Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Abubaker, Khalid ^a,b   Luwor, Rodney B ^b   Zhu, Hongjian ^b   McNally, Orla ^a,b   Quinn, Michael A ^a,b   Burns, Christopher J ^c   Thompson, Erik W ^b,d   Findlay, Jock K ^a,b,e   Ahmed, Nuzhat ^a,b,e  

^a ROYAL WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Ascites; Cancer stem cell; Chemoresistance; JAK2 STAT3 pathway; Metastasis; Ovarian carcinoma; Recurrence

Indexed keywords

BETA TUBULIN; EPITHELIAL CELL ADHESION MOLECULE; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; JAGGED1; JANUS KINASE 2; MOMELOTINIB; OCTAMER TRANSCRIPTION FACTOR 4; PACLITAXEL; STAT3 PROTEIN; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR NANOG; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; JAK2 PROTEIN, HUMAN; N-(CYANOMETHYL)-4-(2-((4-(4-MORPHOLINYL)PHENYL)AMINO)-4-PYRIMIDINYL)BENZAMIDE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; STAT3 PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; CANCER STEM CELL; CELL GROWTH; CELL LOSS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OVARY CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR GROWTH; TUMOR VOLUME; ADULT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ENZYMOLOGY; METABOLISM; MIDDLE AGED; MINIMAL RESIDUAL DISEASE; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; OVARIAN NEOPLASMS; PATHOLOGY; SIGNAL TRANSDUCTION; TIME; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR RECURRENCE;

ADULT; AGED; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZAMIDES; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; JANUS KINASE 2; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; MOLECULAR TARGETED THERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASM, RESIDUAL; NEOPLASTIC STEM CELLS; OVARIAN NEOPLASMS; PACLITAXEL; PROTEIN KINASE INHIBITORS; PYRIMIDINES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TUMOR BURDEN; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84900865954     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-317     Document Type: Article

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