EE, Assini JM, Lee JK, et al. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. Diabetes. 2011;60:1446-1457.
    • (2011) Diabetes , vol.60 , pp. 1446-1457
    • Mulvihill, E.E.1    Assini, J.M.2    Lee, J.K.3
  • 39
    • 78149299473 scopus 로고    scopus 로고
    • Rapid in vivo whole body composition of rats using cone beam μCT
    • Granton PV, Norley CJ, Umoh J, et al. Rapid in vivo whole body composition of rats using cone beam μCT. J Appl Physiol. 2010;109:1162-1169.
    • (2010) J Appl Physiol , vol.109 , pp. 1162-1169
    • Granton, P.V.1    Norley, C.J.2    Umoh, J.3
  • 40
    • 57849127155 scopus 로고    scopus 로고
    • In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model
    • Luu YK, Lublinsky S, Ozcivici E, et al. In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model. Med Eng Phys. 2009;31:34-41.
    • (2009) Med Eng Phys , vol.31 , pp. 34-41
    • Luu, Y.K.1    Lublinsky, S.2    Ozcivici, E.3
  • 41
    • 70349324370 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    • Hotta Y, Nakamura H, Konishi M, et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 2009;150:4625-4633.
    • (2009) Endocrinology , vol.150 , pp. 4625-4633
    • Hotta, Y.1    Nakamura, H.2    Konishi, M.3
  • 42
    • 84877272187 scopus 로고    scopus 로고
    • An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
    • Holland WL, Adams AC, Brozinick JT, et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab. 2013;17:790-797.
    • (2013) Cell Metab , vol.17 , pp. 790-797
    • Holland, W.L.1    Adams, A.C.2    Brozinick, J.T.3
  • 43
    • 59749094309 scopus 로고    scopus 로고
    • Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia
    • Gutierrez DA, Puglisi MJ, Hasty AH. Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Curr Diab Rep. 2009;9:26-32.
    • (2009) Curr Diab Rep , vol.9 , pp. 26-32
    • Gutierrez, D.A.1    Puglisi, M.J.2    Hasty, A.H.3
  • 44
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012;26:271-281.
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3
  • 46
    • 84899573610 scopus 로고    scopus 로고
    • Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism
    • Ong KT, Mashek MT, Davidson NO, Mashek DG. Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism. J Lipid Res. 2014;55:808-815.
    • (2014) J Lipid Res , vol.55 , pp. 808-815
    • Ong, K.T.1    Mashek, M.T.2    Davidson, N.O.3    Mashek, D.G.4
  • 47
    • 34249799917 scopus 로고    scopus 로고
    • The physiology of obese-hyperglycemic mice [ob/ob mice]
    • Lindstrom P. The physiology of obese-hyperglycemic mice [ob/ob mice]. ScientificWorldJournal. 2007;7:666-685.
    • (2007) ScientificWorldJournal , vol.7 , pp. 666-685
    • Lindstrom, P.1
  • 48
    • 84883260199 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
    • Adams AC, Coskun T, Cheng CC, O Farrell LS, Dubois SL, Kharitonenkov A. Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones. Mol Metab. 2013;2:205-214.
    • (2013) Mol Metab , vol.2 , pp. 205-214
    • Adams, A.C.1    Coskun, T.2    Cheng, C.C.3    OFarrell, L.S.4    Dubois, S.L.5    Kharitonenkov, A.6
  • 49
    • 33846970555 scopus 로고    scopus 로고
    • Metabolic syndrome: A multiplex cardiovascular risk factor
    • Grundy SM. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab. 2007;92:399-404.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 399-404
    • Grundy, S.M.1
  • 50
    • 0036300137 scopus 로고    scopus 로고
    • Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes
    • van Harmelen V, Dicker A, Ryden M, et al. Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes. Diabetes. 2002;51:2029-2036.
    • (2002) Diabetes , vol.51 , pp. 2029-2036
    • Van Harmelen, V.1    Dicker, A.2    Ryden, M.3
  • 51
    • 2942741295 scopus 로고    scopus 로고
    • The case of visceral fat: Argument for the defense
    • Klein S. The case of visceral fat: argument for the defense. J Clin Invest. 2004;113:1530-1532.
    • (2004) J Clin Invest , vol.113 , pp. 1530-1532
    • Klein, S.1
  • 53
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008;7:45-56.
    • (2008) Cell Metab , vol.7 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3
  • 54
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade. Diabetes. 1999;48:1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 55
    • 84897109882 scopus 로고    scopus 로고
    • Inventing new medicines: The FGF21 story
    • Kharitonenkov A, Adams AC. Inventing new medicines: the FGF21 story. Mol Metab. 2014;3:221-229.
    • (2014) Mol Metab , vol.3 , pp. 221-229
    • Kharitonenkov, A.1    Adams, A.C.2
  • 56
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • Dutchak PA, Katafuchi T, Bookout AL, et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell. 2012;148:556-567.
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3
  • 57
    • 84877260638 scopus 로고    scopus 로고
    • Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
    • Lin Z, Tian H, Lam KS, et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 2013;17:779-789.
    • (2013) Cell Metab , vol.17 , pp. 779-789
    • Lin, Z.1    Tian, H.2    Lam, K.S.3
  • 58
    • 84908018672 scopus 로고    scopus 로고
    • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
    • Owen BM, Ding X, Morgan DA, et al. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab. 2014;20:670-6077.
    • (2014) Cell Metab , vol.20 , pp. 670-6077
    • Owen, B.M.1    Ding, X.2    Morgan, D.A.3
  • 60
    • 18344394556 scopus 로고    scopus 로고
    • Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
    • Tomlinson E, Fu L, John L, et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology. 2002;143:1741-1747.
    • (2002) Endocrinology , vol.143 , pp. 1741-1747
    • Tomlinson, E.1    Fu, L.2    John, L.3
  • 61
    • 2542505481 scopus 로고    scopus 로고
    • Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
    • Fu L, John LM, Adams SH, et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology. 2004;145:2594-2603.
    • (2004) Endocrinology , vol.145 , pp. 2594-2603
    • Fu, L.1    John, L.M.2    Adams, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.