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Volumn 10, Issue 2, 2011, Pages 614-623

Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices

Author keywords

Aflatoxin B1; Hepatotoxicology; Metabonomics; Nuclear magnetic resonance (NMR)

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE; AFLATOXIN B1; AMINO ACID; BETAINE; CHOLINE; CITRIC ACID; FORMIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLYCEROPHOSPHORYLCHOLINE; GLYCINE; GLYCOGEN; HISTIDINE; INOSINE; ISOLEUCINE; LEUCINE; LYSINE; NICOTINE; PHENYLALANINE; PHOSPHORYLCHOLINE; TYROSINE; URIDINE; VALINE;

EID: 79955451518     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100792q     Document Type: Article
Times cited : (137)

References (55)
  • 1
    • 0001406888 scopus 로고
    • Influence of temperature, pH, water activity and antifungal agents on growth of aspergillus flavus and A. parasiticus
    • Holmquist, G. U.; Walker, H. W.; Stahr, H. M. Influence of temperature, pH, water activity and antifungal agents on growth of aspergillus flavus and A. parasiticus. J. Food Sci. 1983, 48, 778-782.
    • (1983) J. Food Sci. , vol.48 , pp. 778-782
    • Holmquist, G.U.1    Walker, H.W.2    Stahr, H.M.3
  • 2
    • 0001940132 scopus 로고
    • Mycotoxins and food safety
    • Bullerman, L. B. Mycotoxins and food safety. Food Technol 1986, 40, 59-66.
    • (1986) Food Technol , vol.40 , pp. 59-66
    • Bullerman, L.B.1
  • 3
    • 0034113808 scopus 로고    scopus 로고
    • Primary prevention of hepatocellular carcinoma in developing countries
    • DOI 10.1016/S1383-5742(00)00027-2, PII S1383574200000272
    • Wild, C. P.; Hall, A. J. Primary prevention of hepatocellular carcinoma in developing countries. Mutat. Res., Rev. Mutat. Res. 2000, 462, 381-393. (Pubitemid 30190243)
    • (2000) Mutation Research - Reviews in Mutation Research , vol.462 , Issue.2-3 , pp. 381-393
    • Wild, C.P.1    Hall, A.J.2
  • 4
    • 84904803064 scopus 로고    scopus 로고
    • A Review on the use of mycotoxin sequestering agents in agricultural livestock production
    • Siantar, D. et al., Eds; ACS Symposium Series, American Chemical Society: Washington DC
    • Diaz, D. E. A Review on the use of mycotoxin sequestering agents in agricultural livestock production. In Food Contaminants: Myotoxins and Food Allergens; Siantar, D. et al., Eds; ACS Symposium Series Vol 1001; American Chemical Society: Washington DC, 2008; pp 125-150.
    • (2008) Food Contaminants: Myotoxins and Food Allergens , vol.1001 , pp. 125-150
    • Diaz, D.E.1
  • 5
    • 0032457650 scopus 로고    scopus 로고
    • Potential protective effect of HSCAS and bentonite against dietary aflatoxicosis in rat: With special reference to chromosomal aberrations
    • DOI 10.1002/(SICI)1522-7189(199809/10) 6:5<211::AID-NT31>3.0.CO;2-8
    • Abdel-Wahhab, M. A.; Nada, S. A.; Farag, I. M.; Abbas, N. F.; Amra, H. A. Potential protective effect of HSCAS and bentonite against dietary alatoxicosis in rat: with special reference to chromosomal aberrations. Nat. Toxins 1998, 6, 211-218. (Pubitemid 29261225)
    • (1998) Natural Toxins , vol.6 , Issue.5 , pp. 211-218
    • Abdel-Wahhab, M.A.1    Nada, S.A.2    Farag, I.M.3    Abbas, N.F.4    Amra, H.A.5
  • 6
    • 0015185253 scopus 로고
    • Structure-activity relationships in toxicity and carcinogenicity of alatoxins and analogs
    • Wogan, G. N.; Newberne, P. M.; Edwards, G. S. Structure-activity relationships in toxicity and carcinogenicity of alatoxins and analogs. Cancer Res. 1971, 31, 1936-1942.
    • (1971) Cancer Res. , vol.31 , pp. 1936-1942
    • Wogan, G.N.1    Newberne, P.M.2    Edwards, G.S.3
  • 8
    • 4444349616 scopus 로고    scopus 로고
    • 1 and ochratoxin-a-induced cell damage in a human hepatoma cell line (Hep G2)
    • DOI 10.1002/jat.982
    • Renzulli, C.; Galvano, F.; Pierdomenico, L.; Speroni, E.; Guerra, M. C. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin A-induced cell damage in a human hepatoma cell line (Hep G2). J. Appl. Toxicol. 2004, 24, 289-296. (Pubitemid 39173208)
    • (2004) Journal of Applied Toxicology , vol.24 , Issue.4 , pp. 289-296
    • Renzulli, C.1    Galvano, F.2    Pierdomenico, L.3    Speroni, E.4    Guerra, M.C.5
  • 9
    • 42949123190 scopus 로고    scopus 로고
    • Protective effects of melatonin and N-acetylserotonin on aflatoxin B1-induced lipid peroxidation in rats
    • DOI 10.1002/cbf.1438
    • Gesing, A.; Karbownik-Lewinska, M. Protective effects of melatonin and N-acetylserotonin on aflatoxin B1-induced lipid peroxidation in rats. Cell Biochem. Funct. 2008, 26, 314-319. (Pubitemid 351613171)
    • (2008) Cell Biochemistry and Function , vol.26 , Issue.3 , pp. 314-319
    • Gesing, A.1    Karbownik-Lewinska, M.2
  • 12
    • 0027337582 scopus 로고
    • 1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin
    • Hayes, J. D.; Judah, D. J.; Neal, G. E. Resistance to alatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the Toxin. Cancer Res. 1993, 53, 3887-3894. (Pubitemid 23267683)
    • (1993) Cancer Research , vol.53 , Issue.17 , pp. 3887-3894
    • Hayes, J.D.1    Judah, D.J.2    Neal, G.E.3
  • 13
    • 31844452262 scopus 로고    scopus 로고
    • Quantitative analysis and chronic dosimetry of the alatoxin B1 plasma albumin adduct lys-AFB1 in rats by isotope dilution mass spectrometry
    • Scholl, P. F.; McCoy, L.; Kensler, T. W.; Groopman, J. D. Quantitative analysis and chronic dosimetry of the alatoxin B1 plasma albumin adduct lys-AFB1 in rats by isotope dilution mass spectrometry. Chem. Res. Toxicol. 2005, 19, 44-49.
    • (2005) Chem. Res. Toxicol. , vol.19 , pp. 44-49
    • Scholl, P.F.1    McCoy, L.2    Kensler, T.W.3    Groopman, J.D.4
  • 14
    • 0028965135 scopus 로고
    • Cellular Interactions and metabolism of aflatoxin: An update
    • Mclean, M.; Dutton, M. F. Cellular Interactions and metabolism of aflatoxin: an update. Pharmacol. Ther. 1995, 65, 163-192.
    • (1995) Pharmacol. Ther. , vol.65 , pp. 163-192
    • McLean, M.1    Dutton, M.F.2
  • 15
    • 33746718046 scopus 로고    scopus 로고
    • 1-induced DNA damage and its repair
    • DOI 10.1016/j.canlet.2005.11.018, PII S0304383505010177
    • Bedard, L. L.; Massey, T. E. Aflatoxin B1-induced DNA damage and its repair. Cancer Lett. 2006, 241, 174-183. (Pubitemid 44163046)
    • (2006) Cancer Letters , vol.241 , Issue.2 , pp. 174-183
    • Bedard, L.L.1    Massey, T.E.2
  • 16
    • 0025921742 scopus 로고
    • Quantitation of alatoxin B1-DNA adducts in woodchuck hepatocytes and rat liver tissue by indirect immunofluorescence analysis
    • Zhang, Y. J.; Chen, C. J.; Haghighi, B.; Yang, G. Y.; Hsieh, L. L.; Wang, L. W.; Santella, R. M. Quantitation of alatoxin B1-DNA adducts in woodchuck hepatocytes and rat liver tissue by indirect immunofluorescence analysis. Cancer Res. 1991, 51, 1720-1725.
    • (1991) Cancer Res. , vol.51 , pp. 1720-1725
    • Zhang, Y.J.1    Chen, C.J.2    Haghighi, B.3    Yang, G.Y.4    Hsieh, L.L.5    Wang, L.W.6    Santella, R.M.7
  • 17
    • 0000808069 scopus 로고
    • Biochemical mechanism of action of mycotoxins
    • Kiessling, K. H. Biochemical mechanism of action of mycotoxins. Pure Appl. Chem. 1986, 58, 327-338.
    • (1986) Pure Appl. Chem. , vol.58 , pp. 327-338
    • Kiessling, K.H.1
  • 18
    • 0023734654 scopus 로고
    • Immunological detection of aflatoxin B1-DNA adducts formed in vivo
    • Hsieh, L. L.; Hsu, S. W.; Chen, D. S.; Santella, R. M. Immunological detection of aflatoxin B1-DNA adducts formed in vivo. Cancer Res. 1988, 48, 6328-6331.
    • (1988) Cancer Res. , vol.48 , pp. 6328-6331
    • Hsieh, L.L.1    Hsu, S.W.2    Chen, D.S.3    Santella, R.M.4
  • 19
    • 84872585634 scopus 로고    scopus 로고
    • Aflatoxin-DNA adducts as biomarkers of cancer: Nature, formation, kinds of AF-DNA adducts, methodology, effects and control. in
    • Siantar, D. et al, Eds; ACS symposium Series, American Chemical Society: Washington DC
    • Carvajal, M. Aflatoxin-DNA adducts as biomarkers of cancer: nature, formation, kinds of AF-DNA adducts, methodology, effects and control. In Food Contaminants: Mycotoxins and Food Allergens; Siantar, D. et al, Eds; ACS symposium Series Vol 1001; American Chemical Society: Washington, DC, 2008; pp 13-55.
    • (2008) Food Contaminants: Mycotoxins and Food Allergens , vol.1001 , pp. 13-55
    • Carvajal, M.1
  • 20
    • 36348960223 scopus 로고    scopus 로고
    • Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: The consortium on metabonomic toxicology screening approach
    • DOI 10.1021/pr0703021
    • Ebbels, T. M.; Keun, H. C.; Beckonert, O. P.; Bollard, M. E.; Lindon, J. C.; Holmes, E.; Nicholson, J. K. Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J. Proteome Res. 2007, 6, 4407-4422. (Pubitemid 350158516)
    • (2007) Journal of Proteome Research , vol.6 , Issue.11 , pp. 4407-4422
    • Ebbels, T.M.D.1    Keun, H.C.2    Beckonert, O.P.3    Bollard, M.E.4    Lindon, J.C.5    Holmes, E.6    Nicholson, J.K.7
  • 22
    • 6944246168 scopus 로고    scopus 로고
    • Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa
    • DOI 10.1097/00008571-200410000-00007
    • Wojnowski, L.; Turner, P. C.; Pedersen, B.; Hustert, E.; Brockmoller, J.; Mendy, M.; Whittle, H. C.; Kirk, G.; Wild, C. P. Increased levels of alatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. Pharmacogenetics 2004, 14, 691-700. (Pubitemid 39411269)
    • (2004) Pharmacogenetics , vol.14 , Issue.10 , pp. 691-700
    • Wojnowski, L.1    Turner, P.C.2    Pedersen, B.3    Hustert, E.4    Brockmoller, J.5    Mendy, M.6    Whittle, H.C.7    Kirk, G.8    Wild, C.P.9
  • 23
    • 0034775361 scopus 로고    scopus 로고
    • NMR and pattern recognition studies on the time-related metabolic effects of α-naphthylisothiocyanate on liver, urine, and plasma in the rat: An integrative metabonomic approach
    • DOI 10.1021/tx010067f
    • Waters, N. J.; Holmes, E.; Williams, A.; Waterfield, C. J.; Farrant, R. D.; Nicholson, J. K. NMR and pattern recognition studies on the time-related metabolic effects of α-Naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach. Chem. Res. Toxicol. 2001, 14, 1401-1412. (Pubitemid 32983265)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.10 , pp. 1401-1412
    • Waters, N.J.1    Holmes, E.2    Williams, A.3    Waterfield, C.J.4    Duncan Farrant, R.5    Nicholson, J.K.6
  • 24
    • 27944497372 scopus 로고    scopus 로고
    • Chemometric analysis of biofluids following toxicant induced hepatotoxicity: A metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products
    • DOI 10.1080/00498250500297940
    • Azmi, J.; Griffin, J. L.; Shore, R. F.; Holmes, E.; Nicholson, J. K. Chemometric analysis of bioluids following toxicant induced hepatotoxicity: Ametabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products. Xenobiotica 2005, 35, 839-852. (Pubitemid 41665519)
    • (2005) Xenobiotica , vol.35 , Issue.8 , pp. 839-852
    • Azmi, J.1    Griffin, J.L.2    Shore, R.F.3    Holmes, E.4    Nicholson, J.K.5
  • 27
    • 0037348405 scopus 로고    scopus 로고
    • An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy
    • DOI 10.1021/tx0256127
    • Coen, M.; Lenz, E. M.; Nicholson, J. K.; Wilson, I. D.; Pognan, F.; Lindon, J. C. An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy. Chem. Res. Toxicol. 2003, 16, 295-303. (Pubitemid 36373694)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.3 , pp. 295-303
    • Coen, M.1    Lenz, E.M.2    Nicholson, J.K.3    Wilson, I.D.4    Pognan, F.5    Lindon, J.C.6
  • 28
    • 67049159462 scopus 로고    scopus 로고
    • Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies
    • Ding, L.; Hao, F.; Shi, Z.; Wang, Y.; Zhang, H.; Tang, H.; Dai, J. Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies. J. Proteome Res. 2009, 8, 2882-2891.
    • (2009) J. Proteome Res. , vol.8 , pp. 2882-2891
    • Ding, L.1    Hao, F.2    Shi, Z.3    Wang, Y.4    Zhang, H.5    Tang, H.6    Dai, J.7
  • 29
    • 65349128823 scopus 로고    scopus 로고
    • An optimized buffer system for NMR-based urinary metabonomics with effective pH control, chemical shift consistency and dilution minimization
    • Xiao, C.; Hao, F.; Qin, X.; Wang, Y.; Tang, H. An optimized buffer system for NMR-based urinary metabonomics with effective pH control, chemical shift consistency and dilution minimization. Analyst 2009, 134, 916-925.
    • (2009) Analyst , vol.134 , pp. 916-925
    • Xiao, C.1    Hao, F.2    Qin, X.3    Wang, Y.4    Tang, H.5
  • 30
    • 77949779562 scopus 로고    scopus 로고
    • Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion
    • Dai, H.; Xiao, C.; Liu, H.; Tang, H. Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion. J. Proteome Res. 2010, 9, 1460-1475.
    • (2010) J. Proteome Res. , vol.9 , pp. 1460-1475
    • Dai, H.1    Xiao, C.2    Liu, H.3    Tang, H.4
  • 31
    • 77949803652 scopus 로고    scopus 로고
    • Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Miltiorrhiza Bunge
    • Dai, H.; Xiao, C.; Liu, H.; Hao, F.; Tang, H. Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Miltiorrhiza Bunge. J. Proteome Res. 2010, 9, 1565-1578.
    • (2010) J. Proteome Res. , vol.9 , pp. 1565-1578
    • Dai, H.1    Xiao, C.2    Liu, H.3    Hao, F.4    Tang, H.5
  • 32
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • Trygg, J.; Wold, S. Orthogonal projections to latent structures (O-PLS). J. Chemom. 2002, 16, 119-128.
    • (2002) J. Chemom. , vol.16 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 33
    • 33746256595 scopus 로고    scopus 로고
    • Megavariate analysis of environmental QSAR data. Part I - A basic framework founded on principal component analysis (PCA), partial least squares (PLS), and statistical molecular design (SMD)
    • DOI 10.1007/s11030-006-9024-6
    • Eriksson, L.; Andersson, P. L.; Johansson, E.; Tysklind, M. Megavariate analysis of environmental QSAR data. Part I: A basic framework founded on principal component analysis (PCA), partial least squares (PLS), and statistical molecular design (SMD). Mol. Diversity 2006, 10, 169-186. (Pubitemid 44092207)
    • (2006) Molecular Diversity , vol.10 , Issue.2 , pp. 169-186
    • Eriksson, L.1    Andersson, P.L.2    Johansson, E.3    Tysklind, M.4
  • 34
    • 1642456637 scopus 로고    scopus 로고
    • Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma
    • DOI 10.1016/j.ab.2003.10.033
    • Tang, H.; Wang, Y.; Nicholson, J. K.; Lindon, J. C. Use ofrelaxationedited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma. Anal. Biochem. 2004, 325, 260-272. (Pubitemid 38134363)
    • (2004) Analytical Biochemistry , vol.325 , Issue.2 , pp. 260-272
    • Tang, H.1    Wang, Y.2    Nicholson, J.K.3    Lindon, J.C.4
  • 35
    • 0034718217 scopus 로고    scopus 로고
    • Non-invasive in vivo magnetic resonance imaging assessment of acute aflatoxin B1 hepatotoxicity in rats
    • DOI 10.1016/S0304-4165(00)00084-2, PII S0304416500000842
    • Towner, R. A.; Hashimoto, H.; Summers, P. M. Non-invasive in vivo magnetic resonance imaging assessment of acute aflatoxin B1 hepatotoxicity in rats. Biochim. Biophys. Acta, Gen. Subj. 2000, 1475, 314-320. (Pubitemid 30458845)
    • (2000) Biochimica et Biophysica Acta - General Subjects , vol.1475 , Issue.3 , pp. 314-320
    • Towner, R.A.1    Hashimoto, H.2    Summers, P.M.3
  • 37
    • 0030004773 scopus 로고    scopus 로고
    • Molecular analysis of cellular loci disrupted by papillomavirus 16 integration in cervical cancer: Frequent viral integration in topologically destabilized and transcriptionally active chromosomal regions
    • Choo, K. B.; Chen, C. M.; Han, C. P.; Cheng, W. T. K.; Au, L. C. Molecular analysis of cellular loci disrupted by papillomavirus 16 integration in cervical cancer: Frequent viral integration in topologically destabilized and transcriptionally active chromosomal regions. J. Med. Virol. 1996, 49, 15-22.
    • (1996) J. Med. Virol. , vol.49 , pp. 15-22
    • Choo, K.B.1    Chen, C.M.2    Han, C.P.3    Cheng, W.T.K.4    Au, L.C.5
  • 38
    • 0030004154 scopus 로고    scopus 로고
    • Hepatic regeneration: The role of regeneration in pathogenesis of chronic liver diseases
    • Bisgaard, H. C. Thorgeirsson, S. S. Hepatic regeneration: the role of regeneration in pathogenesis of chronic liver diseases. Clin. Lab. Med. 1996, 16, 325-339. (Pubitemid 26185270)
    • (1996) Clinics in Laboratory Medicine , vol.16 , Issue.2 , pp. 325-339
    • Bisgaard, H.C.1    Thorgeirsson, S.S.2
  • 41
    • 0027252775 scopus 로고
    • High resolution proton NMR investigations of rat blood plasma. Assignment of resonances for the molecularly mobile carbohydrate side-chains of 'acute-phase' glycoproteins
    • DOI 10.1016/0014-5793(93)81584-M
    • Grootveld, M.; Claxson, A. W.; Chander, C. L.; Haycock, P.; Blake, D. R.; Hawkes, G. E. High resolution proton NMR investigations of rat blood plasma: assignment of resonances for the moleculary mobile carbohydrate side-chains of acute-phase glycoproteins. FEBS Lett. 1993, 322, 266-276. (Pubitemid 23144702)
    • (1993) FEBS Letters , vol.322 , Issue.3 , pp. 266-276
    • Grootveld, M.1    Claxson, A.W.D.2    Chander, C.L.3    Haycock, P.4    Blake, D.R.5    Hawkes, G.E.6
  • 42
    • 0033791814 scopus 로고    scopus 로고
    • Membrane breakdown in acute and chronic neurodegeneration: Focus on choline-containing phospholipids
    • Klein, J. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids. J. Neural Transm. 2000, 107, 1027-1063.
    • (2000) J. Neural Transm. , vol.107 , pp. 1027-1063
    • Klein, J.1
  • 44
    • 1642504808 scopus 로고    scopus 로고
    • Characteristic expression profiles induced by genotoxic carcinogens in rat liver
    • DOI 10.1093/toxsci/kfh016
    • Ellinger-Ziegelbauer, H.; Stuart, B.; Wahle, B.; Bomann, W.; Ahr, H. J. Characteristic expression profiles induced by genotoxic carcinogens in rat liver. Toxicol. Sci. 2004, 77, 19-34. (Pubitemid 38128642)
    • (2004) Toxicological Sciences , vol.77 , Issue.1 , pp. 19-34
    • Ellinger-Ziegelbauer, H.1    Stuart, B.2    Wahle, B.3    Bomann, W.4    Ahr, H.-J.5
  • 45
    • 0033961939 scopus 로고    scopus 로고
    • Difference of the liver and kidney in glycine conjugation of ortho- substituted benzoic acids
    • DOI 10.1016/S0009-2797(99)00163-5, PII S0009279799001635
    • Kasuya, F.; Yamaoka, Y.; Osawa, E.; Igarashi, K.; Fukui, M. Difference of the liver and kidney in glycine conjugation of orthosubstituted benzoic acids. Chem. Biol. Interact. 2000, 125, 39-50. (Pubitemid 30084783)
    • (2000) Chemico-Biological Interactions , vol.125 , Issue.1 , pp. 39-50
    • Kasuya, F.1    Yamaoka, Y.2    Osawa, E.3    Igarashi, K.4    Fukui, M.5
  • 46
    • 0029865940 scopus 로고    scopus 로고
    • Participation of a medium chain acyl-CoA synthetase in glycine conjugation of the benzoic acid derivatives with the electron-donating groups
    • DOI 10.1016/0006-2952(95)02399-2
    • Kasuya, F.; Igarashi, K.; Fukui, M. Participation of a medium chain acyl-CoA synthetase in glycine conjugation of the benzoic acid derivatives with the electron-donating groups. Biochem. Pharmacol. 1996, 51, 805-809. (Pubitemid 26096293)
    • (1996) Biochemical Pharmacology , vol.51 , Issue.6 , pp. 805-809
    • Kasuya, F.1    Igarashi, K.2    Fukui, M.3
  • 48
    • 0345714918 scopus 로고    scopus 로고
    • NMR Spectroscopic-Based Metabonomic Studies of Urinary Metabolite Variation in Acclimatizing Germ-Free Rats
    • DOI 10.1021/tx0340293
    • Nicholls, A. W.; Mortishire-Smith, R. J.; Nicholson, J. K. NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chem. Res. Toxicol. 2003, 16, 1395-1404. (Pubitemid 37464460)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.11 , pp. 1395-1404
    • Nicholls, A.W.1    Mortishire-Smith, R.J.2    Nicholson, J.K.3
  • 51
    • 63249087088 scopus 로고    scopus 로고
    • Toxicological and gene expression analysis of the impact of aflatoxin B1 on hepatic function of male broiler chicks
    • Yarru, L. P.; Settivari, R. S.; Antoniou, E.; Ledoux, D. R.; Rottinghaus, G. E. Toxicological and gene expression analysis of the impact of aflatoxin B1 on hepatic function of male broiler chicks. Poult. Sci. 2009, 88, 360-371.
    • (2009) Poult. Sci. , vol.88 , pp. 360-371
    • Yarru, L.P.1    Settivari, R.S.2    Antoniou, E.3    Ledoux, D.R.4    Rottinghaus, G.E.5
  • 52
    • 0024362193 scopus 로고
    • Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation
    • Leighton, F.; Bergseth, S.; Rortveit, T.; Christiansen, E. N.; Bremer, J. Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation. J. Biol. Chem. 1989, 264, 10347-10350. (Pubitemid 19161592)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.18 , pp. 10347-10350
    • Leighton, F.1    Bergseth, S.2    Rortveit, T.3    Christiansen, E.N.4    Bremer, J.5
  • 53
    • 0031595917 scopus 로고    scopus 로고
    • 1-induced carcinogenesis by indole-3-carbinol in rat liver - predicting the outcome using early biomarkers
    • DOI 10.1093/carcin/19.10.1829
    • Manson, M. M.; Hudson, E. A.; Ball, H. W.; Barrett, M. C.; Clark, H. L.; Judah, D. J.; Verschoyle, R. D.; Neal, G. E. Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver-predicting the outcome using early biomarkers. Carcinogenesis 1998, 19, 1829-1836. (Pubitemid 28474649)
    • (1998) Carcinogenesis , vol.19 , Issue.10 , pp. 1829-1836
    • Manson, M.M.1    Ann Hudson, E.2    Ball, H.W.L.3    Barrett, M.C.4    Clark, H.L.5    Judah, D.J.6    Verschoyle, R.D.7    Neal, G.E.8
  • 54
    • 0023122024 scopus 로고
    • 1) on glucose-6-phosphate dehydrogenase in mouse liver
    • DOI 10.1016/0006-2952(87)90434-5
    • Ankrah, N. A.; Wei, R. Effect of a single subtoxic dose of aflatoxin B1 (AFB1) on glucose-6-phosphate dehydrogenase in mouse liver. Biochem. Pharmacol. 1987, 36, 1181-1182. (Pubitemid 17051116)
    • (1987) Biochemical Pharmacology , vol.36 , Issue.7 , pp. 1181-1182
    • Ankrah, N.-A.1    Wei, R.2
  • 55
    • 0031839564 scopus 로고    scopus 로고
    • Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity
    • DOI 10.1080/004982598239443
    • Phipps, A. N.; Stewart, J.; Wright, B.; Wilson, I. D. Effect of Diet on the Urinary Excretion of Hippuric Acid and other Dietary-derived Aromatics in the Rat. A Complex Interaction between Diet, Gut Microflora and Substrate Specificity. Xenobiotica 1998, 28, 527-537. (Pubitemid 28238263)
    • (1998) Xenobiotica , vol.28 , Issue.5 , pp. 527-537
    • Phipps, A.N.1    Stewart, J.2    Wright, B.3    Wilson, I.D.4


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