-
1
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-21
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell, J.E.1
Kerr, I.M.2
Stark, G.R.3
-
2
-
-
1042302005
-
The STATs of cancer-new molecular targets come of age
-
Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004;4:97-105
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
3
-
-
0028148055
-
Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors
-
Raz R, Durbin JE, Levy DE. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J Biol Chem 1994;269:24391-5
-
(1994)
J Biol Chem
, vol.269
, pp. 24391-24395
-
-
Raz, R.1
Durbin, J.E.2
Levy, D.E.3
-
5
-
-
84906316130
-
Cytokine-induced slowing of STAT3 nuclear import; faster basal trafficking of the STAT3β isoform
-
Ng IH, Bogoyevitch MA, Jans DA. Cytokine-induced slowing of STAT3 nuclear import; faster basal trafficking of the STAT3β isoform. Traffic 2014;15:946-60
-
(2014)
Traffic
, vol.15
, pp. 946-960
-
-
Ng, I.H.1
Bogoyevitch, M.A.2
Jans, D.A.3
-
6
-
-
80055072546
-
Antitumorigenic potential of STAT3 alternative splicing modulation
-
Zammarchi F, de Stanchina E, Bournazou E, et al. Antitumorigenic potential of STAT3 alternative splicing modulation. Proc Natl Acad Sci USA 2011;108:17779-84
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 17779-17784
-
-
Zammarchi, F.1
De Stanchina, E.2
Bournazou, E.3
-
7
-
-
84866355165
-
Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes
-
Ng IH, Ng DC, Jans DA, Bogoyevitch MA. Selective STAT3-α or -βb expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochem J 2012;447:125-36
-
(2012)
Biochem J
, vol.447
, pp. 125-136
-
-
Ng, I.H.1
Ng, D.C.2
Jans, D.A.3
Bogoyevitch, M.A.4
-
8
-
-
0031443156
-
Constitutive activation of stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
-
Garcia R, Yu CL, Hudnall A, et al. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ 1997;8:1267-76
-
(1997)
Cell Growth Differ
, vol.8
, pp. 1267-1276
-
-
Garcia, R.1
Yu, C.L.2
Hudnall, A.3
-
9
-
-
0013689209
-
Requirement of stat3 but not stat1 activation for epidermal growth factor receptormediated cell growth in vitro
-
Grandis JR, Drenning SD, Chakraborty A, et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptormediated cell growth in vitro. J Clin Invest 1998;102:1385-92
-
(1998)
J Clin Invest
, vol.102
, pp. 1385-1392
-
-
Grandis, J.R.1
Drenning, S.D.2
Chakraborty, A.3
-
10
-
-
0031864202
-
Variations in the levels of the JAK/STAT and ShcA proteins in human brain tumors
-
Cattaneo E, Magrassi L, De-Fraja C, et al. Variations in the levels of the JAK/STAT and ShcA proteins in human brain tumors. Anticancer Res 1998;18:2381-7
-
(1998)
Anticancer Res
, vol.18
, pp. 2381-2387
-
-
Cattaneo, E.1
Magrassi, L.2
De-Fraja, C.3
-
11
-
-
0033611585
-
Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma
-
Flørenes VA, Lu C, Bhattacharya N, et al. Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma. Oncogene 1999;18:1023-32
-
(1999)
Oncogene
, vol.18
, pp. 1023-1032
-
-
Flørenes, V.A.1
Lu, C.2
Bhattacharya, N.3
-
12
-
-
0033047725
-
Systemic interferon-alpha (IFN-alpha) treatment leads to stat3 inactivation in melanoma precursor lesions
-
Kirkwood JM, Farkas DL, Chakraborty A, et al. Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol Med 1999;5:11-20
-
(1999)
Mol Med
, vol.5
, pp. 11-20
-
-
Kirkwood, J.M.1
Farkas, D.L.2
Chakraborty, A.3
-
13
-
-
0034651980
-
Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway
-
Lou W, Ni Z, Dyer K, et al. Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway. Prostate 2000;42:239-42
-
(2000)
Prostate
, vol.42
, pp. 239-242
-
-
Lou, W.1
Ni, Z.2
Dyer, K.3
-
14
-
-
0032782375
-
Expression of the JAK and STAT superfamilies in human meningiomas
-
Magrassi L, De-Fraja C, Conti L, et al. Expression of the JAK and STAT superfamilies in human meningiomas. J Neurosurg 1999;91:440-6
-
(1999)
J Neurosurg
, vol.91
, pp. 440-446
-
-
Magrassi, L.1
De-Fraja, C.2
Conti, L.3
-
15
-
-
0033973215
-
Defective jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha
-
Pansky A, Hildebrand P, Fasler-Kan E, et al. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha. Int J Cancer 2000;85:720-5
-
(2000)
Int J Cancer
, vol.85
, pp. 720-725
-
-
Pansky, A.1
Hildebrand, P.2
Fasler-Kan, E.3
-
16
-
-
0031894945
-
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: Inhibition of meningioma cell growth in vitro by recombinant oncostatin M
-
Schrell UM, Koch HU, Marschalek R, et al. Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. J Neurosurg 1998;88:541-8
-
(1998)
J Neurosurg
, vol.88
, pp. 541-548
-
-
Schrell, U.M.1
Koch, H.U.2
Marschalek, R.3
-
17
-
-
0032726122
-
STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription
-
Catlett-Falcone R, Dalton WS, Jove R. STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. Curr Opin Oncol 1999;11:490-6
-
(1999)
Curr Opin Oncol
, vol.11
, pp. 490-496
-
-
Catlett-Falcone, R.1
Dalton, W.S.2
Jove, R.3
-
18
-
-
0034658551
-
The role of STATs in myeloid differentiation and leukemia
-
Coffer PJ, Koenderman L, de Groot RP. The role of STATs in myeloid differentiation and leukemia. Oncogene 2000;19:2511-22
-
(2000)
Oncogene
, vol.19
, pp. 2511-2522
-
-
Coffer, P.J.1
Koenderman, L.2
De Groot, R.P.3
-
19
-
-
0031436969
-
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
-
Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest 1997;100:3140-8
-
(1997)
J Clin Invest
, vol.100
, pp. 3140-3148
-
-
Frank, D.A.1
Mahajan, S.2
Ritz, J.3
-
20
-
-
13344279401
-
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
-
Gouilleux-Gruart V, Gouilleux F, Desaint C, et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 1996;87:1692-7
-
(1996)
Blood
, vol.87
, pp. 1692-1697
-
-
Gouilleux-Gruart, V.1
Gouilleux, F.2
Desaint, C.3
-
21
-
-
0029784886
-
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in epstein-barr virus (EBV)-related lymphoma cell lines
-
Weber-Nordt RM, Egen C, Wehinger J, et al. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 1996;88:809-16
-
(1996)
Blood
, vol.88
, pp. 809-816
-
-
Weber-Nordt, R.M.1
Egen, C.2
Wehinger, J.3
-
22
-
-
0029834676
-
Activation of jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and sezary syndrome
-
Zhang Q, Nowak I, Vonderheid EC, et al. Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA 1996;93:9148-53
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9148-9153
-
-
Zhang, Q.1
Nowak, I.2
Vonderheid, E.C.3
-
23
-
-
64849111865
-
Targeting STAT3 in cancer: How successful are we?
-
Yue P, Turkson J. Targeting STAT3 in cancer: how successful are we? Expert Opin Investig Drugs 2009;18:45-56
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 45-56
-
-
Yue, P.1
Turkson, J.2
-
24
-
-
7944233465
-
Role of STATs as downstream signal transducers in src family kinasemediated tumorigenesis
-
Silva CM. Role of STATs as downstream signal transducers in Src family kinasemediated tumorigenesis. Oncogene 2004;23:8017-23
-
(2004)
Oncogene
, vol.23
, pp. 8017-8023
-
-
Silva, C.M.1
-
25
-
-
7244255836
-
Getting the message across, STAT! design principles of a molecular signaling circuit
-
Vinkemeier U. Getting the message across, STAT! Design principles of a molecular signaling circuit. J Cell Biol 2004;167:197-201
-
(2004)
J Cell Biol
, vol.167
, pp. 197-201
-
-
Vinkemeier, U.1
-
26
-
-
0039115156
-
Transport into and out of the cell nucleus
-
Gorlich D. Transport into and out of the cell nucleus. Embo J 1998;17:2721-7
-
(1998)
Embo J
, vol.17
, pp. 2721-2727
-
-
Gorlich, D.1
-
27
-
-
0042206459
-
A novel sequence in the coiled-coil domain of stat3 essential for its nuclear translocation
-
Ma J, Zhang T, Novotny-Diermayr V, et al. A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J Biol Chem 2003;278:29252-60
-
(2003)
J Biol Chem
, vol.278
, pp. 29252-29260
-
-
Ma, J.1
Zhang, T.2
Novotny-Diermayr, V.3
-
28
-
-
34247600538
-
STAT3 as a central mediator of neoplastic cellular transformation
-
Frank DA. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 2007;251:199-210
-
(2007)
Cancer Lett
, vol.251
, pp. 199-210
-
-
Frank, D.A.1
-
30
-
-
0028349735
-
Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264:95-8
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell, J.E.3
-
31
-
-
84897051279
-
Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer
-
West NR, Murray JI, Watson PH. Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer. Oncogene 2014;33:1485-94
-
(2014)
Oncogene
, vol.33
, pp. 1485-1494
-
-
West, N.R.1
Murray, J.I.2
Watson, P.H.3
-
32
-
-
84881303278
-
Stat3-coordinated lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelia lmesenchymal transition
-
Guo L, Chen C, Shi M, et al. Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelia lmesenchymal transition. Oncogene 2013;32:5272-82
-
(2013)
Oncogene
, vol.32
, pp. 5272-5282
-
-
Guo, L.1
Chen, C.2
Shi, M.3
-
33
-
-
0029117304
-
Maximal activation of transcription by stat1 and stat3 requires both tyrosine and serine phosphorylation
-
Wen Z, Zhong Z, Darnell JE. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995;82:241-50
-
(1995)
Cell
, vol.82
, pp. 241-250
-
-
Wen, Z.1
Zhong, Z.2
Darnell, J.E.3
-
34
-
-
0030772458
-
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
-
Chung J, Uchida E, Grammer TC, Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 1997;17:6508-16
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6508-6516
-
-
Chung, J.1
Uchida, E.2
Grammer, T.C.3
Blenis, J.4
-
37
-
-
0034624986
-
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts
-
Morita Y, Naka T, Kawazoe Y, et al. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc Natl Acad Sci USA 2000;97:5405-10
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5405-5410
-
-
Morita, Y.1
Naka, T.2
Kawazoe, Y.3
-
38
-
-
32644449048
-
Acetylation of stat1 modulates NF-kappaB activity
-
Kramer OH, Baus D, Knauer SK, et al. Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev 2006;20:473-85
-
(2006)
Genes Dev
, vol.20
, pp. 473-485
-
-
Kramer, O.H.1
Baus, D.2
Knauer, S.K.3
-
39
-
-
58849139353
-
A phosphorylation-acetylation switch regulates STAT1 signaling
-
Kramer OH, Knauer SK, Greiner G, et al. A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev 2009;23:223-35
-
(2009)
Genes Dev
, vol.23
, pp. 223-235
-
-
Kramer, O.H.1
Knauer, S.K.2
Greiner, G.3
-
40
-
-
64049109876
-
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
-
Nie Y, Erion DM, Yuan Z, et al. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol 2009;11:492-500
-
(2009)
Nat Cell Biol
, vol.11
, pp. 492-500
-
-
Nie, Y.1
Erion, D.M.2
Yuan, Z.3
-
41
-
-
28644445445
-
Inhibiting stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
Kortylewski M, Kujawski M, Wang T, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-21
-
(2005)
Nat Med
, vol.11
, pp. 1314-1321
-
-
Kortylewski, M.1
Kujawski, M.2
Wang, T.3
-
42
-
-
0030024563
-
Targeted disruption of the mouse stat1 gene results in compromised innate immunity to viral disease
-
Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996;84:443-50
-
(1996)
Cell
, vol.84
, pp. 443-450
-
-
Durbin, J.E.1
Hackenmiller, R.2
Simon, M.C.3
Levy, D.E.4
-
43
-
-
13344282731
-
Targeted disruption of the stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
-
Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-42
-
(1996)
Cell
, vol.84
, pp. 431-442
-
-
Meraz, M.A.1
White, J.M.2
Sheehan, K.C.3
-
44
-
-
41549107522
-
Cytokine signaling modules in inflammatory responses
-
O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity 2008;28:477-87
-
(2008)
Immunity
, vol.28
, pp. 477-487
-
-
O'Shea, J.J.1
Murray, P.J.2
-
45
-
-
75749097320
-
Th1 and Th17 cells: Adversaries and collaborators
-
Damsker JM, Hansen AM, Caspi RR, et al. Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci 2010;1183:211-21
-
(2010)
Ann N y Acad Sci
, vol.1183
, pp. 211-221
-
-
Damsker, J.M.1
Hansen, A.M.2
Caspi, R.R.3
-
46
-
-
70349736116
-
Cross-regulation of signaling pathways by interferon-gamma: Implications for immune responses and autoimmune diseases
-
Hu X, Ivashkiv LB. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 2009;31:539-50
-
(2009)
Immunity
, vol.31
, pp. 539-550
-
-
Hu, X.1
Ivashkiv, L.B.2
-
47
-
-
84907190280
-
Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling
-
Hedrich CM, Rauen T, Apostolidis SA, et al. Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. Proc Natl Acad Sci USA 2014;111:13457-62
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 13457-13462
-
-
Hedrich, C.M.1
Rauen, T.2
Apostolidis, S.A.3
-
48
-
-
0034658541
-
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
-
Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000;19:2548-56
-
(2000)
Oncogene
, vol.19
, pp. 2548-2556
-
-
Hirano, T.1
Ishihara, K.2
Hibi, M.3
-
49
-
-
32044464123
-
Epidermal growth factor receptor (EGFR) signaling in cancer
-
Normanno N, De Luca A, Bianco C, et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 2006;366:2-16
-
(2006)
Gene
, vol.366
, pp. 2-16
-
-
Normanno, N.1
De Luca, A.2
Bianco, C.3
-
50
-
-
36849012237
-
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
-
Gao SP, Mark KG, Leslie K, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007;117:3846-56
-
(2007)
J Clin Invest
, vol.117
, pp. 3846-3856
-
-
Gao, S.P.1
Mark, K.G.2
Leslie, K.3
-
51
-
-
84896702989
-
EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3
-
Concha-Benavente F, Srivastava RM, Ferrone S, Ferris RL. EGFR-mediated tumor immunoescape: the imbalance between phosphorylated STAT1 and phosphorylated STAT3. Oncoimmunology 2013;2:e27215
-
(2013)
Oncoimmunology
, vol.2
, pp. e27215
-
-
Concha-Benavente, F.1
Srivastava, R.M.2
Ferrone, S.3
Ferris, R.L.4
-
52
-
-
84859992161
-
The JAK-STAT pathway at twenty
-
Stark GR, Darnell JE Jr. The JAK-STAT pathway at twenty. Immunity 2012;36:503-14
-
(2012)
Immunity
, vol.36
, pp. 503-514
-
-
Stark, G.R.1
Darnell, J.E.2
-
53
-
-
84856213846
-
The diverse and complex roles of NF-κB subunits in cancer
-
Perkins ND. The diverse and complex roles of NF-κB subunits in cancer. Nat Rev Cancer 2012;12:121-32
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 121-132
-
-
Perkins, N.D.1
-
54
-
-
63249092765
-
Persistently activated stat3 maintains constitutive NF-kappaB activity in tumors
-
Lee H, Herrmann A, Deng JH, et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 2009;15:283-93
-
(2009)
Cancer Cell
, vol.15
, pp. 283-293
-
-
Lee, H.1
Herrmann, A.2
Deng, J.H.3
-
55
-
-
84929366176
-
Sphingosine-1-phosphate: Driver of NFκB and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer
-
Theiss AL. Sphingosine-1-phosphate: Driver of NFκB and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer. JAKSTAT 2013;2:e24150
-
(2013)
JAKSTAT
, vol.2
, pp. e24150
-
-
Theiss, A.L.1
-
56
-
-
78649982367
-
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
-
Lee H, Deng J, Kujawski M, et al. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med 2010;16:1421-8
-
(2010)
Nat Med
, vol.16
, pp. 1421-1428
-
-
Lee, H.1
Deng, J.2
Kujawski, M.3
-
57
-
-
84872406787
-
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis associated cancer
-
Liang J, Nagahashi M, Kim EY, et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis associated cancer. Cancer Cell 2013;23:107-20
-
(2013)
Cancer Cell
, vol.23
, pp. 107-120
-
-
Liang, J.1
Nagahashi, M.2
Kim, E.Y.3
-
58
-
-
84890730237
-
Interplay between microRNAs and the STAT3 signaling pathway in human cancers
-
Cao Q, Li YY, He WF, et al. Interplay between microRNAs and the STAT3 signaling pathway in human cancers. Physiol Genomics 2013;45:1206-14
-
(2013)
Physiol Genomics
, vol.45
, pp. 1206-1214
-
-
Cao, Q.1
Li, Y.Y.2
He, W.F.3
-
59
-
-
84894495362
-
STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes
-
Xiang M, Birkbak NJ, Vafaizadeh V, et al. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal 2014;7:ra11
-
(2014)
Sci Signal
, vol.7
, pp. ra11
-
-
Xiang, M.1
Birkbak, N.J.2
Vafaizadeh, V.3
-
60
-
-
0032984589
-
Constitutive activation of stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999;10:105-15
-
(1999)
Immunity
, vol.10
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
-
61
-
-
55849107422
-
Stat3 mediates myeloid celldependent tumor angiogenesis in mice
-
Kujawski M, Kortylewski M, Lee H, et al. Stat3 mediates myeloid celldependent tumor angiogenesis in mice. J Clin Invest 2008;118:3367-77
-
(2008)
J Clin Invest
, vol.118
, pp. 3367-3377
-
-
Kujawski, M.1
Kortylewski, M.2
Lee, H.3
-
62
-
-
85047698100
-
Inhibition of constitutively active stat3 suppresses growth of human ovarian and breast cancer cells
-
Burke WM, Jin X, Lin HJ, et al. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 2001;20:7925-34
-
(2001)
Oncogene
, vol.20
, pp. 7925-7934
-
-
Burke, W.M.1
Jin, X.2
Lin, H.J.3
-
63
-
-
79955592737
-
Suppression of STAT3 activity sensitizes gefitinib-resistant non small cell lung cancer cells
-
Chiu HC, Chou DL, Huang CT, et al. Suppression of STAT3 activity sensitizes gefitinib-resistant non small cell lung cancer cells. Biochem Pharmacol 2011;81:1263-70
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 1263-1270
-
-
Chiu, H.C.1
Chou, D.L.2
Huang, C.T.3
-
64
-
-
1542786900
-
Regulation of cortical actin networks in cell migration
-
Suetsugu S, Takenawa T. Regulation of cortical actin networks in cell migration. Int Rev Cytol 2003;229:245-86
-
(2003)
Int Rev Cytol
, vol.229
, pp. 245-286
-
-
Suetsugu, S.1
Takenawa, T.2
-
65
-
-
84918773439
-
The involvement of JAK-STAT3 in cell motility, invasion, and metastasis
-
Teng Y, Ross JL, Cowell JK. The involvement of JAK-STAT3 in cell motility, invasion, and metastasis. JAKSTAT 2014;3(1):e28086
-
(2014)
JAKSTAT
, vol.3
, Issue.1
, pp. e28086
-
-
Teng, Y.1
Ross, J.L.2
Cowell, J.K.3
-
67
-
-
84901787644
-
Oncogenic roles of EMT-inducing transcription factors
-
Puisieux A, Brabletz T, Caramel J. Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol 2014;16:488-94
-
(2014)
Nat Cell Biol
, vol.16
, pp. 488-494
-
-
Puisieux, A.1
Brabletz, T.2
Caramel, J.3
-
68
-
-
84856478208
-
STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma
-
Looyenga BD, Hutchings D, Cherni I, et al. STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS One 2012;7:e30820
-
(2012)
PLoS One
, vol.7
, pp. e30820
-
-
Looyenga, B.D.1
Hutchings, D.2
Cherni, I.3
-
69
-
-
84555202760
-
Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma
-
Jiang R, Jin Z, Liu Z, et al. Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma. Mol Diagn Ther 2011;15:347-52
-
(2011)
Mol Diagn Ther
, vol.15
, pp. 347-352
-
-
Jiang, R.1
Jin, Z.2
Liu, Z.3
-
70
-
-
84937522140
-
Differential roles of STAT3 in the initiation and growth of lung cancer
-
Zhou J, Qu Z, Yan S, et al. Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene 2014; doi:10.1038/onc.2014.318
-
(2014)
Oncogene
-
-
Zhou, J.1
Qu, Z.2
Yan, S.3
-
71
-
-
84899051828
-
JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells
-
Liu RY, Zeng Y, Lei Z, et al. JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells. Int J Oncol 2014;44:1643-51
-
(2014)
Int J Oncol
, vol.44
, pp. 1643-1651
-
-
Liu, R.Y.1
Zeng, Y.2
Lei, Z.3
-
72
-
-
84893957093
-
A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer
-
Xu YH, Lu S. A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer. Eur J Surg Oncol 2014;40:311-17
-
(2014)
Eur J Surg Oncol
, vol.40
, pp. 311-317
-
-
Xu, Y.H.1
Lu, S.2
-
73
-
-
84875490171
-
Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFalpha- and NK cytotoxicity
-
Kulesza DW, Carre T, Chouaib S, Kaminska B. Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFalpha- and NK cytotoxicity. Exp Cell Res 2013;319:506-16
-
(2013)
Exp Cell Res
, vol.319
, pp. 506-516
-
-
Kulesza, D.W.1
Carre, T.2
Chouaib, S.3
Kaminska, B.4
-
74
-
-
84867405669
-
Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation
-
Kim SM, Kwon OJ, Hong YK, et al. Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation. Mol Cancer Ther 2012;11:2254-64
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2254-2264
-
-
Kim, S.M.1
Kwon, O.J.2
Hong, Y.K.3
-
75
-
-
84894562833
-
Blockage of STAT3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition
-
Jin HO, Lee YH, Park JA, et al. Blockage of STAT3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition. Biochem Biophys Res Commun 2014;444:502-8
-
(2014)
Biochem Biophys Res Commun
, vol.444
, pp. 502-508
-
-
Jin, H.O.1
Lee, Y.H.2
Park, J.A.3
-
76
-
-
84893530696
-
Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells
-
Chung SS, Aroh C, Vadgama JV. Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells. PLoS ONE 2013;8:e83971
-
(2013)
PLoS ONE
, vol.8
, pp. e83971
-
-
Chung, S.S.1
Aroh, C.2
Vadgama, J.V.3
-
77
-
-
84930932838
-
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate myc and sox2
-
Zhao D, Pan C, Sun J, et al. VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2. Oncogene 2014; doi:10.1038/onc.2014.257
-
(2014)
Oncogene
-
-
Zhao, D.1
Pan, C.2
Sun, J.3
-
78
-
-
84907992899
-
Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
-
Li G, Zhao L, Li W, et al. Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression. Oncotarget 2014;5:8317-29
-
(2014)
Oncotarget
, vol.5
, pp. 8317-8329
-
-
Li, G.1
Zhao, L.2
Li, W.3
-
79
-
-
84918521700
-
An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelialmesenchymal transition and cancer stem cell expansion in human breast cancer cells
-
Yang L, Han S, Sun Y. An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelialmesenchymal transition and cancer stem cell expansion in human breast cancer cells. Biochem Biophys Res Commun 2014;453(3):582-7
-
(2014)
Biochem Biophys Res Commun
, vol.453
, Issue.3
, pp. 582-587
-
-
Yang, L.1
Han, S.2
Sun, Y.3
-
80
-
-
79955445350
-
CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model
-
Hassan S, Buchanan M, Jahan K, et al. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer 2011;129:225-32
-
(2011)
Int J Cancer
, vol.129
, pp. 225-232
-
-
Hassan, S.1
Buchanan, M.2
Jahan, K.3
-
81
-
-
84914704348
-
Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer
-
Liu X, Xiao Q, Bai X, et al. Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer. Oncol Rep 2014;32:2760-8
-
(2014)
Oncol Rep
, vol.32
, pp. 2760-2768
-
-
Liu, X.1
Xiao, Q.2
Bai, X.3
-
82
-
-
38449098731
-
The role of signal transducers and activators of transcription in colon cancer
-
Klampfer L. The role of signal transducers and activators of transcription in colon cancer. Front Biosci 2008;13:2888-99
-
(2008)
Front Biosci
, vol.13
, pp. 2888-2899
-
-
Klampfer, L.1
-
83
-
-
84884376190
-
STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon
-
Nguyen AV, Wu YY, Liu Q, et al. STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon. Neoplasia 2013;15:998-1008
-
(2013)
Neoplasia
, vol.15
, pp. 998-1008
-
-
Nguyen, A.V.1
Wu, Y.Y.2
Liu, Q.3
-
84
-
-
85028276122
-
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-κB to promote colorectal cancer cell growth
-
De Simone V, Franzè E, Ronchetti G, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-κB to promote colorectal cancer cell growth. Oncogene 2014; doi:10.1038/onc.2014.286
-
(2014)
Oncogene
-
-
De Simone, V.1
Franzè, E.2
Ronchetti, G.3
-
85
-
-
84921683452
-
A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells
-
e11
-
Liu S, Sun X, Wang M, et al. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology 2014;147(4):847-59.e11
-
(2014)
Gastroenterology
, vol.147
, Issue.4
, pp. 847-859
-
-
Liu, S.1
Sun, X.2
Wang, M.3
-
86
-
-
84913580379
-
Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
-
Wan S, Zhao E, Kryczek I, et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 2014;147(6):1393-404
-
(2014)
Gastroenterology
, vol.147
, Issue.6
, pp. 1393-1404
-
-
Wan, S.1
Zhao, E.2
Kryczek, I.3
-
87
-
-
84903781265
-
The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression
-
Zhu Q, Zhang X, Zhang L, et al. The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression. Cell Death Dis 2014;5:e1295
-
(2014)
Cell Death Dis
, vol.5
, pp. e1295
-
-
Zhu, Q.1
Zhang, X.2
Zhang, L.3
-
88
-
-
84888264541
-
Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia
-
e1-8
-
Katsha A, Soutto M, Sehdev V, et al. Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology 2013;145:1312-22.e1-8
-
(2013)
Gastroenterology
, vol.145
, pp. 1312-1322
-
-
Katsha, A.1
Soutto, M.2
Sehdev, V.3
-
89
-
-
84911978753
-
AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers
-
Katsha A, Arras J, Soutto M, et al. AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. Mol Oncol 2014;8(8):1419-28
-
(2014)
Mol Oncol
, vol.8
, Issue.8
, pp. 1419-1428
-
-
Katsha, A.1
Arras, J.2
Soutto, M.3
-
90
-
-
35148814410
-
Dynamics of the immune reaction to pancreatic cancer from inception to invasion
-
Clark CE, Hingorani SR, Mick R, et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res 2007;67:9518-27
-
(2007)
Cancer Res
, vol.67
, pp. 9518-9527
-
-
Clark, C.E.1
Hingorani, S.R.2
Mick, R.3
-
91
-
-
84899959071
-
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer
-
Panni RZ, Sanford DE, Belt BA, et al. Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunol Immunother 2014;63:513-28
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 513-528
-
-
Panni, R.Z.1
Sanford, D.E.2
Belt, B.A.3
-
92
-
-
84917732490
-
Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer
-
Wen W, Liang W, Wu J, et al. Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer. Mol Cancer Ther 2014;13(12):3037-48
-
(2014)
Mol Cancer Ther
, vol.13
, Issue.12
, pp. 3037-3048
-
-
Wen, W.1
Liang, W.2
Wu, J.3
-
93
-
-
84900865954
-
Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden
-
Abubaker K, Luwor RB, Zhu H, et al. Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden. BMC Cancer 2014;14:317
-
(2014)
BMC Cancer
, vol.14
, pp. 317
-
-
Abubaker, K.1
Luwor, R.B.2
Zhu, H.3
-
94
-
-
33751575658
-
The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis
-
Rosen DG, Mercado-Uribe I, Yang G, et al. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer 2006;107:2730-40
-
(2006)
Cancer
, vol.107
, pp. 2730-2740
-
-
Rosen, D.G.1
Mercado-Uribe, I.2
Yang, G.3
-
95
-
-
35448943030
-
Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer
-
Puiffe ML, Le Page C, Filali-Mouhim A, et al. Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer. Neoplasia 2007;9:820-9
-
(2007)
Neoplasia
, vol.9
, pp. 820-829
-
-
Puiffe, M.L.1
Le Page, C.2
Filali-Mouhim, A.3
-
96
-
-
84898859312
-
The multifaceted roles of STAT3 signaling in the progression of prostate cancer
-
Bishop JL, Thaper D, Zoubeidi A. The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer. Cancers (Basel) 2014;6:829-59
-
(2014)
Cancers (Basel)
, vol.6
, pp. 829-859
-
-
Bishop, J.L.1
Thaper, D.2
Zoubeidi, A.3
-
97
-
-
84908450155
-
Enzalutamide in metastatic prostate cancer before chemotherapy
-
Beer TM, Armstrong AJ, Rathkopf DE, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med 2014;371:424-33
-
(2014)
N Engl J Med
, vol.371
, pp. 424-433
-
-
Beer, T.M.1
Armstrong, A.J.2
Rathkopf, D.E.3
-
98
-
-
84866770294
-
Increased survival with enzalutamide in prostate cancer after chemotherapy
-
Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 2012;367:1187-97
-
(2012)
N Engl J Med
, vol.367
, pp. 1187-1197
-
-
Scher, H.I.1
Fizazi, K.2
Saad, F.3
-
99
-
-
84891160894
-
Inhibition of constitutively active stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells
-
Liu C, Zhu Y, Lou W, et al. Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells. Prostate 2014;74:201-9
-
(2014)
Prostate
, vol.74
, pp. 201-209
-
-
Liu, C.1
Zhu, Y.2
Lou, W.3
-
100
-
-
84890352055
-
Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma
-
Santoni M, Massari F, Amantini C, et al. Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma. Cancer ImmImmunother 2013;62:1757-68
-
(2013)
Cancer ImmImmunother
, vol.62
, pp. 1757-1768
-
-
Santoni, M.1
Massari, F.2
Amantini, C.3
-
101
-
-
0036186450
-
STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P
-
Horiguchi A, Oya M, Marumo K, Murai M. STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P. Kidney Int 2002;61:926-38
-
(2002)
Kidney Int
, vol.61
, pp. 926-938
-
-
Horiguchi, A.1
Oya, M.2
Marumo, K.3
Murai, M.4
-
102
-
-
84893933808
-
STAT3 activation in glioblastoma: Biochemical and therapeutic implications
-
Kim JE, Patel M, Ruzevick J, et al. STAT3 Activation in Glioblastoma: biochemical and Therapeutic Implications. Cancers (Basel) 2014;6:376-95
-
(2014)
Cancers (Basel)
, vol.6
, pp. 376-395
-
-
Kim, J.E.1
Patel, M.2
Ruzevick, J.3
-
103
-
-
77952296263
-
TRPV2 channel negatively controls glioma cell proliferation and resistance to fas-induced apoptosis in ERK-dependent manner
-
Nabissi M, Morelli MB, Amantini C, et al. TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis 2010;31:794-803
-
(2010)
Carcinogenesis
, vol.31
, pp. 794-803
-
-
Nabissi, M.1
Morelli, M.B.2
Amantini, C.3
-
104
-
-
84864460084
-
The transient receptor vanilloid-2 (TRPV2) cation channel impairs glioblastoma stem cell proliferation and promotes differentiation
-
Morelli MB, Nabissi M, Amantini C, et al. The Transient receptor vanilloid-2 (TRPV2) cation channel impairs glioblastoma stem cell proliferation and promotes differentiation. Int J Cancer 2012;131:E1067-77
-
(2012)
Int J Cancer
, vol.131
, pp. E1067-E1077
-
-
Morelli, M.B.1
Nabissi, M.2
Amantini, C.3
-
105
-
-
84872128254
-
Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
-
Nabissi M, Morelli MB, Santoni M, Santoni G. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 2013;34:48-57
-
(2013)
Carcinogenesis
, vol.34
, pp. 48-57
-
-
Nabissi, M.1
Morelli, M.B.2
Santoni, M.3
Santoni, G.4
-
106
-
-
84925175304
-
TRPM7 channels regulate glioma stem cell through STAT3 and notch signaling pathways
-
Liu M, Inoue K, Leng T, et al. TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal 2014;26:2773-81
-
(2014)
Cell Signal
, vol.26
, pp. 2773-2781
-
-
Liu, M.1
Inoue, K.2
Leng, T.3
-
107
-
-
0035977055
-
Phosphotyrosyl peptides block stat3-mediated DNA binding activity, gene regulation, and cell transformation
-
Turkson J, Ryan D, Kim JS, et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 2001;276:45443-55
-
(2001)
J Biol Chem
, vol.276
, pp. 45443-45455
-
-
Turkson, J.1
Ryan, D.2
Kim, J.S.3
-
108
-
-
77949512140
-
RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotised as a therapeutic platform
-
Bennnett CF, Swayze EE. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotised as a therapeutic platform. Annu Rev Pharmacol Toxicol 2010;50:259-93
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 259-293
-
-
Bennnett, C.F.1
Swayze, E.E.2
-
109
-
-
84890434794
-
A phase I study of ISIS 481464 (AZD9150), a first-in-human, first-inclass, antisense oligonucleotide inhibitor of STAT3, in patients with advanced cancers
-
abstract 8523
-
Hong DS, Younes A, Fayad LH, et al. A phase I study of ISIS 481464 (AZD9150), a first-in-human, first-inclass, antisense oligonucleotide inhibitor of STAT3, in patients with advanced cancers. J Clin Oncol 2013;31(Suppl):abstract 8523
-
(2013)
J Clin Oncol
, vol.31
-
-
Hong, D.S.1
Younes, A.2
Fayad, L.H.3
-
110
-
-
84888424589
-
A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases
-
Hayakawa F, Sugimoto K, Harada Y, et al. A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. Blood Cancer J 2013;3:e166
-
(2013)
Blood Cancer J
, vol.3
, pp. e166
-
-
Hayakawa, F.1
Sugimoto, K.2
Harada, Y.3
-
111
-
-
84878432714
-
OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
-
Kim MJ, Nam HJ, Kim HP, et al. OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett 2013;335:145-52
-
(2013)
Cancer Lett
, vol.335
, pp. 145-152
-
-
Kim, M.J.1
Nam, H.J.2
Kim, H.P.3
-
112
-
-
84903816370
-
Phase 1, open-label, doseescalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors
-
Bendell JC, Hong DS, Burris HA III, et al. Phase 1, open-label, doseescalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors. Cancer Chemother Pharmacol 2014;74:125-30
-
(2014)
Cancer Chemother Pharmacol
, vol.74
, pp. 125-130
-
-
Bendell, J.C.1
Hong, D.S.2
Burris, H.A.3
-
113
-
-
84929298145
-
A phase I, open-label, nonrandomized trial of OPB-31121, a STAT3 inhibitor, in patients with advanced hepatocellular carcinoma (HCC)
-
abstract 2616
-
Ikeda M, Okusaka T, Ishii H, et al. A phase I, open-label, nonrandomized trial of OPB-31121, a STAT3 inhibitor, in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2014;32(5s Suppl):abstract 2616
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
Ikeda, M.1
Okusaka, T.2
Ishii, H.3
-
114
-
-
84929326756
-
Novel small molecule inhibitors of signal transducer and activator of transcription (STAT3) for cancer treatment
-
abstract nr C180
-
Brambilla L, Genini D, Laurini E, et al. Novel small molecule inhibitors of signal transducer and activator of transcription (STAT3) for cancer treatment. Mol Cancer Ther 2013;12(11 Suppl):abstract nr C180
-
(2013)
Mol Cancer Ther
, vol.12
, Issue.11
-
-
Brambilla, L.1
Genini, D.2
Laurini, E.3
-
116
-
-
84900007949
-
Phase I study of OPB51602, a small molecule inhibitor of STAT3 phosphorylation, in patients with refractory solid malignancies
-
abstract 3002
-
Goh BC, Wong ALA, Soo RA, et al. Phase I study of OPB51602, a small molecule inhibitor of STAT3 phosphorylation, in patients with refractory solid malignancies. J Clin Oncol 2012;30(Suppl):abstract 3002
-
(2012)
J Clin Oncol
, vol.30
-
-
Goh, B.C.1
Wong, A.L.A.2
Soo, R.A.3
-
117
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich MA, Sun J, Cantor A, et al. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003;63:1270-9
-
(2003)
Cancer Res
, vol.63
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
-
118
-
-
18844370367
-
Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
-
Sun J, Blaskovich MA, Jove R, et al. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 2005;24:3236-45
-
(2005)
Oncogene
, vol.24
, pp. 3236-3245
-
-
Sun, J.1
Blaskovich, M.A.2
Jove, R.3
-
119
-
-
84906936086
-
Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
-
Zhang X, Blaskovich MA, Forinash KD, Sebti SM. Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours. Br J Cancer 2014;111:894-902
-
(2014)
Br J Cancer
, vol.111
, pp. 894-902
-
-
Zhang, X.1
Blaskovich, M.A.2
Forinash, K.D.3
Sebti, S.M.4
-
121
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012;366:787-98
-
(2012)
N Engl J Med
, vol.366
, pp. 787-798
-
-
Harrison, C.1
Kiladjian, J.J.2
Al-Ali, H.K.3
-
122
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012;366:799-807
-
(2012)
N Engl J Med
, vol.366
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
-
123
-
-
80054094068
-
Safety and efficacy of CYT387, a JAK-1/2 inhibitor, for the treatment of myelofibrosis
-
Pardanani AD, Caramazza D, George G, et al. Safety and efficacy of CYT387, a JAK-1/2 inhibitor, for the treatment of myelofibrosis. ASCO Meeting Abstracts 2011;29(15 Suppl):6514
-
(2011)
ASCO Meeting Abstracts
, vol.29
, Issue.15
, pp. 6514
-
-
Pardanani, A.D.1
Caramazza, D.2
George, G.3
-
124
-
-
70949094349
-
The JAK2 inhibitor AZD1480 potently blocks stat3 signaling and oncogenesis in solid tumors
-
Hedvat M, Huszar D, Herrmann A, et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 2009;16:487-97
-
(2009)
Cancer Cell
, vol.16
, pp. 487-497
-
-
Hedvat, M.1
Huszar, D.2
Herrmann, A.3
-
125
-
-
84880691700
-
AZD1480: A phase I study of a novel JAK2 inhibitor in solid tumors
-
Plimack ER, Lorusso PM, McCoon P, et al. AZD1480: a phase I study of a novel JAK2 inhibitor in solid tumors. Oncologist 2013;18:819-12
-
(2013)
Oncologist
, vol.18
, pp. 819-912
-
-
Plimack, E.R.1
Lorusso, P.M.2
McCoon, P.3
-
126
-
-
84893429662
-
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
-
Siveen KS, Sikka S, Surana R, et al. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochim Biophys Acta 2014;1845:136-54
-
(2014)
Biochim Biophys Acta
, vol.1845
, pp. 136-154
-
-
Siveen, K.S.1
Sikka, S.2
Surana, R.3
-
127
-
-
10044246299
-
Review of the flavonoids quercetin, hesperetin, and naringenin: Dietary sources, bioactivities, bioavailability, and epidemiology
-
Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin: dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res 2004;24:851-74
-
(2004)
Nutr Res
, vol.24
, pp. 851-874
-
-
Erlund, I.1
-
128
-
-
0030891773
-
Bioavailability of the dietary antioxidant flavonol quercetin in man
-
Hollman PCH, van Trijp JMP, Mengelers MJB, et al. Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett 1997;114:139-40
-
(1997)
Cancer Lett
, vol.114
, pp. 139-140
-
-
Hollman, P.C.H.1
Van Trijp, J.M.P.2
Mengelers, M.J.B.3
-
129
-
-
80052166441
-
Quercetin
-
Kelly GS. Quercetin. Altern Med Rev 2011;16:172-94
-
(2011)
Altern Med Rev
, vol.16
, pp. 172-194
-
-
Kelly, G.S.1
-
130
-
-
84892933053
-
Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
-
Cao HH, Tse AKW, Kwan HY, et al. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol 2014;87:424-34
-
(2014)
Biochem Pharmacol
, vol.87
, pp. 424-434
-
-
Cao, H.H.1
Tse, A.K.W.2
Kwan, H.Y.3
-
131
-
-
33749007655
-
Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma
-
Rosner K, Röpke C, Pless V, Skovgaard GL. Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma. Biosci Biotechnol Biochem 2006;70:2169-77
-
(2006)
Biosci Biotechnol Biochem
, vol.70
, pp. 2169-2177
-
-
Rosner, K.1
Röpke, C.2
Pless, V.3
Skovgaard, G.L.4
-
132
-
-
84925283220
-
Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: Inhibition of constitutive and interleukin 6 (IL6)-induced activation by iron depletion
-
Lui GY, Kovacevic Z, Menezes S, et al. Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6 (IL6)-induced activation by iron depletion. Mol Pharmacol 2015;87(3):543-60
-
(2015)
Mol Pharmacol
, vol.87
, Issue.3
, pp. 543-560
-
-
Lui, G.Y.1
Kovacevic, Z.2
Menezes, S.3
-
133
-
-
84918572981
-
The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients
-
Li X, Yu Z, Li Y, et al. The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients. Int J Oncol 2015;46:798-808
-
(2015)
Int J Oncol
, vol.46
, pp. 798-808
-
-
Li, X.1
Yu, Z.2
Li, Y.3
-
134
-
-
84918813211
-
HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the in colorectal cancer cells
-
Lee DH, Sung KS, Bartlett DL, et al. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the in colorectal cancer cells. Cell Signal 2015;27:293-305
-
(2015)
Cell Signal
, vol.27
, pp. 293-305
-
-
Lee, D.H.1
Sung, K.S.2
Bartlett, D.L.3
-
135
-
-
84858230349
-
A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line
-
Souissi I, Ladam P, Cognet JA, et al. A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. Mol Cancer 2012;11:12
-
(2012)
Mol Cancer
, vol.11
, pp. 12
-
-
Souissi, I.1
Ladam, P.2
Cognet, J.A.3
-
136
-
-
84908161000
-
Revisiting STAT3 signalling in cancer: New and unexpected biological functions
-
Yu H, Lee H, Herrmann A, et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 2014;14:736-46
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 736-746
-
-
Yu, H.1
Lee, H.2
Herrmann, A.3
-
137
-
-
84921897519
-
Inhibition of IL-6/STAT3 axis and targeting axl and tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
-
Suh Y, Jo S, Lee H, Lee C. Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells. Int J Oncol 2014;46(3):1405-11
-
(2014)
Int J Oncol
, vol.46
, Issue.3
, pp. 1405-1411
-
-
Suh, Y.1
Jo, S.2
Lee, H.3
Lee, C.4
-
138
-
-
84920573170
-
The role of STAT3 signaling in mediating tumor resistance to cancer therapy
-
Tan FH, Putoczki TL, Stylli SS, Luwor RB. The Role of STAT3 signaling in mediating tumor resistance to cancer therapy. Curr Drug Targets 2014;15:1341-53
-
(2014)
Curr Drug Targets
, vol.15
, pp. 1341-1353
-
-
Tan, F.H.1
Putoczki, T.L.2
Stylli, S.S.3
Luwor, R.B.4
-
139
-
-
84905726946
-
Drug resistance via feedback activation of stat3 in oncogene-addicted cancer cells
-
Lee HJ, Zhuang G, Cao Y, et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell 2014;26:207-21
-
(2014)
Cancer Cell
, vol.26
, pp. 207-221
-
-
Lee, H.J.1
Zhuang, G.2
Cao, Y.3
-
140
-
-
84907992899
-
Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
-
Li G, Zhao L, Li W, et al. Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression. Oncotarget 2014;5:8317-29
-
(2014)
Oncotarget
, vol.5
, pp. 8317-8329
-
-
Li, G.1
Zhao, L.2
Li, W.3
-
141
-
-
84928770707
-
SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma
-
Su JC, Tseng PH, Wu SH, et al. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. Neoplasia 2014;16:595-605
-
(2014)
Neoplasia
, vol.16
, pp. 595-605
-
-
Su, J.C.1
Tseng, P.H.2
Wu, S.H.3
|