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Volumn 145, Issue 6, 2013, Pages

Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia

Author keywords

Gene Regulation; Mouse Model; Stomach Cancer; TNF

Indexed keywords

ALISERTIB; AURORA A KINASE; I KAPPA B ALPHA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84888264541     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.08.050     Document Type: Article
Times cited : (89)

References (44)
  • 1
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • 8:S4-S66
    • D.M. Parkin, F.I. Bray, and S.S. Devesa Cancer burden in the year 2000. The global picture Eur J Cancer 37 Suppl 2001 8:S4-S66
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL.
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 2
    • 0037569704 scopus 로고    scopus 로고
    • The epidemiology of gastric cancer
    • D.M. Roder The epidemiology of gastric cancer Gastric Cancer 5 Suppl 1 2002 5 11
    • (2002) Gastric Cancer , vol.5 , Issue.SUPPL. 1 , pp. 5-11
    • Roder, D.M.1
  • 3
    • 33845901485 scopus 로고    scopus 로고
    • Medicinal prevention of gastrointestinal tumors: Aspirin, Helicobacter and more?
    • 1232-1234, 1236-1238
    • J.C. Becker, W. Domschke, and T. Pohle [Medicinal prevention of gastrointestinal tumors: aspirin, Helicobacter and more?] Internist (Berl) 47 2006 1229 1230 1232-1234, 1236-1238
    • (2006) Internist (Berl) , vol.47 , pp. 1229-1230
    • Becker, J.C.1    Domschke, W.2    Pohle, T.3
  • 4
    • 43649109029 scopus 로고    scopus 로고
    • Inflammation and cancer: Role of nuclear factor-kappaB activation
    • S. Maeda, and M. Omata Inflammation and cancer: role of nuclear factor-kappaB activation Cancer Sci 99 2008 836 842
    • (2008) Cancer Sci , vol.99 , pp. 836-842
    • Maeda, S.1    Omata, M.2
  • 5
    • 33845981808 scopus 로고    scopus 로고
    • Inflammation, atrophy, and gastric cancer
    • J.G. Fox, and T.C. Wang Inflammation, atrophy, and gastric cancer J Clin Invest 117 2007 60 69
    • (2007) J Clin Invest , vol.117 , pp. 60-69
    • Fox, J.G.1    Wang, T.C.2
  • 6
    • 79955509042 scopus 로고    scopus 로고
    • Loss of TFF1 is associated with activation of NF-kappaB-mediated inflammation and gastric neoplasia in mice and humans
    • M. Soutto, A. Belkhiri, and M.B. Piazuelo Loss of TFF1 is associated with activation of NF-kappaB-mediated inflammation and gastric neoplasia in mice and humans J Clin Invest 121 2011 1753 1767
    • (2011) J Clin Invest , vol.121 , pp. 1753-1767
    • Soutto, M.1    Belkhiri, A.2    Piazuelo, M.B.3
  • 7
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 8
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • H. Hacker, and M. Karin Regulation and function of IKK and IKK-related kinases Sci STKE 2006 2006 re13
    • (2006) Sci STKE , vol.2006 , pp. 13
    • Hacker, H.1    Karin, M.2
  • 9
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • M. Karin Nuclear factor-kappaB in cancer development and progression Nature 441 2006 431 436
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 10
    • 33645971047 scopus 로고    scopus 로고
    • Good cop, bad cop: The different faces of NF-kappaB
    • N.D. Perkins, and T.D. Gilmore Good cop, bad cop: the different faces of NF-kappaB Cell Death Differ 13 2006 759 772
    • (2006) Cell Death Differ , vol.13 , pp. 759-772
    • Perkins, N.D.1    Gilmore, T.D.2
  • 11
    • 77449136104 scopus 로고    scopus 로고
    • XIAP as a ubiquitin ligase in cellular signaling
    • S. Galban, and C.S. Duckett XIAP as a ubiquitin ligase in cellular signaling Cell Death Differ 17 2010 54 60
    • (2010) Cell Death Differ , vol.17 , pp. 54-60
    • Galban, S.1    Duckett, C.S.2
  • 12
    • 0034352334 scopus 로고    scopus 로고
    • Regulation of Bcl-xL: A little bit of this and a little bit of STAT
    • J.M. Grad, X.R. Zeng, and L.H. Boise Regulation of Bcl-xL: a little bit of this and a little bit of STAT Curr Opin Oncol 12 2000 543 549
    • (2000) Curr Opin Oncol , vol.12 , pp. 543-549
    • Grad, J.M.1    Zeng, X.R.2    Boise, L.H.3
  • 13
    • 26444605834 scopus 로고    scopus 로고
    • IKK/NF-kappaB signaling: Balancing life and death-a new approach to cancer therapy
    • J.L. Luo, H. Kamata, and M. Karin IKK/NF-kappaB signaling: balancing life and death-a new approach to cancer therapy J Clin Invest 115 2005 2625 2632
    • (2005) J Clin Invest , vol.115 , pp. 2625-2632
    • Luo, J.L.1    Kamata, H.2    Karin, M.3
  • 14
    • 76649120544 scopus 로고    scopus 로고
    • Aurora kinase inhibitors - Rising stars in cancer therapeutics?
    • A.A. Dar, L.W. Goff, and S. Majid Aurora kinase inhibitors - rising stars in cancer therapeutics? Mol Cancer Ther 9 2010 268 278
    • (2010) Mol Cancer Ther , vol.9 , pp. 268-278
    • Dar, A.A.1    Goff, L.W.2    Majid, S.3
  • 15
    • 78649476052 scopus 로고    scopus 로고
    • Shared and separate functions of polo-like kinases and aurora kinases in cancer
    • S.M. Lens, E.E. Voest, and R.H. Medema Shared and separate functions of polo-like kinases and aurora kinases in cancer Nat Rev Cancer 10 2010 825 841
    • (2010) Nat Rev Cancer , vol.10 , pp. 825-841
    • Lens, S.M.1    Voest, E.E.2    Medema, R.H.3
  • 16
    • 55349124289 scopus 로고    scopus 로고
    • Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells
    • A.A. Dar, A. Belkhiri, and J. Ecsedy Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells Cancer Res 68 2008 8998 9004
    • (2008) Cancer Res , vol.68 , pp. 8998-9004
    • Dar, A.A.1    Belkhiri, A.2    Ecsedy, J.3
  • 18
    • 84859405151 scopus 로고    scopus 로고
    • The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells
    • V. Sehdev, D. Peng, and M. Soutto The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells Mol Cancer Ther 11 2012 763 774
    • (2012) Mol Cancer Ther , vol.11 , pp. 763-774
    • Sehdev, V.1    Peng, D.2    Soutto, M.3
  • 19
    • 77956588949 scopus 로고    scopus 로고
    • Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state
    • J. den Hollander, S. Rimpi, and J.R. Doherty Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state Blood 116 2010 1498 1505
    • (2010) Blood , vol.116 , pp. 1498-1505
    • Den Hollander, J.1    Rimpi, S.2    Doherty, J.R.3
  • 20
    • 60149085428 scopus 로고    scopus 로고
    • The aurora kinase A regulates GSK-3beta in gastric cancer cells
    • A.A. Dar, A. Belkhiri, and W. El-Rifai The aurora kinase A regulates GSK-3beta in gastric cancer cells Oncogene 28 2009 866 875
    • (2009) Oncogene , vol.28 , pp. 866-875
    • Dar, A.A.1    Belkhiri, A.2    El-Rifai, W.3
  • 21
    • 9144251019 scopus 로고    scopus 로고
    • Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    • H. Katayama, K. Sasai, and H. Kawai Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 Nat Genet 36 2004 55 62
    • (2004) Nat Genet , vol.36 , pp. 55-62
    • Katayama, H.1    Sasai, K.2    Kawai, H.3
  • 22
    • 33749605644 scopus 로고    scopus 로고
    • Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells
    • H. Yang, L. He, and P. Kruk Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells Int J Cancer 119 2006 2304 2312
    • (2006) Int J Cancer , vol.119 , pp. 2304-2312
    • Yang, H.1    He, L.2    Kruk, P.3
  • 23
    • 79958117200 scopus 로고    scopus 로고
    • Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells
    • K. Sumi, K. Tago, and T. Kasahara Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells FEBS Lett 585 2011 1884 1890
    • (2011) FEBS Lett , vol.585 , pp. 1884-1890
    • Sumi, K.1    Tago, K.2    Kasahara, T.3
  • 24
    • 57849107571 scopus 로고    scopus 로고
    • Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
    • T. Otto, S. Horn, and M. Brockmann Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma Cancer Cell 15 2009 67 78
    • (2009) Cancer Cell , vol.15 , pp. 67-78
    • Otto, T.1    Horn, S.2    Brockmann, M.3
  • 25
    • 77954686021 scopus 로고    scopus 로고
    • A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
    • G. Gorgun, E. Calabrese, and T. Hideshima A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma Blood 115 2010 5202 5213
    • (2010) Blood , vol.115 , pp. 5202-5213
    • Gorgun, G.1    Calabrese, E.2    Hideshima, T.3
  • 26
    • 79957528550 scopus 로고    scopus 로고
    • The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib
    • K.R. Kelly, J. Ecsedy, and E. Medina The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib J Cell Mol Med 15 2011 2057 2070
    • (2011) J Cell Mol Med , vol.15 , pp. 2057-2070
    • Kelly, K.R.1    Ecsedy, J.2    Medina, E.3
  • 27
    • 84055217855 scopus 로고    scopus 로고
    • Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays
    • M.G. Manfredi, J.A. Ecsedy, and A. Chakravarty Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays Clin Cancer Res 17 2011 7614 7624
    • (2011) Clin Cancer Res , vol.17 , pp. 7614-7624
    • Manfredi, M.G.1    Ecsedy, J.A.2    Chakravarty, A.3
  • 28
    • 10244252625 scopus 로고    scopus 로고
    • Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein
    • O. Lefebvre, M.P. Chenard, and R. Masson Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein Science 274 1996 259 262
    • (1996) Science , vol.274 , pp. 259-262
    • Lefebvre, O.1    Chenard, M.P.2    Masson, R.3
  • 29
    • 0038179858 scopus 로고    scopus 로고
    • 3′-[18F]fluoro-3′-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease
    • M. Wagner, U. Seitz, and A. Buck 3′-[18F]fluoro-3′- deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease Cancer Res 63 2003 2681 2687
    • (2003) Cancer Res , vol.63 , pp. 2681-2687
    • Wagner, M.1    Seitz, U.2    Buck, A.3
  • 30
    • 0035379555 scopus 로고    scopus 로고
    • Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38
    • L.V. Madrid, M.W. Mayo, and J.Y. Reuther Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38 J Biol Chem 276 2001 18934 18940
    • (2001) J Biol Chem , vol.276 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3
  • 31
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
    • L.V. Madrid, C.Y. Wang, and D.C. Guttridge Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB Mol Cell Biol 20 2000 1626 1638
    • (2000) Mol Cell Biol , vol.20 , pp. 1626-1638
    • Madrid, L.V.1    Wang, C.Y.2    Guttridge, D.C.3
  • 32
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • O.N. Ozes, L.D. Mayo, and J.A. Gustin NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase Nature 401 1999 82 85
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3
  • 33
    • 54449088686 scopus 로고    scopus 로고
    • Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    • C.M. Cahill, and J.T. Rogers Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1 J Biol Chem 283 2008 25900 25912
    • (2008) J Biol Chem , vol.283 , pp. 25900-25912
    • Cahill, C.M.1    Rogers, J.T.2
  • 34
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    • H.C. Dan, M.J. Cooper, and P.C. Cogswell Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK Genes Dev 22 2008 1490 1500
    • (2008) Genes Dev , vol.22 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3
  • 35
    • 71049172548 scopus 로고    scopus 로고
    • Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival
    • J.E. Yao, M. Yan, and Z. Guan Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival Mol Cancer 8 2009 95
    • (2009) Mol Cancer , vol.8 , pp. 95
    • Yao, J.E.1    Yan, M.2    Guan, Z.3
  • 36
    • 84873408412 scopus 로고    scopus 로고
    • The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas
    • V. Sehdev, A. Katsha, and J. Ecsedy The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas Cancer 119 2013 904 914
    • (2013) Cancer , vol.119 , pp. 904-914
    • Sehdev, V.1    Katsha, A.2    Ecsedy, J.3
  • 37
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • V. Baud, and M. Karin Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls Nat Rev Drug Discov 8 2009 33 40
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 38
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-kappaB in p53-mediated programmed cell death
    • K.M. Ryan, M.K. Ernst, and N.R. Rice Role of NF-kappaB in p53-mediated programmed cell death Nature 404 2000 892 897
    • (2000) Nature , vol.404 , pp. 892-897
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3
  • 39
    • 0442323562 scopus 로고    scopus 로고
    • NF-kappaB: Tumor promoter or suppressor?
    • N.D. Perkins NF-kappaB: tumor promoter or suppressor? Trends Cell Biol 14 2004 64 69
    • (2004) Trends Cell Biol , vol.14 , pp. 64-69
    • Perkins, N.D.1
  • 40
    • 0043172452 scopus 로고    scopus 로고
    • P53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor
    • S. Rocha, K.J. Campbell, and N.D. Perkins p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor Mol Cell 12 2003 15 25
    • (2003) Mol Cell , vol.12 , pp. 15-25
    • Rocha, S.1    Campbell, K.J.2    Perkins, N.D.3
  • 41
    • 78650993111 scopus 로고    scopus 로고
    • 7th edition of the AJCC cancer staging manual: Stomach
    • K. Washington 7th edition of the AJCC cancer staging manual: stomach Ann Surg Oncol 17 2010 3077 3079
    • (2010) Ann Surg Oncol , vol.17 , pp. 3077-3079
    • Washington, K.1
  • 42
    • 77955299406 scopus 로고    scopus 로고
    • Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis
    • K. Mukherjee, D. Peng, and Z. Brifkani Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis Surgery 148 2010 354 363
    • (2010) Surgery , vol.148 , pp. 354-363
    • Mukherjee, K.1    Peng, D.2    Brifkani, Z.3
  • 43
    • 77954686021 scopus 로고    scopus 로고
    • A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
    • G. Gorgun, E. Calabrese, and T. Hideshima A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma Blood 115 2010 5202 5213
    • (2010) Blood , vol.115 , pp. 5202-5213
    • Gorgun, G.1    Calabrese, E.2    Hideshima, T.3
  • 44
    • 0036897237 scopus 로고    scopus 로고
    • Gastric cancers overexpress S100A calcium-binding proteins
    • W. El-Rifai, C.A. Moskaluk, and M.K. Abdrabbo Gastric cancers overexpress S100A calcium-binding proteins Cancer Res 62 2002 6823 6826
    • (2002) Cancer Res , vol.62 , pp. 6823-6826
    • El-Rifai, W.1    Moskaluk, C.A.2    Abdrabbo, M.K.3


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