A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells

Gastroenterology

Volumn 147, Issue 4, 2014, Pages 847-859.e11

  Liu, Sanhong ^a   Sun, Xiaohua ^a   Wang, Mingliang ^b   Hou, Yingyong ^c   Zhan, Yu ^a   Jiang, Yuhang ^a   Liu, Zhanjie ^a   Cao, Xinwei ^a   Chen, Pengfei ^a   Liu, Zhi ^a   Chen, Xi ^a   Tao, Yu ^a   Xu, Chen ^c   Mao, Jie ^a   Cheng, Chunyan ^a   Li, Cuifeng ^a   Hu, Yiming ^a   Wang, Lunshan ^a   Chin, Y Eugene ^a   Shi, Yufang ^a   Siebenlist, Ulrich ^d   Zhang, Xiaoren ^a   more..

^a SHANGHAI UNIVERSITY OF MEDICINE AND HEALTH SCIENCES   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c FUDAN UNIVERSITY   (China)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

222 Colon; Cancer; Carcinogenesis; microRNA; microRNA 221

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; AZOXYMETHANE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIM PROTEIN; MESSENGER RNA; MICRORNA 221; MICRORNA 222; MYC PROTEIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PDZ AND LIM DOMAIN 2; PDZ PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P100; PROTEIN P27; PROTEIN P50; PROTEIN P52; S PHASE KINASE ASSOCIATED PROTEIN 2; STAT3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; ACTIN BINDING PROTEIN; MICRORNA; MIRN221 MICRORNA, HUMAN; MIRN222 MICRORNA, HUMAN; PDLIM2 PROTEIN, HUMAN; RELA PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER GROWTH; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; COLITIS; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DRUG POTENTIATION; EPITHELIAL MESENCHYMAL TRANSITION; FEEDBACK SYSTEM; G1 PHASE CELL CYCLE CHECKPOINT; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENETIC CODE; GENETIC TRANSCRIPTION; HCT116 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POINT MUTATION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN STABILITY; REGULATORY MECHANISM; T LYMPHOCYTE; TUMOR VOLUME; UBIQUITINATION; UNTRANSLATED REGION; UPREGULATION; VIRAL GENE THERAPY; 3' UNTRANSLATED REGION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL SURVIVAL; COLORECTAL NEOPLASMS; DISEASE MODEL; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HT 29 CELL LINE; MALE; METABOLISM; NUDE MOUSE; OPEN READING FRAME; PATHOLOGY; REPORTER GENE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME;

3' UNTRANSLATED REGIONS; ANIMALS; BINDING SITES; CELL PROLIFERATION; CELL SURVIVAL; COLITIS; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HCT116 CELLS; HT29 CELLS; HUMANS; LIM DOMAIN PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; MICROFILAMENT PROTEINS; MICRORNAS; NF-KAPPA B; OPEN READING FRAMES; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TRANSFECTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84921683452     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.06.006     Document Type: Article

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