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Volumn 87, Issue 3, 2014, Pages 424-434

Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling

Author keywords

Apoptosis; Invasion; Melanoma; Migration; STAT3

Indexed keywords

ANTINEOPLASTIC AGENT; GELATINASE A; GELATINASE B; JANUS KINASE 2; PROTEIN MCL 1; QUERCETIN; STAT3 PROTEIN; VASCULOTROPIN;

EID: 84892933053     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.11.008     Document Type: Article
Times cited : (149)

References (49)
  • 3
    • 79951960017 scopus 로고    scopus 로고
    • Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: A study of 522 consecutive cases
    • Z.H. Chi, S.M. Li, X.N. Sheng, L. Si, C.L. Cui, and M. Han et al. Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: a study of 522 consecutive cases BMC Cancer 11 2011 10
    • (2011) BMC Cancer , vol.11 , pp. 10
    • Chi, Z.H.1    Li, S.M.2    Sheng, X.N.3    Si, L.4    Cui, C.L.5    Han, M.6
  • 5
    • 84899549892 scopus 로고    scopus 로고
    • Comparison of acute toxicity and mortality after two different dosing regimens of high-dose interleukin-2 for patients with metastatic melanoma
    • 10.1007/s11523-013-0276-7 [Epub ahead of print]
    • L.M. Alwan, K. Grossmann, D. Sageser, J. Van Atta, N. Agarwal, and J.A. Gilreath Comparison of acute toxicity and mortality after two different dosing regimens of high-dose interleukin-2 for patients with metastatic melanoma Target Oncol 2013 10.1007/s11523-013-0276-7 [Epub ahead of print]
    • (2013) Target Oncol
    • Alwan, L.M.1    Grossmann, K.2    Sageser, D.3    Van Atta, J.4    Agarwal, N.5    Gilreath, J.A.6
  • 7
    • 41149170819 scopus 로고    scopus 로고
    • Understanding signaling cascades in melanoma
    • DOI 10.1111/j.1751-1097.2007.00254.x
    • P. Lopez-Bergami, B. Fitchman, and Z. Ronai Understanding signaling cascades in melanoma Photochem Photobiol 84 2008 289 306 (Pubitemid 351424029)
    • (2008) Photochemistry and Photobiology , vol.84 , Issue.2 , pp. 289-306
    • Lopez-Bergami, P.1    Fitchman, B.2    Ronai, Z.3
  • 8
    • 79953208248 scopus 로고    scopus 로고
    • STAT3 signaling: Anticancer strategies and challenges
    • P.A. Johnston, and J.R. Grandis STAT3 signaling: anticancer strategies and challenges Mol Interv 11 2011 18 26
    • (2011) Mol Interv , vol.11 , pp. 18-26
    • Johnston, P.A.1    Grandis, J.R.2
  • 9
    • 38849199799 scopus 로고    scopus 로고
    • STAT3 as a target for inducing apoptosis in solid and hematological tumors
    • DOI 10.1038/cr.2008.18, PII CR200818
    • K. Al Zaid Siddiquee, and J. Turkson STAT3 as a target for inducing apoptosis in solid and hematological tumors Cell Res 18 2008 254 267 (Pubitemid 351206162)
    • (2008) Cell Research , vol.18 , Issue.2 , pp. 254-267
    • Al Zaid Siddiquee, K.1    Turkson, J.2
  • 11
    • 0032718891 scopus 로고    scopus 로고
    • Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo
    • G. Niu, R. Heller, R. Catlett-Falcone, D. Coppola, M. Jaroszeski, and W. Dalton et al. Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo Cancer Res 59 1999 5059 5063 (Pubitemid 29503958)
    • (1999) Cancer Research , vol.59 , Issue.20 , pp. 5059-5063
    • Niu, G.1    Heller, R.2    Catlett-Falcone, R.3    Coppola, D.4    Jaroszeski, M.5    Dalton, W.6    Jove, R.7    Yu, H.8
  • 15
    • 79957910877 scopus 로고    scopus 로고
    • 6-Bromoindirubin-3′-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells
    • L. Liu, S. Nam, Y. Tian, F. Yang, J. Wu, and Y. Wang et al. 6-Bromoindirubin-3′-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells Cancer Res 71 2011 3972 3979
    • (2011) Cancer Res , vol.71 , pp. 3972-3979
    • Liu, L.1    Nam, S.2    Tian, Y.3    Yang, F.4    Wu, J.5    Wang, Y.6
  • 16
    • 84868363095 scopus 로고    scopus 로고
    • A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling
    • L. Liu, M. Kritsanida, P. Magiatis, N. Gaboriaud, Y. Wang, and J. Wu et al. A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling Cancer Biol Ther 13 2012 1255 1261
    • (2012) Cancer Biol Ther , vol.13 , pp. 1255-1261
    • Liu, L.1    Kritsanida, M.2    Magiatis, P.3    Gaboriaud, N.4    Wang, Y.5    Wu, J.6
  • 17
    • 84878360680 scopus 로고    scopus 로고
    • Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway
    • M.Z. Kamran, and R.P. Gude Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway Biomed Pharmacother 67 2013 399 405
    • (2013) Biomed Pharmacother , vol.67 , pp. 399-405
    • Kamran, M.Z.1    Gude, R.P.2
  • 18
    • 32944472519 scopus 로고    scopus 로고
    • Safety of quercetin for clinical application (Review)
    • T. Okamoto Safety of quercetin for clinical application (Review) Int J Mol Med 16 2005 275 278
    • (2005) Int J Mol Med , vol.16 , pp. 275-278
    • Okamoto, T.1
  • 19
    • 0016811010 scopus 로고
    • Disposition of quercetin in man after single oral and intravenous doses
    • R. Gugler, M. Leschik, and H.J. Dengler Disposition of quercetin in man after single oral and intravenous doses Eur J Clin Pharmacol 9 1975 229 234
    • (1975) Eur J Clin Pharmacol , vol.9 , pp. 229-234
    • Gugler, R.1    Leschik, M.2    Dengler, H.J.3
  • 20
    • 82955181000 scopus 로고    scopus 로고
    • Quercetin as a systemic chemopreventative agent: Structural and functional mechanisms
    • E.E. Mendoza, and R. Burd Quercetin as a systemic chemopreventative agent: structural and functional mechanisms Mini Rev Med Chem 11 2011 1216 1221
    • (2011) Mini Rev Med Chem , vol.11 , pp. 1216-1221
    • Mendoza, E.E.1    Burd, R.2
  • 21
    • 81855164783 scopus 로고    scopus 로고
    • The flavonoid quercetin in disease prevention and therapy: Facts and fancies
    • M. Russo, C. Spagnuolo, I. Tedesco, S. Bilotto, and G.L. Russo The flavonoid quercetin in disease prevention and therapy: facts and fancies Biochem Pharmacol 83 2012 6 15
    • (2012) Biochem Pharmacol , vol.83 , pp. 6-15
    • Russo, M.1    Spagnuolo, C.2    Tedesco, I.3    Bilotto, S.4    Russo, G.L.5
  • 22
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • E. Middleton Jr., C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol Rev 52 2000 673 751
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, Jr.E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 24
    • 33644926465 scopus 로고    scopus 로고
    • Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions
    • M. Piantelli, C. Rossi, M. Iezzi, R. La Sorda, S. Iacobelli, and S. Alberti et al. Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions J Cell Physiol 207 2006 23 29
    • (2006) J Cell Physiol , vol.207 , pp. 23-29
    • Piantelli, M.1    Rossi, C.2    Iezzi, M.3    La Sorda, R.4    Iacobelli, S.5    Alberti, S.6
  • 25
    • 12444337495 scopus 로고    scopus 로고
    • Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ
    • DOI 10.1007/s00280-004-0863-5
    • X.M. Zhang, J. Chen, Y.G. Xia, and Q. Xu Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta Cancer Chemother Pharmacol 55 2005 251 262 (Pubitemid 40142890)
    • (2005) Cancer Chemotherapy and Pharmacology , vol.55 , Issue.3 , pp. 251-262
    • Zhang, X.-M.1    Chen, J.2    Xia, Y.-G.3    Xu, Q.4
  • 26
    • 0034949925 scopus 로고    scopus 로고
    • Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression
    • DOI 10.1023/A:1010960615370
    • X. Zhang, Q. Xu, and I. Saiki Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression Clin Exp Metastasis 18 2000 415 421 (Pubitemid 32588622)
    • (2000) Clinical and Experimental Metastasis , vol.18 , Issue.5 , pp. 415-421
    • Zhang, X.1    Xu, Q.2    Saiki, I.3
  • 27
    • 0029096256 scopus 로고
    • Tamoxifen and quercetin interact with type II estrogen binding sites and inhibit the growth of human melanoma cells
    • M. Piantelli, N. Maggiano, R. Ricci, L.M. Larocca, A. Capelli, and G. Scambia et al. Tamoxifen and quercetin interact with type II estrogen binding sites and inhibit the growth of human melanoma cells J Invest Dermatol 105 1995 248 253
    • (1995) J Invest Dermatol , vol.105 , pp. 248-253
    • Piantelli, M.1    Maggiano, N.2    Ricci, R.3    Larocca, L.M.4    Capelli, A.5    Scambia, G.6
  • 28
    • 71449088014 scopus 로고    scopus 로고
    • Antioxidant and antiproliferative activity of Diospyros lotus L. Extract and isolated compounds
    • M.R. Loizzo, A. Said, R. Tundis, U.W. Hawas, K. Rashed, and F. Menichini et al. Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds Plant Foods Hum Nutr 64 2009 264 270
    • (2009) Plant Foods Hum Nutr , vol.64 , pp. 264-270
    • Loizzo, M.R.1    Said, A.2    Tundis, R.3    Hawas, U.W.4    Rashed, K.5    Menichini, F.6
  • 29
    • 33749007655 scopus 로고    scopus 로고
    • Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma
    • DOI 10.1271/bbb.60129
    • K. Rosner, C. Ropke, V. Pless, and G.L. Skovgaard Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma Biosci Biotechnol Biochem 70 2006 2169 2177 (Pubitemid 44451894)
    • (2006) Bioscience, Biotechnology and Biochemistry , vol.70 , Issue.9 , pp. 2169-2177
    • Rosner, K.1    Ropke, C.2    Pless, V.3    Skovgaard, G.L.4
  • 30
    • 84859158918 scopus 로고    scopus 로고
    • Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration
    • J. Michaud-Levesque, N. Bousquet-Gagnon, and R. Beliveau Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration Exp Cell Res 318 2013 925 935
    • (2013) Exp Cell Res , vol.318 , pp. 925-935
    • Michaud-Levesque, J.1    Bousquet-Gagnon, N.2    Beliveau, R.3
  • 31
    • 84862258292 scopus 로고    scopus 로고
    • Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway
    • Y. Qin, L.Y. He, Y. Chen, W.Y. Wang, X.H. Zhao, and M.Y. Wu Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28 2012 12 16
    • (2012) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.28 , pp. 12-16
    • Qin, Y.1    He, L.Y.2    Chen, Y.3    Wang, W.Y.4    Zhao, X.H.5    Wu, M.Y.6
  • 32
    • 84866022781 scopus 로고    scopus 로고
    • Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells
    • S. Nam, J. Xie, A. Perkins, Y. Ma, F. Yang, and J. Wu et al. Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells Mol Oncol 6 2012 484 493
    • (2012) Mol Oncol , vol.6 , pp. 484-493
    • Nam, S.1    Xie, J.2    Perkins, A.3    Ma, Y.4    Yang, F.5    Wu, J.6
  • 33
    • 84860508683 scopus 로고    scopus 로고
    • Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: Role of Cav1 in Shh heterotypic signaling and transendothelial migration
    • F. Capozza, C. Trimmer, R. Castello-Cros, S. Katiyar, D. Whitaker-Menezes, and A. Follenzi et al. Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration Cancer Res 72 2012 2262 2274
    • (2012) Cancer Res , vol.72 , pp. 2262-2274
    • Capozza, F.1    Trimmer, C.2    Castello-Cros, R.3    Katiyar, S.4    Whitaker-Menezes, D.5    Follenzi, A.6
  • 34
    • 84869438296 scopus 로고    scopus 로고
    • Galangin inhibits tumor growth and metastasis of B16F10 melanoma
    • W. Zhang, B. Tang, Q. Huang, and Z. Hua Galangin inhibits tumor growth and metastasis of B16F10 melanoma J Cell Biochem 114 2013 152 161
    • (2013) J Cell Biochem , vol.114 , pp. 152-161
    • Zhang, W.1    Tang, B.2    Huang, Q.3    Hua, Z.4
  • 35
    • 84867539636 scopus 로고    scopus 로고
    • RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy
    • I. Yajima, M.Y. Kumasaka, N.D. Thang, Y. Goto, K. Takeda, and O. Yamanoshita et al. RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy Dermatol Res Pract 2012 2012 354191
    • (2012) Dermatol Res Pract , vol.2012 , pp. 354191
    • Yajima, I.1    Kumasaka, M.Y.2    Thang, N.D.3    Goto, Y.4    Takeda, K.5    Yamanoshita, O.6
  • 36
    • 33947598446 scopus 로고    scopus 로고
    • Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
    • DOI 10.1038/modpathol.3800750, PII 3800750
    • L. Zhuang, C.S. Lee, R.A. Scolyer, S.W. McCarthy, X.D. Zhang, and J.F. Thompson et al. Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma Mod Pathol 20 2007 416 426 (Pubitemid 46482365)
    • (2007) Modern Pathology , vol.20 , Issue.4 , pp. 416-426
    • Zhuang, L.1    Lee, C.S.2    Scolyer, R.A.3    McCarthy, S.W.4    Zhang, X.D.5    Thompson, J.F.6    Hersey, P.7
  • 38
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • DOI 10.1016/j.fct.2007.05.015, PII S0278691507001780
    • M. Harwood, B. Danielewska-Nikiel, J.F. Borzelleca, G.W. Flamm, G.M. Williams, and T.C. Lines A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties Food Chem Toxicol 45 2007 2179 2205 (Pubitemid 47451573)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.11 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 39
    • 51049095905 scopus 로고    scopus 로고
    • Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans
    • S. Egert, S. Wolffram, A. Bosy-Westphal, C. Boesch-Saadatmandi, A.E. Wagner, and J. Frank et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans J Nutr 138 2008 1615 1621
    • (2008) J Nutr , vol.138 , pp. 1615-1621
    • Egert, S.1    Wolffram, S.2    Bosy-Westphal, A.3    Boesch-Saadatmandi, C.4    Wagner, A.E.5    Frank, J.6
  • 41
    • 0030891773 scopus 로고    scopus 로고
    • Bioavailability of the dietary antioxidant flavonol quercetin in man
    • DOI 10.1016/S0304-3835(97)04644-2, PII S0304383597046442
    • P.C. Hollman, J.M. van Trijp, M.J. Mengelers, J.H. de Vries, and M.B. Katan Bioavailability of the dietary antioxidant flavonol quercetin in man Cancer Lett 114 1997 139 140 (Pubitemid 27140094)
    • (1997) Cancer Letters , vol.114 , Issue.1-2 , pp. 139-140
    • Hollman, P.C.H.1    Van Trijp, J.M.P.2    Mengelers, M.J.B.3    De Vries, J.H.M.4    Katan, M.B.5
  • 43
    • 77954604880 scopus 로고    scopus 로고
    • Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: Its inhibition by quercetin
    • Z.J. Sun, G. Chen, X. Hu, W. Zhang, Y. Liu, and L.X. Zhu et al. Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin Apoptosis 15 2010 850 863
    • (2010) Apoptosis , vol.15 , pp. 850-863
    • Sun, Z.J.1    Chen, G.2    Hu, X.3    Zhang, W.4    Liu, Y.5    Zhu, L.X.6
  • 44
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship?
    • B.B. Aggarwal, A.B. Kunnumakkara, K.B. Harikumar, S.R. Gupta, S.T. Tharakan, and C. Koca et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann N Y Acad Sci 1171 2009 59 76
    • (2009) Ann N y Acad Sci , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3    Gupta, S.R.4    Tharakan, S.T.5    Koca, C.6
  • 45
    • 84873336707 scopus 로고    scopus 로고
    • The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition
    • X. Jiang, J. Zhou, A. Giobbie-Hurder, J. Wargo, and F.S. Hodi The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition Clin Cancer Res 19 2013 598 609
    • (2013) Clin Cancer Res , vol.19 , pp. 598-609
    • Jiang, X.1    Zhou, J.2    Giobbie-Hurder, A.3    Wargo, J.4    Hodi, F.S.5
  • 46
    • 84898016171 scopus 로고    scopus 로고
    • MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines
    • 10.1038/onc.2013.131 [Epub ahead of print]
    • A. Vultur, J. Villanueva, C. Krepler, G. Rajan, Q. Chen, and M. Xiao et al. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines Oncogene 2013 10.1038/onc.2013.131 [Epub ahead of print]
    • (2013) Oncogene
    • Vultur, A.1    Villanueva, J.2    Krepler, C.3    Rajan, G.4    Chen, Q.5    Xiao, M.6
  • 47
    • 84873524063 scopus 로고    scopus 로고
    • Anti-apoptotic proteins on guard of melanoma cell survival
    • M.L. Hartman, and M. Czyz Anti-apoptotic proteins on guard of melanoma cell survival Cancer Lett 331 2013 24 34
    • (2013) Cancer Lett , vol.331 , pp. 24-34
    • Hartman, M.L.1    Czyz, M.2
  • 48
    • 23044479718 scopus 로고    scopus 로고
    • Expression and serum levels of MMP-2 and MMP-9 during human melanoma progression
    • DOI 10.1111/j.1365-2230.2005.01849.x
    • P. Redondo, P. Lloret, M. Idoate, and S. Inoges Expression and serum levels of MMP-2 and MMP-9 during human melanoma progression Clin Exp Dermatol 30 2005 541 545 (Pubitemid 41076024)
    • (2005) Clinical and Experimental Dermatology , vol.30 , Issue.5 , pp. 541-545
    • Redondo, P.1    Lloret, P.2    Idoate, M.3    Inogest, S.4
  • 49
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • DOI 10.1038/sj.onc.1207383
    • T.X. Xie, D. Wei, M. Liu, A.C. Gao, F. Ali-Osman, and R. Sawaya et al. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis Oncogene 23 2004 3550 3560 (Pubitemid 38658421)
    • (2004) Oncogene , vol.23 , Issue.20 , pp. 3550-3560
    • Xie, T.-X.1    Wei, D.2    Liu, M.3    Gao, A.C.4    Ali-Osman, F.5    Sawaya, R.6    Huang, S.7


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