Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

Toxicology in Vitro

Volumn 27, Issue 6, 2013, Pages 1877-1887

  Sun, Bin ^a   Ross, Susan M ^a   Joseph Trask, O ^a   Carmichael, Paul L ^b   Dent, Matthew ^b   White, Andrew ^b   Andersen, Melvin E ^a   Clewell, Rebecca A ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Curcumin; DNA damage; DNA repair; Micronucleus; P53; Polyphenols; Quercetin

Indexed keywords

CURCUMIN; DNA; ETOPOSIDE; HISTONE H2AX; HYDROGEN PEROXIDE; PROTEIN MDM2; PROTEIN P53; QUERCETIN; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL CYCLE PROGRESSION; CELL FATE; CELL LEVEL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DOUBLE STRANDED DNA BREAK; G2 PHASE CELL CYCLE CHECKPOINT; GENOTOXICITY; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MICRONUCLEUS; MOLECULAR MECHANICS; OXIDATION; OXIDATIVE STRESS; PROTEIN FUNCTION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; S PHASE CELL CYCLE CHECKPOINT; STRUCTURE ACTIVITY RELATION;

CURCUMIN; DNA DAMAGE; DNA REPAIR; MICRONUCLEUS; P53; POLYPHENOLS; QUERCETIN;

APOPTOSIS; CELL CYCLE; CELL LINE; CURCUMIN; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTONES; HUMANS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENS; NECROSIS; OXIDANTS; OXIDATIVE STRESS; QUERCETIN; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84880365655     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.05.015     Document Type: Article

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