메뉴 건너뛰기




Volumn 14, Issue 5, 2015, Pages 2237-2254

Metabonomic changes associated with atherosclerosis progression for LDLR -/- mice

Author keywords

atherosclerosis; gut microbiota; high fat diet; LDLR mice; metabonomics; NMR

Indexed keywords

ALLANTOIN; AMINO ACID; CHOLESTEROL; CHOLINE; COLLAGEN; GELATINASE A; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINAMIDE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; ACYL COENZYME A DESATURASE; CCL2 PROTEIN, MOUSE; FATTY ACID; LOW DENSITY LIPOPROTEIN RECEPTOR; MMP2 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; SCD1 PROTEIN, MOUSE;

EID: 84929659225     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.5b00032     Document Type: Article
Times cited : (57)

References (68)
  • 1
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby, P. Inflammation in atherosclerosis Nature 2002, 420 (6917) 868-874
    • (2002) Nature , vol.420 , Issue.6917 , pp. 868-874
    • Libby, P.1
  • 2
    • 81255188900 scopus 로고    scopus 로고
    • Atherosclerosis: Current pathogenesis and therapeutic options
    • Weber, C.; Noels, H. Atherosclerosis: current pathogenesis and therapeutic options Nat. Med. 2011, 17 (11) 1410-1422
    • (2011) Nat. Med. , vol.17 , Issue.11 , pp. 1410-1422
    • Weber, C.1    Noels, H.2
  • 4
    • 84886674980 scopus 로고    scopus 로고
    • Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1 alpha and sterile vascular inflammation in atherosclerosis
    • Freigang, S.; Ampenberger, F.; Weiss, A.; Kanneganti, T. D.; Iwakura, Y.; Hersberger, M.; Kopf, M. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1 alpha and sterile vascular inflammation in atherosclerosis Nat. Immunol. 2013, 14 (10) 1045-1053
    • (2013) Nat. Immunol. , vol.14 , Issue.10 , pp. 1045-1053
    • Freigang, S.1    Ampenberger, F.2    Weiss, A.3    Kanneganti, T.D.4    Iwakura, Y.5    Hersberger, M.6    Kopf, M.7
  • 5
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis, A. J. Atherosclerosis Nature 2000, 407 (6801) 233-241
    • (2000) Nature , vol.407 , Issue.6801 , pp. 233-241
    • Lusis, A.J.1
  • 7
    • 0030024169 scopus 로고    scopus 로고
    • Mouse models of atherosclerosis
    • Breslow, J. L. Mouse models of atherosclerosis Science 1996, 272 (5262) 685-688
    • (1996) Science , vol.272 , Issue.5262 , pp. 685-688
    • Breslow, J.L.1
  • 8
    • 79952736069 scopus 로고    scopus 로고
    • Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques
    • Feig, J. E.; Parathath, S.; Rong, J. X.; Mick, S. L.; Vengrenyuk, Y.; Grauer, L.; Young, S. G.; Fisher, E. A. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques Circulation 2011, 123 (9) 989-998
    • (2011) Circulation , vol.123 , Issue.9 , pp. 989-998
    • Feig, J.E.1    Parathath, S.2    Rong, J.X.3    Mick, S.L.4    Vengrenyuk, Y.5    Grauer, L.6    Young, S.G.7    Fisher, E.A.8
  • 9
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein-E
    • Zhang, S. H.; Reddick, R. L.; Piedrahita, J. A.; Maeda, N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein-E Science 1992, 258 (5081) 468-471
    • (1992) Science , vol.258 , Issue.5081 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 10
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein-E deficient mice created by homologous recombination in es cells
    • Plump, A. S.; Smith, J. D.; Hayek, T.; Aaltosetala, K.; Walsh, A.; Verstuyft, J. G.; Rubin, E. M.; Breslow, J. L. Severe hypercholesterolemia and atherosclerosis in apolipoprotein-E deficient mice created by homologous recombination in es cells Cell 1992, 71 (2) 343-353
    • (1992) Cell , vol.71 , Issue.2 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aaltosetala, K.4    Walsh, A.5    Verstuyft, J.G.6    Rubin, E.M.7    Breslow, J.L.8
  • 11
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low-density-lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi, S.; Brown, M. S.; Goldstein, J. L.; Gerard, R. D.; Hammer, R. E.; Herz, J. Hypercholesterolemia in low-density-lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery J. Clin. Invest. 1993, 92 (2) 883-893
    • (1993) J. Clin. Invest. , vol.92 , Issue.2 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 12
    • 0028268018 scopus 로고
    • The 2-receptor model of lipoprotein clearance- tests of the hypothesis in knockout mice lacking the low-density-lipoprotein receptor, apolipoprotein-E, or both proteins
    • Ishibashi, S.; Herz, J.; Maeda, N.; Goldstein, J. L.; Brown, M. S. The 2-receptor model of lipoprotein clearance- tests of the hypothesis in knockout mice lacking the low-density-lipoprotein receptor, apolipoprotein-E, or both proteins Proc. Natl. Acad. Sci. U.S.A. 1994, 91 (10) 4431-4435
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , Issue.10 , pp. 4431-4435
    • Ishibashi, S.1    Herz, J.2    Maeda, N.3    Goldstein, J.L.4    Brown, M.S.5
  • 13
    • 0028345073 scopus 로고
    • Massive xanthomatosis and atherosclerosis in cholesterol-fed low-density-lipoprotein receptor-negative mice
    • Ishibashi, S.; Goldstein, J. L.; Brown, M. S.; Herz, J.; Burns, D. K. Massive xanthomatosis and atherosclerosis in cholesterol-fed low-density-lipoprotein receptor-negative mice J. Clin. Invest. 1994, 93 (5) 1885-1893
    • (1994) J. Clin. Invest. , vol.93 , Issue.5 , pp. 1885-1893
    • Ishibashi, S.1    Goldstein, J.L.2    Brown, M.S.3    Herz, J.4    Burns, D.K.5
  • 14
    • 78650861117 scopus 로고    scopus 로고
    • Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques
    • Tang, J. J.; Li, J. G.; Qi, W.; Qiu, W. W.; Li, P. S.; Li, B. L.; Song, B. L. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques Cell Metab. 2011, 13 (1) 44-56
    • (2011) Cell Metab. , vol.13 , Issue.1 , pp. 44-56
    • Tang, J.J.1    Li, J.G.2    Qi, W.3    Qiu, W.W.4    Li, P.S.5    Li, B.L.6    Song, B.L.7
  • 17
    • 0033597952 scopus 로고    scopus 로고
    • Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation
    • Iiyama, K.; Hajra, L.; Iiyama, M.; Li, H. M.; DiChiara, M.; Medoff, B. D.; Cybulsky, M. I. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation Circ. Res. 1999, 85 (2) 199-207
    • (1999) Circ. Res. , vol.85 , Issue.2 , pp. 199-207
    • Iiyama, K.1    Hajra, L.2    Iiyama, M.3    Li, H.M.4    Dichiara, M.5    Medoff, B.D.6    Cybulsky, M.I.7
  • 18
    • 0034060198 scopus 로고    scopus 로고
    • Characterization of atherosclerosis in LDL receptor knockout mice: Macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE
    • Kowala, M. C.; Recce, R.; Beyer, S.; Gu, C.; Valentine, M. Characterization of atherosclerosis in LDL receptor knockout mice: macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE Atherosclerosis 2000, 149 (2) 323-330
    • (2000) Atherosclerosis , vol.149 , Issue.2 , pp. 323-330
    • Kowala, M.C.1    Recce, R.2    Beyer, S.3    Gu, C.4    Valentine, M.5
  • 19
    • 20444378931 scopus 로고    scopus 로고
    • The PPAR delta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice
    • Graham, T. L.; Mookherjee, C.; Suckling, K. E.; Palmer, C. N. A.; Patel, L. The PPAR delta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice Atherosclerosis 2005, 181 (1) 29-37
    • (2005) Atherosclerosis , vol.181 , Issue.1 , pp. 29-37
    • Graham, T.L.1    Mookherjee, C.2    Suckling, K.E.3    Palmer, C.N.A.4    Patel, L.5
  • 21
    • 84892418595 scopus 로고    scopus 로고
    • Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: Results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study
    • Nozue, T.; Yamamoto, S.; Tohyama, S.; Fukui, K.; Umezawa, S.; Onishi, Y.; Kunishima, T.; Sato, A.; Nozato, T.; Miyake, S.; Takeyama, Y.; Morino, Y.; Yamauchi, T.; Muramatsu, T.; Hibi, K.; Terashima, M.; Michishita, I. Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study Cardiovasc. Diabetol. 2014, 13, 13
    • (2014) Cardiovasc. Diabetol. , vol.13 , pp. 13
    • Nozue, T.1    Yamamoto, S.2    Tohyama, S.3    Fukui, K.4    Umezawa, S.5    Onishi, Y.6    Kunishima, T.7    Sato, A.8    Nozato, T.9    Miyake, S.10    Takeyama, Y.11    Morino, Y.12    Yamauchi, T.13    Muramatsu, T.14    Hibi, K.15    Terashima, M.16    Michishita, I.17
  • 22
    • 70349849654 scopus 로고    scopus 로고
    • PPAR delta ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice
    • Lim, H. J.; Park, J. H.; Lee, S.; Choi, H. E.; Lee, K. S.; Park, H. Y. PPAR delta ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice Eur. J. Pharmacol. 2009, 622 (1-3) 45-51
    • (2009) Eur. J. Pharmacol. , vol.622 , Issue.13 , pp. 45-51
    • Lim, H.J.1    Park, J.H.2    Lee, S.3    Choi, H.E.4    Lee, K.S.5    Park, H.Y.6
  • 23
    • 33746309537 scopus 로고    scopus 로고
    • Metabonomics: A revolution in progress
    • Tang, H. R.; Wang, Y. L. Metabonomics: a revolution in progress Prog. Biochem. Biophys. 2006, 33 (5) 401-417
    • (2006) Prog. Biochem. Biophys. , vol.33 , Issue.5 , pp. 401-417
    • Tang, H.R.1    Wang, Y.L.2
  • 24
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J. K.; Lindon, J. C.; Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29 (11) 1181-1189
    • (1999) Xenobiotica , vol.29 , Issue.11 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 25
    • 84879946097 scopus 로고    scopus 로고
    • Multiple univariate data analysis reveals the inulin effects on the high-fat-diet induced metabolic alterations in rat myocardium and testicles in the preobesity state
    • Duan, Y. X.; An, Y. P.; Li, N.; Liu, B. F.; Wang, Y. L.; Tang, H. R. Multiple univariate data analysis reveals the inulin effects on the high-fat-diet induced metabolic alterations in rat myocardium and testicles in the preobesity state J. Proteome Res. 2013, 12 (7) 3480-3495
    • (2013) J. Proteome Res. , vol.12 , Issue.7 , pp. 3480-3495
    • Duan, Y.X.1    An, Y.P.2    Li, N.3    Liu, B.F.4    Wang, Y.L.5    Tang, H.R.6
  • 27
    • 84890026574 scopus 로고    scopus 로고
    • Metabonomic profiling revealed an alteration in purine nucleotide metabolism associated with cardiac hypertrophy in rats treated with thiazolidinediones
    • Liu, Y.; Yan, X.; Mao, G. M.; Fang, L.; Zhao, B. L.; Liu, Y. H.; Tang, H. R.; Wang, N. P. Metabonomic profiling revealed an alteration in purine nucleotide metabolism associated with cardiac hypertrophy in rats treated with thiazolidinediones J. Proteome Res. 2013, 12 (12) 5634-5641
    • (2013) J. Proteome Res. , vol.12 , Issue.12 , pp. 5634-5641
    • Liu, Y.1    Yan, X.2    Mao, G.M.3    Fang, L.4    Zhao, B.L.5    Liu, Y.H.6    Tang, H.R.7    Wang, N.P.8
  • 29
    • 84890077875 scopus 로고    scopus 로고
    • Combined NMR and GC-MS analyses revealed dynamic metabolic changes associated with the carrageenan-induced rat pleurisy
    • Li, H. H.; An, Y. P.; Zhang, L. L.; Lei, H. H.; Zhang, L. M.; Wang, Y. L.; Tang, H. R. Combined NMR and GC-MS analyses revealed dynamic metabolic changes associated with the carrageenan-induced rat pleurisy J. Proteome Res. 2013, 12 (12) 5520-5534
    • (2013) J. Proteome Res. , vol.12 , Issue.12 , pp. 5520-5534
    • Li, H.H.1    An, Y.P.2    Zhang, L.L.3    Lei, H.H.4    Zhang, L.M.5    Wang, Y.L.6    Tang, H.R.7
  • 30
    • 84870622344 scopus 로고    scopus 로고
    • Metabolic response to klebsiella pneumoniae infection in an experimental rat model
    • Dong, F. C.; Wang, B.; Zhang, L. L.; Tang, H. R.; Li, J. S.; Wang, Y. L. Metabolic response to klebsiella pneumoniae infection in an experimental rat model PLoS One 2012, 7 (11) e51060
    • (2012) PLoS One , vol.7 , Issue.11 , pp. 51060
    • Dong, F.C.1    Wang, B.2    Zhang, L.L.3    Tang, H.R.4    Li, J.S.5    Wang, Y.L.6
  • 32
    • 84855477382 scopus 로고    scopus 로고
    • Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach
    • He, Q. H.; Ren, P. P.; Kong, X. F.; Wu, Y. N.; Wu, G. Y.; Li, P.; Hao, F. H.; Tang, H. R.; Blachier, F.; Yin, Y. L. Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach J. Nutr. Biochem. 2012, 23 (2) 133-139
    • (2012) J. Nutr. Biochem. , vol.23 , Issue.2 , pp. 133-139
    • He, Q.H.1    Ren, P.P.2    Kong, X.F.3    Wu, Y.N.4    Wu, G.Y.5    Li, P.6    Hao, F.H.7    Tang, H.R.8    Blachier, F.9    Yin, Y.L.10
  • 34
    • 80655147179 scopus 로고    scopus 로고
    • Dietary supplementation with L-arginine partially counteracts serum metabonome induced by weaning stress in piglets
    • He, Q. H.; Tang, H. R.; Ren, P. P.; Kong, X. F.; Wu, G. Y.; Yin, Y. L.; Wang, Y. L. Dietary supplementation with L-arginine partially counteracts serum metabonome induced by weaning stress in piglets J. Proteome Res. 2011, 10 (11) 5214-5221
    • (2011) J. Proteome Res. , vol.10 , Issue.11 , pp. 5214-5221
    • He, Q.H.1    Tang, H.R.2    Ren, P.P.3    Kong, X.F.4    Wu, G.Y.5    Yin, Y.L.6    Wang, Y.L.7
  • 35
    • 1542407093 scopus 로고    scopus 로고
    • Ethyl glucoside in human urine following dietary exposure: Detection by H-1 NMR spectroscopy as a result of metabonomic screening of humans
    • Teague, C.; Holmes, E.; Maibaum, E.; Nicholson, J.; Tang, H. R.; Chan, Q. N.; Elliott, P.; Wilson, I. Ethyl glucoside in human urine following dietary exposure: detection by H-1 NMR spectroscopy as a result of metabonomic screening of humans Analyst 2004, 129 (3) 259-264
    • (2004) Analyst , vol.129 , Issue.3 , pp. 259-264
    • Teague, C.1    Holmes, E.2    Maibaum, E.3    Nicholson, J.4    Tang, H.R.5    Chan, Q.N.6    Elliott, P.7    Wilson, I.8
  • 36
    • 84873339943 scopus 로고    scopus 로고
    • Gallic acid intake induces alterations to systems metabolism in rats
    • Shi, X. H.; Xiao, C. N.; Wang, Y. L.; Tang, H. R. Gallic acid intake induces alterations to systems metabolism in rats J. Proteome Res. 2013, 12 (2) 991-1006
    • (2013) J. Proteome Res. , vol.12 , Issue.2 , pp. 991-1006
    • Shi, X.H.1    Xiao, C.N.2    Wang, Y.L.3    Tang, H.R.4
  • 37
    • 77952941236 scopus 로고    scopus 로고
    • Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice
    • Cheng, K. K.; Benson, G. M.; Grimsditch, D. C.; Reid, D. G.; Connor, S. C.; Griffin, J. L. Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice Physiol. Genomics 2010, 41 (3) 224-231
    • (2010) Physiol. Genomics , vol.41 , Issue.3 , pp. 224-231
    • Cheng, K.K.1    Benson, G.M.2    Grimsditch, D.C.3    Reid, D.G.4    Connor, S.C.5    Griffin, J.L.6
  • 38
    • 84865007833 scopus 로고    scopus 로고
    • Eliminating the dication-induced intersample chemical-shift variations for NMR-based biofluid metabonomic analysis
    • Jiang, L. M.; Huang, J.; Wang, Y. L.; Tang, H. R. Eliminating the dication-induced intersample chemical-shift variations for NMR-based biofluid metabonomic analysis Analyst 2012, 137 (18) 4209-4219
    • (2012) Analyst , vol.137 , Issue.18 , pp. 4209-4219
    • Jiang, L.M.1    Huang, J.2    Wang, Y.L.3    Tang, H.R.4
  • 39
    • 84892145934 scopus 로고    scopus 로고
    • Metabonomic analysis reveals efficient ameliorating effects of acupoint stimulations on the menopause-caused alterations in mammalian metabolism
    • Zhang, L. M.; Wang, Y. L.; Xu, Y. X.; Lei, H. H.; Zhao, Y.; Li, H. H.; Lin, X. S.; Chen, G. Z.; Tang, H. R. Metabonomic analysis reveals efficient ameliorating effects of acupoint stimulations on the menopause-caused alterations in mammalian metabolism Sci. Rep. 2014, 4, 3641
    • (2014) Sci. Rep. , vol.4 , pp. 3641
    • Zhang, L.M.1    Wang, Y.L.2    Xu, Y.X.3    Lei, H.H.4    Zhao, Y.5    Li, H.H.6    Lin, X.S.7    Chen, G.Z.8    Tang, H.R.9
  • 40
    • 79955451518 scopus 로고    scopus 로고
    • Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices
    • Zhang, L. M.; Ye, Y. F.; An, Y. P.; Tian, Y. A.; Wang, Y. L.; Tang, H. R. Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices J. Proteome Res. 2011, 10 (2) 614-623
    • (2011) J. Proteome Res. , vol.10 , Issue.2 , pp. 614-623
    • Zhang, L.M.1    Ye, Y.F.2    An, Y.P.3    Tian, Y.A.4    Wang, Y.L.5    Tang, H.R.6
  • 41
    • 84863628151 scopus 로고    scopus 로고
    • Metabonomic analysis reveals the CCl4-induced systems alterations for multiple rat organs
    • Jiang, L. M.; Huang, J.; Wang, Y. L.; Tang, H. R. Metabonomic analysis reveals the CCl4-induced systems alterations for multiple rat organs J. Proteome Res. 2012, 11 (7) 3848-3859
    • (2012) J. Proteome Res. , vol.11 , Issue.7 , pp. 3848-3859
    • Jiang, L.M.1    Huang, J.2    Wang, Y.L.3    Tang, H.R.4
  • 42
    • 84863012692 scopus 로고    scopus 로고
    • Age-Related Topographical Metabolic Signatures for the Rat Gastrointestinal Contents
    • Tian, Y.; Zhang, L.; Wang, Y.; Tang, H. Age-Related Topographical Metabolic Signatures for the Rat Gastrointestinal Contents J. Proteome Res. 2012, 11 (2) 1397-1411
    • (2012) J. Proteome Res. , vol.11 , Issue.2 , pp. 1397-1411
    • Tian, Y.1    Zhang, L.2    Wang, Y.3    Tang, H.4
  • 43
    • 57149116166 scopus 로고    scopus 로고
    • CV-ANOVA for significance testing of PLS and OPLS (R) models
    • Eriksson, L.; Trygg, J.; Wold, S. CV-ANOVA for significance testing of PLS and OPLS (R) models J. Chemometr. 2008, 22 (11-12) 594-600
    • (2008) J. Chemometr. , vol.22 , Issue.1112 , pp. 594-600
    • Eriksson, L.1    Trygg, J.2    Wold, S.3
  • 44
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • Trygg, J.; Wold, S. Orthogonal projections to latent structures (O-PLS) J. Chemometr. 2002, 16 (3) 119-128
    • (2002) J. Chemometr. , vol.16 , Issue.3 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 45
    • 12244293657 scopus 로고    scopus 로고
    • Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in H-1 NMR spectroscopic metabonomic studies
    • Cloarec, O.; Dumas, M. E.; Trygg, J.; Craig, A.; Barton, R. H.; Lindon, J. C.; Nicholson, J. K.; Holmes, E. Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in H-1 NMR spectroscopic metabonomic studies Anal. Chem. 2005, 77 (2) 517-526
    • (2005) Anal. Chem. , vol.77 , Issue.2 , pp. 517-526
    • Cloarec, O.1    Dumas, M.E.2    Trygg, J.3    Craig, A.4    Barton, R.H.5    Lindon, J.C.6    Nicholson, J.K.7    Holmes, E.8
  • 49
    • 77949779562 scopus 로고    scopus 로고
    • Combined NMR and LC-MS analysis reveals the metabonomic changes in salvia miltiorrhiza bunge induced by water depletion
    • Dai, H.; Xiao, C. N.; Liu, H. B.; Tang, H. R. Combined NMR and LC-MS analysis reveals the metabonomic changes in salvia miltiorrhiza bunge induced by water depletion J. Proteome Res. 2010, 9 (3) 1460-1475
    • (2010) J. Proteome Res. , vol.9 , Issue.3 , pp. 1460-1475
    • Dai, H.1    Xiao, C.N.2    Liu, H.B.3    Tang, H.R.4
  • 51
    • 79960273531 scopus 로고    scopus 로고
    • INOS induction and PARP-1 activation in human atherosclerotic lesions: An immunohistochemical and ultrastructural approach
    • Perrotta, I.; Brunelli, E.; Sciangula, A.; Conforti, F.; Perrotta, E.; Tripepi, S.; Donato, G.; Cassese, M. iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach Cardiovasc. Pathol. 2011, 20 (4) 195-203
    • (2011) Cardiovasc. Pathol. , vol.20 , Issue.4 , pp. 195-203
    • Perrotta, I.1    Brunelli, E.2    Sciangula, A.3    Conforti, F.4    Perrotta, E.5    Tripepi, S.6    Donato, G.7    Cassese, M.8
  • 52
    • 67049096255 scopus 로고    scopus 로고
    • Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase
    • Ponnuswamy, P.; Ostermeier, E.; Schrottle, A.; Chen, J.; Huang, P. L.; Ertl, G.; Nieswandt, B.; Kuhlencordt, P. J. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase Am. J. Pathol. 2009, 174 (6) 2400-2410
    • (2009) Am. J. Pathol. , vol.174 , Issue.6 , pp. 2400-2410
    • Ponnuswamy, P.1    Ostermeier, E.2    Schrottle, A.3    Chen, J.4    Huang, P.L.5    Ertl, G.6    Nieswandt, B.7    Kuhlencordt, P.J.8
  • 54
    • 0032573640 scopus 로고    scopus 로고
    • Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet
    • Murakami, S.; Kondo-Ohta, Y.; Tomisawa, K. Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet Life Sci. 1998, 64 (1) 83-91
    • (1998) Life Sci. , vol.64 , Issue.1 , pp. 83-91
    • Murakami, S.1    Kondo-Ohta, Y.2    Tomisawa, K.3
  • 55
    • 58249092178 scopus 로고    scopus 로고
    • The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents
    • Zhou, Y. E.; Egeland, G. M.; Meltzer, S. J.; Kubow, S. The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents Metabolism 2009, 58 (2) 158-166
    • (2009) Metabolism , vol.58 , Issue.2 , pp. 158-166
    • Zhou, Y.E.1    Egeland, G.M.2    Meltzer, S.J.3    Kubow, S.4
  • 57
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning, J. D.; Horton, J. D. Molecular mediators of hepatic steatosis and liver injury J. Clin. Invest. 2004, 114 (2) 147-152
    • (2004) J. Clin. Invest. , vol.114 , Issue.2 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 58
    • 79960685038 scopus 로고    scopus 로고
    • Hyperglycemic Ins2(Akita)Ldlr(-/-) mice show severely elevated lipid levels and increased atherosclerosis: A model of type 1 diabetic macrovascular disease
    • Zhou, C. C.; Pridgen, B.; King, N.; Xu, J. X.; Breslow, J. L. Hyperglycemic Ins2(Akita)Ldlr(-/-) mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease J. Lipid Res. 2011, 52 (8) 1483-1493
    • (2011) J. Lipid Res. , vol.52 , Issue.8 , pp. 1483-1493
    • Zhou, C.C.1    Pridgen, B.2    King, N.3    Xu, J.X.4    Breslow, J.L.5
  • 60
    • 26244457653 scopus 로고    scopus 로고
    • Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism
    • Mayr, M.; Chung, Y. L.; Mayr, U.; Yin, X. K.; Ly, L.; Troy, H.; Fredericks, S.; Hu, Y. H.; Griffiths, J. R.; Xu, Q. B. Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism Arterioscler., Thromb., Vasc. Biol. 2005, 25 (10) 2135-2142
    • (2005) Arterioscler., Thromb., Vasc. Biol. , vol.25 , Issue.10 , pp. 2135-2142
    • Mayr, M.1    Chung, Y.L.2    Mayr, U.3    Yin, X.K.4    Ly, L.5    Troy, H.6    Fredericks, S.7    Hu, Y.H.8    Griffiths, J.R.9    Xu, Q.B.10
  • 61
    • 0023244710 scopus 로고
    • Measurement of allantoin and uric acid in human-body fluids- a potential index of free-radical reactions invivo
    • Grootveld, M.; Halliwell, B. Measurement of allantoin and uric acid in human-body fluids- a potential index of free-radical reactions invivo Biochem. J. 1987, 243 (3) 803-808
    • (1987) Biochem. J. , vol.243 , Issue.3 , pp. 803-808
    • Grootveld, M.1    Halliwell, B.2
  • 62
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • Simopoulos, A. P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases Exp. Biol. Med. 2008, 233 (6) 674-688
    • (2008) Exp. Biol. Med. , vol.233 , Issue.6 , pp. 674-688
    • Simopoulos, A.P.1
  • 63
    • 84879359598 scopus 로고    scopus 로고
    • Systemic responses of mice to dextran sulfate sodium-induced acute ulcerative colitis using H-1 NMR spectroscopy
    • Dong, F. C.; Zhang, L. L.; Hao, F. H.; Tang, H. R.; Wang, Y. L. Systemic responses of mice to dextran sulfate sodium-induced acute ulcerative colitis using H-1 NMR spectroscopy J. Proteome Res. 2013, 12 (6) 2958-2966
    • (2013) J. Proteome Res. , vol.12 , Issue.6 , pp. 2958-2966
    • Dong, F.C.1    Zhang, L.L.2    Hao, F.H.3    Tang, H.R.4    Wang, Y.L.5
  • 64
    • 79957818865 scopus 로고    scopus 로고
    • Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters
    • Sun, Y.; Wang, Y. H.; Qu, K.; Zhu, H. B. Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters J. Asian Nat. Prod. Res. 2011, 13 (6) 534-546
    • (2011) J. Asian Nat. Prod. Res. , vol.13 , Issue.6 , pp. 534-546
    • Sun, Y.1    Wang, Y.H.2    Qu, K.3    Zhu, H.B.4
  • 66
    • 49049113111 scopus 로고    scopus 로고
    • Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice
    • Murdoch, T. B.; Fu, H.; MacFarlane, S.; Sydora, B. C.; Fedorak, R. N.; Slupsky, C. M. Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice Anal. Chem. 2008, 80 (14) 5524-5531
    • (2008) Anal. Chem. , vol.80 , Issue.14 , pp. 5524-5531
    • Murdoch, T.B.1    Fu, H.2    Macfarlane, S.3    Sydora, B.C.4    Fedorak, R.N.5    Slupsky, C.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.