Blocking of PDL-1 interaction enhances primary and secondary CD8 t cell response to herpes simplex virus-1 infection

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Channappanavar, Rudragouda ^a   Twardy, Brandon S ^a   Suvas, Susmit ^a  

^a OAKLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PEPTIDE DERIVATIVE; PEPTIDE SSIEFARL; PROGRAMMED DEATH 1 LIGAND 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; DEGRANULATION; DENDRITIC CELL; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 1 INFECTION; LYMPH NODE; MEMORY CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN; VIRAL CLEARANCE; VIRUS LOAD;

ACUTE DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD11C; ANTIGENS, CD274; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNOASSAY; IMMUNODOMINANT EPITOPES; IMMUNOLOGIC MEMORY; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MICE; MICE, INBRED C57BL; OLIGOPEPTIDES;

HUMAN HERPESVIRUS 1;

EID: 84863734405     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039757     Document Type: Article

References (35)

1. Crawford A, Wherry EJ, (2009) The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses. Curr Opin Immunol 21: 179-186.
2. Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687.
3. Velu V, Kannanganat S, Ibegbu C, Chennareddi L, Villinger F, et al. (2007) Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J Virol 81: 5819-5828.
4. Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, et al. (2006) Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 12: 1198-1202.
5. Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, et al. (2007) Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 81: 2545-2553.
6. Keir ME, Butte MJ, Freeman GJ, Sharpe AH, (2008) PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 26: 677-704.
7. Velu V, Titanji K, Zhu B, Husain S, Pladevega A, et al. (2009) Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458: 206-210.
8. Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, et al. (2006) PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443: 350-354.
9. Seo SK, Jeong HY, Park SG, Lee SW, Choi IW, et al. (2008) Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection. Immunology 123: 90-99.
10. Rowe JH, Johanns TM, Ertelt JM, Way SS, (2008) PDL-1 blockade impedes T cell expansion and protective immunity primed by attenuated Listeria monocytogenes. J Immunol 180: 7553-7557.
11. Telcian AG, Laza-Stanca V, Edwards MR, Harker JA, Wang H, et al. (2011) RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity. J Infect Dis 203: 85-94.
12. Urbani S, Amadei B, Tola D, Massari M, Schivazappa S, et al. (2006) PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol 80: 11398-11403.
13. Zelinskyy G, Myers L, Dietze KK, Gibbert K, Roggendorf M, et al. (2011) Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication. J Immunol 187: 3730-3737.
14. Coles RM, Mueller SN, Heath WR, Carbone FR, Brooks AG, (2002) Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. J Immunol 168: 834-838.
15. Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, et al. (2010) PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest 120: 2508-2515.
16. Smith CM, Belz GT, Wilson NS, Villadangos JA, Shortman K, et al. (2003) Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1. J Immunol 170: 4437-4440.
17. Hokey DA, Johnson FB, Smith J, Weber JL, Yan J, et al. (2008) Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol 38: 1435-1445.
18. Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, et al. (2011) The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol 85: 4184-4197.
19. Blackburn SD, Shin H, Freeman GJ, Wherry EJ, (2008) Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proc Natl Acad Sci U S A 105: 15016-15021.
20. Lafon M, Megret F, Meuth SG, Simon O, Velandia Romero ML, et al. (2008) Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. J Immunol 180: 7506-7515.
21. Talay O, Shen CH, Chen L, Chen J, (2009) B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation. Proc Natl Acad Sci U S A 106: 2741-2746.
22. Jun H, Seo SK, Jeong HY, Seo HM, Zhu G, et al. (2005) B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK). FEBS Lett 579: 6259-6264.
23. Bryant-Hudson KM, Carr DJ, (2012) PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection. Clin Dev Immunol 2012: 924619.
24. Liu T, Khanna KM, Chen X, Fink DJ, Hendricks RL, (2000) CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J Exp Med 191: 1459-1466.
25. Mott KR, Bresee CJ, Allen SJ, BenMohamed L, Wechsler SL, et al. (2009) Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice. J Virol 83: 2246-2254.
26. Chentoufi AA, Kritzer E, Tran MV, Dasgupta G, Lim CH, et al. (2011) The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. J Virol 85: 9127-9138.
27. Chentoufi AA, Dervillez X, Dasgupta G, Nguyen C, Kabbara KW, et al. (2012) The Herpes Simplex Virus Type 1 Latency-Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells. Viral Immunol 25(3): 204-215.
28. Masopust D, Kaech SM, Wherry EJ, Ahmed R, (2004) The role of programming in memory T-cell development. Curr Opin Immunol 16: 217-225.
29. Allie SR, Zhang W, Fuse S, Usherwood EJ, (2011) Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection. J Immunol 186: 6280-6286.
30. Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, et al. (2009) Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog 5: e1000313.
31. Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, et al. (2010) Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A 107: 14733-14738.
32. Finnefrock AC, Tang A, Li F, Freed DC, Feng M, et al. (2009) PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination. J Immunol 182: 980-987.
33. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, et al. (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281: 65-78.
34. Wolint P, Betts MR, Koup RA, Oxenius A, (2004) Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. J Exp Med 199: 925-936.
35. Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT, (2003) CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 198: 889-901.