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Volumn 24, Issue 6, 2015, Pages 809-824

Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer

Author keywords

Cancer; Clinical trial; Signal transducer and activator of transcription 3; Tumor microenvironment

Indexed keywords

ANTINEOPLASTIC AGENT; AZD 9150; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE 2 INHIBITOR; MICRORNA; NATURAL PRODUCT; OPB 31121; OPB 51602; SPHINGOSINE 1 PHOSPHATE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84929321217     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2015.1020370     Document Type: Review
Times cited : (47)

References (141)
  • 1
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-21
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 2
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer-new molecular targets come of age
    • Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004;4:97-105
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 3
    • 0028148055 scopus 로고
    • Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors
    • Raz R, Durbin JE, Levy DE. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J Biol Chem 1994;269:24391-5
    • (1994) J Biol Chem , vol.269 , pp. 24391-24395
    • Raz, R.1    Durbin, J.E.2    Levy, D.E.3
  • 5
    • 84906316130 scopus 로고    scopus 로고
    • Cytokine-induced slowing of STAT3 nuclear import; faster basal trafficking of the STAT3β isoform
    • Ng IH, Bogoyevitch MA, Jans DA. Cytokine-induced slowing of STAT3 nuclear import; faster basal trafficking of the STAT3β isoform. Traffic 2014;15:946-60
    • (2014) Traffic , vol.15 , pp. 946-960
    • Ng, I.H.1    Bogoyevitch, M.A.2    Jans, D.A.3
  • 6
    • 80055072546 scopus 로고    scopus 로고
    • Antitumorigenic potential of STAT3 alternative splicing modulation
    • Zammarchi F, de Stanchina E, Bournazou E, et al. Antitumorigenic potential of STAT3 alternative splicing modulation. Proc Natl Acad Sci USA 2011;108:17779-84
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17779-17784
    • Zammarchi, F.1    De Stanchina, E.2    Bournazou, E.3
  • 7
    • 84866355165 scopus 로고    scopus 로고
    • Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes
    • Ng IH, Ng DC, Jans DA, Bogoyevitch MA. Selective STAT3-α or -βb expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochem J 2012;447:125-36
    • (2012) Biochem J , vol.447 , pp. 125-136
    • Ng, I.H.1    Ng, D.C.2    Jans, D.A.3    Bogoyevitch, M.A.4
  • 8
    • 0031443156 scopus 로고    scopus 로고
    • Constitutive activation of stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
    • Garcia R, Yu CL, Hudnall A, et al. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ 1997;8:1267-76
    • (1997) Cell Growth Differ , vol.8 , pp. 1267-1276
    • Garcia, R.1    Yu, C.L.2    Hudnall, A.3
  • 9
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of stat3 but not stat1 activation for epidermal growth factor receptormediated cell growth in vitro
    • Grandis JR, Drenning SD, Chakraborty A, et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptormediated cell growth in vitro. J Clin Invest 1998;102:1385-92
    • (1998) J Clin Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3
  • 10
    • 0031864202 scopus 로고    scopus 로고
    • Variations in the levels of the JAK/STAT and ShcA proteins in human brain tumors
    • Cattaneo E, Magrassi L, De-Fraja C, et al. Variations in the levels of the JAK/STAT and ShcA proteins in human brain tumors. Anticancer Res 1998;18:2381-7
    • (1998) Anticancer Res , vol.18 , pp. 2381-2387
    • Cattaneo, E.1    Magrassi, L.2    De-Fraja, C.3
  • 11
    • 0033611585 scopus 로고    scopus 로고
    • Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma
    • Flørenes VA, Lu C, Bhattacharya N, et al. Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma. Oncogene 1999;18:1023-32
    • (1999) Oncogene , vol.18 , pp. 1023-1032
    • Flørenes, V.A.1    Lu, C.2    Bhattacharya, N.3
  • 12
    • 0033047725 scopus 로고    scopus 로고
    • Systemic interferon-alpha (IFN-alpha) treatment leads to stat3 inactivation in melanoma precursor lesions
    • Kirkwood JM, Farkas DL, Chakraborty A, et al. Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol Med 1999;5:11-20
    • (1999) Mol Med , vol.5 , pp. 11-20
    • Kirkwood, J.M.1    Farkas, D.L.2    Chakraborty, A.3
  • 13
    • 0034651980 scopus 로고    scopus 로고
    • Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway
    • Lou W, Ni Z, Dyer K, et al. Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway. Prostate 2000;42:239-42
    • (2000) Prostate , vol.42 , pp. 239-242
    • Lou, W.1    Ni, Z.2    Dyer, K.3
  • 14
    • 0032782375 scopus 로고    scopus 로고
    • Expression of the JAK and STAT superfamilies in human meningiomas
    • Magrassi L, De-Fraja C, Conti L, et al. Expression of the JAK and STAT superfamilies in human meningiomas. J Neurosurg 1999;91:440-6
    • (1999) J Neurosurg , vol.91 , pp. 440-446
    • Magrassi, L.1    De-Fraja, C.2    Conti, L.3
  • 15
    • 0033973215 scopus 로고    scopus 로고
    • Defective jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha
    • Pansky A, Hildebrand P, Fasler-Kan E, et al. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha. Int J Cancer 2000;85:720-5
    • (2000) Int J Cancer , vol.85 , pp. 720-725
    • Pansky, A.1    Hildebrand, P.2    Fasler-Kan, E.3
  • 16
    • 0031894945 scopus 로고    scopus 로고
    • Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: Inhibition of meningioma cell growth in vitro by recombinant oncostatin M
    • Schrell UM, Koch HU, Marschalek R, et al. Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. J Neurosurg 1998;88:541-8
    • (1998) J Neurosurg , vol.88 , pp. 541-548
    • Schrell, U.M.1    Koch, H.U.2    Marschalek, R.3
  • 17
    • 0032726122 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription
    • Catlett-Falcone R, Dalton WS, Jove R. STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. Curr Opin Oncol 1999;11:490-6
    • (1999) Curr Opin Oncol , vol.11 , pp. 490-496
    • Catlett-Falcone, R.1    Dalton, W.S.2    Jove, R.3
  • 18
    • 0034658551 scopus 로고    scopus 로고
    • The role of STATs in myeloid differentiation and leukemia
    • Coffer PJ, Koenderman L, de Groot RP. The role of STATs in myeloid differentiation and leukemia. Oncogene 2000;19:2511-22
    • (2000) Oncogene , vol.19 , pp. 2511-2522
    • Coffer, P.J.1    Koenderman, L.2    De Groot, R.P.3
  • 19
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest 1997;100:3140-8
    • (1997) J Clin Invest , vol.100 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 20
    • 13344279401 scopus 로고    scopus 로고
    • STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
    • Gouilleux-Gruart V, Gouilleux F, Desaint C, et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 1996;87:1692-7
    • (1996) Blood , vol.87 , pp. 1692-1697
    • Gouilleux-Gruart, V.1    Gouilleux, F.2    Desaint, C.3
  • 21
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in epstein-barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt RM, Egen C, Wehinger J, et al. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 1996;88:809-16
    • (1996) Blood , vol.88 , pp. 809-816
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3
  • 22
    • 0029834676 scopus 로고    scopus 로고
    • Activation of jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and sezary syndrome
    • Zhang Q, Nowak I, Vonderheid EC, et al. Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA 1996;93:9148-53
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9148-9153
    • Zhang, Q.1    Nowak, I.2    Vonderheid, E.C.3
  • 23
    • 64849111865 scopus 로고    scopus 로고
    • Targeting STAT3 in cancer: How successful are we?
    • Yue P, Turkson J. Targeting STAT3 in cancer: how successful are we? Expert Opin Investig Drugs 2009;18:45-56
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 45-56
    • Yue, P.1    Turkson, J.2
  • 24
    • 7944233465 scopus 로고    scopus 로고
    • Role of STATs as downstream signal transducers in src family kinasemediated tumorigenesis
    • Silva CM. Role of STATs as downstream signal transducers in Src family kinasemediated tumorigenesis. Oncogene 2004;23:8017-23
    • (2004) Oncogene , vol.23 , pp. 8017-8023
    • Silva, C.M.1
  • 25
    • 7244255836 scopus 로고    scopus 로고
    • Getting the message across, STAT! design principles of a molecular signaling circuit
    • Vinkemeier U. Getting the message across, STAT! Design principles of a molecular signaling circuit. J Cell Biol 2004;167:197-201
    • (2004) J Cell Biol , vol.167 , pp. 197-201
    • Vinkemeier, U.1
  • 26
    • 0039115156 scopus 로고    scopus 로고
    • Transport into and out of the cell nucleus
    • Gorlich D. Transport into and out of the cell nucleus. Embo J 1998;17:2721-7
    • (1998) Embo J , vol.17 , pp. 2721-2727
    • Gorlich, D.1
  • 27
    • 0042206459 scopus 로고    scopus 로고
    • A novel sequence in the coiled-coil domain of stat3 essential for its nuclear translocation
    • Ma J, Zhang T, Novotny-Diermayr V, et al. A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J Biol Chem 2003;278:29252-60
    • (2003) J Biol Chem , vol.278 , pp. 29252-29260
    • Ma, J.1    Zhang, T.2    Novotny-Diermayr, V.3
  • 28
    • 34247600538 scopus 로고    scopus 로고
    • STAT3 as a central mediator of neoplastic cellular transformation
    • Frank DA. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 2007;251:199-210
    • (2007) Cancer Lett , vol.251 , pp. 199-210
    • Frank, D.A.1
  • 30
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264:95-8
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 31
    • 84897051279 scopus 로고    scopus 로고
    • Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer
    • West NR, Murray JI, Watson PH. Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer. Oncogene 2014;33:1485-94
    • (2014) Oncogene , vol.33 , pp. 1485-1494
    • West, N.R.1    Murray, J.I.2    Watson, P.H.3
  • 32
    • 84881303278 scopus 로고    scopus 로고
    • Stat3-coordinated lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelia lmesenchymal transition
    • Guo L, Chen C, Shi M, et al. Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelia lmesenchymal transition. Oncogene 2013;32:5272-82
    • (2013) Oncogene , vol.32 , pp. 5272-5282
    • Guo, L.1    Chen, C.2    Shi, M.3
  • 33
    • 0029117304 scopus 로고
    • Maximal activation of transcription by stat1 and stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995;82:241-50
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, J.E.3
  • 34
    • 0030772458 scopus 로고    scopus 로고
    • STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    • Chung J, Uchida E, Grammer TC, Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 1997;17:6508-16
    • (1997) Mol Cell Biol , vol.17 , pp. 6508-6516
    • Chung, J.1    Uchida, E.2    Grammer, T.C.3    Blenis, J.4
  • 35
    • 0037327154 scopus 로고    scopus 로고
    • Regulation of stat3 nuclear export
    • Bhattacharya S, Schindler C. Regulation of Stat3 nuclear export. J Clin Invest 2003;111:553-9
    • (2003) J Clin Invest , vol.111 , pp. 553-559
    • Bhattacharya, S.1    Schindler, C.2
  • 36
    • 84918825673 scopus 로고    scopus 로고
    • STAT3 and epithelialmesenchymal transitions in carcinomas
    • Wendt MK, Balanis N, Carlin CR, Schiemann WP. STAT3 and epithelialmesenchymal transitions in carcinomas. JAKSTAT 2014;3:e28975
    • (2014) JAKSTAT , vol.3 , pp. e28975
    • Wendt, M.K.1    Balanis, N.2    Carlin, C.R.3    Schiemann, W.P.4
  • 37
    • 0034624986 scopus 로고    scopus 로고
    • Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts
    • Morita Y, Naka T, Kawazoe Y, et al. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc Natl Acad Sci USA 2000;97:5405-10
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5405-5410
    • Morita, Y.1    Naka, T.2    Kawazoe, Y.3
  • 38
    • 32644449048 scopus 로고    scopus 로고
    • Acetylation of stat1 modulates NF-kappaB activity
    • Kramer OH, Baus D, Knauer SK, et al. Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev 2006;20:473-85
    • (2006) Genes Dev , vol.20 , pp. 473-485
    • Kramer, O.H.1    Baus, D.2    Knauer, S.K.3
  • 39
    • 58849139353 scopus 로고    scopus 로고
    • A phosphorylation-acetylation switch regulates STAT1 signaling
    • Kramer OH, Knauer SK, Greiner G, et al. A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev 2009;23:223-35
    • (2009) Genes Dev , vol.23 , pp. 223-235
    • Kramer, O.H.1    Knauer, S.K.2    Greiner, G.3
  • 40
    • 64049109876 scopus 로고    scopus 로고
    • STAT3 inhibition of gluconeogenesis is downregulated by SirT1
    • Nie Y, Erion DM, Yuan Z, et al. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol 2009;11:492-500
    • (2009) Nat Cell Biol , vol.11 , pp. 492-500
    • Nie, Y.1    Erion, D.M.2    Yuan, Z.3
  • 41
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, Kujawski M, Wang T, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-21
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3
  • 42
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse stat1 gene results in compromised innate immunity to viral disease
    • Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996;84:443-50
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 43
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-42
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1    White, J.M.2    Sheehan, K.C.3
  • 44
    • 41549107522 scopus 로고    scopus 로고
    • Cytokine signaling modules in inflammatory responses
    • O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity 2008;28:477-87
    • (2008) Immunity , vol.28 , pp. 477-487
    • O'Shea, J.J.1    Murray, P.J.2
  • 45
    • 75749097320 scopus 로고    scopus 로고
    • Th1 and Th17 cells: Adversaries and collaborators
    • Damsker JM, Hansen AM, Caspi RR, et al. Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci 2010;1183:211-21
    • (2010) Ann N y Acad Sci , vol.1183 , pp. 211-221
    • Damsker, J.M.1    Hansen, A.M.2    Caspi, R.R.3
  • 46
    • 70349736116 scopus 로고    scopus 로고
    • Cross-regulation of signaling pathways by interferon-gamma: Implications for immune responses and autoimmune diseases
    • Hu X, Ivashkiv LB. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 2009;31:539-50
    • (2009) Immunity , vol.31 , pp. 539-550
    • Hu, X.1    Ivashkiv, L.B.2
  • 47
    • 84907190280 scopus 로고    scopus 로고
    • Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling
    • Hedrich CM, Rauen T, Apostolidis SA, et al. Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. Proc Natl Acad Sci USA 2014;111:13457-62
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 13457-13462
    • Hedrich, C.M.1    Rauen, T.2    Apostolidis, S.A.3
  • 48
    • 0034658541 scopus 로고    scopus 로고
    • Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
    • Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000;19:2548-56
    • (2000) Oncogene , vol.19 , pp. 2548-2556
    • Hirano, T.1    Ishihara, K.2    Hibi, M.3
  • 49
    • 32044464123 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) signaling in cancer
    • Normanno N, De Luca A, Bianco C, et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 2006;366:2-16
    • (2006) Gene , vol.366 , pp. 2-16
    • Normanno, N.1    De Luca, A.2    Bianco, C.3
  • 50
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007;117:3846-56
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3
  • 51
    • 84896702989 scopus 로고    scopus 로고
    • EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3
    • Concha-Benavente F, Srivastava RM, Ferrone S, Ferris RL. EGFR-mediated tumor immunoescape: the imbalance between phosphorylated STAT1 and phosphorylated STAT3. Oncoimmunology 2013;2:e27215
    • (2013) Oncoimmunology , vol.2 , pp. e27215
    • Concha-Benavente, F.1    Srivastava, R.M.2    Ferrone, S.3    Ferris, R.L.4
  • 52
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at twenty
    • Stark GR, Darnell JE Jr. The JAK-STAT pathway at twenty. Immunity 2012;36:503-14
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell, J.E.2
  • 53
    • 84856213846 scopus 로고    scopus 로고
    • The diverse and complex roles of NF-κB subunits in cancer
    • Perkins ND. The diverse and complex roles of NF-κB subunits in cancer. Nat Rev Cancer 2012;12:121-32
    • (2012) Nat Rev Cancer , vol.12 , pp. 121-132
    • Perkins, N.D.1
  • 54
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated stat3 maintains constitutive NF-kappaB activity in tumors
    • Lee H, Herrmann A, Deng JH, et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 2009;15:283-93
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1    Herrmann, A.2    Deng, J.H.3
  • 55
    • 84929366176 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: Driver of NFκB and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer
    • Theiss AL. Sphingosine-1-phosphate: Driver of NFκB and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer. JAKSTAT 2013;2:e24150
    • (2013) JAKSTAT , vol.2 , pp. e24150
    • Theiss, A.L.1
  • 56
    • 78649982367 scopus 로고    scopus 로고
    • STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
    • Lee H, Deng J, Kujawski M, et al. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med 2010;16:1421-8
    • (2010) Nat Med , vol.16 , pp. 1421-1428
    • Lee, H.1    Deng, J.2    Kujawski, M.3
  • 57
    • 84872406787 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis associated cancer
    • Liang J, Nagahashi M, Kim EY, et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis associated cancer. Cancer Cell 2013;23:107-20
    • (2013) Cancer Cell , vol.23 , pp. 107-120
    • Liang, J.1    Nagahashi, M.2    Kim, E.Y.3
  • 58
    • 84890730237 scopus 로고    scopus 로고
    • Interplay between microRNAs and the STAT3 signaling pathway in human cancers
    • Cao Q, Li YY, He WF, et al. Interplay between microRNAs and the STAT3 signaling pathway in human cancers. Physiol Genomics 2013;45:1206-14
    • (2013) Physiol Genomics , vol.45 , pp. 1206-1214
    • Cao, Q.1    Li, Y.Y.2    He, W.F.3
  • 59
    • 84894495362 scopus 로고    scopus 로고
    • STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes
    • Xiang M, Birkbak NJ, Vafaizadeh V, et al. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal 2014;7:ra11
    • (2014) Sci Signal , vol.7 , pp. ra11
    • Xiang, M.1    Birkbak, N.J.2    Vafaizadeh, V.3
  • 60
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999;10:105-15
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 61
    • 55849107422 scopus 로고    scopus 로고
    • Stat3 mediates myeloid celldependent tumor angiogenesis in mice
    • Kujawski M, Kortylewski M, Lee H, et al. Stat3 mediates myeloid celldependent tumor angiogenesis in mice. J Clin Invest 2008;118:3367-77
    • (2008) J Clin Invest , vol.118 , pp. 3367-3377
    • Kujawski, M.1    Kortylewski, M.2    Lee, H.3
  • 62
    • 85047698100 scopus 로고    scopus 로고
    • Inhibition of constitutively active stat3 suppresses growth of human ovarian and breast cancer cells
    • Burke WM, Jin X, Lin HJ, et al. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 2001;20:7925-34
    • (2001) Oncogene , vol.20 , pp. 7925-7934
    • Burke, W.M.1    Jin, X.2    Lin, H.J.3
  • 63
    • 79955592737 scopus 로고    scopus 로고
    • Suppression of STAT3 activity sensitizes gefitinib-resistant non small cell lung cancer cells
    • Chiu HC, Chou DL, Huang CT, et al. Suppression of STAT3 activity sensitizes gefitinib-resistant non small cell lung cancer cells. Biochem Pharmacol 2011;81:1263-70
    • (2011) Biochem Pharmacol , vol.81 , pp. 1263-1270
    • Chiu, H.C.1    Chou, D.L.2    Huang, C.T.3
  • 64
    • 1542786900 scopus 로고    scopus 로고
    • Regulation of cortical actin networks in cell migration
    • Suetsugu S, Takenawa T. Regulation of cortical actin networks in cell migration. Int Rev Cytol 2003;229:245-86
    • (2003) Int Rev Cytol , vol.229 , pp. 245-286
    • Suetsugu, S.1    Takenawa, T.2
  • 65
    • 84918773439 scopus 로고    scopus 로고
    • The involvement of JAK-STAT3 in cell motility, invasion, and metastasis
    • Teng Y, Ross JL, Cowell JK. The involvement of JAK-STAT3 in cell motility, invasion, and metastasis. JAKSTAT 2014;3(1):e28086
    • (2014) JAKSTAT , vol.3 , Issue.1 , pp. e28086
    • Teng, Y.1    Ross, J.L.2    Cowell, J.K.3
  • 66
    • 84901856759 scopus 로고    scopus 로고
    • AAG8 promotes carcinogenesis by activating STAT3
    • Sun B, Kawahara M, Ehata S, Nagamune T. AAG8 promotes carcinogenesis by activating STAT3. Cell Signal 2014;26:1863-9
    • (2014) Cell Signal , vol.26 , pp. 1863-1869
    • Sun, B.1    Kawahara, M.2    Ehata, S.3    Nagamune, T.4
  • 67
    • 84901787644 scopus 로고    scopus 로고
    • Oncogenic roles of EMT-inducing transcription factors
    • Puisieux A, Brabletz T, Caramel J. Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol 2014;16:488-94
    • (2014) Nat Cell Biol , vol.16 , pp. 488-494
    • Puisieux, A.1    Brabletz, T.2    Caramel, J.3
  • 68
    • 84856478208 scopus 로고    scopus 로고
    • STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma
    • Looyenga BD, Hutchings D, Cherni I, et al. STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS One 2012;7:e30820
    • (2012) PLoS One , vol.7 , pp. e30820
    • Looyenga, B.D.1    Hutchings, D.2    Cherni, I.3
  • 69
    • 84555202760 scopus 로고    scopus 로고
    • Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma
    • Jiang R, Jin Z, Liu Z, et al. Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma. Mol Diagn Ther 2011;15:347-52
    • (2011) Mol Diagn Ther , vol.15 , pp. 347-352
    • Jiang, R.1    Jin, Z.2    Liu, Z.3
  • 70
    • 84937522140 scopus 로고    scopus 로고
    • Differential roles of STAT3 in the initiation and growth of lung cancer
    • Zhou J, Qu Z, Yan S, et al. Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene 2014; doi:10.1038/onc.2014.318
    • (2014) Oncogene
    • Zhou, J.1    Qu, Z.2    Yan, S.3
  • 71
    • 84899051828 scopus 로고    scopus 로고
    • JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells
    • Liu RY, Zeng Y, Lei Z, et al. JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells. Int J Oncol 2014;44:1643-51
    • (2014) Int J Oncol , vol.44 , pp. 1643-1651
    • Liu, R.Y.1    Zeng, Y.2    Lei, Z.3
  • 72
    • 84893957093 scopus 로고    scopus 로고
    • A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer
    • Xu YH, Lu S. A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer. Eur J Surg Oncol 2014;40:311-17
    • (2014) Eur J Surg Oncol , vol.40 , pp. 311-317
    • Xu, Y.H.1    Lu, S.2
  • 73
    • 84875490171 scopus 로고    scopus 로고
    • Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFalpha- and NK cytotoxicity
    • Kulesza DW, Carre T, Chouaib S, Kaminska B. Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFalpha- and NK cytotoxicity. Exp Cell Res 2013;319:506-16
    • (2013) Exp Cell Res , vol.319 , pp. 506-516
    • Kulesza, D.W.1    Carre, T.2    Chouaib, S.3    Kaminska, B.4
  • 74
    • 84867405669 scopus 로고    scopus 로고
    • Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation
    • Kim SM, Kwon OJ, Hong YK, et al. Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation. Mol Cancer Ther 2012;11:2254-64
    • (2012) Mol Cancer Ther , vol.11 , pp. 2254-2264
    • Kim, S.M.1    Kwon, O.J.2    Hong, Y.K.3
  • 75
    • 84894562833 scopus 로고    scopus 로고
    • Blockage of STAT3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition
    • Jin HO, Lee YH, Park JA, et al. Blockage of STAT3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition. Biochem Biophys Res Commun 2014;444:502-8
    • (2014) Biochem Biophys Res Commun , vol.444 , pp. 502-508
    • Jin, H.O.1    Lee, Y.H.2    Park, J.A.3
  • 76
    • 84893530696 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells
    • Chung SS, Aroh C, Vadgama JV. Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells. PLoS ONE 2013;8:e83971
    • (2013) PLoS ONE , vol.8 , pp. e83971
    • Chung, S.S.1    Aroh, C.2    Vadgama, J.V.3
  • 77
    • 84930932838 scopus 로고    scopus 로고
    • VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate myc and sox2
    • Zhao D, Pan C, Sun J, et al. VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2. Oncogene 2014; doi:10.1038/onc.2014.257
    • (2014) Oncogene
    • Zhao, D.1    Pan, C.2    Sun, J.3
  • 78
    • 84907992899 scopus 로고    scopus 로고
    • Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
    • Li G, Zhao L, Li W, et al. Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression. Oncotarget 2014;5:8317-29
    • (2014) Oncotarget , vol.5 , pp. 8317-8329
    • Li, G.1    Zhao, L.2    Li, W.3
  • 79
    • 84918521700 scopus 로고    scopus 로고
    • An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelialmesenchymal transition and cancer stem cell expansion in human breast cancer cells
    • Yang L, Han S, Sun Y. An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelialmesenchymal transition and cancer stem cell expansion in human breast cancer cells. Biochem Biophys Res Commun 2014;453(3):582-7
    • (2014) Biochem Biophys Res Commun , vol.453 , Issue.3 , pp. 582-587
    • Yang, L.1    Han, S.2    Sun, Y.3
  • 80
    • 79955445350 scopus 로고    scopus 로고
    • CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model
    • Hassan S, Buchanan M, Jahan K, et al. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer 2011;129:225-32
    • (2011) Int J Cancer , vol.129 , pp. 225-232
    • Hassan, S.1    Buchanan, M.2    Jahan, K.3
  • 81
    • 84914704348 scopus 로고    scopus 로고
    • Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer
    • Liu X, Xiao Q, Bai X, et al. Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer. Oncol Rep 2014;32:2760-8
    • (2014) Oncol Rep , vol.32 , pp. 2760-2768
    • Liu, X.1    Xiao, Q.2    Bai, X.3
  • 82
    • 38449098731 scopus 로고    scopus 로고
    • The role of signal transducers and activators of transcription in colon cancer
    • Klampfer L. The role of signal transducers and activators of transcription in colon cancer. Front Biosci 2008;13:2888-99
    • (2008) Front Biosci , vol.13 , pp. 2888-2899
    • Klampfer, L.1
  • 83
    • 84884376190 scopus 로고    scopus 로고
    • STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon
    • Nguyen AV, Wu YY, Liu Q, et al. STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon. Neoplasia 2013;15:998-1008
    • (2013) Neoplasia , vol.15 , pp. 998-1008
    • Nguyen, A.V.1    Wu, Y.Y.2    Liu, Q.3
  • 84
    • 85028276122 scopus 로고    scopus 로고
    • Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-κB to promote colorectal cancer cell growth
    • De Simone V, Franzè E, Ronchetti G, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-κB to promote colorectal cancer cell growth. Oncogene 2014; doi:10.1038/onc.2014.286
    • (2014) Oncogene
    • De Simone, V.1    Franzè, E.2    Ronchetti, G.3
  • 85
    • 84921683452 scopus 로고    scopus 로고
    • A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells
    • e11
    • Liu S, Sun X, Wang M, et al. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology 2014;147(4):847-59.e11
    • (2014) Gastroenterology , vol.147 , Issue.4 , pp. 847-859
    • Liu, S.1    Sun, X.2    Wang, M.3
  • 86
    • 84913580379 scopus 로고    scopus 로고
    • Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
    • Wan S, Zhao E, Kryczek I, et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 2014;147(6):1393-404
    • (2014) Gastroenterology , vol.147 , Issue.6 , pp. 1393-1404
    • Wan, S.1    Zhao, E.2    Kryczek, I.3
  • 87
    • 84903781265 scopus 로고    scopus 로고
    • The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression
    • Zhu Q, Zhang X, Zhang L, et al. The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression. Cell Death Dis 2014;5:e1295
    • (2014) Cell Death Dis , vol.5 , pp. e1295
    • Zhu, Q.1    Zhang, X.2    Zhang, L.3
  • 88
    • 84888264541 scopus 로고    scopus 로고
    • Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia
    • e1-8
    • Katsha A, Soutto M, Sehdev V, et al. Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology 2013;145:1312-22.e1-8
    • (2013) Gastroenterology , vol.145 , pp. 1312-1322
    • Katsha, A.1    Soutto, M.2    Sehdev, V.3
  • 89
    • 84911978753 scopus 로고    scopus 로고
    • AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers
    • Katsha A, Arras J, Soutto M, et al. AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. Mol Oncol 2014;8(8):1419-28
    • (2014) Mol Oncol , vol.8 , Issue.8 , pp. 1419-1428
    • Katsha, A.1    Arras, J.2    Soutto, M.3
  • 90
    • 35148814410 scopus 로고    scopus 로고
    • Dynamics of the immune reaction to pancreatic cancer from inception to invasion
    • Clark CE, Hingorani SR, Mick R, et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res 2007;67:9518-27
    • (2007) Cancer Res , vol.67 , pp. 9518-9527
    • Clark, C.E.1    Hingorani, S.R.2    Mick, R.3
  • 91
    • 84899959071 scopus 로고    scopus 로고
    • Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer
    • Panni RZ, Sanford DE, Belt BA, et al. Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunol Immunother 2014;63:513-28
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 513-528
    • Panni, R.Z.1    Sanford, D.E.2    Belt, B.A.3
  • 92
    • 84917732490 scopus 로고    scopus 로고
    • Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer
    • Wen W, Liang W, Wu J, et al. Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer. Mol Cancer Ther 2014;13(12):3037-48
    • (2014) Mol Cancer Ther , vol.13 , Issue.12 , pp. 3037-3048
    • Wen, W.1    Liang, W.2    Wu, J.3
  • 93
    • 84900865954 scopus 로고    scopus 로고
    • Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden
    • Abubaker K, Luwor RB, Zhu H, et al. Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden. BMC Cancer 2014;14:317
    • (2014) BMC Cancer , vol.14 , pp. 317
    • Abubaker, K.1    Luwor, R.B.2    Zhu, H.3
  • 94
    • 33751575658 scopus 로고    scopus 로고
    • The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis
    • Rosen DG, Mercado-Uribe I, Yang G, et al. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer 2006;107:2730-40
    • (2006) Cancer , vol.107 , pp. 2730-2740
    • Rosen, D.G.1    Mercado-Uribe, I.2    Yang, G.3
  • 95
    • 35448943030 scopus 로고    scopus 로고
    • Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer
    • Puiffe ML, Le Page C, Filali-Mouhim A, et al. Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer. Neoplasia 2007;9:820-9
    • (2007) Neoplasia , vol.9 , pp. 820-829
    • Puiffe, M.L.1    Le Page, C.2    Filali-Mouhim, A.3
  • 96
    • 84898859312 scopus 로고    scopus 로고
    • The multifaceted roles of STAT3 signaling in the progression of prostate cancer
    • Bishop JL, Thaper D, Zoubeidi A. The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer. Cancers (Basel) 2014;6:829-59
    • (2014) Cancers (Basel) , vol.6 , pp. 829-859
    • Bishop, J.L.1    Thaper, D.2    Zoubeidi, A.3
  • 97
    • 84908450155 scopus 로고    scopus 로고
    • Enzalutamide in metastatic prostate cancer before chemotherapy
    • Beer TM, Armstrong AJ, Rathkopf DE, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med 2014;371:424-33
    • (2014) N Engl J Med , vol.371 , pp. 424-433
    • Beer, T.M.1    Armstrong, A.J.2    Rathkopf, D.E.3
  • 98
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 2012;367:1187-97
    • (2012) N Engl J Med , vol.367 , pp. 1187-1197
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3
  • 99
    • 84891160894 scopus 로고    scopus 로고
    • Inhibition of constitutively active stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells
    • Liu C, Zhu Y, Lou W, et al. Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells. Prostate 2014;74:201-9
    • (2014) Prostate , vol.74 , pp. 201-209
    • Liu, C.1    Zhu, Y.2    Lou, W.3
  • 100
    • 84890352055 scopus 로고    scopus 로고
    • Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma
    • Santoni M, Massari F, Amantini C, et al. Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma. Cancer ImmImmunother 2013;62:1757-68
    • (2013) Cancer ImmImmunother , vol.62 , pp. 1757-1768
    • Santoni, M.1    Massari, F.2    Amantini, C.3
  • 101
    • 0036186450 scopus 로고    scopus 로고
    • STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P
    • Horiguchi A, Oya M, Marumo K, Murai M. STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P. Kidney Int 2002;61:926-38
    • (2002) Kidney Int , vol.61 , pp. 926-938
    • Horiguchi, A.1    Oya, M.2    Marumo, K.3    Murai, M.4
  • 102
    • 84893933808 scopus 로고    scopus 로고
    • STAT3 activation in glioblastoma: Biochemical and therapeutic implications
    • Kim JE, Patel M, Ruzevick J, et al. STAT3 Activation in Glioblastoma: biochemical and Therapeutic Implications. Cancers (Basel) 2014;6:376-95
    • (2014) Cancers (Basel) , vol.6 , pp. 376-395
    • Kim, J.E.1    Patel, M.2    Ruzevick, J.3
  • 103
    • 77952296263 scopus 로고    scopus 로고
    • TRPV2 channel negatively controls glioma cell proliferation and resistance to fas-induced apoptosis in ERK-dependent manner
    • Nabissi M, Morelli MB, Amantini C, et al. TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis 2010;31:794-803
    • (2010) Carcinogenesis , vol.31 , pp. 794-803
    • Nabissi, M.1    Morelli, M.B.2    Amantini, C.3
  • 104
    • 84864460084 scopus 로고    scopus 로고
    • The transient receptor vanilloid-2 (TRPV2) cation channel impairs glioblastoma stem cell proliferation and promotes differentiation
    • Morelli MB, Nabissi M, Amantini C, et al. The Transient receptor vanilloid-2 (TRPV2) cation channel impairs glioblastoma stem cell proliferation and promotes differentiation. Int J Cancer 2012;131:E1067-77
    • (2012) Int J Cancer , vol.131 , pp. E1067-E1077
    • Morelli, M.B.1    Nabissi, M.2    Amantini, C.3
  • 105
    • 84872128254 scopus 로고    scopus 로고
    • Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
    • Nabissi M, Morelli MB, Santoni M, Santoni G. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 2013;34:48-57
    • (2013) Carcinogenesis , vol.34 , pp. 48-57
    • Nabissi, M.1    Morelli, M.B.2    Santoni, M.3    Santoni, G.4
  • 106
    • 84925175304 scopus 로고    scopus 로고
    • TRPM7 channels regulate glioma stem cell through STAT3 and notch signaling pathways
    • Liu M, Inoue K, Leng T, et al. TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal 2014;26:2773-81
    • (2014) Cell Signal , vol.26 , pp. 2773-2781
    • Liu, M.1    Inoue, K.2    Leng, T.3
  • 107
    • 0035977055 scopus 로고    scopus 로고
    • Phosphotyrosyl peptides block stat3-mediated DNA binding activity, gene regulation, and cell transformation
    • Turkson J, Ryan D, Kim JS, et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 2001;276:45443-55
    • (2001) J Biol Chem , vol.276 , pp. 45443-45455
    • Turkson, J.1    Ryan, D.2    Kim, J.S.3
  • 108
    • 77949512140 scopus 로고    scopus 로고
    • RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotised as a therapeutic platform
    • Bennnett CF, Swayze EE. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotised as a therapeutic platform. Annu Rev Pharmacol Toxicol 2010;50:259-93
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 259-293
    • Bennnett, C.F.1    Swayze, E.E.2
  • 109
    • 84890434794 scopus 로고    scopus 로고
    • A phase I study of ISIS 481464 (AZD9150), a first-in-human, first-inclass, antisense oligonucleotide inhibitor of STAT3, in patients with advanced cancers
    • abstract 8523
    • Hong DS, Younes A, Fayad LH, et al. A phase I study of ISIS 481464 (AZD9150), a first-in-human, first-inclass, antisense oligonucleotide inhibitor of STAT3, in patients with advanced cancers. J Clin Oncol 2013;31(Suppl):abstract 8523
    • (2013) J Clin Oncol , vol.31
    • Hong, D.S.1    Younes, A.2    Fayad, L.H.3
  • 110
    • 84888424589 scopus 로고    scopus 로고
    • A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases
    • Hayakawa F, Sugimoto K, Harada Y, et al. A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. Blood Cancer J 2013;3:e166
    • (2013) Blood Cancer J , vol.3 , pp. e166
    • Hayakawa, F.1    Sugimoto, K.2    Harada, Y.3
  • 111
    • 84878432714 scopus 로고    scopus 로고
    • OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
    • Kim MJ, Nam HJ, Kim HP, et al. OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett 2013;335:145-52
    • (2013) Cancer Lett , vol.335 , pp. 145-152
    • Kim, M.J.1    Nam, H.J.2    Kim, H.P.3
  • 112
    • 84903816370 scopus 로고    scopus 로고
    • Phase 1, open-label, doseescalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors
    • Bendell JC, Hong DS, Burris HA III, et al. Phase 1, open-label, doseescalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors. Cancer Chemother Pharmacol 2014;74:125-30
    • (2014) Cancer Chemother Pharmacol , vol.74 , pp. 125-130
    • Bendell, J.C.1    Hong, D.S.2    Burris, H.A.3
  • 113
    • 84929298145 scopus 로고    scopus 로고
    • A phase I, open-label, nonrandomized trial of OPB-31121, a STAT3 inhibitor, in patients with advanced hepatocellular carcinoma (HCC)
    • abstract 2616
    • Ikeda M, Okusaka T, Ishii H, et al. A phase I, open-label, nonrandomized trial of OPB-31121, a STAT3 inhibitor, in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2014;32(5s Suppl):abstract 2616
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • Ikeda, M.1    Okusaka, T.2    Ishii, H.3
  • 114
    • 84929326756 scopus 로고    scopus 로고
    • Novel small molecule inhibitors of signal transducer and activator of transcription (STAT3) for cancer treatment
    • abstract nr C180
    • Brambilla L, Genini D, Laurini E, et al. Novel small molecule inhibitors of signal transducer and activator of transcription (STAT3) for cancer treatment. Mol Cancer Ther 2013;12(11 Suppl):abstract nr C180
    • (2013) Mol Cancer Ther , vol.12 , Issue.11
    • Brambilla, L.1    Genini, D.2    Laurini, E.3
  • 115
  • 116
    • 84900007949 scopus 로고    scopus 로고
    • Phase I study of OPB51602, a small molecule inhibitor of STAT3 phosphorylation, in patients with refractory solid malignancies
    • abstract 3002
    • Goh BC, Wong ALA, Soo RA, et al. Phase I study of OPB51602, a small molecule inhibitor of STAT3 phosphorylation, in patients with refractory solid malignancies. J Clin Oncol 2012;30(Suppl):abstract 3002
    • (2012) J Clin Oncol , vol.30
    • Goh, B.C.1    Wong, A.L.A.2    Soo, R.A.3
  • 117
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, et al. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003;63:1270-9
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3
  • 118
    • 18844370367 scopus 로고    scopus 로고
    • Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
    • Sun J, Blaskovich MA, Jove R, et al. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 2005;24:3236-45
    • (2005) Oncogene , vol.24 , pp. 3236-3245
    • Sun, J.1    Blaskovich, M.A.2    Jove, R.3
  • 119
    • 84906936086 scopus 로고    scopus 로고
    • Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
    • Zhang X, Blaskovich MA, Forinash KD, Sebti SM. Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours. Br J Cancer 2014;111:894-902
    • (2014) Br J Cancer , vol.111 , pp. 894-902
    • Zhang, X.1    Blaskovich, M.A.2    Forinash, K.D.3    Sebti, S.M.4
  • 121
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012;366:787-98
    • (2012) N Engl J Med , vol.366 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3
  • 122
    • 84863393110 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
    • Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012;366:799-807
    • (2012) N Engl J Med , vol.366 , pp. 799-807
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 123
    • 80054094068 scopus 로고    scopus 로고
    • Safety and efficacy of CYT387, a JAK-1/2 inhibitor, for the treatment of myelofibrosis
    • Pardanani AD, Caramazza D, George G, et al. Safety and efficacy of CYT387, a JAK-1/2 inhibitor, for the treatment of myelofibrosis. ASCO Meeting Abstracts 2011;29(15 Suppl):6514
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.15 , pp. 6514
    • Pardanani, A.D.1    Caramazza, D.2    George, G.3
  • 124
    • 70949094349 scopus 로고    scopus 로고
    • The JAK2 inhibitor AZD1480 potently blocks stat3 signaling and oncogenesis in solid tumors
    • Hedvat M, Huszar D, Herrmann A, et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 2009;16:487-97
    • (2009) Cancer Cell , vol.16 , pp. 487-497
    • Hedvat, M.1    Huszar, D.2    Herrmann, A.3
  • 125
    • 84880691700 scopus 로고    scopus 로고
    • AZD1480: A phase I study of a novel JAK2 inhibitor in solid tumors
    • Plimack ER, Lorusso PM, McCoon P, et al. AZD1480: a phase I study of a novel JAK2 inhibitor in solid tumors. Oncologist 2013;18:819-12
    • (2013) Oncologist , vol.18 , pp. 819-912
    • Plimack, E.R.1    Lorusso, P.M.2    McCoon, P.3
  • 126
    • 84893429662 scopus 로고    scopus 로고
    • Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
    • Siveen KS, Sikka S, Surana R, et al. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochim Biophys Acta 2014;1845:136-54
    • (2014) Biochim Biophys Acta , vol.1845 , pp. 136-154
    • Siveen, K.S.1    Sikka, S.2    Surana, R.3
  • 127
    • 10044246299 scopus 로고    scopus 로고
    • Review of the flavonoids quercetin, hesperetin, and naringenin: Dietary sources, bioactivities, bioavailability, and epidemiology
    • Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin: dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res 2004;24:851-74
    • (2004) Nutr Res , vol.24 , pp. 851-874
    • Erlund, I.1
  • 128
    • 0030891773 scopus 로고    scopus 로고
    • Bioavailability of the dietary antioxidant flavonol quercetin in man
    • Hollman PCH, van Trijp JMP, Mengelers MJB, et al. Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett 1997;114:139-40
    • (1997) Cancer Lett , vol.114 , pp. 139-140
    • Hollman, P.C.H.1    Van Trijp, J.M.P.2    Mengelers, M.J.B.3
  • 129
  • 130
    • 84892933053 scopus 로고    scopus 로고
    • Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
    • Cao HH, Tse AKW, Kwan HY, et al. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol 2014;87:424-34
    • (2014) Biochem Pharmacol , vol.87 , pp. 424-434
    • Cao, H.H.1    Tse, A.K.W.2    Kwan, H.Y.3
  • 131
    • 33749007655 scopus 로고    scopus 로고
    • Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma
    • Rosner K, Röpke C, Pless V, Skovgaard GL. Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma. Biosci Biotechnol Biochem 2006;70:2169-77
    • (2006) Biosci Biotechnol Biochem , vol.70 , pp. 2169-2177
    • Rosner, K.1    Röpke, C.2    Pless, V.3    Skovgaard, G.L.4
  • 132
    • 84925283220 scopus 로고    scopus 로고
    • Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: Inhibition of constitutive and interleukin 6 (IL6)-induced activation by iron depletion
    • Lui GY, Kovacevic Z, Menezes S, et al. Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6 (IL6)-induced activation by iron depletion. Mol Pharmacol 2015;87(3):543-60
    • (2015) Mol Pharmacol , vol.87 , Issue.3 , pp. 543-560
    • Lui, G.Y.1    Kovacevic, Z.2    Menezes, S.3
  • 133
    • 84918572981 scopus 로고    scopus 로고
    • The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients
    • Li X, Yu Z, Li Y, et al. The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients. Int J Oncol 2015;46:798-808
    • (2015) Int J Oncol , vol.46 , pp. 798-808
    • Li, X.1    Yu, Z.2    Li, Y.3
  • 134
    • 84918813211 scopus 로고    scopus 로고
    • HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the in colorectal cancer cells
    • Lee DH, Sung KS, Bartlett DL, et al. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the in colorectal cancer cells. Cell Signal 2015;27:293-305
    • (2015) Cell Signal , vol.27 , pp. 293-305
    • Lee, D.H.1    Sung, K.S.2    Bartlett, D.L.3
  • 135
    • 84858230349 scopus 로고    scopus 로고
    • A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line
    • Souissi I, Ladam P, Cognet JA, et al. A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. Mol Cancer 2012;11:12
    • (2012) Mol Cancer , vol.11 , pp. 12
    • Souissi, I.1    Ladam, P.2    Cognet, J.A.3
  • 136
    • 84908161000 scopus 로고    scopus 로고
    • Revisiting STAT3 signalling in cancer: New and unexpected biological functions
    • Yu H, Lee H, Herrmann A, et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 2014;14:736-46
    • (2014) Nat Rev Cancer , vol.14 , pp. 736-746
    • Yu, H.1    Lee, H.2    Herrmann, A.3
  • 137
    • 84921897519 scopus 로고    scopus 로고
    • Inhibition of IL-6/STAT3 axis and targeting axl and tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
    • Suh Y, Jo S, Lee H, Lee C. Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells. Int J Oncol 2014;46(3):1405-11
    • (2014) Int J Oncol , vol.46 , Issue.3 , pp. 1405-1411
    • Suh, Y.1    Jo, S.2    Lee, H.3    Lee, C.4
  • 138
    • 84920573170 scopus 로고    scopus 로고
    • The role of STAT3 signaling in mediating tumor resistance to cancer therapy
    • Tan FH, Putoczki TL, Stylli SS, Luwor RB. The Role of STAT3 signaling in mediating tumor resistance to cancer therapy. Curr Drug Targets 2014;15:1341-53
    • (2014) Curr Drug Targets , vol.15 , pp. 1341-1353
    • Tan, F.H.1    Putoczki, T.L.2    Stylli, S.S.3    Luwor, R.B.4
  • 139
    • 84905726946 scopus 로고    scopus 로고
    • Drug resistance via feedback activation of stat3 in oncogene-addicted cancer cells
    • Lee HJ, Zhuang G, Cao Y, et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell 2014;26:207-21
    • (2014) Cancer Cell , vol.26 , pp. 207-221
    • Lee, H.J.1    Zhuang, G.2    Cao, Y.3
  • 140
    • 84907992899 scopus 로고    scopus 로고
    • Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
    • Li G, Zhao L, Li W, et al. Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression. Oncotarget 2014;5:8317-29
    • (2014) Oncotarget , vol.5 , pp. 8317-8329
    • Li, G.1    Zhao, L.2    Li, W.3
  • 141
    • 84928770707 scopus 로고    scopus 로고
    • SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma
    • Su JC, Tseng PH, Wu SH, et al. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. Neoplasia 2014;16:595-605
    • (2014) Neoplasia , vol.16 , pp. 595-605
    • Su, J.C.1    Tseng, P.H.2    Wu, S.H.3


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