Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice

Physiological Genomics

Volumn 41, Issue 3, 2010, Pages 224-231

  Cheng, Kian Kai ^a,b   Benson, G Martin ^c   Grimsditch, David C ^d   Reid, David G ^d   Connor, Susan C ^a,d   Griffin, Julian L ^a,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

^c Hoffmann La Roche   (Switzerland)

^d GLAXOSMITHKLINE   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apolipoprotein E; Atherosclerotic mouse model; Hypercholesterolemia; Low density lipoprotein; Metabolomics; Systems biology

Indexed keywords

APOLIPOPROTEIN E; BETAINE; CHOLIC ACID; CHOLINE; DIMETHYLGLYCINE; LOW DENSITY LIPOPROTEIN RECEPTOR; TRICARBOXYLIC ACID; CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL DIET; CONTROLLED STUDY; FATTY ACID METABOLISM; FEMALE; HYPERCHOLESTEROLEMIA; KNOCKOUT MOUSE; LIPID DIET; METABOLOMICS; MOUSE; MULTIVARIATE ANALYSIS; NONHUMAN; OXIDATION; PLASMA; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTON NUCLEAR MAGNETIC RESONANCE; SHAM FEEDING; URINARY EXCRETION; URINE; ANIMAL; BIOLOGICAL MODEL; BLOOD; C57BL MOUSE; DEFICIENCY; DIET; DISCRIMINANT ANALYSIS; GENETIC DATABASE; GENOTYPE; METABOLISM; PROCEDURES; REGRESSION ANALYSIS;

ANIMALIA; MUS;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; CHOLINE; DATABASES, GENETIC; DIET; DIET, HIGH-FAT; DISCRIMINANT ANALYSIS; FEMALE; GENOTYPE; HYPERCHOLESTEROLEMIA; LEAST-SQUARES ANALYSIS; METABOLOMICS; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PROTON MAGNETIC RESONANCE SPECTROSCOPY; RECEPTORS, LDL;

EID: 77952941236     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00188.2009     Document Type: Article

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