메뉴 건너뛰기




Volumn 40, Issue , 2015, Pages 27-34

Extracellular vesicles as modulators of the cancer microenvironment

Author keywords

Angiogenesis; Exosomes; Immune evasion; Metastatic niche; Microvesicles; Stroma

Indexed keywords

ANGIOGENIC PROTEIN; MESSENGER RNA;

EID: 84929293007     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2015.01.013     Document Type: Review
Times cited : (129)

References (95)
  • 1
    • 33646416463 scopus 로고    scopus 로고
    • The regulation of exosome secretion: a novel function of the p53 protein
    • Yu X., Harris S.L., Levine A.J. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res 2006, 66:4795-4801.
    • (2006) Cancer Res , vol.66 , pp. 4795-4801
    • Yu, X.1    Harris, S.L.2    Levine, A.J.3
  • 2
    • 77953142134 scopus 로고    scopus 로고
    • Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
    • Park J.E., Tan H.S., Datta A., Lai R.C., Zhang H., Meng W., et al. Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics 2010, 9:1085-1099.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1085-1099
    • Park, J.E.1    Tan, H.S.2    Datta, A.3    Lai, R.C.4    Zhang, H.5    Meng, W.6
  • 3
  • 4
    • 85013156831 scopus 로고    scopus 로고
    • Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
    • de Jong O.G., Verhaar M.C., Chen Y., Vader P., Gremmels H., Posthuma G., et al. Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. J Extracell Vesicles 2012, 1:18396.
    • (2012) J Extracell Vesicles , vol.1 , pp. 18396
    • de Jong, O.G.1    Verhaar, M.C.2    Chen, Y.3    Vader, P.4    Gremmels, H.5    Posthuma, G.6
  • 5
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: coping with an imperfect nomenclature for extracellular vesicles
    • Gould S.J., Raposo G. As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles 2013, 2. 10.3402/jev.v2i0.20389.
    • (2013) J Extracell Vesicles , vol.2
    • Gould, S.J.1    Raposo, G.2
  • 7
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
    • Johnstone R., Adam M., Hammond J., Orr L., Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem 1987, 262:9412-9420.
    • (1987) J Biol Chem , vol.262 , pp. 9412-9420
    • Johnstone, R.1    Adam, M.2    Hammond, J.3    Orr, L.4    Turbide, C.5
  • 9
  • 11
    • 84879046970 scopus 로고    scopus 로고
    • Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1
    • Svensson K.J., Christianson H.C., Wittrup A., Bourseau-Guilmain E., Lindqvist E., Svensson L.M., et al. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem 2013, 288:17713-17724.
    • (2013) J Biol Chem , vol.288 , pp. 17713-17724
    • Svensson, K.J.1    Christianson, H.C.2    Wittrup, A.3    Bourseau-Guilmain, E.4    Lindqvist, E.5    Svensson, L.M.6
  • 12
    • 23944509766 scopus 로고    scopus 로고
    • Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
    • del Conde I., Shrimpton C.N., Thiagarajan P., López J.A. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 2005, 106:1604-1611.
    • (2005) Blood , vol.106 , pp. 1604-1611
    • del Conde, I.1    Shrimpton, C.N.2    Thiagarajan, P.3    López, J.A.4
  • 13
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi K., Meehan B., Micallef J., Lhotak V., May L., Guha A., et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 2008, 10:619-624.
    • (2008) Nat Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4    May, L.5    Guha, A.6
  • 15
    • 0037114287 scopus 로고    scopus 로고
    • Production and characterization of clinical grade exosomes derived from dendritic cells
    • Lamparski H., Metha-Damani A., Yao J., Patel S., Hsu D., Ruegg C., et al. Production and characterization of clinical grade exosomes derived from dendritic cells. J Immunol Methods 2002, 270:211-226.
    • (2002) J Immunol Methods , vol.270 , pp. 211-226
    • Lamparski, H.1    Metha-Damani, A.2    Yao, J.3    Patel, S.4    Hsu, D.5    Ruegg, C.6
  • 16
    • 18144369346 scopus 로고    scopus 로고
    • A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
    • Morse M., Garst J., Osada T., Khan S., Hobeika A., Clay T., et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med 2005, 3:9.
    • (2005) J Transl Med , vol.3 , pp. 9
    • Morse, M.1    Garst, J.2    Osada, T.3    Khan, S.4    Hobeika, A.5    Clay, T.6
  • 17
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial
    • Escudier B., Dorval T., Chaput N., André F., Caby M., Novault S., et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J Transl Med 2005, 3:10.
    • (2005) J Transl Med , vol.3 , pp. 10
    • Escudier, B.1    Dorval, T.2    Chaput, N.3    André, F.4    Caby, M.5    Novault, S.6
  • 18
    • 10744220836 scopus 로고    scopus 로고
    • Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection
    • Chaput N., Schartz N.E.C., Andre F., Taieb J., Novault S., Bonnaventure P., et al. Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection. J Immunol 2004, 172:2137-2146.
    • (2004) J Immunol , vol.172 , pp. 2137-2146
    • Chaput, N.1    Schartz, N.E.C.2    Andre, F.3    Taieb, J.4    Novault, S.5    Bonnaventure, P.6
  • 19
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers J., Lozier A., Raposo G., Regnault A., Thery C., Masurier C., et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 2001, 7:297-303.
    • (2001) Nat Med , vol.7 , pp. 297-303
    • Wolfers, J.1    Lozier, A.2    Raposo, G.3    Regnault, A.4    Thery, C.5    Masurier, C.6
  • 20
    • 39449101177 scopus 로고    scopus 로고
    • Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses
    • Zeelenberg I.S., Ostrowski M., Krumeich S., Bobrie A., Jancic C., Boissonnas A., et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res 2008, 68:1228-1235.
    • (2008) Cancer Res , vol.68 , pp. 1228-1235
    • Zeelenberg, I.S.1    Ostrowski, M.2    Krumeich, S.3    Bobrie, A.4    Jancic, C.5    Boissonnas, A.6
  • 21
    • 33745362875 scopus 로고    scopus 로고
    • Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells
    • Weilin C., Jianli W., Chuansen S., Shuxun L., Yizhi Y., Qingqing W., et al. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol 2006, 36:1598-1607.
    • (2006) Eur J Immunol , vol.36 , pp. 1598-1607
    • Weilin, C.1    Jianli, W.2    Chuansen, S.3    Shuxun, L.4    Yizhi, Y.5    Qingqing, W.6
  • 22
    • 34447549680 scopus 로고    scopus 로고
    • Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells
    • Dai S., Zhou X., Wang B., Wang Q., Fu Y., Chen T., et al. Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells. J Mol Med 2006, 84:1067-1076.
    • (2006) J Mol Med , vol.84 , pp. 1067-1076
    • Dai, S.1    Zhou, X.2    Wang, B.3    Wang, Q.4    Fu, Y.5    Chen, T.6
  • 23
    • 84880049306 scopus 로고    scopus 로고
    • Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes
    • Gehrmann U., Hiltbrunner S., Georgoudaki A.-M., Karlsson M.C., Näslund T.I., Gabrielsson S. Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes. Cancer Res 2013, 73:3865-3876.
    • (2013) Cancer Res , vol.73 , pp. 3865-3876
    • Gehrmann, U.1    Hiltbrunner, S.2    Georgoudaki, A.-M.3    Karlsson, M.C.4    Näslund, T.I.5    Gabrielsson, S.6
  • 24
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola G., Rivoltini L., Castelli C., Huber V., Perego P., Deho P., et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med 2002, 195:1303-1316.
    • (2002) J Exp Med , vol.195 , pp. 1303-1316
    • Andreola, G.1    Rivoltini, L.2    Castelli, C.3    Huber, V.4    Perego, P.5    Deho, P.6
  • 25
    • 20444453596 scopus 로고    scopus 로고
    • Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape
    • Huber V., Fais S., Iero M., Lugini L., Canese P., Squarcina P., et al. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Gastroenterology 2005, 128:1796-1804.
    • (2005) Gastroenterology , vol.128 , pp. 1796-1804
    • Huber, V.1    Fais, S.2    Iero, M.3    Lugini, L.4    Canese, P.5    Squarcina, P.6
  • 26
    • 0242525678 scopus 로고    scopus 로고
    • T-cell apoptosis and suppression of T-cell receptor/CD3-ξ by Fas ligand-containing membrane vesicles shed from ovarian tumors
    • Taylor D.D., Gerçel-Taylor Ç., Lyons K.S., Stanson J., Whiteside T.L. T-cell apoptosis and suppression of T-cell receptor/CD3-ξ by Fas ligand-containing membrane vesicles shed from ovarian tumors. Clin Cancer Res 2003, 9:5113-5119.
    • (2003) Clin Cancer Res , vol.9 , pp. 5113-5119
    • Taylor, D.D.1    Gerçel-Taylor, Ç.2    Lyons, K.S.3    Stanson, J.4    Whiteside, T.L.5
  • 27
    • 61849139471 scopus 로고    scopus 로고
    • Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
    • Klibi J., Niki T., Riedel A., Pioche-Durieu C., Souquere S., Rubinstein E., et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood 2009, 113:1957-1966.
    • (2009) Blood , vol.113 , pp. 1957-1966
    • Klibi, J.1    Niki, T.2    Riedel, A.3    Pioche-Durieu, C.4    Souquere, S.5    Rubinstein, E.6
  • 28
    • 14844334129 scopus 로고    scopus 로고
    • Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    • Taylor D., Gerçel-Taylor C. Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer 2005, 92:305-311.
    • (2005) Br J Cancer , vol.92 , pp. 305-311
    • Taylor, D.1    Gerçel-Taylor, C.2
  • 29
    • 33747189760 scopus 로고    scopus 로고
    • ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15
    • Sutherland C.L., Rabinovich B., Chalupny N.J., Brawand P., Miller R., Cosman D. ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15. Blood 2006, 108:1313-1319.
    • (2006) Blood , vol.108 , pp. 1313-1319
    • Sutherland, C.L.1    Rabinovich, B.2    Chalupny, N.J.3    Brawand, P.4    Miller, R.5    Cosman, D.6
  • 30
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh V., Wu J., Yee C., Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 2002, 419:734-738.
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 31
    • 18844376919 scopus 로고    scopus 로고
    • Exosomes and the MICA-NKG2D system in cancer
    • Clayton A., Tabi Z. Exosomes and the MICA-NKG2D system in cancer. Blood Cells Mol Dis 2005, 34:206-213.
    • (2005) Blood Cells Mol Dis , vol.34 , pp. 206-213
    • Clayton, A.1    Tabi, Z.2
  • 33
    • 68949117871 scopus 로고    scopus 로고
    • Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function
    • Hedlund M., Stenqvist A.-C., Nagaeva O., Kjellberg L., Wulff M., Baranov V., et al. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. J Immunol 2009, 183:340-351.
    • (2009) J Immunol , vol.183 , pp. 340-351
    • Hedlund, M.1    Stenqvist, A.-C.2    Nagaeva, O.3    Kjellberg, L.4    Wulff, M.5    Baranov, V.6
  • 34
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu C., Yu S., Zinn K., Wang J., Zhang L., Jia Y., et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J Immunol 2006, 176:1375-1385.
    • (2006) J Immunol , vol.176 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn, K.3    Wang, J.4    Zhang, L.5    Jia, Y.6
  • 35
    • 84879716313 scopus 로고    scopus 로고
    • Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity
    • Reiners K.S., Topolar D., Henke A., Simhadri V.R., Kessler J., Sauer M., et al. Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity. Blood 2013, 121:3658-3665.
    • (2013) Blood , vol.121 , pp. 3658-3665
    • Reiners, K.S.1    Topolar, D.2    Henke, A.3    Simhadri, V.R.4    Kessler, J.5    Sauer, M.6
  • 36
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • Clayton A., Mitchell J.P., Court J., Mason M.D., Tabi Z. Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res 2007, 67:7458-7466.
    • (2007) Cancer Res , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 37
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • Szajnik M., Czystowska M., Szczepanski M.J., Mandapathil M., Whiteside T.L. tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS ONE 2010, 5:e11469.
    • (2010) PLoS ONE , vol.5 , pp. e11469
    • Szajnik, M.1    Czystowska, M.2    Szczepanski, M.J.3    Mandapathil, M.4    Whiteside, T.L.5
  • 38
    • 70349315105 scopus 로고    scopus 로고
    • Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes
    • Wieckowski E.U., Visus C., Szajnik M., Szczepanski M.J., Storkus W.J., Whiteside T.L. Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes. J Immunol 2009, 183:3720-3730.
    • (2009) J Immunol , vol.183 , pp. 3720-3730
    • Wieckowski, E.U.1    Visus, C.2    Szajnik, M.3    Szczepanski, M.J.4    Storkus, W.J.5    Whiteside, T.L.6
  • 39
    • 77958553947 scopus 로고    scopus 로고
    • Surface-bound TGF-beta-1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions
    • Wada J., Onishi H., Suzuki H., Yamasaki A., Nagai S., Morisaki T., et al. Surface-bound TGF-beta-1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions. Anticancer Res 2010, 30:3747-3757.
    • (2010) Anticancer Res , vol.30 , pp. 3747-3757
    • Wada, J.1    Onishi, H.2    Suzuki, H.3    Yamasaki, A.4    Nagai, S.5    Morisaki, T.6
  • 40
    • 84883502274 scopus 로고    scopus 로고
    • Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction
    • Yu L., Yang F., Jiang L., Chen Y., Wang K., Xu F., et al. Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction. Eur J Immunol 2013, 43:2461-2472.
    • (2013) Eur J Immunol , vol.43 , pp. 2461-2472
    • Yu, L.1    Yang, F.2    Jiang, L.3    Chen, Y.4    Wang, K.5    Xu, F.6
  • 41
    • 84865355844 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling
    • Mokarizadeh A., Delirezh N., Morshedi A., Mosayebi G., Farshid A.-A., Mardani K. Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling. Immunol Lett 2012, 147:47-54.
    • (2012) Immunol Lett , vol.147 , pp. 47-54
    • Mokarizadeh, A.1    Delirezh, N.2    Morshedi, A.3    Mosayebi, G.4    Farshid, A.-A.5    Mardani, K.6
  • 42
    • 79960984966 scopus 로고    scopus 로고
    • Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model
    • Yang C., Kim S.-H., Bianco N.R., Robbins P.D. Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model. PLoS ONE 2011, 6:e22517.
    • (2011) PLoS ONE , vol.6 , pp. e22517
    • Yang, C.1    Kim, S.-H.2    Bianco, N.R.3    Robbins, P.D.4
  • 43
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-{beta}-mediated suppressive activity on T lymphocytes
    • Valenti R., Huber V., Filipazzi P., Pilla L., Sovena G., Villa A., et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-{beta}-mediated suppressive activity on T lymphocytes. Cancer Res 2006, 66:9290-9298.
    • (2006) Cancer Res , vol.66 , pp. 9290-9298
    • Valenti, R.1    Huber, V.2    Filipazzi, P.3    Pilla, L.4    Sovena, G.5    Villa, A.6
  • 44
    • 34249792918 scopus 로고    scopus 로고
    • Tumor exosomes inhibit differentiation of bone marrow dendritic cells
    • Yu S., Liu C., Su K., Wang J., Liu Y., Zhang L., et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells. J Immunol 2007, 178:6867-6875.
    • (2007) J Immunol , vol.178 , pp. 6867-6875
    • Yu, S.1    Liu, C.2    Su, K.3    Wang, J.4    Liu, Y.5    Zhang, L.6
  • 45
    • 64249115813 scopus 로고    scopus 로고
    • Induction of myeloid-derived suppressor cells by tumor exosomes
    • Xiang A., P C., L Y., L Z.B., D J.W., et al. Induction of myeloid-derived suppressor cells by tumor exosomes. Int J Cancer 2009, 124:2621-2633.
    • (2009) Int J Cancer , vol.124 , pp. 2621-2633
    • Xiang, A.1    P, C.2    L, Y.3    L, Z.B.4    D, J.W.5
  • 46
    • 77952042113 scopus 로고    scopus 로고
    • Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells
    • Liu Y., Xiang X., Zhuang X., Zhang S., Liu C., Cheng Z., et al. Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells. Am J Pathol 2010, 176:2490-2499.
    • (2010) Am J Pathol , vol.176 , pp. 2490-2499
    • Liu, Y.1    Xiang, X.2    Zhuang, X.3    Zhang, S.4    Liu, C.5    Cheng, Z.6
  • 47
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F., Ladoire S., Mignot G., Vincent J., Bruchard M., Remy-Martin J.P., et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest 2010, 120:457-471.
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Remy-Martin, J.P.6
  • 48
    • 79955548092 scopus 로고    scopus 로고
    • Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC
    • Battke C., Ruiss R., Welsch U., Wimberger P., Lang S., Jochum S., et al. Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC. Cancer Immunol Immunother 2011, 60:639-648.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 639-648
    • Battke, C.1    Ruiss, R.2    Welsch, U.3    Wimberger, P.4    Lang, S.5    Jochum, S.6
  • 49
    • 79960516623 scopus 로고    scopus 로고
    • Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production
    • Clayton A., Al-Taei S., Webber J., Mason M.D., Tabi Z. Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. J Immunol 2011, 187:676-683.
    • (2011) J Immunol , vol.187 , pp. 676-683
    • Clayton, A.1    Al-Taei, S.2    Webber, J.3    Mason, M.D.4    Tabi, Z.5
  • 51
    • 84881232071 scopus 로고    scopus 로고
    • Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
    • Welti J., Loges S., Dimmeler S., Carmeliet P. Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J Clin Invest 2013, 123:3190-3200.
    • (2013) J Clin Invest , vol.123 , pp. 3190-3200
    • Welti, J.1    Loges, S.2    Dimmeler, S.3    Carmeliet, P.4
  • 52
    • 77950948813 scopus 로고    scopus 로고
    • Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy
    • Abdollahi A., Folkman J. Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy. Drug Resist Updat 2010, 13:16-28.
    • (2010) Drug Resist Updat , vol.13 , pp. 16-28
    • Abdollahi, A.1    Folkman, J.2
  • 53
    • 33746886963 scopus 로고    scopus 로고
    • Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029
    • Gesierich S., Berezovskiy I., Ryschich E., Zoller M. Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029. Cancer Res 2006, 66:7083-7094.
    • (2006) Cancer Res , vol.66 , pp. 7083-7094
    • Gesierich, S.1    Berezovskiy, I.2    Ryschich, E.3    Zoller, M.4
  • 54
    • 76749106591 scopus 로고    scopus 로고
    • Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation
    • Nazarenko I., Rana S., Baumann A., McAlear J., Hellwig A., Trendelenburg M., et al. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res 2010, 70:1668-1678.
    • (2010) Cancer Res , vol.70 , pp. 1668-1678
    • Nazarenko, I.1    Rana, S.2    Baumann, A.3    McAlear, J.4    Hellwig, A.5    Trendelenburg, M.6
  • 55
    • 59649085554 scopus 로고    scopus 로고
    • Angiogenesis: a team effort coordinated by notch
    • Phng L.K., Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell 2009, 16:196-208.
    • (2009) Dev Cell , vol.16 , pp. 196-208
    • Phng, L.K.1    Gerhardt, H.2
  • 56
    • 70449517334 scopus 로고    scopus 로고
    • Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer
    • Jubb A.M., Turley H., Moeller H.C., Steers G., Han C., Li J.L., et al. Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. Br J Cancer 2009, 101:1749-1757.
    • (2009) Br J Cancer , vol.101 , pp. 1749-1757
    • Jubb, A.M.1    Turley, H.2    Moeller, H.C.3    Steers, G.4    Han, C.5    Li, J.L.6
  • 57
    • 77957708340 scopus 로고    scopus 로고
    • New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
    • Sheldon H., Heikamp E., Turley H., Dragovic R., Thomas P., Oon C.E., et al. New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood 2010, 116:2385-2394.
    • (2010) Blood , vol.116 , pp. 2385-2394
    • Sheldon, H.1    Heikamp, E.2    Turley, H.3    Dragovic, R.4    Thomas, P.5    Oon, C.E.6
  • 58
    • 62649095692 scopus 로고    scopus 로고
    • Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
    • Al-Nedawi K., Meehan B., Kerbel R.S., Allison A.C., Rak J. Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. PNAS 2009, 106:3794-3799.
    • (2009) PNAS , vol.106 , pp. 3794-3799
    • Al-Nedawi, K.1    Meehan, B.2    Kerbel, R.S.3    Allison, A.C.4    Rak, J.5
  • 60
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J., Wurdinger T., van Rijn S., Meijer D.H., Gainche L., Curry W.T., et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008, 10:1470-1476.
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    van Rijn, S.3    Meijer, D.H.4    Gainche, L.5    Curry, W.T.6
  • 61
    • 71549122588 scopus 로고    scopus 로고
    • Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells
    • Hong B.S., Cho J.-H., Kim H., Choi E.-J., Rho S., Kim J., et al. Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells. BMC Genomics 2009, 10.
    • (2009) BMC Genomics , pp. 10
    • Hong, B.S.1    Cho, J.-H.2    Kim, H.3    Choi, E.-J.4    Rho, S.5    Kim, J.6
  • 62
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H., Ekström K., Bossios A., Sjöstrand M., Lee J.J., Lötvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 63
    • 84879419464 scopus 로고    scopus 로고
    • Leukemia cell to endothelial cell communication via exosomal miRNAs
    • Umezu T., Ohyashiki K., Kuroda M., Ohyashiki J.H. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 2013, 32:2747-2755.
    • (2013) Oncogene , vol.32 , pp. 2747-2755
    • Umezu, T.1    Ohyashiki, K.2    Kuroda, M.3    Ohyashiki, J.H.4
  • 64
    • 79960960417 scopus 로고    scopus 로고
    • Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche
    • Grange C., Tapparo M., Collino F., Vitillo L., Damasco C., Deregibus M.C., et al. Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res 2011, 71:5346-5356.
    • (2011) Cancer Res , vol.71 , pp. 5346-5356
    • Grange, C.1    Tapparo, M.2    Collino, F.3    Vitillo, L.4    Damasco, C.5    Deregibus, M.C.6
  • 65
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • Vaupel P., Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metast Rev 2007, 26:225-239.
    • (2007) Cancer Metast Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 66
    • 68549128599 scopus 로고    scopus 로고
    • Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors
    • Wysoczynski M., Ratajczak M.Z. Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors. Int J Cancer 2009, 125:1595-1603.
    • (2009) Int J Cancer , vol.125 , pp. 1595-1603
    • Wysoczynski, M.1    Ratajczak, M.Z.2
  • 68
    • 84905643012 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
    • Wang T., Gilkes D.M., Takano N., Xiang L., Luo W., Bishop C.J., et al. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci USA 2014, 111(31):E3234-E3242. 10.1073/pnas.1410041111.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.31 , pp. E3234-E3242
    • Wang, T.1    Gilkes, D.M.2    Takano, N.3    Xiang, L.4    Luo, W.5    Bishop, C.J.6
  • 69
    • 84866502787 scopus 로고    scopus 로고
    • Hypoxic enhancement of exosome release by breast cancer cells
    • King H., Michael M., Gleadle J. Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer 2012, 12:421.
    • (2012) BMC Cancer , vol.12 , pp. 421
    • King, H.1    Michael, M.2    Gleadle, J.3
  • 70
    • 84888986034 scopus 로고    scopus 로고
    • Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells
    • Tadokoro H., Umezu T., Ohyashiki K., Hirano T., Ohyashiki J.H. Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells. J Biol Chem 2013, 288:34343-34351.
    • (2013) J Biol Chem , vol.288 , pp. 34343-34351
    • Tadokoro, H.1    Umezu, T.2    Ohyashiki, K.3    Hirano, T.4    Ohyashiki, J.H.5
  • 71
    • 84876927914 scopus 로고    scopus 로고
    • Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
    • Kucharzewska P., Christianson H.C., Welch J.E., Svensson K.J., Fredlund E., Ringnér M., et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci USA 2013, 110:7312-7317.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 7312-7317
    • Kucharzewska, P.1    Christianson, H.C.2    Welch, J.E.3    Svensson, K.J.4    Fredlund, E.5    Ringnér, M.6
  • 74
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Özdemir Berna C., Pentcheva-Hoang T., Carstens Julienne L., Zheng X., Wu C.-C., Simpson Tyler R., et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 2014, 25:719-734.
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Özdemir Berna, C.1    Pentcheva-Hoang, T.2    Carstens Julienne, L.3    Zheng, X.4    Wu, C.-C.5    Simpson Tyler, R.6
  • 76
    • 78649958307 scopus 로고    scopus 로고
    • Cancer exosomes trigger fibroblast to myofibroblast differentiation
    • Webber J., Steadman R., Mason M.D., Tabi Z., Clayton A. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Res 2010, 70:9621-9630.
    • (2010) Cancer Res , vol.70 , pp. 9621-9630
    • Webber, J.1    Steadman, R.2    Mason, M.D.3    Tabi, Z.4    Clayton, A.5
  • 79
    • 84876721085 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells
    • Polanska U.M., Orimo A. Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol 2013, 228:1651-1657.
    • (2013) J Cell Physiol , vol.228 , pp. 1651-1657
    • Polanska, U.M.1    Orimo, A.2
  • 80
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
    • Cho J.A., Park H., Lim E.H., Lee K.W. Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells. Int J Oncol 2012, 40:130-138.
    • (2012) Int J Oncol , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 81
    • 84871451335 scopus 로고    scopus 로고
    • Gastric cancer exosomes trigger differentiation of umbilical cord derived mesenchymal stem cells to carcinoma-associated fibroblasts through TGF-β/Smad pathway
    • Gu J., Qian H., Shen L., Zhang X., Zhu W., Huang L., et al. Gastric cancer exosomes trigger differentiation of umbilical cord derived mesenchymal stem cells to carcinoma-associated fibroblasts through TGF-β/Smad pathway. PLoS ONE 2012, 7:e52465.
    • (2012) PLoS ONE , vol.7 , pp. e52465
    • Gu, J.1    Qian, H.2    Shen, L.3    Zhang, X.4    Zhu, W.5    Huang, L.6
  • 82
    • 84892607130 scopus 로고    scopus 로고
    • Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion
    • Atay S., Banskota S., Crow J., Sethi G., Rink L., Godwin A.K. Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion. Proc Natl Acad Sci USA 2014, 111:711-716.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 711-716
    • Atay, S.1    Banskota, S.2    Crow, J.3    Sethi, G.4    Rink, L.5    Godwin, A.K.6
  • 83
    • 84871563123 scopus 로고    scopus 로고
    • Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration
    • Luga V., Zhang L., Viloria-Petit Alicia M., Ogunjimi Abiodun A., Inanlou Mohammad R., Chiu E., et al. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 2012, 151:1542-1556.
    • (2012) Cell , vol.151 , pp. 1542-1556
    • Luga, V.1    Zhang, L.2    Viloria-Petit Alicia, M.3    Ogunjimi Abiodun, A.4    Inanlou Mohammad, R.5    Chiu, E.6
  • 84
    • 84900549711 scopus 로고    scopus 로고
    • WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells
    • Ekström E.J., Bergenfelz C., von Bülow V., Serifler F., Carlemalm E., Jönsson G., et al. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer 2014, 13:88.
    • (2014) Mol Cancer , vol.13 , pp. 88
    • Ekström, E.J.1    Bergenfelz, C.2    von Bülow, V.3    Serifler, F.4    Carlemalm, E.5    Jönsson, G.6
  • 85
    • 81955167406 scopus 로고    scopus 로고
    • Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
    • Zhu W., Huang L., Li Y., Zhang X., Gu J., Yan Y., et al. Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett 2012, 315:28-37.
    • (2012) Cancer Lett , vol.315 , pp. 28-37
    • Zhu, W.1    Huang, L.2    Li, Y.3    Zhang, X.4    Gu, J.5    Yan, Y.6
  • 86
    • 84875846330 scopus 로고    scopus 로고
    • BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
    • Roccaro A.M., Sacco A., Maiso P., Azab A.K., Tai Y.-T., Reagan M., et al. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest 2013, 123:1542-1555.
    • (2013) J Clin Invest , vol.123 , pp. 1542-1555
    • Roccaro, A.M.1    Sacco, A.2    Maiso, P.3    Azab, A.K.4    Tai, Y.-T.5    Reagan, M.6
  • 87
    • 84874091042 scopus 로고    scopus 로고
    • Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth
    • Bruno S., Collino F., Deregibus M.C., Grange C., Tetta C., Camussi G. Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth. Stem cells Dev 2013, 22:758-771.
    • (2013) Stem cells Dev , vol.22 , pp. 758-771
    • Bruno, S.1    Collino, F.2    Deregibus, M.C.3    Grange, C.4    Tetta, C.5    Camussi, G.6
  • 88
    • 79957879331 scopus 로고    scopus 로고
    • Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    • Hood J.L., San R.S., Wickline S.A. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res 2011, 71:3792-3801.
    • (2011) Cancer Res , vol.71 , pp. 3792-3801
    • Hood, J.L.1    San, R.S.2    Wickline, S.A.3
  • 89
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado H., Aleckovic M., Lavotshkin S., Matei I., Costa-Silva B., Moreno-Bueno G., et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012, 18:883-891.
    • (2012) Nat Med , vol.18 , pp. 883-891
    • Peinado, H.1    Aleckovic, M.2    Lavotshkin, S.3    Matei, I.4    Costa-Silva, B.5    Moreno-Bueno, G.6
  • 90
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce J.A., Pollard J.W. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009, 9:239-252.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 91
    • 84867120348 scopus 로고    scopus 로고
    • Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression
    • Bobrie A., Krumeich S., Reyal F., Recchi C., Moita L.F., Seabra M.C., et al. Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res 2012, 72:4920-4930.
    • (2012) Cancer Res , vol.72 , pp. 4920-4930
    • Bobrie, A.1    Krumeich, S.2    Reyal, F.3    Recchi, C.4    Moita, L.F.5    Seabra, M.C.6
  • 94
    • 84887361291 scopus 로고    scopus 로고
    • Tumor-derived tissue factor - positive microparticles and venous thrombosis in cancer patients
    • Geddings J.E., Mackman N. Tumor-derived tissue factor - positive microparticles and venous thrombosis in cancer patients. Blood 2013, 122:1873-1880.
    • (2013) Blood , vol.122 , pp. 1873-1880
    • Geddings, J.E.1    Mackman, N.2
  • 95
    • 84862734041 scopus 로고    scopus 로고
    • Exosome removal as a therapeutic adjuvant in cancer
    • Marleau A., Chen C.-S., Joyce J., Tullis R. Exosome removal as a therapeutic adjuvant in cancer. J Transl Med 2012, 10:134.
    • (2012) J Transl Med , vol.10 , pp. 134
    • Marleau, A.1    Chen, C.-S.2    Joyce, J.3    Tullis, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.