Characterization of atherosclerosis in LDL receptor knockout mice: Macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE

Atherosclerosis

Volumn 149, Issue 2, 2000, Pages 323-330

  Kowala, Mark C ^a   Recce, Ron ^a   Beyer, Sophie ^a   Gu, Candice ^a   Valentine, Maria ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Atherosclerosis; LDL receptor knockout mice; Macrophage; Monocyte chemoattractant protein 1

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FOAM CELL; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AORTA; ARTERIOSCLEROSIS; CHEMOKINE CCL2; CHOLESTEROL, DIETARY; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOHISTOCHEMISTRY; LIPOPROTEINS; MACROPHAGES; MICE; MICE, KNOCKOUT; PROBABILITY; RECEPTORS, LDL; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SOFTWARE; STATISTICS, NONPARAMETRIC; TUNICA INTIMA;

EID: 0034060198     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00342-1     Document Type: Article

References (34)

1. Florentin R.A., Nam S.C. Dietary-induced atherosclerosis in miniature swine: I. Gross and light microscopy observations: time of development and morphologic characteristics of lesions. Exp. Mol. Pathol. 8:1968;263-301.
2. Faggiotto A., Ross R. Studies of hypercholesterolemia in the non-human primate. II. Fatty streak conversion to fibrous plaque. Arteriosclerosis. 4:1984;341-356.
3. Rogers W.R., Carey K.D., McMahan A. et al. Cigarette smoking, dietary hyperlipidemia and experimental atherosclerosis in the baboon. Exp. Mol. Pathol. 48:1988;135-151.
4. Rosenfeld M.E., Tsukada T., Chait A., Bierman E.L., Gown A.M., Ross R. Fatty streak expansion and maturation in Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis. 7:1987;24-34.
5. de la Llera-Moya M., Rothblat G.H., Glick J.M., England J.M. Etoposide treatment suppressed atherosclerotic plaque development in cholesterol-fed rabbits. Arterioscler. Thromb. 12:1992;1363-1370.
6. Nistor A., Bulla A., Filip D.A., Radu A. The hyperlipidemic hamster as a model of experimental atherosclerosis. Atherosclerosis. 68:1987;159-173.
7. Kowala M.C., Rose P.M., Stein P.D. et al. Selective blockade of the endothelin type A receptor decreases early atherosclerosis in hamsters fed cholesterol. Am. J. Pathol. 146:1995;819-826.
8. Joris I., Zand T., Nunnari J.J., Krolikowski F.J., Majno G. Studies of the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats. Am. J. Pathol. 113:1983;341-358.
9. Paigen B., Ishida B.Y., Verstuyft J., Winters R.B., Albee D. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis. 10:1990;316-323.
10. Plump AS, Smith JD, Heyek T, Aalto-Setala K, Walsh A, Verstyft, Rubin EM, Breslow JL, Severe hypercholesterolemia and atherosclerosis in Apo E-deficient mice created by homologous recombination, Cell 1992;71:343-353.
11. Zhang S.H., Reddick R.L., Piedrahita J.A., Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 258:1992;468-471.
12. Ishibashi S., Brown M.S., Goldstein J.L., Gerard R.D., Hamer R.E., Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Ivest. 92:1993;883-893.
13. Ishibashi S., Goldstein J.L., Brown M.S., Burns D.K. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93:1994;1885-1893.
14. Reddick R.L., Zhang S.H., Maeda N. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler. Thromb. 14:1994;141-147.
15. Nakashimi Y., Plump A.S., Raines E.W., Breslow J.L., Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 14:1994;133-140.
16. Tangirala R.K., Rubin E.M., Palinski W. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL-receptor deficient and apolipoprotein E-deficient mice. J. Lipid. Res. 36:1995;2320-2328.
17. Kowala M.C., Valentine M., Recce R. et al. Enhanced reduction of atherosclerosis in hamsters treated with pravastatin and captopril: ACE in atheromas provides cellular targets for captopril. J. Cardiovasc. Pharmacol. 32:1998;29-38.
18. Chensue S.W., Warmington K.S., Lukacs N.W. et al. Monocyte chemotactic protein expression during schistosome egg granuloma formation. Sequence of production, localization, contribution and regulation. Am. J. Pathol. 146:1995;130-138.
19. Ross R. Atherosclerosis - an inflammatory disease. New Engl. J. Med. 340:1999;116-126.
20. Rollins B.J., Yoshimura T., Leonard E.J., Pober J.S. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am. J. Pathol. 136:1990;1229-1233.
21. Taub D.D., Proost P., Murphy W.J. et al. Monocyte chemotactic protein-1 (MCP-1), -2, -3 are chemotactic for human T lymphocytes. J. Clin. Invest. 95:1995;1370-1376.
22. Charro I.F., Myers S.J., Herman A., Franci C., Connolly A.J., Coughlin S. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. 91:1994;2752-2756.
23. Nelken N.A., Coughlin S.R., Gordon D., Wilcox J.N. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88:1991;1121-1127.
24. Yla-Herttuala S., Lipton B.A., Rosenfeld M.E. et al. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Natl. Acad. Sci. 88:1991;5252-5256.
25. Takeya M., Yoshimura T., Leonard E.J., Takahashi K. Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody. Hum. Pathol. 24:1993;534-539.
26. Navab M., Imes S.S., Hama S.Y. et al. Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J. Clin. Invest. 88:1991;2039-2046.
27. Cushing S.D., Folgleman A.M. Monocytes may amplify their recruitment into inflammatory lesions by inducing monocyte chemotactic protein. Arterioscler. Thromb. 12:1992;78-82.
28. Takahashi M., Masuyama J.-I., Ikeda U. et al. Induction of monocyte chemoattractant protein-1 synthesis in human monocytes during transendothelial migration in vitro. Cir. Res. 76:1995;750-757.
29. Gu L., Okada Y., Clinton S.K. et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor deficient mice. Mol. Cell. 2:1998;275-281.
30. Boring L., Gosling J., Cleary M., Charo I.F. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 394:1998;894-897.
31. Fuster V., Badimon L., Badimon J.J., Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes. New Eng. J. Med. 326:1992;242-250.
32. van der Wal A.C., Becker A.E., van der Loos C.M., Das P.K. Site of intimal plaque rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 89:1994;36-44.
33. Moreno P.R., Falk E., Palacios I.F., Newell J.B., Fuster V., Fallon J.T. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation. 90:1994;775-778.
34. Matsumori A., Furukawa Y., Hashimoto T. et al. Plasma levels of the monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 are elevated in patients with acute myocardial infarction. J. Mol. Cell. Cardiol. 29:1997;419-423.