메뉴 건너뛰기




Volumn 33, Issue S2, 2015, Pages B21-B28

Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity

Author keywords

Cancer; CTLA 4; IL 2; MTOR; PD 1; Treg cells

Indexed keywords

CD8 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN; PROGRAMMED DEATH 1 RECEPTOR; TARGET OF RAPAMYCIN KINASE;

EID: 84929868317     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2014.12.082     Document Type: Review
Times cited : (25)

References (120)
  • 1
    • 77958498224 scopus 로고    scopus 로고
    • Vaccine adjuvants: putting innate immunity to work
    • Coffman R.L., Sher A., Seder R.A. Vaccine adjuvants: putting innate immunity to work. Immunity 2010, 33:492-503.
    • (2010) Immunity , vol.33 , pp. 492-503
    • Coffman, R.L.1    Sher, A.2    Seder, R.A.3
  • 2
    • 84889770121 scopus 로고    scopus 로고
    • Key roles of adjuvants in modern vaccines
    • Reed S.G., Orr M.T., Fox C.B. Key roles of adjuvants in modern vaccines. Nat Med 2013, 19:1597-1608.
    • (2013) Nat Med , vol.19 , pp. 1597-1608
    • Reed, S.G.1    Orr, M.T.2    Fox, C.B.3
  • 3
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I., Coukos G., Dranoff G. Cancer immunotherapy comes of age. Nature 2011, 480:480-489.
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 4
    • 77951258833 scopus 로고    scopus 로고
    • Features of responding T cells in cancer and chronic infection
    • Kim P.S., Ahmed R. Features of responding T cells in cancer and chronic infection. Curr Opin Immunol 2010, 22:223-230.
    • (2010) Curr Opin Immunol , vol.22 , pp. 223-230
    • Kim, P.S.1    Ahmed, R.2
  • 5
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen L., Flies D.B. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol 2013, 13:227-242.
    • (2013) Nat Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 6
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn S.D., Shin H., Haining W.N., Zou T., Workman C.J., Polley A., et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 2009, 10:29-37.
    • (2009) Nat Immunol , vol.10 , pp. 29-37
    • Blackburn, S.D.1    Shin, H.2    Haining, W.N.3    Zou, T.4    Workman, C.J.5    Polley, A.6
  • 7
    • 65349083187 scopus 로고    scopus 로고
    • Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
    • Pentcheva-Hoang T., Corse E., Allison J.P. Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections. Immunol Rev 2009, 229:67-87.
    • (2009) Immunol Rev , vol.229 , pp. 67-87
    • Pentcheva-Hoang, T.1    Corse, E.2    Allison, J.P.3
  • 8
    • 0029100024 scopus 로고
    • Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4
    • Kearney E.R., Walunas T.L., Karr R.W., Morton P.A., Loh D.Y., Bluestone J.A., et al. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol 1995, 155:1032-1036.
    • (1995) J Immunol , vol.155 , pp. 1032-1036
    • Kearney, E.R.1    Walunas, T.L.2    Karr, R.W.3    Morton, P.A.4    Loh, D.Y.5    Bluestone, J.A.6
  • 9
    • 0030872154 scopus 로고    scopus 로고
    • Protective immunity to nematode infection is induced by CTLA-4 blockade
    • McCoy K., Camberis M., Gros G.L. Protective immunity to nematode infection is induced by CTLA-4 blockade. J Exp Med 1997, 186:183-187.
    • (1997) J Exp Med , vol.186 , pp. 183-187
    • McCoy, K.1    Camberis, M.2    Gros, G.L.3
  • 10
    • 78651072784 scopus 로고    scopus 로고
    • Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance
    • Pedicord V.A., Montalvo W., Leiner I.M., Allison J.P. Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance. Proc Natl Acad Sci U S A 2011, 108:266-271.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 266-271
    • Pedicord, V.A.1    Montalvo, W.2    Leiner, I.M.3    Allison, J.P.4
  • 12
    • 80051944092 scopus 로고    scopus 로고
    • Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
    • Wing K., Yamaguchi T., Sakaguchi S. Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation. Trends Immunol 2011, 32:428-433.
    • (2011) Trends Immunol , vol.32 , pp. 428-433
    • Wing, K.1    Yamaguchi, T.2    Sakaguchi, S.3
  • 13
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4
    • Qureshi O.S., Zheng Y., Nakamura K., Attridge K., Manzotti C., Schmidt E.M., et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4. Science 2011, 332:600-603.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6
  • 14
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol E.A., Borriello F., Schweitzer A.N., Lynch W.P., Bluestone J.A., Sharpe A.H. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995, 3:541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 15
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P., Penninger J.M., Timms E., Wakeham A., Shahinian A., Lee K.P., et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995, 270:985-988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3    Wakeham, A.4    Shahinian, A.5    Lee, K.P.6
  • 16
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001, 27:68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 17
    • 63049090504 scopus 로고    scopus 로고
    • CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    • Friedline R.H., Brown D.S., Nguyen H., Kornfeld H., Lee J., Zhang Y., et al. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 2009, 206:421-434.
    • (2009) J Exp Med , vol.206 , pp. 421-434
    • Friedline, R.H.1    Brown, D.S.2    Nguyen, H.3    Kornfeld, H.4    Lee, J.5    Zhang, Y.6
  • 18
    • 84938070889 scopus 로고    scopus 로고
    • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations
    • Schubert D., Bode C., Kenefeck R., Hou T.Z., Wing J.B., Kennedy A., et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med 2014, 20:1410-1416.
    • (2014) Nat Med , vol.20 , pp. 1410-1416
    • Schubert, D.1    Bode, C.2    Kenefeck, R.3    Hou, T.Z.4    Wing, J.B.5    Kennedy, A.6
  • 19
    • 84884229186 scopus 로고    scopus 로고
    • Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
    • Bulliard Y., Jolicoeur R., Windman M., Rue S.M., Ettenberg S., Knee D.A., et al. Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med 2013, 210:1685-1693.
    • (2013) J Exp Med , vol.210 , pp. 1685-1693
    • Bulliard, Y.1    Jolicoeur, R.2    Windman, M.3    Rue, S.M.4    Ettenberg, S.5    Knee, D.A.6
  • 20
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • Selby M.J., Engelhardt J.J., Quigley M., Henning K.A., Chen T., Srinivasan M., et al. Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res 2013, 1:32-42.
    • (2013) Cancer Immunol Res , vol.1 , pp. 32-42
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3    Henning, K.A.4    Chen, T.5    Srinivasan, M.6
  • 21
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson T.R., Li F., Montalvo-Ortiz W., Sepulveda M.A., Bergerhoff K., Arce F., et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013, 210:1695-1710.
    • (2013) J Exp Med , vol.210 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3    Sepulveda, M.A.4    Bergerhoff, K.5    Arce, F.6
  • 22
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs K.S., Quezada S.A., Chambers C.A., Korman A.J., Allison J.P. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 2009, 206:1717-1725.
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 23
    • 84880511594 scopus 로고    scopus 로고
    • Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma
    • Wolchok J.D., Hodi F.S., Weber J.S., Allison J.P., Urba W.J., Robert C., et al. Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma. Ann N Y Acad Sci 2013, 1291:1-13.
    • (2013) Ann N Y Acad Sci , vol.1291 , pp. 1-13
    • Wolchok, J.D.1    Hodi, F.S.2    Weber, J.S.3    Allison, J.P.4    Urba, W.J.5    Robert, C.6
  • 25
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman M.Z., Desantis G., Janji B., Hasmim M., Karray S., Dessen P., et al. PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med 2014, 211:781-790.
    • (2014) J Exp Med , vol.211 , pp. 781-790
    • Noman, M.Z.1    Desantis, G.2    Janji, B.3    Hasmim, M.4    Karray, S.5    Dessen, P.6
  • 26
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou W., Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008, 8:467-477.
    • (2008) Nat Rev Immunol , vol.8 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 27
    • 77954966127 scopus 로고    scopus 로고
    • PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
    • Mueller S.N., Vanguri V.K., Ha S.J., West E.E., Keir M.E., Glickman J.N., et al. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest 2010, 120:2508-2515.
    • (2010) J Clin Invest , vol.120 , pp. 2508-2515
    • Mueller, S.N.1    Vanguri, V.K.2    Ha, S.J.3    West, E.E.4    Keir, M.E.5    Glickman, J.N.6
  • 28
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y., Ishida M., Tanaka Y., Okazaki T., Honjo T., Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 2002, 99:12293-12297.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 29
    • 84863734405 scopus 로고    scopus 로고
    • Blocking of PDL-1 interaction enhances primary and secondary CD8 T cell response to herpes simplex virus-1 infection
    • Channappanavar R., Twardy B.S., Suvas S. Blocking of PDL-1 interaction enhances primary and secondary CD8 T cell response to herpes simplex virus-1 infection. PLoS ONE 2012, 7:e39757.
    • (2012) PLoS ONE , vol.7 , pp. e39757
    • Channappanavar, R.1    Twardy, B.S.2    Suvas, S.3
  • 31
    • 60549087784 scopus 로고    scopus 로고
    • PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination
    • Finnefrock A.C., Tang A., Li F., Freed D.C., Feng M., Cox K.S., et al. PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination. J Immunol 2009, 182:980-987.
    • (2009) J Immunol , vol.182 , pp. 980-987
    • Finnefrock, A.C.1    Tang, A.2    Li, F.3    Freed, D.C.4    Feng, M.5    Cox, K.S.6
  • 32
    • 66149123225 scopus 로고    scopus 로고
    • Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection
    • Blattman J.N., Wherry E.J., Ha S.J., van der Most R.G., Ahmed R. Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J Virol 2009, 83:4386-4394.
    • (2009) J Virol , vol.83 , pp. 4386-4394
    • Blattman, J.N.1    Wherry, E.J.2    Ha, S.J.3    van der Most, R.G.4    Ahmed, R.5
  • 33
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006, 439:682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3    Zhu, B.4    Allison, J.P.5    Sharpe, A.H.6
  • 34
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry E.J. T cell exhaustion. Nat Immunol 2011, 12:492-499.
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 35
    • 34548050436 scopus 로고    scopus 로고
    • CD8 T cell dysfunction during chronic viral infection
    • Shin H., Wherry E.J. CD8 T cell dysfunction during chronic viral infection. Curr Opin Immunol 2007, 19:408-415.
    • (2007) Curr Opin Immunol , vol.19 , pp. 408-415
    • Shin, H.1    Wherry, E.J.2
  • 36
    • 66949111877 scopus 로고    scopus 로고
    • PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients
    • Fourcade J., Kudela P., Sun Z., Shen H., Land S.R., Lenzner D., et al. PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients. J Immunol 2009, 182:5240-5249.
    • (2009) J Immunol , vol.182 , pp. 5240-5249
    • Fourcade, J.1    Kudela, P.2    Sun, Z.3    Shen, H.4    Land, S.R.5    Lenzner, D.6
  • 37
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi K., Apetoh L., Sullivan J.M., Blazar B.R., Kuchroo V.K., Anderson A.C. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med 2010, 207:2187-2194.
    • (2010) J Exp Med , vol.207 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3    Blazar, B.R.4    Kuchroo, V.K.5    Anderson, A.C.6
  • 38
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day C.L., Kaufmann D.E., Kiepiela P., Brown J.A., Moodley E.S., Reddy S., et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3    Brown, J.A.4    Moodley, E.S.5    Reddy, S.6
  • 39
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    • Urbani S., Amadei B., Tola D., Massari M., Schivazappa S., Missale G., et al. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol 2006, 80:11398-11403.
    • (2006) J Virol , vol.80 , pp. 11398-11403
    • Urbani, S.1    Amadei, B.2    Tola, D.3    Massari, M.4    Schivazappa, S.5    Missale, G.6
  • 40
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L., Janbazian L., Chomont N., Said E.A., Gimmig S., Bessette B., et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006, 12:1198-1202.
    • (2006) Nat Med , vol.12 , pp. 1198-1202
    • Trautmann, L.1    Janbazian, L.2    Chomont, N.3    Said, E.A.4    Gimmig, S.5    Bessette, B.6
  • 42
    • 84878089612 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection
    • Gardiner D., Lalezari J., Lawitz E., DiMicco M., Ghalib R., Reddy K.R., et al. A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection. PLoS ONE 2013, 8:e63818.
    • (2013) PLoS ONE , vol.8 , pp. e63818
    • Gardiner, D.1    Lalezari, J.2    Lawitz, E.3    DiMicco, M.4    Ghalib, R.5    Reddy, K.R.6
  • 43
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O., Robert C., Daud A., Hodi F.S., Hwu W.J., Kefford R., et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013, 369:134-144.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 45
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer J.R., Tykodi S.S., Chow L.Q., Hwu W.J., Topalian S.L., Hwu P., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012, 366:2455-2465.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 46
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
    • Powles T., Vogelzang N.J., Fine G.D., Eder J.P., Braiteh F.S., Loriot Y., et al. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). J Clin Oncol 2014, 32. abstr 5011.
    • (2014) J Clin Oncol , vol.32
    • Powles, T.1    Vogelzang, N.J.2    Fine, G.D.3    Eder, J.P.4    Braiteh, F.S.5    Loriot, Y.6
  • 47
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M., Johnson L.A., Heemskerk B., Wunderlich J.R., Dudley M.E., White D.E., et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009, 114:1537-1544.
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3    Wunderlich, J.R.4    Dudley, M.E.5    White, D.E.6
  • 49
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo S.R., Turnis M.E., Goldberg M.V., Bankoti J., Selby M., Nirschl C.J., et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012, 72:917-927.
    • (2012) Cancer Res , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3    Bankoti, J.4    Selby, M.5    Nirschl, C.J.6
  • 50
    • 77957059176 scopus 로고    scopus 로고
    • Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
    • Jin H.T., Anderson A.C., Tan W.G., West E.E., Ha S.J., Araki K., et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A 2010, 107:14733-14738.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14733-14738
    • Jin, H.T.1    Anderson, A.C.2    Tan, W.G.3    West, E.E.4    Ha, S.J.5    Araki, K.6
  • 51
    • 84855911057 scopus 로고    scopus 로고
    • Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection
    • Butler N.S., Moebius J., Pewe L.L., Traore B., Doumbo O.K., Tygrett L.T., et al. Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol 2012, 13:188-195.
    • (2012) Nat Immunol , vol.13 , pp. 188-195
    • Butler, N.S.1    Moebius, J.2    Pewe, L.L.3    Traore, B.4    Doumbo, O.K.5    Tygrett, L.T.6
  • 52
    • 47249098958 scopus 로고    scopus 로고
    • Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections
    • Ha S.J., West E.E., Araki K., Smith K.A., Ahmed R. Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections. Immunol Rev 2008, 223:317-333.
    • (2008) Immunol Rev , vol.223 , pp. 317-333
    • Ha, S.J.1    West, E.E.2    Araki, K.3    Smith, K.A.4    Ahmed, R.5
  • 53
    • 84879215734 scopus 로고    scopus 로고
    • Manipulating the PD-1 pathway to improve immunity
    • Kamphorst A.O., Ahmed R. Manipulating the PD-1 pathway to improve immunity. Curr Opin Immunol 2013, 25:381-388.
    • (2013) Curr Opin Immunol , vol.25 , pp. 381-388
    • Kamphorst, A.O.1    Ahmed, R.2
  • 54
    • 41149112957 scopus 로고    scopus 로고
    • Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection
    • Ha S.J., Mueller S.N., Wherry E.J., Barber D.L., Aubert R.D., Sharpe A.H., et al. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med 2008, 205:543-555.
    • (2008) J Exp Med , vol.205 , pp. 543-555
    • Ha, S.J.1    Mueller, S.N.2    Wherry, E.J.3    Barber, D.L.4    Aubert, R.D.5    Sharpe, A.H.6
  • 55
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas A., Hurwitz A.A., Allison J.P. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 1999, 190:355-366.
    • (1999) J Exp Med , vol.190 , pp. 355-366
    • van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 56
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • Hurwitz A.A., Foster B.A., Kwon E.D., Truong T., Choi E.M., Greenberg N.M., et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 2000, 60:2444-2448.
    • (2000) Cancer Res , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1    Foster, B.A.2    Kwon, E.D.3    Truong, T.4    Choi, E.M.5    Greenberg, N.M.6
  • 57
    • 63449124514 scopus 로고    scopus 로고
    • Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor - secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors
    • Li B., VanRoey M., Wang C., Chen T.H., Korman A., Jooss K. Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor - secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors. Clin Cancer Res 2009, 15:1623-1634.
    • (2009) Clin Cancer Res , vol.15 , pp. 1623-1634
    • Li, B.1    VanRoey, M.2    Wang, C.3    Chen, T.H.4    Korman, A.5    Jooss, K.6
  • 59
    • 84870696545 scopus 로고    scopus 로고
    • Anti-viral CD8 T cells and the cytokines that they love
    • Cox M.A., Kahan S.M., Zajac A.J. Anti-viral CD8 T cells and the cytokines that they love. Virology 2013, 435:157-169.
    • (2013) Virology , vol.435 , pp. 157-169
    • Cox, M.A.1    Kahan, S.M.2    Zajac, A.J.3
  • 60
    • 77953541634 scopus 로고    scopus 로고
    • Inflammatory cytokines as a third signal for T cell activation
    • Curtsinger J.M., Mescher M.F. Inflammatory cytokines as a third signal for T cell activation. Curr Opin Immunol 2010, 22:333-340.
    • (2010) Curr Opin Immunol , vol.22 , pp. 333-340
    • Curtsinger, J.M.1    Mescher, M.F.2
  • 61
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea J.J., Paul W.E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010, 327:1098-1102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 62
    • 84877893902 scopus 로고    scopus 로고
    • Promoting immunity during chronic infection - the therapeutic potential of common gamma-chain cytokines
    • Toe J.G., Pellegrini M., Mak T.W. Promoting immunity during chronic infection - the therapeutic potential of common gamma-chain cytokines. Mol Immunol 2013, 56:38-47.
    • (2013) Mol Immunol , vol.56 , pp. 38-47
    • Toe, J.G.1    Pellegrini, M.2    Mak, T.W.3
  • 63
    • 80052772272 scopus 로고    scopus 로고
    • Opposing functions of IL-2 and IL-7 in the regulation of immune responses
    • Katzman S.D., Hoyer K.K., Dooms H., Gratz I.K., Rosenblum M.D., Paw J.S., et al. Opposing functions of IL-2 and IL-7 in the regulation of immune responses. Cytokine 2011, 56:116-121.
    • (2011) Cytokine , vol.56 , pp. 116-121
    • Katzman, S.D.1    Hoyer, K.K.2    Dooms, H.3    Gratz, I.K.4    Rosenblum, M.D.5    Paw, J.S.6
  • 65
    • 84892920498 scopus 로고    scopus 로고
    • IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients
    • Sim G.C., Martin-Orozco N., Jin L., Yang Y., Wu S., Washington E., et al. IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients. J Clin Invest 2014, 124:99-110.
    • (2014) J Clin Invest , vol.124 , pp. 99-110
    • Sim, G.C.1    Martin-Orozco, N.2    Jin, L.3    Yang, Y.4    Wu, S.5    Washington, E.6
  • 67
    • 74549162832 scopus 로고    scopus 로고
    • Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo
    • Kalia V., Sarkar S., Subramaniam S., Haining W.N., Smith K.A., Ahmed R. Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity 2010, 32:91-103.
    • (2010) Immunity , vol.32 , pp. 91-103
    • Kalia, V.1    Sarkar, S.2    Subramaniam, S.3    Haining, W.N.4    Smith, K.A.5    Ahmed, R.6
  • 68
    • 74549216531 scopus 로고    scopus 로고
    • Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
    • Pipkin M.E., Sacks J.A., Cruz-Guilloty F., Lichtenheld M.G., Bevan M.J., Rao A. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 2010, 32:79-90.
    • (2010) Immunity , vol.32 , pp. 79-90
    • Pipkin, M.E.1    Sacks, J.A.2    Cruz-Guilloty, F.3    Lichtenheld, M.G.4    Bevan, M.J.5    Rao, A.6
  • 69
    • 0023115642 scopus 로고
    • A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone
    • Rosenberg S.A., Lotze M.T., Muul L.M., Chang A.E., Avis F.P., Leitman S., et al. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 1987, 316:889-897.
    • (1987) N Engl J Med , vol.316 , pp. 889-897
    • Rosenberg, S.A.1    Lotze, M.T.2    Muul, L.M.3    Chang, A.E.4    Avis, F.P.5    Leitman, S.6
  • 70
    • 84902191817 scopus 로고    scopus 로고
    • IL-2: the first effective immunotherapy for human cancer
    • Rosenberg S.A. IL-2: the first effective immunotherapy for human cancer. J Immunol 2014, 192:5451-5458.
    • (2014) J Immunol , vol.192 , pp. 5451-5458
    • Rosenberg, S.A.1
  • 72
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg S.A., Yang J.C., Sherry R.M., Kammula U.S., Hughes M.S., Phan G.Q., et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res 2011, 17:4550-4557.
    • (2011) Clin Cancer Res , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3    Kammula, U.S.4    Hughes, M.S.5    Phan, G.Q.6
  • 73
    • 84870230232 scopus 로고    scopus 로고
    • Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection
    • Paley M.A., Kroy D.C., Odorizzi P.M., Johnnidis J.B., Dolfi D.V., Barnett B.E., et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 2012, 338:1220-1225.
    • (2012) Science , vol.338 , pp. 1220-1225
    • Paley, M.A.1    Kroy, D.C.2    Odorizzi, P.M.3    Johnnidis, J.B.4    Dolfi, D.V.5    Barnett, B.E.6
  • 74
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech S.M., Tan J.T., Wherry E.J., Konieczny B.T., Surh C.D., Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 2003, 4:1191-1198.
    • (2003) Nat Immunol , vol.4 , pp. 1191-1198
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5    Ahmed, R.6
  • 75
    • 27844458057 scopus 로고    scopus 로고
    • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study
    • Maker A.V., Phan G.Q., Attia P., Yang J.C., Sherry R.M., Topalian S.L., et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005, 12:1005-1016.
    • (2005) Ann Surg Oncol , vol.12 , pp. 1005-1016
    • Maker, A.V.1    Phan, G.Q.2    Attia, P.3    Yang, J.C.4    Sherry, R.M.5    Topalian, S.L.6
  • 76
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim J.M., Rasmussen J.P., Rudensky A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007, 8:191-197.
    • (2007) Nat Immunol , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 77
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 78
    • 82755184094 scopus 로고    scopus 로고
    • Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions
    • Yamaguchi T., Wing J.B., Sakaguchi S. Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol 2011, 23:424-430.
    • (2011) Semin Immunol , vol.23 , pp. 424-430
    • Yamaguchi, T.1    Wing, J.B.2    Sakaguchi, S.3
  • 79
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach E.M. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009, 30:636-645.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 80
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz S.Z., Lu L.F., Rudensky A.Y. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012, 30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 81
    • 8644290853 scopus 로고    scopus 로고
    • CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1
    • Toka F.N., Suvas S., Rouse B.T. CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J Virol 2004, 78:13082-13089.
    • (2004) J Virol , vol.78 , pp. 13082-13089
    • Toka, F.N.1    Suvas, S.2    Rouse, B.T.3
  • 82
    • 28244482371 scopus 로고    scopus 로고
    • Anti-CD25 antibody enhancement of vaccine-induced immunogenicity: increased durable cellular immunity with reduced immunodominance
    • Moore A.C., Gallimore A., Draper S.J., Watkins K.R., Gilbert S.C., Hill A.V. Anti-CD25 antibody enhancement of vaccine-induced immunogenicity: increased durable cellular immunity with reduced immunodominance. J Immunol 2005, 175:7264-7273.
    • (2005) J Immunol , vol.175 , pp. 7264-7273
    • Moore, A.C.1    Gallimore, A.2    Draper, S.J.3    Watkins, K.R.4    Gilbert, S.C.5    Hill, A.V.6
  • 83
    • 84867767000 scopus 로고    scopus 로고
    • Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory
    • Pace L., Tempez A., Arnold-Schrauf C., Lemaitre F., Bousso P., Fetler L., et al. Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 2012, 338:532-536.
    • (2012) Science , vol.338 , pp. 532-536
    • Pace, L.1    Tempez, A.2    Arnold-Schrauf, C.3    Lemaitre, F.4    Bousso, P.5    Fetler, L.6
  • 84
    • 45849153869 scopus 로고    scopus 로고
    • Coordination of early protective immunity to viral infection by regulatory T cells
    • Lund J.M., Hsing L., Pham T.T., Rudensky A.Y. Coordination of early protective immunity to viral infection by regulatory T cells. Science 2008, 320:1220-1224.
    • (2008) Science , vol.320 , pp. 1220-1224
    • Lund, J.M.1    Hsing, L.2    Pham, T.T.3    Rudensky, A.Y.4
  • 85
    • 84892448554 scopus 로고    scopus 로고
    • Regulatory T cells in cancer immunotherapy
    • Nishikawa H., Sakaguchi S. Regulatory T cells in cancer immunotherapy. Curr Opin Immunol 2014, 27:1-7.
    • (2014) Curr Opin Immunol , vol.27 , pp. 1-7
    • Nishikawa, H.1    Sakaguchi, S.2
  • 86
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006, 6:295-307.
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 87
    • 67649138829 scopus 로고    scopus 로고
    • Regulatory T cells in the control of host-microorganism interactions
    • Belkaid Y., Tarbell K. Regulatory T cells in the control of host-microorganism interactions. Annu Rev Immunol 2009, 27:551-589.
    • (2009) Annu Rev Immunol , vol.27 , pp. 551-589
    • Belkaid, Y.1    Tarbell, K.2
  • 88
  • 89
    • 84860507700 scopus 로고    scopus 로고
    • T-regulatory cells: key players in tumor immune escape and angiogenesis
    • Facciabene A., Motz G.T., Coukos G. T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res 2012, 72:2162-2171.
    • (2012) Cancer Res , vol.72 , pp. 2162-2171
    • Facciabene, A.1    Motz, G.T.2    Coukos, G.3
  • 90
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10:942-949.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 91
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory T cells in tumor immunity
    • Nishikawa H., Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer 2010, 127:759-767.
    • (2010) Int J Cancer , vol.127 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 92
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato E., Olson S.H., Ahn J., Bundy B., Nishikawa H., Qian F., et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A 2005, 102:18538-18543.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3    Bundy, B.4    Nishikawa, H.5    Qian, F.6
  • 93
    • 0024255820 scopus 로고
    • Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity
    • Awwad M., North R.J. Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity. J Exp Med 1988, 168:2193-2206.
    • (1988) J Exp Med , vol.168 , pp. 2193-2206
    • Awwad, M.1    North, R.J.2
  • 94
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S., Tawara I., Shimizu J., Sakaguchi S., Fujita T., Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999, 59:3128-3133.
    • (1999) Cancer Res , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 95
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
    • Lahl K., Loddenkemper C., Drouin C., Freyer J., Arnason J., Eberl G., et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 2007, 204:57-63.
    • (2007) J Exp Med , vol.204 , pp. 57-63
    • Lahl, K.1    Loddenkemper, C.2    Drouin, C.3    Freyer, J.4    Arnason, J.5    Eberl, G.6
  • 96
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng M.W., Ngiow S.F., von Scheidt B., McLaughlin N., Sparwasser T., Smyth M.J. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res 2010, 70:7800-7809.
    • (2010) Cancer Res , vol.70 , pp. 7800-7809
    • Teng, M.W.1    Ngiow, S.F.2    von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5    Smyth, M.J.6
  • 97
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    • Klages K., Mayer C.T., Lahl K., Loddenkemper C., Teng M.W., Ngiow S.F., et al. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res 2010, 70:7788-7799.
    • (2010) Cancer Res , vol.70 , pp. 7788-7799
    • Klages, K.1    Mayer, C.T.2    Lahl, K.3    Loddenkemper, C.4    Teng, M.W.5    Ngiow, S.F.6
  • 98
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller R.P., van Duivenvoorde L.M., van Elsas A., Schumacher T.N., Wildenberg M.E., Allison J.P., et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001, 194:823-832.
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1    van Duivenvoorde, L.M.2    van Elsas, A.3    Schumacher, T.N.4    Wildenberg, M.E.5    Allison, J.P.6
  • 99
    • 84886805255 scopus 로고    scopus 로고
    • Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhance radiotherapy
    • Bos P.D., Plitas G., Rudra D., Lee S.Y., Rudensky A.Y. Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhance radiotherapy. J Exp Med 2013, 210:2435-2466.
    • (2013) J Exp Med , vol.210 , pp. 2435-2466
    • Bos, P.D.1    Plitas, G.2    Rudra, D.3    Lee, S.Y.4    Rudensky, A.Y.5
  • 100
    • 34547423966 scopus 로고    scopus 로고
    • Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras
    • Komatsu N., Hori S. Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras. Proc Natl Acad Sci U S A 2007, 104:8959-8964.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8959-8964
    • Komatsu, N.1    Hori, S.2
  • 101
    • 84865553173 scopus 로고    scopus 로고
    • Combination immunotherapy approaches
    • Drake C.G. Combination immunotherapy approaches. Ann Oncol 2012, 23(Suppl. 8):viii41-viii46.
    • (2012) Ann Oncol , vol.23 , pp. 841-846
    • Drake, C.G.1
  • 102
    • 84906536054 scopus 로고    scopus 로고
    • Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
    • Penaloza-MacMaster P., Kamphorst A.O., Wieland A., Araki K., Iyer S.S., West E.E., et al. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med 2014, 211:1905-1918.
    • (2014) J Exp Med , vol.211 , pp. 1905-1918
    • Penaloza-MacMaster, P.1    Kamphorst, A.O.2    Wieland, A.3    Araki, K.4    Iyer, S.S.5    West, E.E.6
  • 103
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong H., Strome S.E., Salomao D.R., Tamura H., Hirano F., Flies D.B., et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002, 8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 104
    • 84863924314 scopus 로고    scopus 로고
    • Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective
    • Le D.T., Jaffee E.M. Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer Res 2012, 72:3439-3444.
    • (2012) Cancer Res , vol.72 , pp. 3439-3444
    • Le, D.T.1    Jaffee, E.M.2
  • 105
    • 84887081136 scopus 로고    scopus 로고
    • Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
    • Sugiyama D., Nishikawa H., Maeda Y., Nishioka M., Tanemura A., Katayama I., et al. Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci U S A 2013, 110:17945-17950.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 17945-17950
    • Sugiyama, D.1    Nishikawa, H.2    Maeda, Y.3    Nishioka, M.4    Tanemura, A.5    Katayama, I.6
  • 106
    • 84884206864 scopus 로고    scopus 로고
    • Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis
    • Delgoffe G.M., Woo S.R., Turnis M.E., Gravano D.M., Guy C., Overacre A.E., et al. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 2013, 501:252-256.
    • (2013) Nature , vol.501 , pp. 252-256
    • Delgoffe, G.M.1    Woo, S.R.2    Turnis, M.E.3    Gravano, D.M.4    Guy, C.5    Overacre, A.E.6
  • 107
    • 84869777544 scopus 로고    scopus 로고
    • Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth
    • Hansen W., Hutzler M., Abel S., Alter C., Stockmann C., Kliche S., et al. Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med 2012, 209:2001-2016.
    • (2012) J Exp Med , vol.209 , pp. 2001-2016
    • Hansen, W.1    Hutzler, M.2    Abel, S.3    Alter, C.4    Stockmann, C.5    Kliche, S.6
  • 108
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 109
    • 84894523716 scopus 로고    scopus 로고
    • Making new contacts: the mTOR network in metabolism and signalling crosstalk
    • Shimobayashi M., Hall M.N. Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol 2014, 15:155-162.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 155-162
    • Shimobayashi, M.1    Hall, M.N.2
  • 111
    • 84859439098 scopus 로고    scopus 로고
    • Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines
    • Bassett J.D., Swift S.L., VanSeggelen H., Hammill J.A., McGray A.J., Evelegh C., et al. Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines. Mol Ther 2012, 20:860-869.
    • (2012) Mol Ther , vol.20 , pp. 860-869
    • Bassett, J.D.1    Swift, S.L.2    VanSeggelen, H.3    Hammill, J.A.4    McGray, A.J.5    Evelegh, C.6
  • 112
    • 74649085700 scopus 로고    scopus 로고
    • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and eomesodermin
    • Rao R.R., Li Q., Odunsi K., Shrikant P.A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and eomesodermin. Immunity 2010, 32:67-78.
    • (2010) Immunity , vol.32 , pp. 67-78
    • Rao, R.R.1    Li, Q.2    Odunsi, K.3    Shrikant, P.A.4
  • 113
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • Pearce E.L., Walsh M.C., Cejas P.J., Harms G.M., Shen H., Wang L.S., et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009, 460:103-107.
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1    Walsh, M.C.2    Cejas, P.J.3    Harms, G.M.4    Shen, H.5    Wang, L.S.6
  • 114
    • 77956893188 scopus 로고    scopus 로고
    • Cutting edge: rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses
    • Ferrer I.R., Wagener M.E., Robertson J.M., Turner A.P., Araki K., Ahmed R., et al. Cutting edge: rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J Immunol 2010, 185:2004-2008.
    • (2010) J Immunol , vol.185 , pp. 2004-2008
    • Ferrer, I.R.1    Wagener, M.E.2    Robertson, J.M.3    Turner, A.P.4    Araki, K.5    Ahmed, R.6
  • 115
    • 84874271196 scopus 로고    scopus 로고
    • MTOR, linking metabolism and immunity
    • Xu X., Ye L., Araki K., Ahmed R. mTOR, linking metabolism and immunity. Semin Immunol 2012, 24:429-435.
    • (2012) Semin Immunol , vol.24 , pp. 429-435
    • Xu, X.1    Ye, L.2    Araki, K.3    Ahmed, R.4
  • 117
    • 84881399035 scopus 로고    scopus 로고
    • B cell-specific deficiencies in mTOR limit humoral immune responses
    • Zhang S., Pruitt M., Tran D., Du Bois W., Zhang K., Patel R., et al. B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol 2013, 191:1692-1703.
    • (2013) J Immunol , vol.191 , pp. 1692-1703
    • Zhang, S.1    Pruitt, M.2    Tran, D.3    Du Bois, W.4    Zhang, K.5    Patel, R.6
  • 118
    • 84892941233 scopus 로고    scopus 로고
    • Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity
    • Berezhnoy A., Castro I., Levay A., Malek T.R., Gilboa E. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. J Clin Invest 2014, 124:188-197.
    • (2014) J Clin Invest , vol.124 , pp. 188-197
    • Berezhnoy, A.1    Castro, I.2    Levay, A.3    Malek, T.R.4    Gilboa, E.5
  • 119
    • 35349014587 scopus 로고    scopus 로고
    • Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    • Wherry E.J., Ha S.J., Kaech S.M., Haining W.N., Sarkar S., Kalia V., et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 2007, 27:670-684.
    • (2007) Immunity , vol.27 , pp. 670-684
    • Wherry, E.J.1    Ha, S.J.2    Kaech, S.M.3    Haining, W.N.4    Sarkar, S.5    Kalia, V.6
  • 120
    • 80155142474 scopus 로고    scopus 로고
    • Rapamycin passes the torch: a new generation of mTOR inhibitors
    • Benjamin D., Colombi M., Moroni C., Hall M.N. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov 2011, 10:868-880.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 868-880
    • Benjamin, D.1    Colombi, M.2    Moroni, C.3    Hall, M.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.