Quercetin suppresses early colon carcinogenesis partly through inhibition of inflammatory mediators

Acta Horticulturae

Volumn 841, Issue , 2009, Pages 237-241

  Turner, N D ^a   Paulhill, K J ^a   Warren, C A ^a   Davidson, L A ^a   Chapkin, R S ^a   Lupton, J R ^a   Carroll, R J ^a   Wang, N ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Aberrant crypt foci; COX 1; COX 2; INOS

Indexed keywords

RATTUS; ZEA MAYS;

EID: 75449085336     PISSN: 05677572     EISSN: None     Source Type: Book Series    
DOI: 10.17660/actahortic.2009.841.28     Document Type: Article

References (18)

1. Ambs, S., Merriam, W. G., Bennett, W. P., Felley-Bosco, E., Ogunfusika, M. O., Oser, S. M., Klein, S., Shields, P. G., Billiar, T. R. and Harris, C. C. 1998. Frequent nitric oxide synthase-2 expression in human colon adenomas: Implications for tumor angiogenesis and colon cancer progression. Cancer Res. 58:334-341.
2. Bruce, W. R., Giacca, A. and Medline, A. 2000. Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol. Biomarkers Prev. 9:1271-1279.
3. Chang, W. C., Chapkin, R. S. and Lupton, J. R. 1997. Predictive value of proliferation, differentiation, and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 18:721-730.
4. Corona, G., Deiana, M., Incani, A., Vauzour, D., Dessi, M. A. and Spencer, J. P. E. 2007. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem. Biophys. Res. Commun. 362:606-611.
5. Davidson, L. A., Nguyen, D. V., Hokanson, R. M., Callaway, E. S., Isett, R. B., Turner, N. D., Dougherty, E. R., Lupton, J. R., Carroll, R. J. and Chapkin, R. S. 2004. Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Res. 64:6797-6804.
6. Hong, M. H., Chapkin, R. S., Morris, J. S., Wang, N., Carroll, R. J., Turner, N. D., Chang, W.-C. L., Davidson, L. A. and Lupton, J. R. 2001. Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model. Carcinogenesis 22:1831-1835.
7. Karin, M. 2006. NF-κB and cancer: Mechanisms and targets. Mol. Carcinog. 45:355-361.
8. Kawanishi, S., Hiraku, Y., Pinlaor, S. and Ma, N. 2006. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol. Chem. 387:365-372.
9. Koushik, A., Hunter, D. J., Spiegelman, D., Beeson, W. L., van den Brandt, P. A., Buring, J. E., Calle, E. E., Cho, E., Fraser, G. E., Freudenheim, J. L., et al. 2007. Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies. J. Natl. Cancer Inst. 99:1471-1483.
10. McCullough, M. L., Robertson, A. S., Chao, A., Jacobs, E. J., Stampfer, M. J., Jacobs, D. R., Diver, W. R., Calle, E. E. and Thun, M. J. 2003. A prospective study of whole grains, fruits, vegetables and colon cancer risk. Cancer Causes Control 14:959-970.
11. Patil, B. S., Pike, L. M. and Yoo, K. S. 1995. Variation in the quercetin content in different colored onions (Allium cepa L). J. Amer. Soc. Hort. Sci. 120:909-913.
12. Takeda, H., Sonoshita, M., Oshima, H., Sugihara, K.-I., Chulada, P. C., Langenbach, R., Oshima, M. and Taketo, M. M. 2003. Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyps. Cancer Res. 63:4872-4877.
13. Terry, P., Giovannucci, E., Michels, K. B., Bergkvist, L., Hansen, H., Holmberg, L. and Wolk, A. 2001. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J. Natl. Cancer Inst. 93:525-533.
14. Vanamala, J., Leonardi, T., Patil, B. S., Taddeo, S. S., Murphy, M. E., Pike, L. M., Chapkin, R. S., Lupton, J. R. and Turner, N. D. 2006. Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis 27:1257-1265.
15. Volate, S. R., Davenport, D. M., Muga, S. J. and Wargovich, M. J. 2005. Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogenesis 26:1450-1456.
16. Wargovich, M. J. Experimental evidence for cancer preventive elements in foods. Cancer Lett. 114:11-17.
17. Warren, C. A., Lupton, J. R., Popovic, N., Hong, M. Y., Taddeo, S. S., Murphy, M. E., Chapkin, R. S. and Turner, N. D. 2003. The chemopreventive action of quercetin decreases the number of high multiplicity aberrant crypt foci (ACF), reduces proliferation, and increases apoptosis in rat colonocytes. FASEB J. 17:A1202.
18. Yang, C. S., Landau, J. M., Huang, M. T. and Newmark, H. L. 2001. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21:381-406.