Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: Role in immune escape

Gastroenterology

Volumn 128, Issue 7, 2005, Pages 1796-1804

  Huber, Veronica ^a   Fais, Stefano ^b   Iero, Manuela ^a   Lugini, Luana ^b   Canese, Paola ^a   Squarcina, Paola ^a   Zaccheddu, Annamaria ^a   Colone, Marisa ^b   Arancia, Giuseppe ^b   Gentile, Massimo ^c   Seregni, Ettore ^a   Valenti, Roberta ^a   Ballabio, Giuseppina ^a   Belli, Filiberto ^a   Leo, Ermanno ^a   Parmiani, Giorgio ^a   Rivoltini, Licia ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CASPASE; CD63 ANTIGEN; CD8 ANTIGEN; FAS LIGAND; HLA ANTIGEN CLASS 1; LIPOCORTIN 5; PROPIDIUM IODIDE; TUMOR MARKER; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL DESTRUCTION; CELL DEATH; CELL VACUOLE; COLORECTAL CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; IN VITRO STUDY; LYSOSOME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURIFICATION; SECRETORY VESICLE; T LYMPHOCYTE; WESTERN BLOTTING;

EID: 20444453596     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.03.045     Document Type: Article

References (30)

1. G. Van Niel, G. Raposo, C. Candalh, M. Boussac, R. Hershberg, N. Cerf-Bensussan, M. Heyman Intestinal epithelial cells secrete exosome-like vesicles Gastroenterology 121 2001 337 349
2. B. Fevrier, G. Raposo Exosomes endosomal-derived vesicles shipping extracellular messages Curr Opin Cell Biol 16 2004 415 421
3. K. Denzer, M.J. Kleijmeer, H.F. Heijnen, W. Stoorvogel, H.J. Geuze Exosome from internal vesicle of the multivesicular body to intercellular signaling device J Cell Sci 113 2000 3365 3374
4. M. Karlsson, S. Lundin, U. Dahlgren, H. Kahu, I. Pettersson, E. Telemo "Tolerosomes" are produced by intestinal epithelial cells Eur J Immunol 31 2001 2892 2900
5. H. Peche, M. Heslan, C. Usal, S. Amigorena, M.C. Cuturi Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection Transplantation 76 2003 1503 1510
6. A.E. Morelli, A.T. Larregina, W.J. Shufesky, M.L. Sullivan, D.B. Stolz, G.D. Papworth, A.F. Zahorchak, A.J. Logar, Z. Wang, S.C. Watkins, L.D. Falo Jr, A.W. Thomson Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells Blood 104 2004 3257 3266
7. F.M. Marincola, E.M. Jaffee, D.J. Hicklin, S. Ferrone Escape of human solid tumors from T-cell recognition molecular mechanisms and significance Adv Immunol 74 2000 181 273
8. P. Dalerba, C. Maccalli, C. Casati, C. Castelli, G. Parmiani Immunology and immunotherapy of colorectal cancer Crit Rev Oncol Hematol 46 2003 33 57
9. J. O'Connell, G.C. O'Sullivan, J.K. Collins, F. Shanahan The Fas counterattack Fas-mediated T cell killing by colon cancer cells expressing Fas ligand J Exp Med 184 1996 1075 1082
10. R.M. Siegel, F.K. Chan, H.J. Chun, M.J. Lenardo The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity Nat Immunol 1 2000 469 474
11. J. O'Connell, M.W. Bennett, G.C. O'Sullivan, J.K. Collins, F. Shanahan The Fas counterattack cancer as a site of immune privilege Immunol Today 20 1999 46 52
12. J. O'Connell, M.W. Bennett, K. Nally, A. Houston, G.C. O'Sullivan, F. Shanahan Altered mechanisms of apoptosis in colon cancer Fas resistance and counterattack in the tumor-immune conflict Ann N Y Acad Sci 910 2000 178 192
13. H. Inoue, K. Shiraki, T. Yamanaka, S. Ohmori, T. Sakai, M. Deguchi, H. Okano, K. Murata, K. Sugimoto, T. Nakano Functional expression of tumor necrosis factor-related apoptosis-inducing ligand in human colonic adenocarcinoma cells Lab Invest 82 2002 1111 1119
14. K. Takeda, M.J. Smyth, E. Cretney, Y. Hayakawa, N. Kayagaki, H. Yagita, K. Okumura Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development J Exp Med 195 2002 161 169
15. S.R. Wiley, K. Schooley, P.J. Smolak, W.S. Din, C.P. Huang, J.K. Nicholl, G.R. Sutherland, T.D. Smith, C. Rauch, C.A. Smith, R.G. Goodwin Identification and characterization of a new member of the TNF family that induces apoptosis Immunity 3 1995 673 682
16. M. Giovarelli, P. Musiani, G. Garotta, R. Ebner, E. Di Carlo, Y. Kim, P. Cappello, L. Rigamonti, P. Bernabei, F. Novelli, A. Modesti, A. Coletti, A.K. Ferrie, P.L. Lollini, S. Ruben, T. Salcedo, G. Forni A "stealth effect" adenocarcinoma cells engineered to express TRAIL elude tumor-specific and allogeneic T cell reactions J Immunol 163 1999 4886 4893
17. + T lymphocytes Cancer Res 63 2003 6735 6743
18. C.C. Uphoff, H.G. Drexler Detection of Mycoplasma contaminations in cell cultures by PCR analysis Hum Cell 12 1999 229 236
19. F. Andre, N.E. Schartz, M. Movassagh, C. Flament, P. Pautier, P. Morice, C. Pomel, C. Lhomme, B. Escudier, T. Le Chevalier, T. Tursz, S. Amigorena, G. Raposo, E. Angevin, L. Zitvogel Malignant effusions and immunogenic tumour-derived exosomes Lancet 360 2002 295 305
20. G. Andreola, L. Rivoltini, C. Castelli, V. Huber, P. Perego, P. Deho, P. Squarcina, P. Accornero, F. Lozupone, L. Lugini, A. Stringaro, A. Molinari, G. Arancia, M. Gentile, G. Parmiani, S. Fais Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles J Exp Med 195 2002 1303 1316
21. K.T. Tokuyasu A technique for ultracryotomy of cell suspensions and tissues J Cell Biol 57 1973 551 565
22. R. Mears, R.A. Craven, S. Hanrahan, N. Totty, C. Upton, S.L. Young, P. Patel, P.J. Selby, R.E. Banks Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry Proteomics 4 2004 4019 4031
23. D. Nagorsen, U. Keilholz, L. Rivoltini, A. Schmittel, A. Letsch, A.M. Asemissen, G. Berger, H.J. Buhr, E. Thiel, C. Scheibenbogen Natural T-cell response against MHC class I epitopes of epithelial cell adhesion molecule, her-2/neu, and carcinoembryonic antigen in patients with colorectal cancer Cancer Res 60 2000 4850 4854
24. M.W. Bennett, J. O'Connell, A. Houston, J. Kelly, G.C. O'Sullivan, J.K. Collins, F. Shanahan Fas ligand upregulation is an early event in colonic carcinogenesis J Clin Pathol 54 2001 598 604
25. K. Shiraki, N. Tsuji, T. Shioda, K.J. Isselbacher, H. Takahashi Expression of Fas ligand in liver metastases of human colonic adenocarcinomas Proc Natl Acad Sci U S A 94 1997 6420 6425
26. A. Houston, F.D. Waldron-Lynch, M.W. Bennett, D. Roche, G.C. O'Sullivan, F. Shanahan, J. O'Connell Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo Int J Cancer 107 2003 209 214
27. H. LeBlanc, D. Lawrence, E. Varfolomeev, K. Totpal, J. Morlan, P. Schow, S. Fong, R. Schwall, D. Sinicropi, A. Ashkenazi Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax Nat Med 8 2002 274 281
28. J. Strater, H. Walczak, T. Pukrop, L. Von Muller, C. Hasel, M. Kornmann, T. Mertens, P. Moller TRAIL and its receptors in the colonic epithelium a putative role in the defense of viral infections Gastroenterology 122 2002 659 666
29. V. Baranov, M.M. Yeung, S. Hammarstrom Expression of carcinoembryonic antigen and nonspecific cross-reacting 50-kDa antigen in human normal and cancerous colon mucosa comparative ultrastructural study with monoclonal antibodies Cancer Res 54 1994 3305 3314
30. G. Van Niel, J. Mallegol, C. Bevilacqua, C. Candalh, S. Brugiere, E. Tomaskovic-Crook, J.K. Heath, N. Cerf-Bensussan, M. Heyman Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice Gut 52 2003 1690 1697