Emission of membrane vesicles: Roles in complement resistance, immunity and cancer

Springer Seminars in Immunopathology

Volumn 27, Issue 3, 2005, Pages 375-387

  Pilzer, David ^a   Gasser, Olivier ^b   Moskovich, Oren ^a   Schifferli, Jurg A ^b   Fishelson, Zvi ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCIUM ION; COMPLEMENT; COMPLEMENT MEMBRANE ATTACK COMPLEX; HEAT SHOCK PROTEIN 70; LIPID; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE C;

ANGIOGENESIS; BLOOD CLOTTING; CANCER; CELL ACTIVATION; CELL DEATH; CELL MEMBRANE; CELL PROTECTION; ENDOCYTOSIS; ENZYME ACTIVATION; EXOCYTOSIS; HUMAN; IMMUNITY; MEMBRANE VESICLE; MORBIDITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; TUMOR CELL; WOUND HEALING;

ANIMALS; APOPTOSIS; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; EXOCYTOSIS; HUMANS; MODELS, IMMUNOLOGICAL; NEOPLASMS; TRANSPORT VESICLES;

EID: 27844531030     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00281-005-0004-1     Document Type: Review

References (104)

1. Ahn YS, Jy W, Jimenez JJ et al (2004) More on: cellular microparticles: what are they bad or good for? J Thromb Haemost 2:1215
2. Anderson HC (2003) Matrix vesicles and calcification. Curr Rheumatol Rep 5:222
3. Andre F, Escudier B, Angevin E et al (2004) Exosomes for cancer immunotherapy. Ann Oncol 15(Suppl 4):iv141
4. Arvidson G, Ronquist G, Wikander G et al (1989) Human prostasome membranes exhibit very high cholesterol/phospholipid ratios yielding high molecular ordering. Biochim Biophys Acta 984:167
5. Bohana-Kashtan O, Pinna LA, Fishelson Z (2005) Extracellular phosphorylation of C9 by protein kinase CK2 regulates complement-mediated lysis. Eur J Immunol 35:1939
6. Bohana-Kashtan O, Ziporen L, Donin N et al (2004) Cell signals transduced by complement. Mol Immunol 41:583
7. Butikofer P, Kuypers FA, Xu CM et al (1989) Enrichment of two glycosyl-phosphatidylinositol-anchored proteins, acetylcholinesterase and decay accelerating factor, in vesicles released from human red blood cells. Blood 74:1481
8. Campbell AK, Daw RA, Hallett MB et al (1981) Direct measurement of the increase in intracellular free calcium ion concentration in response to the action of complement. Biochem J 194:551
9. Campbell AK, Daw RA, Luzio JP (1979) Rapid increase in intracellular free Ca2+ induced by antibody plus complement. FEBS Lett 107:55
10. Campbell AK, Morgan BP (1985) Monoclonal antibodies demonstrate protection of polymorphonuclear leukocytes against complement attack. Nature 317:164
11. Carette J, Lehnert S, Chow TY (2002) Implication of PBP74/mortalin/GRP75 in the radio-adaptive response. Int J Radiat Biol 78:183
12. Carney DF, Hammer CH, Shin ML (1986) Elimination of terminal complement complexes in the plasma membrane of nucleated cells: influence of extracellular Ca2+ and association with cellular Ca2+. J Immunol 137:263
13. Carney DF, Koski CL, Shin ML (1985) Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited number of C5b-9. J Immunol 134:1804
14. Carney DF, Lang TJ, Shin ML (1990) Multiple signal messengers generated by terminal complement complexes and their role in terminal complement complex elimination. J Immunol 145:623
15. Clayton A, Harris CL, Court J et al (2003) Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol 33:522
16. Cybulsky AV, Bonventre JV, Quigg RJ et al (1990) Cytosolic calcium and protein kinase C reduce complement-mediated glomerular epithelial injury. Kidney Int 38:803
17. Dolo V, D'Ascenzo S, Violini S et al (1999) Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer cells in vivo and in vitro. Clin Exp Metastasis 17:131
18. Dundas SR, Lawrie LC, Rooney PH et al (2005) Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol 205:74
19. Dworniczak B, Mirault ME (1987) Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. Nucleic Acids Res 15:5181
20. Fevrier B, Raposo G (2004) Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 16:415
21. Fishelson Z, Attali G, Mevorach D (2001a) Complement and apoptosis. Mol Immunol 38:207
22. Fishelson Z, Hochman I, Greene LE et al (2001b) Contribution of heat shock proteins to cell protection from complement-mediated lysis. Int Immunol 13:983
23. Fishelson Z, Kopf E, Paas Yet al (1989) Protein phosphorylation as a mechanism of resistance against complement damage. Prog Immunol 7:205
24. Frade R (1999) Structure and functions of proteases which cleave human C3 and are expressed on normal or tumor human cells: some are involved in tumorigenic and metastatic properties of human melanoma cells. Immunopharmacology 42:39
25. Freyssinet JM (2003) Cellular microparticles: what are they bad or good for? J Thromb Haemost 1:1655
26. Gasser O, Hess C, Miot S et al (2003) Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp Cell Res 285:243
27. Gasser O, Schifferli JA (2004) Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 104:2543
28. Gasser O, Schifferli JA (2005) Microparticles released by human neutrophils adhere to erythrocytes in the presence of complement. Exp Cell Res 307:381. DOI 10.116/j.yexcr.2005.03.011
29. Gilbert GE, Sims PJ, Wiedmer T et al (1991) Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem 266:17261
30. Ginestra A, Miceli D, Dolo V et al (1999) Membrane vesicles in ovarian cancer fluids: a new potential marker. Anticancer Res 19:3439
31. Graves LE, Ariztia EV, Navari JR et al (2004) Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res 64:7045
32. Hakulinen J, Junnikkala S, Sorsa T et al (2004) Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form. Eur J Immunol 34:2620
33. Halperin JA, Taratuska A, Nicholson-Weller A (1993) Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells. J Clin Invest 91:1974
34. Heijnen HF, Schiel AE, Fijnheer R et al (1999) Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 94:3791
35. Hess C, Sadallah S, Hefti A et al (1999) Ectosomes released by human neutrophils are specialized functional units. J Immunol 163:4564
36. Iida K, Whitlow MB, Nussenzweig V (1991) Membrane vesiculation protects erythrocytes from destruction by complement. J Immunol 147:2638
37. Jurianz K, Ziegler S, Donin N et al (2001) K562 erythroleukemic cells are equipped with multiple mechanisms of resistance to lysis by complement. Int J Cancer 93:848
38. Jurianz K, Ziegler S, Garcia-Schuler H et al (1999) Complement resistance of tumor cells: basal and induced mechanisms. Mol Immunol 36:929
39. Kerjaschki D, Schulze M, Binder S et al (1989) Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol 143:546
40. Kilgore KS, Schmid E, Shanley TP et al (1997) Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-kappa B activation. Am J Pathol 150:2019
41. Kim CW, Lee HM, Lee TH et al (2002) Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res 62:6312
42. Kim HT, Nelson EL, Clayberger C et al (1995) Gamma delta T cell recognition of tumor Ig peptide. J Immunol 154:1614
43. Kojima A, Iwata K, Seya T et al (1993) Membrane cofactor protein (CD46) protects cells predominantly from alternative complement pathway-mediated C3-fragment deposition and cytolysis. J Immunol 151: 1519
44. Koski CL, Ramm LE, Hammer CH et al (1983) Cytolysis of nucleated cells by complement: cell death displays multi-hit characteristics. Proc Natl Acad Sci U S A 80:3816
45. Kraus S, Fishelson Z (2000) Cell desensitization by sublytic C5b-9 complexes and calcium ionophores depends on activation of protein kinase C. Eur J Immunol 30:1272
46. Kraus S, Seger R, Fishelson Z (2001) Involvement of the ERK mitogen-activated protein kinase in cell resistance to complement-mediated lysis. Clin Exp Immunol 123:366
47. Liu D, Liu F, Song YK (1995) Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin. Biochim Biophys Acta 1235:140
48. Llorente A, de Marco MC, Alonso MA (2004) Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. J Cell Sci 117:5343
49. Lutz HU, Liu SC, Palek J (1977) Release of spectrin-free vesicles from human erythrocytes during ATP depletion. I. Characterization of spectrin-free vesicles. J Cell Biol 73:548
50. Mack M, Kleinschmidt A, Bruhl H et al (2000) Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nat Med 6:769
51. MacKenzie A, Wilson HL, Kiss-Toth E et al (2001) Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15:825
52. Martin S, Tesse A, Hugel B et al (2004) Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation 109:1653
53. Martinez MC, Tesse A, Zobairi F et al (2005) Shed membrane microparticles from circulating and vascular cells in regulating vascular function. Am J Physiol Heart Circ Physiol 288:H1004
54. Mayer MM (1961) On the destruction of erythrocytes and other cells by antibody and complement. Cancer Res 21:1262
55. Meri S, Morgan BP, Davies A et al (1990) Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology 71:1
56. Morel O, Toti F, Hugel B et al (2004) Cellular microparticles: a disseminated storage pool of bioactive vascular effectors. Curr Opin Hematol 11:156
57. Morgan BP (1989) Complement membrane attack on nucleated cells: resistance, recovery and non-lethal effects. Biochem J 264:1
58. Morgan BP, Campbell AK (1985) The recovery of human polymorphonuclear leucocytes from sublytic complement attack is mediated by changes in intracellular free calcium. Biochem J 231:205
59. Morgan BP, Dankert JR, Esser AF (1987) Recovery of human neutrophils from complement attack: removal of the membrane attack complex by endocytosis and exocytosis. J Immunol 138:246
60. Morgan BP, Imagawa DK, Dankert JR et al (1986) Complement lysis of U937, a nucleated mammalian cell line in the absence of C9: effect of C9 on C5b-8 mediated cell lysis. J Immunol 136:3402
61. Morgan BP, Luzio JP, Campbell AK (1986) Intracellular Ca2+ and cell injury: a paradoxical role of Ca2+ in complement membrane attack. Cell Calcium 7:399
62. Muller-Eberhard HJ (1986) The membrane attack complex of complement. Annu Rev Immunol 4:503
63. Nauta AJ, Daha MR, Tijsma O et al (2002) The membrane attack complex of complement induces caspase activation and apoptosis. Eur J Immunol 32:783
64. Nicholson-Weller A, Wang CE (1994) Structure and function of decay accelerating factor CD55. J Lab Clin Med 123:485
65. Niculescu F, Badea T, Rus H (1999) Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and phosphatidylinositol 3-kinase. Atherosclerosis 142:47
66. Niculescu F, Rus H, Shin S et al (1993) Generation of diacylglycerol and ceramide during homologous complement activation. J Immunol 150:214
67. Nusbaum P, Laine C, Bouaouina M et al (2005) Distinct signaling pathways are involved in leukosialin (CD43) down-regulation, membrane blebbing, and phospholipid scrambling during neutrophil apoptosis. J Biol Chem 280:5843
68. Ohanian SH, Schlager SI, Borsos T (1978) Molecular interactions of cells with antibody and complement: influence of metabolic and physical properties of the target on the outcome of humoral immune attack. Contemp Topics Mol Immunol 7:153
69. Paas Y, Bohana-Kashtan O, Fishelson Z (1999) Phosphorylation of the complement component, C9, by an ecto-protein kinase of human leukemic cells. Immunopharmacology 42:175
70. Pan BT, Johnstone RM (1983) Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33:967
71. Papadimitriou JC, Drachenberg CB, Shin ML et al (1994) Ultrastructural studies of complement mediated cell death: a biological reaction model to plasma membrane injury. Virchows Arch 424:677
72. Pascual M, Lutz HU, Steiger G et al (1993) Release of vesicles enriched in complement receptor 1 from human erythrocytes. J Immunol 151:397
73. Pilzer D, Fishelson Z (2005) Mortalin/GRP75 promotes release of membrane vesicles from immune attacked cells and protection from complement-mediated lysis. Int Immunol 17:1239
74. Ramm LE, Whitlow MB, Koski CL et al (1983) Elimination of complement channels from the plasma membranes of U937, a nucleated mammalian cell line: temperature dependence of the elimination rate. J Immunol 131:1411
75. Ran Q, Wadhwa R, Kawai R et al (2000) Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75. Biochem Biophys Res Commun 275:174
76. Reiter Y, Ciobotariu A, Fishelson Z (1992) Sublytic complement attack protects tumor cells from lytic doses of antibody and complement. Eur J Immunol 22:1207
77. Riteau B, Faure F, Menier C et al (2003) Exosomes bearing HLA-G are released by melanoma cells. Hum Immunol 64:1064
78. Ronquist G, Brody I (1985) The prostasome: its secretion and function in man. Biochim Biophys Acta 822:203
79. Rus HG, Niculescu F, Shin ML (1996) Sublytic complement attack induces cell cycle in oligodendrocytes. J Immunol 156:4892
80. Sabatier F, Roux V, Anfosso F et al (2002) Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity. Blood 99:3962
81. Satta N, Toti F, Feugeas O et al (1994) Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide. J Immunol 153:3245
82. Scolding NJ, Morgan BP, Houston WA et al (1989) Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement. Nature 339:620
83. Shimizu A, Masuda Y, Kitamura H et al (2000) Complement-mediated killing of mesangial cells in experimental glomerulonephritis: cell death by a combination of apoptosis and necrosis. Nephron 86:152
84. Shirazi Y, McMorris FA, Shin ML (1989) Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids. J Immunol 142:4385
85. Sims PJ, Faioni EM, Wiedmer T et al (1988) Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem 263:18205
86. Skokos D, Botros HG, Demeure C et al (2003) Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J Immunol 170:3037
87. Soane L, Cho HJ, Niculescu F et al (2001) C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol 167:2305
88. Sreedhar AS, Mihaly K, Pato B et al (2003) Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. J Biol Chem 278:35231
89. Stein JM, Luzio JP (1991) Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles. Biochem J 274(Pt 2):381
90. Takano S, Wadhwa R, Yoshii Y et al (1997) Elevated levels of mortalin expression in human brain tumors. Exp Cell Res 237:38
91. Taylor DD, Gercel-Taylor C (2005) Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer 92:305
92. Tedesco F, Pausa M, Nardon E et al (1997) The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity. J Exp Med 185: 1619
93. Thery C, Duban L, Segura E et al (2002) Indirect activation of naive CD4+T cells by dendritic cell-derived exosomes. Nat Immunol 3:1156
94. Tschopp J, Podack ER, Muller-Eberhard HJ (1982) Ultrastructure of the membrane attack complex of complement: detection of the tetramolecular C9-polymerizing complex C5b-8. Proc Natl Acad Sci U S A 79:7474
95. van Blitterswijk WJ, Emmelot P, Hilkmann HA et al (1979) Rigid plasma-membrane-derived vesicles, enriched in tumour-associated surface antigens (MLr), occurring in the ascites fluid of a murine leukaemia (GRSL). Int J Cancer 23:62
96. Van Niel G, Mallegol J, Bevilacqua C et al (2003) Intestinal epithelial exosomes carry MHC class II/ peptides able to inform the immune system in mice. Gut 52:1690
97. Vanbuskirk A, Crump BL, Margoliash E et al (1989) A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. J Exp Med 170:1799
98. Voisine C, Craig EA, Zufall N et al (1999) The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70. Cell 97:565
99. Wadhwa R, Taira K, Kaul SC (2002) An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones 7:309
100. Whitlow M, Iida K, Marshall P et al (1993) Cells lacking glycan phosphatidylinositol-linked proteins have impaired ability to vesiculate. Blood 81:510
101. Wiedmer T, Ando B, Sims PJ (1987) Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases. J Biol Chem 262:13674
102. Wiedmer T, Hall SE, Ortel TL et al (1993) Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. Blood 82:1192
103. Wiedmer T, Sims PJ (1991) Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles. Blood 78:2880
104. Wubbolts R, Leckie RS, Veenhuizen PT et al (2003) Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J Biol Chem 278:10963