Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia

Current Diabetes Reports

Volumn 9, Issue 1, 2009, Pages 26-32

  Gutierrez, Dario A ^b   Puglisi, Michael J ^b   Hasty, Alyssa H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; SERUM AMYLOID A; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; APOPTOSIS; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CHOLESTEROL TRANSPORT; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DYSLIPIDEMIA; HUMAN; HYPERINSULINEMIA; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; LIPOPROTEIN METABOLISM; LYMPHOCYTIC INFILTRATION; MACROPHAGE ACTIVATION; NEUTROPHIL CHEMOTAXIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; REVIEW; T LYMPHOCYTE;

ADIPOCYTES; ADIPOSE TISSUE; APOPTOSIS; CELL DIFFERENTIATION; CHEMOKINES; DYSLIPIDEMIAS; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; LEPTIN; OBESITY; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 59749094309     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-009-0006-9     Document Type: Review

References (57)

1. Weisberg SP, McCann D, Desai M, et al.: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
2. Xu H, Barnes G, Yang Q, et al.: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003, 112:1821-1830.
3. Apovian CM, Bigomia S, Mott M, et al.: Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol 2008, 28:1654-1659.
4. Vitseva OI, Tanriverdi K, Tchkonia TT, et al.: Inducible toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring) 2008, 16:932-937.
5. Huber J, Kiefer FW, Zeyda M, et al.: CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. J Clin Endocrinol Metab 2008, 93:3215-3221.
6. Hosogai N, Fukuhara A, Oshima K, et al.: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007, 56:901-911.
7. Ye J, Gao Z, Yin J, He Q: Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007, 293:E1118-E1128.
8. Cinti S, Mitchell G, Barbatelli G, et al.: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005, 46:2347-2355.
9. Strissel KJ, Stancheva Z, Miyoshi H, et al.: Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 2007, 56:2910-2918.
10. Kanda H, Tateya S, Tamori Y, et al.: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006, 116:1494-1505.
11. Sartipy P, Loskutoff DJ: Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A 2003, 100:7265-7270.
12. Chen A, Mumick S, Zhang C, et al.: Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes Res 2005, 13:1311-1320.
13. Coenen KR, Gruen ML, Chait A, Hasty AH: Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes 2007, 56:564-573.
14. Weisberg SP, Hunter D, Huber R, et al.: CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006, 116:115-124.
15. Inouye KE, Shi H, Howard JK, et al.: Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 2007, 56:2242-2250.
16. Kirk EA, Sagawa ZK, McDonald TO, et al.: Macrophage chemoattractant protein-1 deficiency fails to restrain macrophage infiltration into adipose tissue. Diabetes 2008, 57:1254-1261.
17. Kintscher U, Hartge M, Hess K, et al.: T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 2008, 28:1304-1310.
18. Rausch ME, Weisberg S, Vardhana P, Tortoriello DV: Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 2008, 32:451-463.
19. Wu H, Ghosh S, Perrard XD, et al.: T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 2007, 115:1029-1038.
20. Curat CA, Miranville A, Sengenes C, et al.: From blood monocytes to adipose tissue-resident macrophages: Induction of diapedesis by human mature adipocytes. Diabetes 2004, 53:1285-1292.
21. Gruen ML, Hao M, Piston DW, Hasty AH: Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol 2007, 293:C1481-C1488.
22. Charriere G, Cousin B, Arnaud E, et al.: Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem 2003, 278:9850-9855.
23. Martinez FO, Sica A, Mantovani A, Locati M: Macrophage activation and polarization. Front Biosci 2008, 13:453-461.
24. Lumeng CN, Bodzin JL, Saltiel AR: Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007, 117:175-184.
25. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR: Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007, 56:16-23.
26. Stienstra R, Duval C, Keshtkar S, et al.: Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue. J Biol Chem 2008, 283:22620-22627.
27. Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, et al.: Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab 2008, 7:496-507.
28. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al.: Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007, 447: 1116-1120.
29. Hotamisligil GS: Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 2003, 27(Suppl 3):S53-S55.
30. Souza SC, Palmer HJ, Kang YH, et al.: TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. J Cell Biochem 2003, 89:1077-1086.
31. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS: Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-614.
32. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM: Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A 1994, 91:4854-4858.
33. Hoene M, Weigert C: The role of interleukin-6 in insulin resistance, body fat distribution and energy balance. Obes Rev 2008, 9:20-29.
34. Perreault M, Marette A: Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 2001, 7:1138-1143.
35. Toyoda T, Kamei Y, Kato H, et al.: Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue. Obesity (Silver Spring) 2008, 16:1199-1207.
36. Suganami T, Nishida J, Ogawa Y: A paracrine loop between adipocytes and macrophages aggravates inflammatory changes. role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 2005, 25:2062-2068.
37. Suganami T, Tanimoto-Koyama K, Nishida J, et al.: Role of the toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 2007, 27:84-91.
38. Unger RH, Zhou YT, Orci L: Regulation of fatty acid homeostasis in cells: Novel role of leptin. Proc Natl Acad Sci U S A 1999, 96:2327-2332.
39. Tomas E, Tsao TS, Saha AK, et al.: Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A 2002, 99:16309-16313.
40. Engfeldt P, Arner P: Lipolysis in human adipocytes, effects of cell size, age and of regional differences. Horm Metab Res Suppl 1988, 19:26-29.
41. Sam S, Haffner S, Davidson MH, et al.: Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes. Diabetes 2008, 57:2022-2027.
42. Fontana L, Eagon JC, Trujillo ME, et al.: Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007, 56:1010-1013.
43. Phillips SA, Ciaraldi TP, Oh DK, et al.: Adiponectin secretion and response is depot-dependent in cultured human adipose tissue. Am J Physiol Endocrinol Metab 2008, 295:E842-E850.
44. Cancello R, Tordjman J, Poitou C, et al.: Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 2006, 55:1554-1561.
45. Jovinge S, Hamsten A, Tornvall P, et al.: Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease. Metabolism 1998, 47:113-118.
46. Bartolome N, Rodriguez L, Martinez MJ, et al.: Upregulation of apolipoprotein B secretion, but not lipid, by tumor necrosis factor-alpha in rat hepatocyte cultures in the absence of extracellular fatty acids. Ann N Y Acad Sci 2007, 1096:55-69.
47. Qin B, Anderson RA, Adeli K: Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling. Am J Physiol Gastrointest Liver Physiol 2008, 294:G1120-G1129.
48. Qin B, Qiu W, Avramoglu RK, Adeli K: Tumor necrosis factor-alpha induces intestinal insulin resistance and stimulates the overproduction of intestinal apolipoprotein B48-containing lipoproteins. Diabetes 2007, 56:450-461.
49. O'Brien KD,TChait A: Serum amyloid A: the "other" inflammatory protein. Curr Atheroscler Rep 2006, 8:62-68.
50. Poitou C, VPguerie N, Cancello R, et al.: Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition. Diabetologia 2005, 48:519-528.
51. Chen CH, Wang PH, Liu BH, et al.: Serum amyloid A protein regulates the expression of porcine genes related to lipid metabolism. J Nutr 2008, 138:674-679.
52. Cai L, de Beer MC, de Beer FC, van der Westhuyzen DR: Serum amyloid A is a ligand for scavenger receptor class B type I and inhibits high density lipoprotein binding and selective lipid uptake. J Biol Chem 2005, 280:2954-2961.
53. Lewis KE, Kirk EA, McDonald TO, et al.: Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice. Circulation 2004, 110:540-545.
54. Cnop M, Havel PJ, Utzschneider KM, et al.: Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003, 46:459-469.
55. Yamauchi T, Kamon J, Minokoshi Y, et al.: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002, 8:1288-1295.
56. Berneis KK, Krauss RM: Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res 2002, 43:1363-1379.
57. Saraswathi V, Gao L, Morrow JD, et al.: Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J Nutr 2007, 137: 1776-1782.