메뉴 건너뛰기




Volumn 13, Issue 1-2, 2010, Pages 16-28

Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy

Author keywords

Angiogenesis; Bevacizumab; Evolution; Invasion; Metastasis; Radiotherapy; Resistance; Stroma; Sunitinib

Indexed keywords

ANGIOGENESIS INHIBITOR;

EID: 77950948813     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drup.2009.12.001     Document Type: Article
Times cited : (211)

References (152)
  • 1
    • 24344489566 scopus 로고    scopus 로고
    • Genome wide expression profiling of irradiated human lung endothelial cells reveals the activation of genes involved in coagulation, inflammation and angiogenic pathways
    • (Abstract)
    • Abdollahi A., Gong P., Rastert R., Debus J., Hlatky L., Hahnfeldt P., Maercker C., and Huber P.E. Genome wide expression profiling of irradiated human lung endothelial cells reveals the activation of genes involved in coagulation, inflammation and angiogenic pathways. Proc. Am. Assoc. Cancer Res. 44 (2003) 6155 (Abstract)
    • (2003) Proc. Am. Assoc. Cancer Res. , vol.44 , pp. 6155
    • Abdollahi, A.1    Gong, P.2    Rastert, R.3    Debus, J.4    Hlatky, L.5    Hahnfeldt, P.6    Maercker, C.7    Huber, P.E.8
  • 2
    • 0038756364 scopus 로고    scopus 로고
    • SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro
    • Abdollahi A., Lipson K.E., Han X., Krempien R., Trinh T., Weber K.J., Hahnfeldt P., Hlatky L., Debus J., Howlett A.R., and Huber P.E. SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res. 63 (2003) 3755-3763
    • (2003) Cancer Res. , vol.63 , pp. 3755-3763
    • Abdollahi, A.1    Lipson, K.E.2    Han, X.3    Krempien, R.4    Trinh, T.5    Weber, K.J.6    Hahnfeldt, P.7    Hlatky, L.8    Debus, J.9    Howlett, A.R.10    Huber, P.E.11
  • 6
  • 9
    • 4844220794 scopus 로고    scopus 로고
    • Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro
    • Abedini M.R., Qiu Q., Yan X., and Tsang B.K. Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro. Oncogene 23 (2004) 6997-7004
    • (2004) Oncogene , vol.23 , pp. 6997-7004
    • Abedini, M.R.1    Qiu, Q.2    Yan, X.3    Tsang, B.K.4
  • 11
    • 62649095692 scopus 로고    scopus 로고
    • Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
    • Al-Nedawi K., Meehan B., Kerbel R.S., Allison A.C., and Rak J. Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc. Natl. Acad. Sci. (USA) 106 (2009) 3794-3799
    • (2009) Proc. Natl. Acad. Sci. (USA) , vol.106 , pp. 3794-3799
    • Al-Nedawi, K.1    Meehan, B.2    Kerbel, R.S.3    Allison, A.C.4    Rak, J.5
  • 13
    • 45449113946 scopus 로고    scopus 로고
    • Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells
    • Amin D.N., Bielenberg D.R., Lifshits E., Heymach J.V., and Klagsbrun M. Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells. Microvasc. Res. 76 (2008) 15-22
    • (2008) Microvasc. Res. , vol.76 , pp. 15-22
    • Amin, D.N.1    Bielenberg, D.R.2    Lifshits, E.3    Heymach, J.V.4    Klagsbrun, M.5
  • 14
    • 33644546368 scopus 로고    scopus 로고
    • Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors
    • Amin D.N., Hida K., Bielenberg D.R., and Klagsbrun M. Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors. Cancer Res. 66 (2006) 2173-2180
    • (2006) Cancer Res. , vol.66 , pp. 2173-2180
    • Amin, D.N.1    Hida, K.2    Bielenberg, D.R.3    Klagsbrun, M.4
  • 15
    • 0036715867 scopus 로고    scopus 로고
    • Radiation Research Society. 1952-2002. Historical and current highlights in radiation biology: has anything important been learned by irradiating cells?
    • Bedford J.S., and Dewey W.C. Radiation Research Society. 1952-2002. Historical and current highlights in radiation biology: has anything important been learned by irradiating cells?. Radiat. Res. 158 (2002) 251-291
    • (2002) Radiat. Res. , vol.158 , pp. 251-291
    • Bedford, J.S.1    Dewey, W.C.2
  • 19
    • 0035432151 scopus 로고    scopus 로고
    • Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review)
    • Blagosklonny M.V. Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review). Int. J. Oncol. 19 (2001) 257-262
    • (2001) Int. J. Oncol. , vol.19 , pp. 257-262
    • Blagosklonny, M.V.1
  • 20
    • 1642472018 scopus 로고    scopus 로고
    • Antiangiogenic therapy and tumor progression
    • Blagosklonny M.V. Antiangiogenic therapy and tumor progression. Cancer Cell 5 (2004) 13-17
    • (2004) Cancer Cell , vol.5 , pp. 13-17
    • Blagosklonny, M.V.1
  • 21
    • 59949090762 scopus 로고    scopus 로고
    • Dual-antibody therapy in advanced colorectal cancer: gather ye rosebuds while ye may
    • Blanke C.D. Dual-antibody therapy in advanced colorectal cancer: gather ye rosebuds while ye may. J. Clin. Oncol. 27 (2009) 655-658
    • (2009) J. Clin. Oncol. , vol.27 , pp. 655-658
    • Blanke, C.D.1
  • 23
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S., Rudzki Z., Walsh S., Grigg A., Arthur C., Taylor K., Herrmann R., Lynch K.P., and Hughes T.P. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99 (2002) 3472-3475
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Grigg, A.4    Arthur, C.5    Taylor, K.6    Herrmann, R.7    Lynch, K.P.8    Hughes, T.P.9
  • 26
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., Shi B., Marshall B., O'Reilly M.S., and Folkman J. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 60 (2000) 1878-1886
    • (2000) Cancer Res. , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3    Shi, B.4    Marshall, B.5    O'Reilly, M.S.6    Folkman, J.7
  • 28
    • 34548821234 scopus 로고    scopus 로고
    • Anticancer therapeutics: a surge of new developments increasingly target tumor and stroma
    • Broxterman H.J., and Georgopapadakou N.H. Anticancer therapeutics: a surge of new developments increasingly target tumor and stroma. Drug Resist. Updat. 10 (2007) 182-193
    • (2007) Drug Resist. Updat. , vol.10 , pp. 182-193
    • Broxterman, H.J.1    Georgopapadakou, N.H.2
  • 29
    • 70349826431 scopus 로고    scopus 로고
    • Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib
    • Broxterman H.J., Gotink K.J., and Verheul H.M. Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist. Updat. 12 (2009) 114-126
    • (2009) Drug Resist. Updat. , vol.12 , pp. 114-126
    • Broxterman, H.J.1    Gotink, K.J.2    Verheul, H.M.3
  • 32
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P., Ferreira V., Breier G., Pollefeyt S., Kieckens L., Gertsenstein M., et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380 (1996) 435-439
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3    Pollefeyt, S.4    Kieckens, L.5    Gertsenstein, M.6
  • 33
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 34
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O., Hicklin D.J., Bergers G., and Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8 (2005) 299-309
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 37
    • 34247277741 scopus 로고    scopus 로고
    • Antibiotic interactions that select against resistance
    • Chait R., Craney A., and Kishony R. Antibiotic interactions that select against resistance. Nature 446 (2007) 668-671
    • (2007) Nature , vol.446 , pp. 668-671
    • Chait, R.1    Craney, A.2    Kishony, R.3
  • 38
    • 75449088610 scopus 로고    scopus 로고
    • FDA drug approval summary: bevacizumab (Avastin(R)) as treatment of recurrent glioblastoma multiforme
    • Cohen M.H., Li S.Y., Keegan P., and Pazdur R. FDA drug approval summary: bevacizumab (Avastin(R)) as treatment of recurrent glioblastoma multiforme. Oncologist 14 (2009) 1131-1138
    • (2009) Oncologist , vol.14 , pp. 1131-1138
    • Cohen, M.H.1    Li, S.Y.2    Keegan, P.3    Pazdur, R.4
  • 39
    • 33746635527 scopus 로고    scopus 로고
    • Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)-phase I/II trial: study protocol
    • Combs S.E., Heeger S., Haselmann R., Edler L., Debus J., and Schulz-Ertner D. Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)-phase I/II trial: study protocol. BMC Cancer 6 (2006) 133
    • (2006) BMC Cancer , vol.6 , pp. 133
    • Combs, S.E.1    Heeger, S.2    Haselmann, R.3    Edler, L.4    Debus, J.5    Schulz-Ertner, D.6
  • 40
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y., Kasman I., Yu L., Zhong C., Wu X., Modrusan Z., Kaminker J., and Ferrara N. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 15 (2009) 21-34
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 42
    • 0041742270 scopus 로고    scopus 로고
    • Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells
    • Di Sano F., Fazi B., Citro G., Lovat P.E., Cesareni G., and Piacentini M. Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. Cancer Res. 63 (2003) 3860-3865
    • (2003) Cancer Res. , vol.63 , pp. 3860-3865
    • Di Sano, F.1    Fazi, B.2    Citro, G.3    Lovat, P.E.4    Cesareni, G.5    Piacentini, M.6
  • 44
    • 34748921698 scopus 로고    scopus 로고
    • Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers
    • Duda D.G., Jain R.K., and Willett C.G. Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J. Clin. Oncol. 25 (2007) 4033-4042
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4033-4042
    • Duda, D.G.1    Jain, R.K.2    Willett, C.G.3
  • 46
    • 36749052895 scopus 로고    scopus 로고
    • Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
    • Ebos J.M., Lee C.R., Christensen J.G., Mutsaers A.J., and Kerbel R.S. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl. Acad. Sci. (USA) 104 (2007) 17069-17074
    • (2007) Proc. Natl. Acad. Sci. (USA) , vol.104 , pp. 17069-17074
    • Ebos, J.M.1    Lee, C.R.2    Christensen, J.G.3    Mutsaers, A.J.4    Kerbel, R.S.5
  • 47
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos J.M., Lee C.R., Cruz-Munoz W., Bjarnason G.A., Christensen J.G., and Kerbel R.S. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15 (2009) 232-239
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 48
    • 0037102157 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation
    • Edwards E., Geng L., Tan J., Onishko H., Donnelly E., and Hallahan D.E. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res. 62 (2002) 4671-4677
    • (2002) Cancer Res. , vol.62 , pp. 4671-4677
    • Edwards, E.1    Geng, L.2    Tan, J.3    Onishko, H.4    Donnelly, E.5    Hallahan, D.E.6
  • 50
    • 70549102293 scopus 로고    scopus 로고
    • Drug resistance associated with antiangiogenesis therapy
    • Eikesdal H.P., and Kalluri R. Drug resistance associated with antiangiogenesis therapy. Semin. Cancer Biol. 19 (2009) 310-317
    • (2009) Semin. Cancer Biol. , vol.19 , pp. 310-317
    • Eikesdal, H.P.1    Kalluri, R.2
  • 51
    • 27144530984 scopus 로고    scopus 로고
    • An open letter to cancer researchers
    • Elledge S.J., and Hannon G.J. An open letter to cancer researchers. Science 310 (2005) 439-441
    • (2005) Science , vol.310 , pp. 439-441
    • Elledge, S.J.1    Hannon, G.J.2
  • 52
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., and Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 8 (2008) 579-591
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 53
    • 73349105243 scopus 로고    scopus 로고
    • Resistance to targeted therapies: refining anticancer therapy in the era of molecular oncology
    • Ellis L.M., and Hicklin D.J. Resistance to targeted therapies: refining anticancer therapy in the era of molecular oncology. Clin. Cancer Res. 15 (2009) 7471-7478
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7471-7478
    • Ellis, L.M.1    Hicklin, D.J.2
  • 55
    • 0022363207 scopus 로고
    • Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves
    • Fertil B., and Malaise E.P. Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves. Int. J. Radiat. Oncol. Biol. Phys. 11 (1985) 1699-1707
    • (1985) Int. J. Radiat. Oncol. Biol. Phys. , vol.11 , pp. 1699-1707
    • Fertil, B.1    Malaise, E.P.2
  • 56
    • 68549115469 scopus 로고    scopus 로고
    • Prostatic metastasis of renal cell carcinoma successfully treated with sunitinib
    • Fokt R.M., Templeton A., Gillessen S., Ohlschlegel C., and Schmid H.P. Prostatic metastasis of renal cell carcinoma successfully treated with sunitinib. Urol. Int. 83 (2009) 122-124
    • (2009) Urol. Int. , vol.83 , pp. 122-124
    • Fokt, R.M.1    Templeton, A.2    Gillessen, S.3    Ohlschlegel, C.4    Schmid, H.P.5
  • 57
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. New Engl. J. Med. 285 (1971) 1182-1186
    • (1971) New Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 58
    • 84975525035 scopus 로고
    • Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
    • Folkman J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. New Engl. J. Med. 333 (1995) 1757-1763
    • (1995) New Engl. J. Med. , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 59
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: an organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat. Rev. Drug Discov. 6 (2007) 273-286
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 273-286
    • Folkman, J.1
  • 60
    • 0035854505 scopus 로고    scopus 로고
    • Cancer. What does radiotherapy do to endothelial cells?
    • Folkman J., and Camphausen K. Cancer. What does radiotherapy do to endothelial cells?. Science 293 (2001) 227-228
    • (2001) Science , vol.293 , pp. 227-228
    • Folkman, J.1    Camphausen, K.2
  • 62
    • 57849117839 scopus 로고    scopus 로고
    • Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy
    • Francia G., Emmenegger U., and Kerbel R.S. Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy. Cancer Cell 15 (2009) 3-5
    • (2009) Cancer Cell , vol.15 , pp. 3-5
    • Francia, G.1    Emmenegger, U.2    Kerbel, R.S.3
  • 63
    • 38149006909 scopus 로고    scopus 로고
    • Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    • Gao D., Nolan D.J., Mellick A.S., Bambino K., McDonnell K., and Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319 (2008) 195-198
    • (2008) Science , vol.319 , pp. 195-198
    • Gao, D.1    Nolan, D.J.2    Mellick, A.S.3    Bambino, K.4    McDonnell, K.5    Mittal, V.6
  • 65
    • 0035866771 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy
    • Geng L., Donnelly E., McMahon G., Lin P.C., Sierra-Rivera E., Oshinka H., and Hallahan D.E. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res. 61 (2001) 2413-2419
    • (2001) Cancer Res. , vol.61 , pp. 2413-2419
    • Geng, L.1    Donnelly, E.2    McMahon, G.3    Lin, P.C.4    Sierra-Rivera, E.5    Oshinka, H.6    Hallahan, D.E.7
  • 66
    • 47149114386 scopus 로고    scopus 로고
    • Intercellular transfer mediated by tunneling nanotubes
    • Gerdes H.H., and Carvalho R.N. Intercellular transfer mediated by tunneling nanotubes. Curr. Opin. Cell Biol. 20 (2008) 470-475
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 470-475
    • Gerdes, H.H.1    Carvalho, R.N.2
  • 67
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre M.E., Mohammed M., Ellwood K., Hsu N., Paquette R., Rao P.N., and Sawyers C.L. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293 (2001) 876-880
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6    Sawyers, C.L.7
  • 69
    • 0036371621 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance
    • Gupta V.K., Jaskowiak N.T., Beckett M.A., Mauceri H.J., Grunstein J., Johnson R.S., et al. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J. 8 (2002) 47-54
    • (2002) Cancer J. , vol.8 , pp. 47-54
    • Gupta, V.K.1    Jaskowiak, N.T.2    Beckett, M.A.3    Mauceri, H.J.4    Grunstein, J.5    Johnson, R.S.6
  • 70
    • 0037458325 scopus 로고    scopus 로고
    • Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis
    • Hahnfeldt P., Folkman J., and Hlatky L. Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis. J. Theor. Biol. 220 (2003) 545-554
    • (2003) J. Theor. Biol. , vol.220 , pp. 545-554
    • Hahnfeldt, P.1    Folkman, J.2    Hlatky, L.3
  • 71
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 72
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht J.R., Mitchell E., Chidiac T., Scroggin C., Hagenstad C., Spigel D., et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 27 (2009) 672-680
    • (2009) J. Clin. Oncol. , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6
  • 74
    • 16844381577 scopus 로고    scopus 로고
    • A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities
    • Hida K., and Klagsbrun M. A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities. Cancer Res. 65 (2005) 2507-2510
    • (2005) Cancer Res. , vol.65 , pp. 2507-2510
    • Hida, K.1    Klagsbrun, M.2
  • 75
    • 33745138232 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia-inducible factor 1
    • Hirota K., and Semenza G.L. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit. Rev. Oncol. Hematol. 59 (2006) 15-26
    • (2006) Crit. Rev. Oncol. Hematol. , vol.59 , pp. 15-26
    • Hirota, K.1    Semenza, G.L.2
  • 76
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L., O'Reilly M.S., and Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. 1 (1995) 149-153
    • (1995) Nat. Med. , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 79
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: bidirectional, allosteric signaling machines
    • Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002) 673-687
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 80
    • 0036491615 scopus 로고    scopus 로고
    • VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis
    • Inoue M., Hager J.H., Ferrara N., Gerber H.P., and Hanahan D. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 1 (2002) 193-202
    • (2002) Cancer Cell , vol.1 , pp. 193-202
    • Inoue, M.1    Hager, J.H.2    Ferrara, N.3    Gerber, H.P.4    Hanahan, D.5
  • 82
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 (2005) 58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 83
    • 41149138113 scopus 로고    scopus 로고
    • Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
    • Jain R.K. Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer. Nat. Rev. Cancer 8 (2008) 309-316
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 309-316
    • Jain, R.K.1
  • 84
    • 33746602232 scopus 로고    scopus 로고
    • Treatment of non-small cell lung cancer with intensity-modulated radiation therapy in combination with cetuximab: the NEAR protocol (NCT00115518)
    • Jensen A.D., Munter M.W., Bischoff H., Haselmann R., Timke C., Krempien R., et al. Treatment of non-small cell lung cancer with intensity-modulated radiation therapy in combination with cetuximab: the NEAR protocol (NCT00115518). BMC Cancer 6 (2006) 122
    • (2006) BMC Cancer , vol.6 , pp. 122
    • Jensen, A.D.1    Munter, M.W.2    Bischoff, H.3    Haselmann, R.4    Timke, C.5    Krempien, R.6
  • 85
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321 (2008) 1801-1806
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 86
    • 46849120183 scopus 로고    scopus 로고
    • Genomics. Billion-dollar cancer mapping project steps forward
    • Kaiser J. Genomics. Billion-dollar cancer mapping project steps forward. Science 321 (2008) 26-27
    • (2008) Science , vol.321 , pp. 26-27
    • Kaiser, J.1
  • 88
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R., and Folkman J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2 (2002) 727-739
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 89
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel R.S. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 13 (1991) 31-36
    • (1991) Bioessays , vol.13 , pp. 31-36
    • Kerbel, R.S.1
  • 90
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel R.S., and Kamen B.A. The anti-angiogenic basis of metronomic chemotherapy. Nat. Rev. Cancer 4 (2004) 423-436
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 92
    • 0141625688 scopus 로고    scopus 로고
    • Angiogenesis inhibitors and hypoxia
    • Kieran M.W., Folkman J., and Heymach J. Angiogenesis inhibitors and hypoxia. Nat. Med. 9 (2003) 1104-1105
    • (2003) Nat. Med. , vol.9 , pp. 1104-1105
    • Kieran, M.W.1    Folkman, J.2    Heymach, J.3
  • 93
    • 73949104695 scopus 로고    scopus 로고
    • Combined anti-angiogenic therapy against VEGF and integrin alpha (ν)beta(3) in an orthotopic model of ovarian cancer
    • Epub ahead of print
    • Kim T.J., Landen C.N., Lin Y.G., Mangala L.S., Lu C., Nick A.M., et al. Combined anti-angiogenic therapy against VEGF and integrin alpha (ν)beta(3) in an orthotopic model of ovarian cancer. Cancer Biol. Ther. (2009) Epub ahead of print
    • (2009) Cancer Biol. Ther.
    • Kim, T.J.1    Landen, C.N.2    Lin, Y.G.3    Mangala, L.S.4    Lu, C.5    Nick, A.M.6
  • 94
    • 0037151079 scopus 로고    scopus 로고
    • An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
    • Kim Y., Suh N., Sporn M., and Reed J.C. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J. Biol. Chem. 277 (2002) 22320-22329
    • (2002) J. Biol. Chem. , vol.277 , pp. 22320-22329
    • Kim, Y.1    Suh, N.2    Sporn, M.3    Reed, J.C.4
  • 95
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein C.A. Parallel progression of primary tumours and metastases. Nat. Rev. Cancer 9 (2009) 302-312
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 96
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G., Baruchel S., Rak J., Man S., Clark K., Hicklin D.J., Bohlen P., and Kerbel R.S. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105 (2000) R15-R24
    • (2000) J. Clin. Invest. , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 98
    • 27644493712 scopus 로고    scopus 로고
    • Randomized phase II-study evaluating EGFR targeting therapy with cetuximab in combination with radiotherapy and chemotherapy for patients with locally advanced pancreatic cancer-PARC: study protocol [ISRCTN56652283]
    • Krempien R., Muenter M.W., Huber P.E., Nill S., Friess H., Timke C., et al. Randomized phase II-study evaluating EGFR targeting therapy with cetuximab in combination with radiotherapy and chemotherapy for patients with locally advanced pancreatic cancer-PARC: study protocol [ISRCTN56652283]. BMC Cancer 5 (2005) 131
    • (2005) BMC Cancer , vol.5 , pp. 131
    • Krempien, R.1    Muenter, M.W.2    Huber, P.E.3    Nill, S.4    Friess, H.5    Timke, C.6
  • 99
    • 0035884609 scopus 로고    scopus 로고
    • Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    • Kunkel P., Ulbricht U., Bohlen P., Brockmann M.A., Fillbrandt R., Stavrou D., Westphal M., and Lamszus K. Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res. 61 (2001) 6624-6628
    • (2001) Cancer Res. , vol.61 , pp. 6624-6628
    • Kunkel, P.1    Ulbricht, U.2    Bohlen, P.3    Brockmann, M.A.4    Fillbrandt, R.5    Stavrou, D.6    Westphal, M.7    Lamszus, K.8
  • 100
    • 27644450912 scopus 로고    scopus 로고
    • Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin
    • Lamszus K., Brockmann M.A., Eckerich C., Bohlen P., May C., Mangold U., Fillbrandt R., and Westphal M. Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin. Clin. Cancer Res. 11 (2005) 4934-4940
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4934-4940
    • Lamszus, K.1    Brockmann, M.A.2    Eckerich, C.3    Bohlen, P.4    May, C.5    Mangold, U.6    Fillbrandt, R.7    Westphal, M.8
  • 101
    • 73349090963 scopus 로고    scopus 로고
    • Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
    • Lee S.L., Rouhi P., Dahl J.L., Zhang D., Ji H., Hauptmann G., Ingham P., and Cao Y. Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc. Natl. Acad. Sci. (USA) 106 (2009) 19485-19490
    • (2009) Proc. Natl. Acad. Sci. (USA) , vol.106 , pp. 19485-19490
    • Lee, S.L.1    Rouhi, P.2    Dahl, J.L.3    Zhang, D.4    Ji, H.5    Hauptmann, G.6    Ingham, P.7    Cao, Y.8
  • 102
    • 70349248380 scopus 로고    scopus 로고
    • Angiostatin regulates the expression of antiangiogenic and pro-apoptotic pathways via targeted inhibition of mitochondrial proteins
    • Lee T.Y., Muschal S., Pravda E.A., Folkman J., Abdollahi A., and Javaherian K. Angiostatin regulates the expression of antiangiogenic and pro-apoptotic pathways via targeted inhibition of mitochondrial proteins. Blood 114 (2009) 1987-1998
    • (2009) Blood , vol.114 , pp. 1987-1998
    • Lee, T.Y.1    Muschal, S.2    Pravda, E.A.3    Folkman, J.4    Abdollahi, A.5    Javaherian, K.6
  • 104
  • 105
    • 67349171532 scopus 로고    scopus 로고
    • Response of renal cell carcinoma pancreatic metastasis to sunitinib treatment: a retrospective analysis
    • Medioni J., Choueiri T.K., Zinzindohoue F., Cho D., Fournier L., and Oudard S. Response of renal cell carcinoma pancreatic metastasis to sunitinib treatment: a retrospective analysis. J. Urol. 181 (2009) 2470-2475
    • (2009) J. Urol. , vol.181 , pp. 2470-2475
    • Medioni, J.1    Choueiri, T.K.2    Zinzindohoue, F.3    Cho, D.4    Fournier, L.5    Oudard, S.6
  • 107
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer R.J., Hutson T.E., Tomczak P., Michaelson M.D., Bukowski R.M., Oudard S., et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27 (2009) 3584-3590
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 110
    • 77950951208 scopus 로고    scopus 로고
    • Identification of novel angiostatin binding partners using a protein array (27K) based high-throughput protein-protein interaction screen
    • (Abstract)
    • Muschal S., Lee T.Y., Korn B., Folkman J., Huber P.E., Javaherian K., and Abdollahi A. Identification of novel angiostatin binding partners using a protein array (27K) based high-throughput protein-protein interaction screen. Proc. Am. Assoc. Cancer Res. 378 (2008) (Abstract)
    • (2008) Proc. Am. Assoc. Cancer Res. , vol.378
    • Muschal, S.1    Lee, T.Y.2    Korn, B.3    Folkman, J.4    Huber, P.E.5    Javaherian, K.6    Abdollahi, A.7
  • 111
    • 77950923581 scopus 로고    scopus 로고
    • E7050: a dual c-Met and VEGFR2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in Mouse xenograft models
    • Epub ahead of print
    • Nakagawa T., Tohyama O., Yamaguchi A., et al. E7050: a dual c-Met and VEGFR2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in Mouse xenograft models. Cancer Sci. (2009 September) Epub ahead of print
    • (2009) Cancer Sci.
    • Nakagawa, T.1    Tohyama, O.2    Yamaguchi, A.3
  • 112
    • 33846220224 scopus 로고    scopus 로고
    • Acute tumor vascular effects following fractionated radiotherapy in human lung cancer: In vivo whole tumor assessment using volumetric perfusion computed tomography
    • Ng Q.S., Goh V., Milner J., Padhani A.R., Saunders M.I., and Hoskin P.J. Acute tumor vascular effects following fractionated radiotherapy in human lung cancer: In vivo whole tumor assessment using volumetric perfusion computed tomography. Int. J. Radiat. Oncol. Biol. Phys. 67 (2007) 417-424
    • (2007) Int. J. Radiat. Oncol. Biol. Phys. , vol.67 , pp. 417-424
    • Ng, Q.S.1    Goh, V.2    Milner, J.3    Padhani, A.R.4    Saunders, M.I.5    Hoskin, P.J.6
  • 113
    • 20144379162 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis
    • Nyberg P., Xie L., and Kalluri R. Endogenous inhibitors of angiogenesis. Cancer Res. 65 (2005) 3967-3979
    • (2005) Cancer Res. , vol.65 , pp. 3967-3979
    • Nyberg, P.1    Xie, L.2    Kalluri, R.3
  • 117
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons D.W., Jones S., Zhang X., Lin J.C., Leary R.J., Angenendt P., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321 (2008) 1807-1812
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 120
    • 1242317802 scopus 로고    scopus 로고
    • Oncogenes and tumor angiogenesis: the question of vascular "supply" and vascular "demand"
    • Rak J., and Yu J.L. Oncogenes and tumor angiogenesis: the question of vascular "supply" and vascular "demand". Semin. Cancer Biol. 14 (2004) 93-104
    • (2004) Semin. Cancer Biol. , vol.14 , pp. 93-104
    • Rak, J.1    Yu, J.L.2
  • 121
    • 67349129399 scopus 로고    scopus 로고
    • Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies
    • Rapisarda A., and Melillo G. Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies. Drug Resist. Updat. 12 (2009) 74-80
    • (2009) Drug Resist. Updat. , vol.12 , pp. 74-80
    • Rapisarda, A.1    Melillo, G.2
  • 122
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M., LeJeune S., Scott P.A., Fox S., Smith K., Leek R., Moghaddam A., Whitehouse R., Bicknell R., and Harris A.L. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res. 57 (1997) 963-969
    • (1997) Cancer Res. , vol.57 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.3    Fox, S.4    Smith, K.5    Leek, R.6    Moghaddam, A.7    Whitehouse, R.8    Bicknell, R.9    Harris, A.L.10
  • 124
    • 0036488496 scopus 로고    scopus 로고
    • Specialization of tumour vasculature
    • Ruoslahti E. Specialization of tumour vasculature. Nat. Rev. Cancer 2 (2002) 83-90
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 83-90
    • Ruoslahti, E.1
  • 125
    • 1142286348 scopus 로고    scopus 로고
    • Nanotubular highways for intercellular organelle transport
    • Rustom A., Saffrich R., Markovic I., Walther P., and Gerdes H.H. Nanotubular highways for intercellular organelle transport. Science 303 (2004) 1007-1010
    • (2004) Science , vol.303 , pp. 1007-1010
    • Rustom, A.1    Saffrich, R.2    Markovic, I.3    Walther, P.4    Gerdes, H.H.5
  • 127
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 128
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah N.P., Nicoll J.M., Nagar B., Gorre M.E., Paquette R.L., Kuriyan J., and Sawyers C.L. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2 (2002) 117-125
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6    Sawyers, C.L.7
  • 130
    • 55949096784 scopus 로고    scopus 로고
    • Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies
    • Shojaei F., and Ferrara N. Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies. Drug Resist. Updat. 11 (2008) 219-230
    • (2008) Drug Resist. Updat. , vol.11 , pp. 219-230
    • Shojaei, F.1    Ferrara, N.2
  • 132
    • 66149092730 scopus 로고    scopus 로고
    • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    • Shojaei F., Wu X., Qu X., Kowanetz M., Yu L., Tan M., Meng Y.G., and Ferrara N. G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc. Natl. Acad. Sci. (USA) 106 (2009) 6742-6747
    • (2009) Proc. Natl. Acad. Sci. (USA) , vol.106 , pp. 6742-6747
    • Shojaei, F.1    Wu, X.2    Qu, X.3    Kowanetz, M.4    Yu, L.5    Tan, M.6    Meng, Y.G.7    Ferrara, N.8
  • 133
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    • Shojaei F., Wu X., Zhong C., Yu L., Liang X.H., Yao J., et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450 (2007) 825-831
    • (2007) Nature , vol.450 , pp. 825-831
    • Shojaei, F.1    Wu, X.2    Zhong, C.3    Yu, L.4    Liang, X.H.5    Yao, J.6
  • 134
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., et al. The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3    Parsons, D.W.4    Lin, J.5    Barber, T.D.6
  • 135
    • 77951887506 scopus 로고    scopus 로고
    • Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy
    • 10.1093/annonc/mdp323
    • Sonpavde G., Periman P.O., Bernold D., Weckstein D., Fleming M.T., Galsky M.D., et al. Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy. Ann. Oncol. (2009) 10.1093/annonc/mdp323
    • (2009) Ann. Oncol.
    • Sonpavde, G.1    Periman, P.O.2    Bernold, D.3    Weckstein, D.4    Fleming, M.T.5    Galsky, M.D.6
  • 136
    • 0037703383 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: motivators of metastasis?
    • Steeg P.S. Angiogenesis inhibitors: motivators of metastasis?. Nat. Med. 9 (2003) 822-823
    • (2003) Nat. Med. , vol.9 , pp. 822-823
    • Steeg, P.S.1
  • 138
    • 64549086684 scopus 로고    scopus 로고
    • Sunitinib malate, a receptor tyrosine kinase inhibitor, is effective in the treatment of restrictive heart failure due to heart metastases from renal cell carcinoma
    • Szmit S., Zagrodzka M., Kurzyna M., Opolski G., and Szczylik C. Sunitinib malate, a receptor tyrosine kinase inhibitor, is effective in the treatment of restrictive heart failure due to heart metastases from renal cell carcinoma. Cardiology 114 (2009) 67-71
    • (2009) Cardiology , vol.114 , pp. 67-71
    • Szmit, S.1    Zagrodzka, M.2    Kurzyna, M.3    Opolski, G.4    Szczylik, C.5
  • 139
    • 0344844473 scopus 로고    scopus 로고
    • Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response
    • Tan J., and Hallahan D.E. Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response. Cancer Res. 63 (2003) 7663-7667
    • (2003) Cancer Res. , vol.63 , pp. 7663-7667
    • Tan, J.1    Hallahan, D.E.2
  • 140
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • TCGA. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008) 1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
    • TCGA1
  • 142
    • 42249115712 scopus 로고    scopus 로고
    • Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy
    • Timke C., Zieher H., Roth A., Hauser K., Lipson K.E., Weber K.J., Debus J., Abdollahi A., and Huber P.E. Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy. Clin. Cancer Res. 14 (2008) 2210-2219
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2210-2219
    • Timke, C.1    Zieher, H.2    Roth, A.3    Hauser, K.4    Lipson, K.E.5    Weber, K.J.6    Debus, J.7    Abdollahi, A.8    Huber, P.E.9
  • 144
    • 12344336357 scopus 로고    scopus 로고
    • P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway
    • Turzanski J., Grundy M., Shang S., Russell N., and Pallis M. P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. Exp. Hematol. 33 (2005) 62-72
    • (2005) Exp. Hematol. , vol.33 , pp. 62-72
    • Turzanski, J.1    Grundy, M.2    Shang, S.3    Russell, N.4    Pallis, M.5
  • 146
    • 1642347163 scopus 로고    scopus 로고
    • Classical radiation biology dogma, bystander effects and paradigm shifts
    • Waldren C.A. Classical radiation biology dogma, bystander effects and paradigm shifts. Hum. Exp. Toxicol. 23 (2004) 95-100
    • (2004) Hum. Exp. Toxicol. , vol.23 , pp. 95-100
    • Waldren, C.A.1
  • 147
    • 0035866813 scopus 로고    scopus 로고
    • Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma
    • Wild-Bode C., Weller M., Rimner A., Dichgans J., and Wick W. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res. 61 (2001) 2744-2750
    • (2001) Cancer Res. , vol.61 , pp. 2744-2750
    • Wild-Bode, C.1    Weller, M.2    Rimner, A.3    Dichgans, J.4    Wick, W.5
  • 149
    • 67649921334 scopus 로고    scopus 로고
    • Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study
    • Willett C.G., Duda D.G., di T.E., Boucher Y., Ancukiewicz M., Sahani D.V., et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J. Clin. Oncol. 27 (2009) 3020-3026
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3020-3026
    • Willett, C.G.1    Duda, D.G.2    di, T.E.3    Boucher, Y.4    Ancukiewicz, M.5    Sahani, D.V.6
  • 150
    • 33645396484 scopus 로고    scopus 로고
    • Functional classification of drugs by properties of their pairwise interactions
    • Yeh P., Tschumi A.I., and Kishony R. Functional classification of drugs by properties of their pairwise interactions. Nat. Genet. 38 (2006) 489-494
    • (2006) Nat. Genet. , vol.38 , pp. 489-494
    • Yeh, P.1    Tschumi, A.I.2    Kishony, R.3
  • 151
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu J.L., Rak J.W., Coomber B.L., Hicklin D.J., and Kerbel R.S. Effect of p53 status on tumor response to antiangiogenic therapy. Science 295 (2002) 1526-1528
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 152
    • 54349114241 scopus 로고    scopus 로고
    • Addition of receptor tyrosine kinase inhibitor to radiation increases tumour control in an orthotopic murine model of breast cancer metastasis in bone
    • Zwolak P., Jasinski P., Terai K., Gallus N.J., Ericson M.E., Clohisy D.R., and Dudek A.Z. Addition of receptor tyrosine kinase inhibitor to radiation increases tumour control in an orthotopic murine model of breast cancer metastasis in bone. Eur. J. Cancer 44 (2008) 2506-2517
    • (2008) Eur. J. Cancer , vol.44 , pp. 2506-2517
    • Zwolak, P.1    Jasinski, P.2    Terai, K.3    Gallus, N.J.4    Ericson, M.E.5    Clohisy, D.R.6    Dudek, A.Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.