Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

Toxicology

Volumn 332, Issue , 2015, Pages 102-111

  Adeleye, Yeyejide ^a   Andersen, Melvin ^b   Clewell, Rebecca ^b   Davies, Michael ^a   Dent, Matthew ^a   Edwards, Sue ^a   Fowler, Paul ^a   Malcomber, Sophie ^a   Nicol, Beate ^a   Scott, Andrew ^a   Scott, Sharon ^a   Sun, Bin ^b   Westmoreland, Carl ^a   White, Andrew ^a   Zhang, Qiang ^b   Carmichael, Paul L ^a  

^a Safety and Environmental Assurance Centre   (United Kingdom)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

AOP; IVIVE; P53; Quercetin; Risk assessment; TT21C

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CASPASE 3; CHECKPOINT KINASE 2; DNA; HISTONE H2AX; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; QUERCETIN; REACTIVE OXYGEN METABOLITE; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CARCINOGENICITY; CELL CYCLE; DNA DAMAGE; FLOW CYTOMETRY; HUMAN; MICRONUCLEUS; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; TOXICITY TESTING; ANIMAL; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; COMPUTER SIMULATION; DOSE RESPONSE; DRUG EFFECTS; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; METABOLISM; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PROCEDURES; PRODUCT SAFETY; RISK FACTOR; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TOXICOLOGY; TRENDS; TUMOR CELL LINE;

ANIMALIA; RODENTIA;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CELL LINE, TUMOR; COMPUTER SIMULATION; CONSUMER PRODUCT SAFETY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IN VITRO TECHNIQUES; MODELS, BIOLOGICAL; NO-OBSERVED-ADVERSE-EFFECT LEVEL; QUERCETIN; RISK ASSESSMENT; RISK FACTORS; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TOXICITY TESTS; TOXICOLOGY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84930091540     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.02.007     Document Type: Article

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