Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization

Journal of Biological Chemistry

Volumn 289, Issue 15, 2014, Pages 10318-10329

  Date, Dipali ^a   Das, Riku ^b   Narla, Goutham ^a   Simon, Daniel I ^a   Jain, Mukesh K ^a   Mahabeleshwar, Ganapati H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; POLARIZATION; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ANTI-INFLAMMATORIES; BIOLOGICAL PROCESS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LOCUS OF CONTROL; MURINE MACROPHAGES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; TRANSCRIPTIONAL LEVELS; TRANSCRIPTIONAL REGULATOR;

MACROPHAGES;

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; KRUPPEL LIKE FACTOR 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; DERMATITIS; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

CELLULAR IMMUNE RESPONSE; GENE REGULATION; INFLAMMATION; KRUPPEL-LIKE TRANSCRIPTION FACTOR 6; MACROPHAGES; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; NF-KAPPA B; PPAR GAMMA; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; U937 CELLS;

EID: 84898627011     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.526749     Document Type: Article

References (26)

1. Olefsky, J. M., and Glass, C. K. (2010) Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219-246
2. Serbina, N. V., Jia, T., Hohl, T. M., and Pamer, E. G. (2008) Monocytemediated defense against microbial pathogens. Annu. Rev. Immunol. 26, 421-452
3. Murray, P. J., and Wynn, T. A. (2011) Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11, 723-737
4. Muller, W. A. (2011) Mechanisms of leukocyte transendothelial migration. Annu. Rev. Pathol. 6, 323-344
5. Auffray, C., Sieweke, M. H., and Geissmann, F. (2009) Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu. Rev. Immunol. 27, 669-692
6. Medzhitov, R., and Horng, T. (2009) Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 9, 692-703
7. Sica, A., and Mantovani, A. (2012) Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 122, 787-795
8. Lawrence, T., and Natoli, G. (2011) Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat. Rev. Immunol. 11, 750-761
9. Biswas, S. K., Chittezhath, M., Shalova, I. N., and Lim, J. Y. (2012) Macrophage polarization and plasticity in health and disease. Immunol. Res. 53, 11-24
10. Szabo, S. J., Sullivan, B. M., Peng, S. L., and Glimcher, L. H. (2003) Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21, 713-758
11. Odegaard, J. I., and Chawla, A. (2011) Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6, 275-297
12. Szanto, A., Balint, B. L., Nagy, Z. S., Barta, E., Dezso, B., Pap, A., Szeles, L., Poliska, S., Oros, M., Evans, R. M., Barak, Y., Schwabe, J., and Nagy, L. (2010) STAT6 transcription factor is a facilitator of the nuclear receptor PPAR γ-regulated gene expression in macrophages and dendritic cells. Immunity 33, 699-712
13. Andreoli, V., Gehrau, R. C., and Bocco, J. L. (2010) Biology of Kruppel-like factor 6 transcriptional regulator in cell life and death. IUBMB Life 62, 896-905
14. Mahabeleshwar, G. H., Kawanami, D., Sharma, N., Takami, Y., Zhou, G., Shi, H., Nayak, L., Jeyaraj, D., Grealy, R., White, M., McManus, R., Ryan, T., Leahy, P., Lin, Z., Haldar, S. M., Atkins, G. B., Wong, H. R., Lingrel, J. B., and Jain, M. K. (2011) The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity 34, 715-728
15. Liao, X., Sharma, N., Kapadia, F., Zhou, G., Lu, Y., Hong, H., Paruchuri, K., Mahabeleshwar, G. H., Dalmas, E., Venteclef, N., Flask, C. A., Kim, J., Doreian, B. W., Lu, K. Q., Kaestner, K. H., Hamik, A., Clément, K., and Jain, M. K. (2011) Kruppel-like factor 4 regulates macrophage polarization. J. Clin. Invest. 121, 2736-2749
16. Davis, B. K. (2013) Isolation, culture, and functional evaluation of bone marrow-derived macrophages. Methods Mol. Biol. 1031, 27-35
17. Leow, C. C., Wang, B. E., Ross, J., Chan, S. M., Zha, J., Carano, R. A., Frantz, G., Shen, M. M., de Sauvage, F. J., and Gao, W. Q. (2009) Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J. Biol. Chem. 284, 21057-21065
18. Nayak, L., Goduni, L., Takami, Y., Sharma, N., Kapil, P., Jain, M. K., and Mahabeleshwar, G. H. (2013) Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation. Am. J. Pathol. 182, 1696-1704
19. Cao, Z., Sun, X., Icli, B., Wara, A. K., and Feinberg, M. W. (2010) Role of Kruppel-like factors in leukocyte development, function, and disease. Blood 116, 4404-4414
20. Matsumoto, N., Kubo, A., Liu, H., Akita, K., Laub, F., Ramirez, F., Keller, G., and Friedman, S. L. (2006) Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood 107, 1357-1365
21. + limits macrophage NF-κB activation and contributes to the resolution of inflammation. Nature 434, 1138-1143
22. McConnell, B. B., and Yang, V. W. (2010) Mammalian Kruppel-like factors in health and diseases. Physiol. Rev. 90, 1337-1381
23. Ye, M., Iwasaki, H., Laiosa, C. V., Stadtfeld, M., Xie, H., Heck, S., Clausen, B., Akashi, K., and Graf, T. (2003) Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19, 689-699
24. Ostuni, R., and Natoli, G. (2011) Transcriptional control of macrophage diversity and specialization. Eur. J. Immunol. 41, 2486-2490
25. Hawiger, J. (2001) Innate immunity and inflammation: a transcriptional paradigm. Immunol. Res. 23, 99-109
26. Martinez, F. O., Helming, L., and Gordon, S. (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27, 451-483