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Volumn 15, Issue 9, 2014, Pages 946-960

Cytokine-induced slowing of stat3 nuclear import; faster basal trafficking of the stat3β Isoform

Author keywords

Cytokines; FRAP; Nuclear transport; STAT3

Indexed keywords

CYTOKINE; GREEN FLUORESCENT PROTEIN; STAT3 PROTEIN; DNA BINDING PROTEIN; ISOPROTEIN; KARYOPHERIN; STAT3 PROTEIN, HUMAN;

EID: 84906316130     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/tra.12181     Document Type: Article
Times cited : (14)

References (50)
  • 1
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994;77:63-71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.6    Yoshida, K.7    Sudo, T.8    Naruto, M.9    Kishimoto, T.10
  • 3
    • 0028148055 scopus 로고
    • Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors
    • Raz R, Durbin JE, Levy DE. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J Biol Chem 1994;269:24391-24395.
    • (1994) J Biol Chem , vol.269 , pp. 24391-24395
    • Raz, R.1    Durbin, J.E.2    Levy, D.E.3
  • 4
    • 0028349735 scopus 로고
    • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264:95-98.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 6
    • 20444400857 scopus 로고    scopus 로고
    • STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3
    • Liu L, McBride KM, Reich NC. STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci USA 2005;102:8150-8155.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8150-8155
    • Liu, L.1    McBride, K.M.2    Reich, N.C.3
  • 7
    • 0036731485 scopus 로고    scopus 로고
    • Stats: transcriptional control and biological impact
    • Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002;3:651-662.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 8
    • 33750040230 scopus 로고    scopus 로고
    • Structure, function, and regulation of STAT proteins
    • Lim CP, Cao X. Structure, function, and regulation of STAT proteins. Mol Biosyst 2006;2:536-550.
    • (2006) Mol Biosyst , vol.2 , pp. 536-550
    • Lim, C.P.1    Cao, X.2
  • 10
    • 0036256644 scopus 로고    scopus 로고
    • What does Stat3 do?
    • Levy DE, Lee CK. What does Stat3 do? J Clin Invest 2002;109:1143-1148.
    • (2002) J Clin Invest , vol.109 , pp. 1143-1148
    • Levy, D.E.1    Lee, C.K.2
  • 11
    • 52949106152 scopus 로고    scopus 로고
    • STAT3 function in vivo
    • Sehgal PB, Levy DE, Hirano T, editors. Dordrecht: Kluwer Academic Publishers
    • Poli V. STAT3 function in vivo. In: Sehgal PB, Levy DE, Hirano T, editors. Signal Transducers and Activators of Transcription (STATs). Dordrecht: Kluwer Academic Publishers; 2003, pp. 492-512.
    • (2003) Signal Transducers and Activators of Transcription (STATs) , pp. 492-512
    • Poli, V.1
  • 12
    • 72049117143 scopus 로고    scopus 로고
    • Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy
    • Yue H, Li W, Desnoyer R, Karnik SS. Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy. Cardiovasc Res 2010;85:90-99.
    • (2010) Cardiovasc Res , vol.85 , pp. 90-99
    • Yue, H.1    Li, W.2    Desnoyer, R.3    Karnik, S.S.4
  • 13
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 2007;21:1396-1408.
    • (2007) Genes Dev , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 15
    • 79956285590 scopus 로고    scopus 로고
    • Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-beta1
    • Cimica V, Chen HC, Iyer JK, Reich NC. Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-beta1. PLoS One 2011;6:e20188.
    • (2011) PLoS One , vol.6
    • Cimica, V.1    Chen, H.C.2    Iyer, J.K.3    Reich, N.C.4
  • 16
    • 33646365075 scopus 로고    scopus 로고
    • Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements
    • Ma J, Cao X. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. Cell Signal 2006;18:1117-1126.
    • (2006) Cell Signal , vol.18 , pp. 1117-1126
    • Ma, J.1    Cao, X.2
  • 17
    • 0042206459 scopus 로고    scopus 로고
    • A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation
    • Ma J, Zhang T, Novotny-Diermayr V, Tan AL, Cao X. A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J Biol Chem 2003;278:29252-29260.
    • (2003) J Biol Chem , vol.278 , pp. 29252-29260
    • Ma, J.1    Zhang, T.2    Novotny-Diermayr, V.3    Tan, A.L.4    Cao, X.5
  • 19
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3
    • Schaefer TS, Sanders LK, Nathans D. Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci USA 1995;92:9097-9101.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9097-9101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 21
    • 0035895101 scopus 로고    scopus 로고
    • Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing
    • Shao H, Quintero AJ, Tweardy DJ. Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing. Blood 2001;98:3853-3856.
    • (2001) Blood , vol.98 , pp. 3853-3856
    • Shao, H.1    Quintero, A.J.2    Tweardy, D.J.3
  • 23
    • 0036008472 scopus 로고    scopus 로고
    • Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
    • Yoo JY, Huso DL, Nathans D, Desiderio S. Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell 2002;108:331-344.
    • (2002) Cell , vol.108 , pp. 331-344
    • Yoo, J.Y.1    Huso, D.L.2    Nathans, D.3    Desiderio, S.4
  • 24
    • 3142728480 scopus 로고    scopus 로고
    • Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway
    • Yeh M, Gharavi NM, Choi J, Hsieh X, Reed E, Mouillesseaux KP, Cole AL, Reddy ST, Berliner JA. Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway. J Biol Chem 2004;279:30175-30181.
    • (2004) J Biol Chem , vol.279 , pp. 30175-30181
    • Yeh, M.1    Gharavi, N.M.2    Choi, J.3    Hsieh, X.4    Reed, E.5    Mouillesseaux, K.P.6    Cole, A.L.7    Reddy, S.T.8    Berliner, J.A.9
  • 26
    • 84858405200 scopus 로고    scopus 로고
    • Splice modulating therapies for human disease
    • Spitali P, Aartsma-Rus A. Splice modulating therapies for human disease. Cell 2012;148:1085-1088.
    • (2012) Cell , vol.148 , pp. 1085-1088
    • Spitali, P.1    Aartsma-Rus, A.2
  • 27
    • 84866355165 scopus 로고    scopus 로고
    • Selective STAT3-alpha or -beta expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes
    • Ng IH, Ng DC, Jans DA, Bogoyevitch MA. Selective STAT3-alpha or -beta expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochem J 2012;447:125-136.
    • (2012) Biochem J , vol.447 , pp. 125-136
    • Ng, I.H.1    Ng, D.C.2    Jans, D.A.3    Bogoyevitch, M.A.4
  • 30
    • 36849026590 scopus 로고    scopus 로고
    • Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end
    • Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem 2007;282:34958-34967.
    • (2007) J Biol Chem , vol.282 , pp. 34958-34967
    • Huang, Y.1    Qiu, J.2    Dong, S.3    Redell, M.S.4    Poli, V.5    Mancini, M.A.6    Tweardy, D.J.7
  • 31
    • 52949104437 scopus 로고    scopus 로고
    • Paradigm shifts in the cell biology of STAT signaling
    • Sehgal PB. Paradigm shifts in the cell biology of STAT signaling. Semin Cell Dev Biol 2008;19:329-340.
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 329-340
    • Sehgal, P.B.1
  • 32
    • 84857739015 scopus 로고    scopus 로고
    • Global enhancement of nuclear localization-dependent nuclear transport in transformed cells
    • Kuusisto HV, Wagstaff KM, Alvisi G, Roth DM, Jans DA. Global enhancement of nuclear localization-dependent nuclear transport in transformed cells. FASEB J 2012;26:1181-1193.
    • (2012) FASEB J , vol.26 , pp. 1181-1193
    • Kuusisto, H.V.1    Wagstaff, K.M.2    Alvisi, G.3    Roth, D.M.4    Jans, D.A.5
  • 33
    • 79954623914 scopus 로고    scopus 로고
    • Mechanism of microtubule-facilitated "fast track" nuclear import
    • Roth DM, Moseley GW, Pouton CW, Jans DA. Mechanism of microtubule-facilitated "fast track" nuclear import. J Biol Chem 2011;286:14335-14351.
    • (2011) J Biol Chem , vol.286 , pp. 14335-14351
    • Roth, D.M.1    Moseley, G.W.2    Pouton, C.W.3    Jans, D.A.4
  • 34
    • 77952294068 scopus 로고    scopus 로고
    • The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal
    • Fulcher AJ, Roth DM, Fatima S, Alvisi G, Jans DA. The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal. FASEB J 2010;24:1454-1466.
    • (2010) FASEB J , vol.24 , pp. 1454-1466
    • Fulcher, A.J.1    Roth, D.M.2    Fatima, S.3    Alvisi, G.4    Jans, D.A.5
  • 36
    • 68049110292 scopus 로고    scopus 로고
    • Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus
    • Roth DM, Harper I, Pouton CW, Jans DA. Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus. J Cell Biochem 2009;107:1160-1167.
    • (2009) J Cell Biochem , vol.107 , pp. 1160-1167
    • Roth, D.M.1    Harper, I.2    Pouton, C.W.3    Jans, D.A.4
  • 37
    • 0033082623 scopus 로고    scopus 로고
    • Photobleaching GFP reveals protein dynamics inside live cells
    • White J, Stelzer E. Photobleaching GFP reveals protein dynamics inside live cells. Trends Cell Biol 1999;9:61-65.
    • (1999) Trends Cell Biol , vol.9 , pp. 61-65
    • White, J.1    Stelzer, E.2
  • 38
    • 0039468008 scopus 로고    scopus 로고
    • The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin
    • Hubner S, Xiao CY, Jans DA. The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin. J Biol Chem 1997;272:17191-17195.
    • (1997) J Biol Chem , vol.272 , pp. 17191-17195
    • Hubner, S.1    Xiao, C.Y.2    Jans, D.A.3
  • 39
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of STATs
    • Decker T, Kovarik P. Serine phosphorylation of STATs. Oncogene 2000;19:2628-2637.
    • (2000) Oncogene , vol.19 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 40
    • 0035917876 scopus 로고    scopus 로고
    • Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation
    • Schuringa JJ, Schepers H, Vellenga E, Kruijer W. Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation. FEBS Lett 2001;495:71-76.
    • (2001) FEBS Lett , vol.495 , pp. 71-76
    • Schuringa, J.J.1    Schepers, H.2    Vellenga, E.3    Kruijer, W.4
  • 41
    • 84855866260 scopus 로고    scopus 로고
    • Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45
    • Wakahara R, Kunimoto H, Tanino K, Kojima H, Inoue A, Shintaku H, Nakajima K. Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45. Genes Cells 2012;17:132-145.
    • (2012) Genes Cells , vol.17 , pp. 132-145
    • Wakahara, R.1    Kunimoto, H.2    Tanino, K.3    Kojima, H.4    Inoue, A.5    Shintaku, H.6    Nakajima, K.7
  • 42
    • 84873648544 scopus 로고    scopus 로고
    • 70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY
    • Kaur G, Lieu KG, Jans DA. 70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY. J Biol Chem 2013;288:4148-4157.
    • (2013) J Biol Chem , vol.288 , pp. 4148-4157
    • Kaur, G.1    Lieu, K.G.2    Jans, D.A.3
  • 44
    • 30944435466 scopus 로고    scopus 로고
    • Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
    • Ng DC, Lin BH, Lim CP, Huang G, Zhang T, Poli V, Cao X. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol 2006;172:245-257.
    • (2006) J Cell Biol , vol.172 , pp. 245-257
    • Ng, D.C.1    Lin, B.H.2    Lim, C.P.3    Huang, G.4    Zhang, T.5    Poli, V.6    Cao, X.7
  • 46
    • 41549154142 scopus 로고    scopus 로고
    • Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in pulmonary arterial hypertension
    • Mukhopadhyay S, Shah M, Xu F, Patel K, Tuder RM, Sehgal PB. Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 2008;294:L449-L468.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Mukhopadhyay, S.1    Shah, M.2    Xu, F.3    Patel, K.4    Tuder, R.M.5    Sehgal, P.B.6
  • 47
    • 35048878660 scopus 로고    scopus 로고
    • Live cell imaging of interleukin-6-induced targeting of "transcription factor" STAT3 to sequestering endosomes in the cytoplasm
    • Xu F, Mukhopadhyay S, Sehgal PB. Live cell imaging of interleukin-6-induced targeting of "transcription factor" STAT3 to sequestering endosomes in the cytoplasm. Am J Physiol Cell Physiol 2007;293:C1374-C1382.
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Xu, F.1    Mukhopadhyay, S.2    Sehgal, P.B.3
  • 49
    • 51649130231 scopus 로고    scopus 로고
    • Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation
    • Kermorgant S, Parker PJ. Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation. J Cell Biol 2008;182:855-863.
    • (2008) J Cell Biol , vol.182 , pp. 855-863
    • Kermorgant, S.1    Parker, P.J.2
  • 50
    • 0036646099 scopus 로고    scopus 로고
    • Cytoplasmic transport of Stat3 by receptor-mediated endocytosis
    • Bild AH, Turkson J, Jove R. Cytoplasmic transport of Stat3 by receptor-mediated endocytosis. EMBO J 2002;21:3255-3263.
    • (2002) EMBO J , vol.21 , pp. 3255-3263
    • Bild, A.H.1    Turkson, J.2    Jove, R.3


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