An active transport system in the blood-brain barrier may reduce levodopa availability

Experimental Neurology

Volumn 195, Issue 1, 2005, Pages 267-271

  Hawkins, Richard A ^a   Mokashi, Ashwini ^a   Simpson, Ian A ^b  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Active transport; Blood brain barrier; Drug delivery; L DOPA; Na + dependent amino acid transport; Neutral amino acid; Parkinson's disease

Indexed keywords

AMINO ACID TRANSPORTER; LEVODOPA; SODIUM;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; CYTOPLASM; DRUG BIOAVAILABILITY; DRUG TRANSPORT; ENDOTHELIUM CELL; EXTRACELLULAR FLUID; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CATTLE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; EXTRACELLULAR FLUID; ISOLEUCINE; LEVODOPA; MODELS, BIOLOGICAL; SODIUM; TIME FACTORS; TRITIUM;

EID: 23644452116     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.04.008     Document Type: Article

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