A mechanistic redefinition of adverse effects - A key step in the toxicity testing paradigm shift

Altex

Volumn 27, Issue 4, 2010, Pages 243-252

  Boekelheide, Kim ^a   Andersen, Melvin E ^b  

^a BROWN UNIVERSITY   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Adverse response; Carcinogenicity testing; Toxicity pathway; Toxicity testing

Indexed keywords

CARCINOGEN; DNA; ESTROGEN RECEPTOR; FREE RADICAL; HISTONE H2AX; HYPOXIA INDUCIBLE FACTOR 1BETA; MUTAGENIC AGENT; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ADVERSE OUTCOME; ANIMAL TESTING ALTERNATIVE; BIOASSAY; CANCER RISK; CARCINOGEN DNA INTERACTION; CARCINOGEN TESTING; CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CYTOTOXICITY; DISEASE MODEL; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DRUG ABSORPTION; DRUG CARCINOGENICITY; DRUG EXPOSURE; DRUG METABOLISM; GENOTOXICITY; HEALTH CARE POLICY; HUMAN; IN VITRO STUDY; MAXIMUM TOLERATED DOSE; MOLECULAR GENETICS; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; PREDICTIVE VALUE; PROTEIN BINDING; REPORTER GENE; REVIEW; RISK ASSESSMENT; SAFETY; TOXICITY TESTING; ANIMAL; ARTICLE; DANGEROUS GOODS; METHODOLOGY; STANDARD;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DNA DAMAGE; HAZARDOUS SUBSTANCES; MUTAGENS; TOXICITY TESTS;

EID: 79955724702     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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