Arginine deprivation and immune suppression in a mouse model of Alzheimer’s disease

Journal of Neuroscience

Volumn 35, Issue 15, 2015, Pages 5969-5982

  Kan, Matthew J ^a   Lee, Jennifer E ^a   Wilson, Joan G ^a   Everhart, Angela L ^a   Brown, Candice M ^b   Hoofnagle, Andrew N ^c   Jansen, Marilyn ^a   Vitek, Michael P ^a   Gunn, Michael D ^a   Colton, Carol A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alzheimer s disease; Amino acid deprivation; Arginase; Arginine; Immune suppression; Microglia

Indexed keywords

AMINO ACID TRANSPORTER; AMYLOID BETA PROTEIN; ARGINASE 1; ARGININE; CD11B ANTIGEN; CD33 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CX3CR1; EFLORNITHINE; EOTAXIN; FLUORESCEIN ISOTHIOCYANATE; GLYCOPROTEIN P 15095; INTERLEUKIN 1BETA; LAT PROTEIN; MEMBRANE RECEPTOR; MESSENGER RNA; PROGRAMMED DEATH 1 LIGAND 1; PUTRESCINE; RNA; TAU PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; IMMUNOLOGIC FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LEUKOCYTE ANTIGEN; NOS2 PROTEIN, MOUSE; ORNITHINE DECARBOXYLASE INHIBITOR;

ALZHEIMER DISEASE; AMINO ACID ANALYSIS; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CATABOLISM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE COURSE; ELECTROSPRAY MASS SPECTROMETRY; FLOW CYTOMETRY; GENE EXPRESSION; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; LEARNING AND MEMORY TEST; MICROARRAY ANALYSIS; MICROGLIA; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIAL ARM MAZE TEST; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; AGE; ANIMAL; BRAIN; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; MAZE TEST; METABOLISM; MUTATION; PATHOLOGY; SHORT TERM MEMORY; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIGENS, CD; ARGININE; BRAIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EFLORNITHINE; HUMANS; IMMUNOLOGIC FACTORS; MAZE LEARNING; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROARRAY ANALYSIS; MICROGLIA; MUTATION; NITRIC OXIDE SYNTHASE TYPE II; ORNITHINE DECARBOXYLASE INHIBITORS;

EID: 84929237397     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4668-14.2015     Document Type: Article

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