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Volumn 11, Issue 6, 2012, Pages 3423-3435

Streptozotocin-induced dynamic metabonomic changes in rat biofluids

Author keywords

1H NMR spectroscopy; diabetes; Metabonomics; multivariate data analysis; unsaturated fatty acids

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACETOACETIC ACID; ALANINE; ARGININE; ASPARTIC ACID; CHOLINE; CITRIC ACID; CREATINE; CREATININE; FORMIC ACID; GLUCOSE; GLUTAMIC ACID; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HISTIDINE; ISOLEUCINE; LACTIC ACID; LEUCINE; LOW DENSITY LIPOPROTEIN; LYSINE; MONOUNSATURATED FATTY ACID; NITRIC OXIDE SYNTHASE; PHENYLALANINE; PROLINE; STREPTOZOCIN; THREONINE; TYROSINE; UNSATURATED FATTY ACID; VALINE; GLUCOSE BLOOD LEVEL;

EID: 84861813306     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr300280t     Document Type: Article
Times cited : (44)

References (70)
  • 2
    • 1042302780 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 2004, 27 (1 Suppl) S5-S10
    • (2004) Diabetes Care , vol.27 , Issue.1 SUPPL.
  • 3
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild, S.; Roglic, G.; Green, A.; Sicree, R.; King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 2004, 27 (5) 1047-1053
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 5
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman, R. R.; Paul, S. K.; Bethel, M. A.; Matthews, D. R.; Neil, H. A. 10-year follow-up of intensive glucose control in type 2 diabetes N. Engl. J. Med. 2008, 359 (15) 1577-1589
    • (2008) N. Engl. J. Med. , vol.359 , Issue.15 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 8
    • 78651338445 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2011
    • American Diabetes Association
    • American Diabetes Association Standards of medical care in diabetes - 2011 Diabetes Care 2011, 34 (Suppl 1) S11-S61
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 1
  • 9
    • 27144512284 scopus 로고    scopus 로고
    • Genetic susceptibility to type 1 diabetes
    • Maier, L. M.; Wicker, L. S. Genetic susceptibility to type 1 diabetes Curr. Opin. Immunol. 2005, 17 (6) 601-608
    • (2005) Curr. Opin. Immunol. , vol.17 , Issue.6 , pp. 601-608
    • Maier, L.M.1    Wicker, L.S.2
  • 11
    • 0023252262 scopus 로고
    • HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • Todd, J. A.; Bell, J. I.; McDevitt, H. O. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus Nature 1987, 329 (6140) 599-604
    • (1987) Nature , vol.329 , Issue.6140 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 14
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen, T. The role of interleukin-1 in the pathogenesis of IDDM Diabetologia 1996, 39 (9) 1005-1029
    • (1996) Diabetologia , vol.39 , Issue.9 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 17
    • 50249094538 scopus 로고    scopus 로고
    • The identification of potential factors associated with the development of type 2 diabetes: A quantitative proteomics approach
    • Lu, H.; Yang, Y.; Allister, E. M.; Wijesekara, N.; Wheeler, M. B. The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach Mol. Cell. Proteomics 2008, 7 (8) 1434-1451
    • (2008) Mol. Cell. Proteomics , vol.7 , Issue.8 , pp. 1434-1451
    • Lu, H.1    Yang, Y.2    Allister, E.M.3    Wijesekara, N.4    Wheeler, M.B.5
  • 18
    • 33746309537 scopus 로고    scopus 로고
    • Metabonomics: A revolution in progress
    • Tang, H. R.; Wang, Y. L. Metabonomics: a revolution in progress Prog. Biophys. Biochem. 2006, 33 (5) 401-417
    • (2006) Prog. Biophys. Biochem. , vol.33 , Issue.5 , pp. 401-417
    • Tang, H.R.1    Wang, Y.L.2
  • 19
    • 0043069547 scopus 로고    scopus 로고
    • Opinion: Understanding "global" systems biology: Metabonomics and the continuum of metabolism
    • Nicholson, J. K.; Wilson, I. D. Opinion: understanding "global" systems biology: metabonomics and the continuum of metabolism Nat. Rev. Drug Discovery 2003, 2 (8) 668-676
    • (2003) Nat. Rev. Drug Discovery , vol.2 , Issue.8 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 20
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: A platform for studying drug toxicity and gene function
    • Nicholson, J. K.; Connelly, J.; Lindon, J. C.; Holmes, E. Metabonomics: a platform for studying drug toxicity and gene function Nat. Rev. Drug Discovery 2002, 1 (2) 153-161
    • (2002) Nat. Rev. Drug Discovery , vol.1 , Issue.2 , pp. 153-161
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 21
    • 0032694577 scopus 로고    scopus 로고
    • "Metabonomics" : Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J. K.; Lindon, J. C.; Holmes, E. "Metabonomics" : understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29 (11) 1181-1189
    • (1999) Xenobiotica , vol.29 , Issue.11 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 22
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis
    • Griffin, J. L. Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis Curr. Opin. Chem. Biol. 2003, 7 (5) 648-654
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , Issue.5 , pp. 648-654
    • Griffin, J.L.1
  • 23
    • 0035796127 scopus 로고    scopus 로고
    • Pattern recognition methods and applications in biomedical magnetic resonance
    • Lindon, J. C.; Holmes, E.; Nicholson, J. K. Pattern recognition methods and applications in biomedical magnetic resonance Prog. Nucl. Magn. Reson. Spectrosc. 2001, 39 (1) 1-40
    • (2001) Prog. Nucl. Magn. Reson. Spectrosc. , vol.39 , Issue.1 , pp. 1-40
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 29
    • 0021321993 scopus 로고
    • Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects
    • Nicholson, J. K.; O'Flynn, M. P.; Sadler, P. J.; Macleod, A. F.; Juul, S. M.; Sonksen, P. H. Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects Biochem. J. 1984, 217 (2) 365-375
    • (1984) Biochem. J. , vol.217 , Issue.2 , pp. 365-375
    • Nicholson, J.K.1    O'Flynn, M.P.2    Sadler, P.J.3    MacLeod, A.F.4    Juul, S.M.5    Sonksen, P.H.6
  • 30
    • 21644479604 scopus 로고    scopus 로고
    • Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis
    • Wang, C.; Kong, H. W.; Guan, Y. F.; Yang, J.; Gu, J. R.; Yang, S. L.; Xu, G. W. Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis Anal. Chem. 2005, 77 (13) 4108-4116
    • (2005) Anal. Chem. , vol.77 , Issue.13 , pp. 4108-4116
    • Wang, C.1    Kong, H.W.2    Guan, Y.F.3    Yang, J.4    Gu, J.R.5    Yang, S.L.6    Xu, G.W.7
  • 36
    • 70449450345 scopus 로고    scopus 로고
    • Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses
    • Zhang, X.; Wang, Y.; Hao, F.; Zhou, X.; Han, X.; Tang, H.; Ji, L. Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses J. Proteome Res. 2009, 8 (11) 5188-5195
    • (2009) J. Proteome Res. , vol.8 , Issue.11 , pp. 5188-5195
    • Zhang, X.1    Wang, Y.2    Hao, F.3    Zhou, X.4    Han, X.5    Tang, H.6    Ji, L.7
  • 38
    • 17144404203 scopus 로고    scopus 로고
    • Animal models of diabetes mellitus
    • Rees, D. A.; Alcolado, J. C. Animal models of diabetes mellitus Diabetic Med. 2005, 22 (4) 359-370
    • (2005) Diabetic Med. , vol.22 , Issue.4 , pp. 359-370
    • Rees, D.A.1    Alcolado, J.C.2
  • 39
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • Lenzen, S. The mechanisms of alloxan- and streptozotocin-induced diabetes Diabetologia 2008, 51 (2) 216-226
    • (2008) Diabetologia , vol.51 , Issue.2 , pp. 216-226
    • Lenzen, S.1
  • 40
    • 0034434893 scopus 로고    scopus 로고
    • Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin
    • Elsner, M.; Guldbakke, B.; Tiedge, M.; Munday, R.; Lenzen, S. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin Diabetologia 2000, 43 (12) 1528-1533
    • (2000) Diabetologia , vol.43 , Issue.12 , pp. 1528-1533
    • Elsner, M.1    Guldbakke, B.2    Tiedge, M.3    Munday, R.4    Lenzen, S.5
  • 43
    • 0014606996 scopus 로고
    • Diabetogenic action of streptozotocin: Relationship of dose to metabolic response
    • Junod, A.; Lambert, A. E.; Stauffacher, W.; Renold, A. E. Diabetogenic action of streptozotocin: relationship of dose to metabolic response J. Clin. Invest. 1969, 48 (11) 2129-2139
    • (1969) J. Clin. Invest. , vol.48 , Issue.11 , pp. 2129-2139
    • Junod, A.1    Lambert, A.E.2    Stauffacher, W.3    Renold, A.E.4
  • 44
    • 65349128823 scopus 로고    scopus 로고
    • An optimized buffer system for NMR-based urinary metabonomics with effective pH control, chemical shift consistency and dilution minimization
    • Xiao, C.; Hao, F.; Qin, X.; Wang, Y.; Tang, H. An optimized buffer system for NMR-based urinary metabonomics with effective pH control, chemical shift consistency and dilution minimization Analyst 2009, 134 (5) 916-925
    • (2009) Analyst , vol.134 , Issue.5 , pp. 916-925
    • Xiao, C.1    Hao, F.2    Qin, X.3    Wang, Y.4    Tang, H.5
  • 46
    • 77949779562 scopus 로고    scopus 로고
    • Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion
    • Dai, H.; Xiao, C.; Liu, H.; Tang, H. Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion J. Proteome Res. 2010, 9 (3) 1460-1475
    • (2010) J. Proteome Res. , vol.9 , Issue.3 , pp. 1460-1475
    • Dai, H.1    Xiao, C.2    Liu, H.3    Tang, H.4
  • 47
    • 77949803652 scopus 로고    scopus 로고
    • Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Miltiorrhiza Bunge
    • Dai, H.; Xiao, C.; Liu, H.; Hao, F.; Tang, H. Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Miltiorrhiza Bunge J. Proteome Res. 2010, 9 (3) 1565-1578
    • (2010) J. Proteome Res. , vol.9 , Issue.3 , pp. 1565-1578
    • Dai, H.1    Xiao, C.2    Liu, H.3    Hao, F.4    Tang, H.5
  • 49
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • Johan, T.; Svante, W. Orthogonal projections to latent structures (O-PLS) J. Chemom. 2002, 16 (3) 119-128
    • (2002) J. Chemom. , vol.16 , Issue.3 , pp. 119-128
    • Johan, T.1    Svante, W.2
  • 50
    • 34248139693 scopus 로고    scopus 로고
    • Pharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats
    • Li, H.; Ni, Y.; Su, M.; Qiu, Y.; Zhou, M.; Qiu, M.; Zhao, A.; Zhao, L.; Jia, W. Pharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats J. Proteome Res. 2007, 6 (4) 1364-1370
    • (2007) J. Proteome Res. , vol.6 , Issue.4 , pp. 1364-1370
    • Li, H.1    Ni, Y.2    Su, M.3    Qiu, Y.4    Zhou, M.5    Qiu, M.6    Zhao, A.7    Zhao, L.8    Jia, W.9
  • 51
    • 0001413420 scopus 로고    scopus 로고
    • Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures
    • Fan, T. W. M. Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures Prog. Nucl. Magn. Reson. Spectrosc. 1996, 28 (1996) 161-219
    • (1996) Prog. Nucl. Magn. Reson. Spectrosc. , vol.28 , Issue.1996 , pp. 161-219
    • Fan, T.W.M.1
  • 52
    • 0013911834 scopus 로고
    • Physiological effects of insulin
    • Lubetzki, J. Physiological effects of insulin Pathol. Biol. 1966, 14 (9) 584-590
    • (1966) Pathol. Biol. , vol.14 , Issue.9 , pp. 584-590
    • Lubetzki, J.1
  • 53
    • 0028172989 scopus 로고
    • 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus
    • 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus J. Clin. Invest. 1994, 94 (6) 2369-2376
    • (1994) J. Clin. Invest. , vol.94 , Issue.6 , pp. 2369-2376
    • Cline, G.W.1    Rothman, D.L.2    Magnusson, I.3    Katz, L.D.4    Shulman, G.I.5
  • 54
    • 84861809902 scopus 로고
    • Branched chain amino acids: (Proceedings of branched chain amino acids, a session from the 2nd international symposium advances in clinical nutrition, May 1982)
    • David, A. B. Branched chain amino acids: (proceedings of branched chain amino acids, a session from the 2nd international symposium advances in clinical nutrition, May 1982) FEBS Lett. 1983, 164 (1) 203-203
    • (1983) FEBS Lett. , vol.164 , Issue.1 , pp. 203-203
    • David, A.B.1
  • 55
    • 0021969039 scopus 로고
    • Changes in plasma histamine concentration in the streptozotocin-diabetic rat
    • Hollis, T. M.; Kern, J. A.; Enea, N. A.; Cosgarea, A. J. Changes in plasma histamine concentration in the streptozotocin-diabetic rat Exp. Mol. Pathol. 1985, 43 (1) 90-96
    • (1985) Exp. Mol. Pathol. , vol.43 , Issue.1 , pp. 90-96
    • Hollis, T.M.1    Kern, J.A.2    Enea, N.A.3    Cosgarea, A.J.4
  • 56
    • 0024516698 scopus 로고
    • Plasma histamine concentrations are elevated in patients with diabetes mellitus and peripheral vascular disease
    • Gill, D. S.; Barradas, M. A.; Fonseca, V. A.; Dandona, P. Plasma histamine concentrations are elevated in patients with diabetes mellitus and peripheral vascular disease Metabolism 1989, 38 (3) 243-247
    • (1989) Metabolism , vol.38 , Issue.3 , pp. 243-247
    • Gill, D.S.1    Barradas, M.A.2    Fonseca, V.A.3    Dandona, P.4
  • 57
    • 0006198863 scopus 로고    scopus 로고
    • Biomarkers of free radical damage applications in experimental animals and in humans
    • de Zwart, L. L.; Meerman, J. H.; Commandeur, J. N.; Vermeulen, N. P. Biomarkers of free radical damage applications in experimental animals and in humans Free Radical Biol. Med. 1999, 26 (1-2) 202-226
    • (1999) Free Radical Biol. Med. , vol.26 , Issue.1-2 , pp. 202-226
    • De Zwart, L.L.1    Meerman, J.H.2    Commandeur, J.N.3    Vermeulen, N.P.4
  • 58
    • 84861831221 scopus 로고    scopus 로고
    • Oxidative deamination of lysine residue in plasma protein from diabetic rat: Alpha-dicarbonyl-mediated mechanism
    • Suyama, K.; Akagawa, M.; Sasaki, T. Oxidative deamination of lysine residue in plasma protein from diabetic rat: alpha-dicarbonyl-mediated mechanism Int. Congr. Ser. 2002, 1245, 243-248
    • (2002) Int. Congr. Ser. , vol.1245 , pp. 243-248
    • Suyama, K.1    Akagawa, M.2    Sasaki, T.3
  • 59
    • 34447252828 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of l -arginine on its metabolism
    • Wilcken, D. E.; Sim, A. S.; Wang, J.; Wang, X. L. Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of l -arginine on its metabolism Mol. Genet. Metab. 2007, 91 (4) 309-317
    • (2007) Mol. Genet. Metab. , vol.91 , Issue.4 , pp. 309-317
    • Wilcken, D.E.1    Sim, A.S.2    Wang, J.3    Wang, X.L.4
  • 60
    • 34249851106 scopus 로고    scopus 로고
    • Uncomplicated type 1 diabetes is associated with increased asymmetric dimethylarginine concentrations
    • Altinova, A. E.; Arslan, M.; Sepici-Dincel, A.; Akturk, M.; Altan, N.; Toruner, F. B. Uncomplicated type 1 diabetes is associated with increased asymmetric dimethylarginine concentrations J. Clin. Endocrinol. Metab. 2007, 92 (5) 1881-1885
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , Issue.5 , pp. 1881-1885
    • Altinova, A.E.1    Arslan, M.2    Sepici-Dincel, A.3    Akturk, M.4    Altan, N.5    Toruner, F.B.6
  • 61
    • 0027504742 scopus 로고
    • Plasma lipid levels at diagnosis in type 2 diabetic patients
    • Sosenko, J. M.; Kato, M.; Soto, R.; Goldberg, R. B. Plasma lipid levels at diagnosis in type 2 diabetic patients Diabetic Med. 1993, 10 (9) 814-819
    • (1993) Diabetic Med. , vol.10 , Issue.9 , pp. 814-819
    • Sosenko, J.M.1    Kato, M.2    Soto, R.3    Goldberg, R.B.4
  • 62
    • 0035095478 scopus 로고    scopus 로고
    • Diabetes-induced changes in retinal NAD-redox status: Pharmacological modulation and implications for pathogenesis of diabetic retinopathy
    • Obrosova, I. G.; Stevens, M. J.; Lang, H. J. Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy Pharmacology 2001, 62 (3) 172-180
    • (2001) Pharmacology , vol.62 , Issue.3 , pp. 172-180
    • Obrosova, I.G.1    Stevens, M.J.2    Lang, H.J.3
  • 63
    • 0017086496 scopus 로고
    • Decay of succinate dehydrogenase activity in rat skeletal muscle following streptozotocin injection
    • Armstrong, R. B.; Ianuzzo, C. D. Decay of succinate dehydrogenase activity in rat skeletal muscle following streptozotocin injection Horm. Metab. Res. 1976, 8 (5) 392-394
    • (1976) Horm. Metab. Res. , vol.8 , Issue.5 , pp. 392-394
    • Armstrong, R.B.1    Ianuzzo, C.D.2
  • 64
    • 0015261202 scopus 로고
    • Alpha-Oxoglutarate carboxylation in liver mitochondria from normal, alloxan diabetic and streptozotocin diabetic rats
    • Mackerer, C. R.; Mehlman, M. A.; Tobin, R. B. alpha-Oxoglutarate carboxylation in liver mitochondria from normal, alloxan diabetic and streptozotocin diabetic rats Proc. Soc. Exp. Biol. Med. 1972, 139 (1) 24-27
    • (1972) Proc. Soc. Exp. Biol. Med. , vol.139 , Issue.1 , pp. 24-27
    • MacKerer, C.R.1    Mehlman, M.A.2    Tobin, R.B.3
  • 65
    • 0020531457 scopus 로고
    • Long-term changes in the diabetic state induced by different doses of streptozotocin in rats
    • Tancrede, G.; Rousseau-Migneron, S.; Nadeau, A. Long-term changes in the diabetic state induced by different doses of streptozotocin in rats Br. J. Exp. Pathol. 1983, 64 (2) 117-123
    • (1983) Br. J. Exp. Pathol. , vol.64 , Issue.2 , pp. 117-123
    • Tancrede, G.1    Rousseau-Migneron, S.2    Nadeau, A.3
  • 66
    • 0031839564 scopus 로고    scopus 로고
    • Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity
    • Phipps, A. N.; Stewart, J.; Wright, B.; Wilson, I. D. Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity Xenobiotica 1998, 28 (5) 527-537
    • (1998) Xenobiotica , vol.28 , Issue.5 , pp. 527-537
    • Phipps, A.N.1    Stewart, J.2    Wright, B.3    Wilson, I.D.4
  • 68
    • 84863012692 scopus 로고    scopus 로고
    • Age-related topographical metabolic signatures for the rat gastrointestinal contents
    • Tian, Y.; Zhang, L.; Wang, Y.; Tang, H. Age-related topographical metabolic signatures for the rat gastrointestinal contents J. Proteome. Res. 2011, 11 (2) 1397-1411
    • (2011) J. Proteome. Res. , vol.11 , Issue.2 , pp. 1397-1411
    • Tian, Y.1    Zhang, L.2    Wang, Y.3    Tang, H.4
  • 70
    • 33645868980 scopus 로고    scopus 로고
    • Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin
    • Thyssen, S.; Arany, E.; Hill, D. J. Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin Endocrinology 2006, 147 (5) 2346-2356
    • (2006) Endocrinology , vol.147 , Issue.5 , pp. 2346-2356
    • Thyssen, S.1    Arany, E.2    Hill, D.J.3


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