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1
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0033579972
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Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain
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Nishimura T., Utsunomiya Y., Hoshikawa M., Ohuchi H., and Itoh N. Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim Biophys Acta 1444 (1999) 148-151
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2
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18344394556
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Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
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This work provides functional and mechanistic insights into FGF19 metabolic actions.
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Tomlinson E., Fu L., John L., Hultgren B., Huang X., Renz M., Stephan J.P., Tsai S.P., Powell-Braxton L., French D., et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 143 (2002) 1741-1747. This work provides functional and mechanistic insights into FGF19 metabolic actions.
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Tomlinson, E.1
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3
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27844546989
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
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This study demonstrates the existence of FGF15/FGF19 gut-to-liver axis of tissue crosscommunication.
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Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 4 (2005) 217-225. This study demonstrates the existence of FGF15/FGF19 gut-to-liver axis of tissue crosscommunication.
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Inagaki, T.1
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Identification of a novel FGF, FGF-21, preferentially expressed in the liver
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Nishimura T., Nakatake Y., Konishi M., and Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 1492 (2000) 203-206
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Nishimura, T.1
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5
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20444435873
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FGF-21 as a novel metabolic regulator
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This work identifies FGF21 as a critical metabolic regulator.
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Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., et al. FGF-21 as a novel metabolic regulator. J Clin Invest 115 (2005) 1627-1635. This work identifies FGF21 as a critical metabolic regulator.
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Kharitonenkov, A.1
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Galbreath, E.J.6
Sandusky, G.E.7
Hammond, L.J.8
Moyers, J.S.9
Owens, R.A.10
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6
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Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
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This study describes cloning of FGF23 based on its role in ADHR.
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The ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26 (2000) 345-348. This study describes cloning of FGF23 based on its role in ADHR.
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The ADHR Consortium1
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Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
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Goetz R., Beenken A., Ibrahimi O.A., Kalinina J., Olsen S.K., Eliseenkova A.V., Xu C., Neubert T.A., Zhang F., Linhardt R.J., et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol 27 (2007) 3417-3428
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8
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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This study reports on the identification of Klotho and functional consequences of its deficiency.
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Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 (1997) 45-51. This study reports on the identification of Klotho and functional consequences of its deficiency.
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9
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0034333526
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Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein
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Ito S., Kinoshita S., Shiraishi N., Nakagawa S., Sekine S., Fujimori T., and Nabeshima Y.I. Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Mech Dev 98 (2000) 115-119
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Liver-specific activities of FGF19 require Klotho beta
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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho
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This work reveals βKlotho as structural part of FGF21 receptor.
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Kharitonenkov A., Dunbar J.D., Bina H.A., Bright S., Moyers J.S., Zhang C., Ding L., Micanovic R., Mehrbod S.F., Knierman M.D., et al. FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho. J Cell Physiol 215 (2008) 1-7. This work reveals βKlotho as structural part of FGF21 receptor.
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Knierman, M.D.10
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12
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33646578195
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Regulation of fibroblast growth factor-23 signaling by klotho
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This work shows the role of Klotho in FGF23 signaling.
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Kurosu H., Ogawa Y., Miyoshi M., Yamamoto M., Nandi A., Rosenblatt K.P., Baum M.G., Schiavi S., Hu M.C., Moe O.W., et al. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281 (2006) 6120-6123. This work shows the role of Klotho in FGF23 signaling.
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FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
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Xie M.H., Holcomb I., Deuel B., Dowd P., Huang A., Vagts A., Foster J., Liang J., Brush J., Gu Q., et al. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine 11 (1999) 729-735
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14
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Co-receptor requirements for fibroblast growth factor-19 signaling
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Wu X., Ge H., Gupte J., Weiszmann J., Shimamoto G., Stevens J., Hawkins N., Lemon B., Shen W., Xu J., et al. Co-receptor requirements for fibroblast growth factor-19 signaling. J Biol Chem 282 (2007) 29069-29072
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15
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57749105436
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C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors
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Wu X., Lemon B., Li X., Gupte J., Weiszmann J., Stevens J., Hawkins N., Shen W., Lindberg R., Chen J.L., et al. C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. J Biol Chem 283 (2008) 33304-33309
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Chen, J.L.10
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16
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Identification of synergistic signals initiating inner ear development
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Ladher R.K., Anakwe K.U., Gurney A.L., Schoenwolf G.C., and Francis-West P.H. Identification of synergistic signals initiating inner ear development. Science 290 (2000) 1965-1967
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17
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Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
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Fu L., John L.M., Adams S.H., Yu X.X., Tomlinson E., Renz M., Williams P.M., Soriano R., Corpuz R., Moffat B., et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 145 (2004) 2594-2603
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Fu, L.1
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Moffat, B.10
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18
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57349098220
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Fibroblast growth factor 21 corrects obesity in mice
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This work provides the functional and mechanistic insights into FGF21 in vivo action.
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Coskun T., Bina H.A., Schneider M.A., Dunbar J.D., Hu C.C., Chen Y., Moller D.E., and Kharitonenkov A. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149 (2008) 6018-6027. This work provides the functional and mechanistic insights into FGF21 in vivo action.
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Coskun, T.1
Bina, H.A.2
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Hu, C.C.5
Chen, Y.6
Moller, D.E.7
Kharitonenkov, A.8
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19
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33845380799
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Forced expression of hepatocyte-specific fibroblast growth factor-21 delays initiation of chemically-induced hepatocarcinogenesis
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This work reports on the nonmitogenic character of FGF21 overexpression in mice.
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Huang X., Yu C., Jin C., Yang C., Xie R., Cao D., Wang F., and McKeehan W.L. Forced expression of hepatocyte-specific fibroblast growth factor-21 delays initiation of chemically-induced hepatocarcinogenesis. Mol Carcinog 45 (2006) 934-942. This work reports on the nonmitogenic character of FGF21 overexpression in mice.
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Huang, X.1
Yu, C.2
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Cao, D.6
Wang, F.7
McKeehan, W.L.8
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20
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0036086285
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A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
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Nicholes K., Guillet S., Tomlinson E., Hillan K., Wright B., Frantz G.D., Pham T.A., Dillard-Telm L., Tsai S.P., Stephan J.P., et al. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am J Pathol 160 (2002) 2295-2307
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Nicholes, K.1
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Pham, T.A.7
Dillard-Telm, L.8
Tsai, S.P.9
Stephan, J.P.10
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21
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33845631059
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Klotho converts canonical FGF receptor into a specific receptor for FGF23
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This work demonstrates Klotho as a cofactor for FGF23 phosphaturic activity.
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Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., Fujita T., Fukumoto S., and Yamashita T. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444 (2006) 770-774. This work demonstrates Klotho as a cofactor for FGF23 phosphaturic activity.
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Nature
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Urakawa, I.1
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Okawa, K.6
Fujita, T.7
Fukumoto, S.8
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22
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23644451052
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Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids
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Yu C., Wang F., Jin C., Huang X., and McKeehan W.L. Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids. J Biol Chem 280 (2005) 17707-17714
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Yu, C.1
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McKeehan, W.L.5
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23
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34948821192
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FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver
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This study points toward FGFRs beyond FGFR4 to support FGF19 metabolic actions.
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Huang X., Yang C., Luo Y., Jin C., Wang F., and McKeehan W.L. FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 56 (2007) 2501-2510. This study points toward FGFRs beyond FGFR4 to support FGF19 metabolic actions.
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Huang, X.1
Yang, C.2
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Wang, F.5
McKeehan, W.L.6
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24
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33751115468
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Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
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Lundåsen T., Gälman C., Angelin B., and Rudling M. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med 260 (2006) 530-536
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Lundåsen, T.1
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25
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33750587755
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Fibroblast growth factor-21 improves pancreatic β-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
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Wente W., Efanov A.M., Brenner M., Kharitonenkov A., Köster A., Sandusky G.E., Sewing S., Treinies I., Zitzer H., and Gromada J. Fibroblast growth factor-21 improves pancreatic β-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 55 (2006) 2470-2478
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Wente, W.1
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Sandusky, G.E.6
Sewing, S.7
Treinies, I.8
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Gromada, J.10
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26
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37549052177
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Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
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Wang H., Qiang L., and Farmer S.R. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol 28 (2008) 188-200
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Wang, H.1
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27
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FGF21 is an Akt-regulated myokine
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Izumiya Y., Bina H.A., Ouchi N., Akasaki Y., Kharitonenkov A., and Walsh K. FGF21 is an Akt-regulated myokine. FEBS Lett 582 (2008) 3805-3810
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Walsh, K.6
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28
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34249711964
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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
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This study describes FGF21 as a PPARα-regulated ketogenic factor.
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Badman M.K., Pissios P., Kennedy A.R., Koukos G., Flier J.S., and Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5 (2007) 426-437. This study describes FGF21 as a PPARα-regulated ketogenic factor.
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Badman, M.K.1
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29
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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
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Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., Li Y., Goetz R., Mohammadi M., Esser V., Elmquist J.K., et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 5 (2007) 415-425
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Inagaki, T.1
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30
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BetaKlotho is required for metabolic activity of fibroblast growth factor 21
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Ogawa Y., Kurosu H., Yamamoto M., Nandi A., Rosenblatt K.P., Goetz R., Eliseenkova A.V., Mohammadi M., and Kuro-o M. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A 104 (2007) 7432-7437
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Ogawa, Y.1
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31
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Different roles of N- and C-termini in the functional activity of FGF21
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Micanovic R., Raches D.W., Dunbar J.D., Driver D.A., Bina H.A., Dickinson C.D., and Kharitonenkov A. Different roles of N- and C-termini in the functional activity of FGF21. J Cell Phys 219 (2009) 227-234
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FGF21 N- and C-termini play different roles in receptor interaction and activation
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Yie J., Hecht R., Patel J., Stevens J., Wang W., Hawkins N., Steavenson S., Smith S., Winters D., Fisher S., et al. FGF21 N- and C-termini play different roles in receptor interaction and activation. FEBS Lett 583 (2009) 19-24
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Yie, J.1
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Comprehensive review focusing on FGF21 pharmacology and mechanism of action.
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Kharitonenkov A., and Shanafelt A.B. FGF21: a novel prospect for the treatment of metabolic diseases. Curr Opin Investig Drugs 10 (2009) 359-364. Comprehensive review focusing on FGF21 pharmacology and mechanism of action.
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FGF21 reverses hepatic steatosis, increases energy expenditure and improves insulin sensitivity in diet-induced obese mice
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This study reports FGF21 ability to reverse obesity and hepatosteatosis.
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Xu J., Lloyd D.J., Hale C., Stanislaus S., Chen M., Sivits G., Vonderfecht S.N., Hecht R., Li L., Lindberg R.A., et al. FGF21 reverses hepatic steatosis, increases energy expenditure and improves insulin sensitivity in diet-induced obese mice. Diabetes 58 (2009) 250-259. This study reports FGF21 ability to reverse obesity and hepatosteatosis.
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Xu, J.1
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35
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33846418834
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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
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This study analyzes FGF21 pharmacology in nonhuman primates.
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Kharitonenkov A., Wroblewski V.J., Koester A., Chen Y.F., Clutinger C.K., Tigno X.T., Hansen B.C., Shanafelt A.B., and Etgen G.J. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 148 (2007) 774-781. This study analyzes FGF21 pharmacology in nonhuman primates.
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43
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Shimada T., Kakitani M., Yamazaki Y., Hasegawa H., Takeuchi Y., Fujita T., Fukumoto S., Tomizuka K., and Yamashita T. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113 (2004) 561-568
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46
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Initial FGF23-mediated signaling occurs in the distal convoluted tubule
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Farrow E.G., Davis S.I., Summers L.J., and White K.E. Initial FGF23-mediated signaling occurs in the distal convoluted tubule. J Am Soc Nephrol 20 (2009) 955-960. This study reveals the localization of FGF23 early action in kidney.
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Bai X., Miao D., Li J., Goltzman D., and Karaplis A.C. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 145 (2004) 5269-5279
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55
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A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism
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This study implicates soluble Klotho in the regulation of phosphate levels and parathyroid function.
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Brownstein C.A., Adler F., Nelson-Williams C., Iijima J., Li P., Imura A., Nabeshima Y., Reyes-Mugica M., Carpenter T.O., and Lifton R.P. A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl Acad Sci U S A 105 (2008) 3455-3460. This study implicates soluble Klotho in the regulation of phosphate levels and parathyroid function.
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56
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57
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Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling
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This study identifies FGF19 as a cancer target.
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Pai R., Dunlap D., Qing J., Mohtashemi I., Hotzel K., and French D.M. Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling. Cancer Res 68 (2008) 5086-5095. This study identifies FGF19 as a cancer target.
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Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23
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