STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P

Kidney International

Volumn 61, Issue 3, 2002, Pages 926-938

  Horiguchi, Akio ^a   Oya, Mototsugu ^a   Marumo, Ken ^a   Murai, Masaru ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Cell proliferation; Extracellular signal regulated kinases; Intracellular signaling; Kidney cancer; Renal cell carcinoma; STAT3

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NEUTRALIZING ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN INHIBITOR; RECEPTOR SUBUNIT; STAT3 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER CELL CULTURE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0036186450     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00206.x     Document Type: Conference Paper

References (42)

1. The biology of interleukin-6
2. Molecular cloning and expression of an IL-6 signal transducer, gp130
3. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
4. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
5. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
6. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
7. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
8. STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727
9. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
10. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT
11. Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3
12. IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade
13. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
14. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins
15. Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases
16. Systemic therapy for renal cell carcinoma
17. Interleukin-6 and TNF alpha production in human renal cell carcinoma
18. Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas
19. Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma
20. Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro
21. Role of reactive oxygen species in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder cancer cells
22. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays
23. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
24. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
25. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
26. Stat3 as an oncogene
27. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
28. Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components
29. Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells
30. The role of STATs in transcriptional control and their impact on cellular function
31. Epidermal growth factor-induced growth inhibition requires Stat1 activation
32. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
33. Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma
34. Mitogen-activated protein kinase pathways
35. Growth regulation of human renal carcinoma cells: Role of transforming growth factor alpha
36. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
37. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells
38. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response
39. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
40. Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers
41. Immunohistochemical analysis of BCL-2 protein expression in renal cell carcinoma
42. Frequent expression of Bcl-2 in renal-cell carcinomas carrying wild- type p53