Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach

Journal of Nutritional Biochemistry

Volumn 23, Issue 2, 2012, Pages 133-139

  He, Qinghua ^a,b   Ren, Pingping ^b   Kong, Xiangfeng ^a   Wu, Yongning ^c   Wu, Guoyao ^a,d   Li, Peng ^d   Hao, Fuhua ^b   Tang, Huiru ^b   Blachier, François ^e   Yin, Yulong ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b Wuhan National Laboratory for Optoelectronics   (China)

^c National Institute for Nutrition and Food Safety   (China)

^d TEXAS A AND M UNIVERSITY   (United States)

^e AGROPARISTECH   (France)

Author keywords

Lean pigs; Metabonomics; Obese pigs; Obesity; Serum

Indexed keywords

CHOLINE; CREATINE; GLUCAGON; GLYCOPROTEIN; HIGH DENSITY LIPOPROTEIN; INOSITOL; INSULIN; PYRUVIC ACID; THREONINE; TRIMETHYLAMINE OXIDE; TYROSINE; UNSATURATED FATTY ACID; UREA; VERY LOW DENSITY LIPOPROTEIN;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMICS; BLOOD LEVEL; BODY COMPOSITION; ENERGY CONSUMPTION; EXPERIMENTAL PIG; FERMENTATION; GLUCAGON BLOOD LEVEL; INSULIN BLOOD LEVEL; INTESTINE FLORA; LEAN BODY WEIGHT; LIPID METABOLISM; LIPID OXIDATION; LIPOGENESIS; LIPOPROTEIN BLOOD LEVEL; MALE; METABONOMICS; MUSCLE MASS; NONHUMAN; OBESITY; PROTEIN METABOLISM; PROTON NUCLEAR MAGNETIC RESONANCE; SERUM; UREA BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; CHOLINE; GLUCAGON; INSULIN; LIPID METABOLISM; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; METHYLAMINES; MULTIVARIATE ANALYSIS; OBESITY; SWINE;

SUIDAE;

EID: 84855477382     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.11.007     Document Type: Article

References (64)

1. WHO Obesity in Europe; 2006 [cited 2010 Apr 26]. Available from:. http://www.euro.who.int/obesity.
2. Powell K. The two faces of fat. Nature 2007, 447:525-527.
3. Epstein L.H., Wing R.R., Koeske R., Valoski A. Long-term effects of family-based treatment of childhood obesity. J Consult Clin Psychol 1987, 55:91-95.
4. Backhed F., Ding H., Wang T., Hooper L.V., Koh G.Y., Nagy A., et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004, 101:15718-15723.
5. Clark J.B., Palmer C.J., Shaw W.N. The diabetic Zucker fatty rat. Proc Soc Exp Biol Med 1983, 173:68-75.
6. Speakman J., Hambly C., Mitchell S., Krol E. Animal models of obesity. Obes Rev 2007, 8(Suppl 1):55-61.
7. Salek R.M., Maguire M.L., Bentley E., Rubtsov D.V., Hough T., Cheeseman M., et al. A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiol Genomics 2007, 29:99-108.
8. Fu W.J., Haynes T.E., Kohli R., Hu J., Shi W., Spencer T.E., et al. Dietary l-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr 2005, 135:714-721.
9. Wijekoon E.P., Skinner C., Brosnan M.E., Brosnan J.T. Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol 2004, 82:506-514.
10. Zhang X.J., Chinkes D.L., Aarsland A., Herndon D.N., Wolfe R.R. Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans. J Nutr 2008, 138:515-518.
11. Dyson M.C., Alloosh M., Vuchetich J.P., Mokelke E.A., Sturek M. Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet. Comp Med 2006, 56:35-45.
12. Tardif S.D., Power M.L., Ross C.N., Rutherford J.N., Layne-Colon D.G., Paulik M.A. Characterization of obese phenotypes in a small nonhuman primate, the common marmoset (Callithrix jacchus). Obesity 2009, 17:1499-1505.
13. Miller E.R., Ullrey D.E. The pig as a model for human-nutrition. Annu Rev Nutr 1987, 7:361-382.
14. Baker D.H. Animal models in nutrition research. J Nutr 2008, 138:391-396.
15. Andersson L., Haley C.S., Ellegren H., Knott S.A., Johansson M., Andersson K., et al. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science 1994, 263:1771-1774.
16. Nicholson J.K., Wilson I.D. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2003, 2:668-676.
17. Nicholson J.K., Holmes E., Lindon J.C., Wilson I.D. The challenges of modeling mammalian biocomplexity. Nat Biotechnol 2004, 22:1268-1274.
18. Van Dorsten F.A., Daykin C.A., Mulder T.P.J., Van Duynhoven J.P.M. Metabonomics approach to determine metabolic differences between green tea and black tea consumption. J Agric Food Chem 2006, 54:6929-6938.
19. He Q., Kong X., Wu G., Ren P., Tang H., Hao F., et al. Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation. Amino Acids 2009, 37:199-208.
20. McNeel R.L., Ding S.T., Smith E.O., Mersmann H.J. Effect of feed restriction on adipose tissue transcript concentrations in genetically lean and obese pigs. J Anim Sci 2000, 78:934-942.
21. Mersmann H.J., Pond W.G., Yen J.T. Plasma glucose, insulin and lipids during growth of genetically lean and obese swine. Growth 1982, 46:189-198.
22. Cheng P. Livestock Breeds of China. Animal Production and Health Paper 46 (E, F, S) 1984, 217. Food and Agriculture Organization, Rome.
23. Porter V. Pigs: A Handbook to the Breeds of the World 1993, 168. Cornell University Press, Ithaca.
24. National Research Council Nutrient Requirements of Swine 1998, 110-142. National Academy Press, Washington. 4th ed.
25. Yin Y.L., Deng Z.Y., Huang H.L., Li T.J., Zhong H.Y. The effect of arabinoxylanase and protease supplementation on nutritional value of diets containing wheat bran or rice bran in growing pig. J Anim Feed Sci 2004, 13:445-461.
26. Beckonert O., Keun H.C., Ebbels T.M., Bundy J., Holmes E., Lindon J.C., et al. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc 2007, 2:2692-2703.
27. 13C NMR spectroscopy of human blood plasma. Anal Chem 1995, 67:793-811.
28. Meiboom S., Gill D. Modified spin-echo method for measuring nuclear relaxation times. Rev Sci Instrum 1958, 29:688-691.
29. Wu D.H., Chen A.D., Johnson C.S. An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulses. J Magn Reson Ser A 1995, 115:260-264.
30. Hurd R.E. Gradient-enhanced spectroscopy. J Magn Reson 1990, 87:422-428.
31. Bax A., Davis D.G. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy. J Magn Reson 1985, 65:355-360.
32. 1H NMR spectroscopy in conjunction with multivariate data analysis. J Proteome Res 2007, 6:2605-2614.
33. Trygg J., Wold S. Orthogonal projections to latent structures (O-PLS). J Chemometr 2002, 16:119-128.
34. 1H NMR spectroscopic metabonomic studies. Anal Chem 2005, 77:517-526.
35. 1H NMR spectroscopy and multivariate data analysis. J Agric Food Chem 2008, 56:10142-10153.
36. Constantinou M.A., Papakonstantinou E., Benaki D., Spraul M., Shulpis K., Koupparis M.A., et al. Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: a metabonomic approach. Anal Chim Acta 2004, 511:303-312.
37. Martin F.P., Verdu E.F., Wang Y., Dumas M.E., Yap I.K., Cloarec O., et al. Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. J Proteome Res 2006, 5:2185-2193.
38. Teahan O., Gamble S., Holmes E., Waxman J., Nicholson J.K., Bevan C., et al. Impact of analytical bias in metabonomic studies of human blood serum and plasma. Anal Chem 2006, 78:4307-4318.
39. Williams R., Lenz E.M., Wilson A.J., Granger J., Wilson I.D., Major H., et al. A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats. Mol Biosyst 2006, 2:174-183.
40. 1H NMR spectroscopy. Anal Biochem 2007, 364:112-121.
41. Zhang X., Wang Y., Hao F., Zhou X., Han X., Tang H., et al. Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses. J Proteome Res 2009, 8:5188-5195.
42. Ding L., Hao F., Shi Z., Wang Y., Zhang H., Tang H., et al. Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies. J Proteome Res 2009, 8:2882-2891.
43. Bouchard C., Tremblay A., Despres J.P., Nadeau A., Lupien P.J., Theriault G., et al. The response to long-term overfeeding in identical twins. N Engl J Med 1990, 322:1477-1482.
44. Chirieac D.V., Collins H.L., Cianci J., Sparks J.D., Sparks C.E. Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 2004, 287:E42-E49.
45. Yen J.T., Mersmann H.J., Hill D.A., Pond W.G. Effects of ractopamine on genetically obese and lean pigs. J Anim Sci 1990, 68:3705-3712.
46. McCrindle B.W. Hyperlipidemia in children. Thromb Res 2006, 118:49-58.
47. McMurray R.G., Harrell J.S., Levine A.A., Gansky S.A. Childhood obesity elevates blood pressure and total cholesterol independent of physical activity. Int J Obes Relat Metab Disord 1995, 19:881-886.
48. Liu X., Perusse F., Bukowiecki L.J. Mechanisms of the antidiabetic effects of the beta 3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats. Am J Physiol-Reg I 1998, 274:R1212-R1219.
49. Leonard B.L., Watson R.N., Loomes K.M., Phillips A.R., Cooper G.J. Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes. Acta Diabetol 2005, 42:162-170.
50. Deckelbaum R.J., Williams C.L. Childhood obesity: the health issue. Obes Res 2001, 9:S239-S243.
51. Ludwig D.S. Childhood obesity-the shape of things to come. N Engl J Med 2007, 357:2325-2327.
52. Litten-Brown J.C., Corson A.M., Clarke L. Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview. Animal 2010, 4:899-920.
53. Mersmann H.J., Smith S.B. Development of white adipose tissue lipid metabolism. Biology of Metabolism in Growing Animals 2005, Elsevier, Oxford, [Chapter 11]:pp 56-66. D.G. Burrin, H.J. Mersmann (Eds.).
54. de Jonge W.J., Marescau B., D'Hooge R., De Deyn P.P., Hallemeesch M.M., Deutz N.E., et al. Overexpression of arginase alters circulating and tissue amino acids and guanidino compounds and affects neuromotor behavior in mice. J Nutr 2001, 131:2732-2740.
55. Kochhar S., Jacobs D.M., Ramadan Z., Berruex F., Fuerhoz A., Fay L.B. Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics. Anal Biochem 2006, 352:274-281.
56. Wu G.Y., Bazer F.W., Davis T.A., Johnson G.A., Kim S.W., Knabe D.A., et al. Important roles for arginine-family amino acids in swine nutrition and production. Livest Sci 2007, 122:8-22.
57. Tannock G.W. A special fondness for lactobacilli. Appl Environ Microbiol 2004, 70:3189-3194.
58. Rezzi S., Ramadan Z., Fay L.B., Kochhar S. Nutritional metabonomics: applications and perspectives. J Proteome Res 2007, 6:513-525.
59. Li M., Wang B., Zhang M., Rantalainen M., Wang S., Zhou H., et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 2008, 105:2117-2122.
60. Ley R.E., Backhed F., Turnbaugh P., Lozupone C.A., Knight R.D., Gordon J.I. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 2005, 102:11070-11075.
61. Tan Bie, Yin Y.L., Liu Z.Q., Li X.G., Xu H.J., Kong X.F., et al. Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino Acids 2009, 37:169-175.
62. Tan B.E., Yin Y.L., Liu Z.Q., Tang W.J., Xu H.J., Konga X.F., et al. Dietary L-arginine supplementation differentially regulates expression of fat-metabolic genes in porcine adipose tissue and skeletal muscle. J Nutr Bioc 2010, PubMed PMID: 20619625.
63. Tan B.E., Yin Y.L., Kong X.F., Li P., Li X.L., Gao H.J., et al. L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells. Amino Acids 2010, 38:1227-1235.
64. Fu W.J., Stromberg A.J., Viele K., Carroll R.J., Wu G. Statistics and bioinformatics in nutritional sciences: analysis of complex data in the era of systems biology. J Nutr Biochem 2010, 21:561-572.