Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation

Diabetes

Volumn 52, Issue 10, 2003, Pages 2554-2561

  Borradaile, Nica M ^b   De Dreu, Linda E ^b   Huff, Murray W ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN B100; FLAVONOID; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LOW DENSITY LIPOPROTEIN RECEPTOR; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; NARINGENIN; PHOSPHATIDYLINOSITOL 3 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STREPTOZOCIN; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CITRUS FRUIT; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HEP 2 CELL; HEPATOMA CELL; HYPERGLYCEMIA; HYPERLIPIDEMIA; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOLIPOPROTEINS B; CARCINOMA, HEPATOCELLULAR; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FATTY ACIDS; FLAVANONES; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, LDL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRIGLYCERIDES; TYROSINE;

EID: 0141643289     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.10.2554     Document Type: Article

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