Metabonomic profiling revealed an alteration in purine nucleotide metabolism associated with cardiac hypertrophy in rats treated with thiazolidinediones

Journal of Proteome Research

Volumn 12, Issue 12, 2013, Pages 5634-5641

  Liu, Yan ^a   Yan, Xing ^b   Mao, Guangmei ^a   Fang, Li ^a   Zhao, Beilei ^a   Liu, Yahan ^a   Tang, Huiru ^b   Wang, Nanping ^a,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Wuhan National Laboratory for Optoelectronics   (China)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

cardiac hypertrophy; metabonomics; PPAR ; purine nucleotide metabolism; thiazolidinediones

Indexed keywords

ADENOSINE PHOSPHATE; ADENYLATE KINASE; ADENYLOSUCCINATE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHORIBOSL PYROPHOSPHATE SYNTHETASE 1; PIOGLITAZONE; PURINE; ROSIGLITAZONE; SYNTHETASE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; INOSINE; RIBOSEPHOSPHATE PYROPHOSPHOKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CATABOLISM; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA FLANKING REGION; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; MALE; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CARDIOMEGALY; CHEMICALLY INDUCED; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE; METABOLISM; METABOLOMICS; MULTIVARIATE ANALYSIS; PATHOLOGY; SPRAGUE DAWLEY RAT;

5' FLANKING REGION; ADENOSINE MONOPHOSPHATE; ADENYLOSUCCINATE SYNTHASE; ANIMALS; CARDIOMEGALY; GENE EXPRESSION REGULATION; HYPOGLYCEMIC AGENTS; INOSINE; MALE; METABOLOMICS; MULTIVARIATE ANALYSIS; MYOCARDIUM; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; RESPONSE ELEMENTS; RIBOSE-PHOSPHATE PYROPHOSPHOKINASE; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES;

EID: 84890026574     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400587y     Document Type: Article

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