Adaptation of plasma membrane amino acid transport mechanisms to physiological demands

Pflugers Archiv European Journal of Physiology

Volumn 444, Issue 4, 2002, Pages 457-466

  Bröer, Stefan ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Amino acid transport; Antiporter; Cloning; Symporter; Transport mechanism

Indexed keywords

ALANINE; AMINO ACID; AMINO ACID TRANSPORTER; ANTIPORTER; CARRIER PROTEIN; COTRANSPORTER; GLUTAMIC ACID; GLUTAMINE; NEUROTRANSMITTER; OSMOLITE; SODIUM ION;

ADAPTATION; AMINO ACID SEQUENCE; AMINO ACID TRANSPORT; CELL LEVEL; CELL MEMBRANE TRANSPORT; EVOLUTION; GENE MUTATION; MAMMAL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; ANIMALS; ANTIPORTERS; CELL MEMBRANE; HUMANS; MOLECULAR STRUCTURE;

EID: 0036453406     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-002-0840-y     Document Type: Review

References (72)

1. + transport by the neural glutamine transporter ATA1. Pflugers Arch 443:92-101
2. Alfieri RR, Petronini PG, Bonelli MA, Caccamo AE, Cavazzoni A, Borghetti AF, Wheeler KP (2001) Osmotic regulation of ATA2 mRNA expression and amino acid transport System A activity. Biochem Biophys Res Commun 283:174-178
3. Avissar NE, Ryan CK, Ganapathy V, Sax HC (2001) Na(+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein. Am J Physiol 281:C963-C971
4. Bendahan A, Armon A, Madani N, Kavanaugh MP, Kanner BI (2000) Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter. J Biol Chem 275:37436-37442
5. Broer A, Albers A, Setiawan I, Edwards RH, Chaudhry FA, Lang F, Wagner CA, Broer S (2002) Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions. J Physiol (Lond) 539:3-14
6. Broer A, Brookes N, Ganapathy V, Dimmer KS, Wagner CA, Lang F, Broer S (1999) The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux. J Neurochem 73: 2184-2194
7. + exchange and a substrate-gated anion conductance. Biochem J 346:705-710
8. Broer A, Wagner CA, Lang F, Broer S (2000) The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine. Biochem J 349:787-795
9. Broer S, Brookes N (2001) Transfer of glutamine between astrocytes and neurons. J Neurochem 77:705-719
10. Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW (1998) Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J 333:167-174
11. Busch AE, Herzer T, Waldegger S, Schmidt F, Palacin M, Biber J, Markovich D, Murer H, Lang F (1994) Opposite directed currents induced by the transport of dibasic and neutral amino acids in Xenopus oocytes expressing the protein rBAT. J Biol Chem 269:25581-25586
12. Campbell WA, Sah DE, Medina MM, Albina JE, Coleman WB, Thompson NL (2000) TA1/LAT-1/CD98 light chain and system L activity, but not 4F2/CD98 heavy chain, respond to arginine availability in rat hepatic cells. Loss of response in tumor cells. J Biol Chem 275:5347-5354
13. Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA (1998) Cloning and characterization of a potassium-coupled amino acid transporter. Proc Natl Acad Sci USA 95:5395-5400
14. Chaudhry FA, Krizaj D, Larsson P, Reimer RJ, Wreden C, Storm-Mathisen J, Copenhagen D, Kavanaugh M, Edwards RH (2001) Coupled and uncoupled proton movement by amino acid transport system N. EMBO J 20:7041-7051
15. Chillaron J, Roca R, Valencia A, Zorzano A, Palacin M (2001) Heteromeric amino acid transporters: Biochemistry, genetics, and physiology. Am J Physiol 281:F995-F1018
16. Christensen HN (1966) Methods for distinguishing amino acid transport systems of a given cell or tissue. Fed Proc 25:850-853
17. +-dependent transport in the intestine and other animal tissues. Fed Proc 24:1000-1006
18. Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1-105
19. Daniel H, Herget M (1997) Cellular and molecular mechanisms of renal peptide transport. Am J Physiol 273:F1-F8
20. DeFelice LJ, Blakely RD (1996) Pore models for transporters? Biophys J 70:579-580
21. +, is alkaline pH-dependent, and is Cl-independent. J Biol Chem 275:24518-24526
22. Galli A, Blakely RD, DeFelice LJ (1998) Patch-clamp and amperometric recordings from norepinephrine transporters: Channel activity and voltage-dependent uptake. Proc Natl Acad Sci USA 95:13260-13265
23. Grewer C, Watzke N, Wiessner M, Rauen T (2000) Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds. Proc Natl Acad Sci USA 97:9706-9711
24. Gu HH, Wall S, Rudnick G (1996) Ion coupling stoichiometry for the norepinephrine transporter in membrane vesicles from stably transfected cells. J Biol Chem 271:6911-6916
25. Gu S, Roderick HL, Camacho P, Jiang JX (2001) Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport. J Biol Chem 276:24137-24144
26. Hatanaka T, Huang W, Nakanishi T, Bridges CC, Smith SB, Prasad PD, Ganapathy ME, Ganapathy V (2002) Transport of d-serine via the amino acid transporter ATB(0,+) expressed in the colon. Biochem Biophys Res Commun 291:291-295
27. Haussinger D (1998) Hepatic glutamine transport and metabolism. Adv Enzymol Relat Areas Mol Biol 72:43-86
28. Hyde R, Christie GR, Litherland GJ, Hajduch E, Taylor PM, Hundal HS (2001) Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes. Biochem J 355: 563-568
29. Kanai Y, Fukasawa Y, Cha SH, Segawa H, Chairoungdua A, Kim DK, Matsuo H, Kim JY, Miyamoto K, Takeda E, Endou H (2000) Transport properties of a system y+L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition. J Biol Chem 275:20787-20793
30. Kavanaugh MP, Bendahan A, Zerangue N, Zhang Y, Kanner BI (1997) Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange. J Biol Chem 272:1703-1708
31. +/monocarboxylate transporters. J Biol Chem 276:17221-17228
32. Kudo Y, Boyd CA (2001) Characterisation of L-tryptophan transporters in human placenta: A comparison of brush border and basal membrane vesicles. J Physiol (Lond) 531:405-416
33. Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (2001) Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature 410:84-88
34. Ling R, Bridges CC, Sugawara M, Fujita T, Leibach FH, Prasad PD, Ganapathy V (2001) Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A. Biochim Biophys Acta 1512:15-21
35. +-coupled cotransporters GAT1 and SGLT1. J Biol Chem 275:37414-37422
36. Matskevitch I, Wagner CA, Stegen C, Broer S, Noll B, Risler T, Kwon HM, Handler JS, Waldegger S, Busch AE, Lang F (1999) Functional characterization of the betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes. J Biol Chem 274:16709-16716
37. Meier C, Ristic Z, Klauser S, Verrey F (2002) Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J 21:580-589
38. Nakanishi T, Kekuda R, Fei YJ, Hatanaka T, Sugawara M, Martindale RG, Leibach FH, Prasad PD, Ganapathy V (2001) Cloning and functional characterization of a new subtype of the amino acid transport system N. Am J Physiol 281: C1757-C1768
39. Nawrath H, Wegener JW, Rupp J, Habermeier A, Closs EI (2000) Voltage dependence of L-arginine transport by hCAT-2A and hCAT-2B expressed in oocytes from Xenopus laevis. Am J Physiol 279:C1336-C1344
40. Orlowski M, Meister A (1970) The gamma-glutamyl cycle: A possible transport system for amino acids. Proc Natl Acad Sci USA 67:1248-1255
41. Otis TS, Kavanaugh MP (2000) Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2. J Neurosci 20:2749-2757
42. Palacin M, Bertran J, Zorzano A (2000) Heteromeric amino acid transporters explain inherited aminoacidurias. Curr Opin Nephrol Hypertens 9:547-553
43. Palacin M, Borsani G, Sebastio G (2001) The molecular bases of cystinuria and lysinuric protein intolerance. Curr Opin Genet Dev 11:328-335
44. Palacin M, Estevez R, Bertran J, Zorzano A (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 78:969-1054
45. Pfeiffer R, Rossier G, Spindler B, Meier C, Kuhn L, Verrey F (1999) Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J 18:49-57
46. Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (1999) Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 274:19738-19744
47. Prasad BM, Amara SG (2001) The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage. J Neurosci 21:7561-7567
48. Rahman B, Schneider HP, Broer A, Deitmer JW, Broer S (1999) Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1. Biochemistry 38:11577-11584
49. Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V (1994) Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J 300:893-900
50. Reimer RJ, Chaudhry FA, Gray AT, Edwards RH (2000) Amino acid transport system A resembles system N in sequence but differs in mechanism. Proc Natl Acad Sci USA 97:7715-7720
51. Rennie MJ, Khogali SE, Low SY, McDowell HE, Hundal HS, Ahmed A, Taylor PM (1996) Amino acid transport in heart and skeletal muscle and the functional consequences. Biochem Soc Trans 24:869-873
52. Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kuhn LC (1999) LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 274:34948-34954
53. Roux MJ, Supplisson S (2000) Neuronal and glial glycine transporters have different stoichiometries. Neuron 25:373-383
54. +-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274:19745-19751
55. Shih JC, Chen K, Ridd MJ (1999) Monoamine oxidase: From genes to behavior. Annu Rev Neurosci 22:197-217
56. Sloan JL, Mager S (1999) Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+). J Biol Chem 274:23740-23745
57. Sonders MS, Amara SG (1996) Channels in transporters. Curr Opin Neurobiol 6:294-302
58. Sonders MS, Zhu SJ, Zahniser NR, Kavanaugh MP, Amara SG (1997) Multiple ionic conductances of the human dopamine transporter: The actions of dopamine and psychostimulants. J Neurosci 17:960-974
59. Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (2000) Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. J Biol Chem 275:16473-16477
60. Tamarappoo BK, McDonald KK, Kilberg MS (1996) Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity. Biochim Biophys Acta 1279:131-136
61. Thwaites DT, McEwan GT, Simmons NL (1995) The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers. J Membr Biol 145:245-256
62. +-zwitterionic amino acid symport at the brush-border membrane of human intestinal epithelial (CACO-2) cells. Exp Physiol 84:275-284
63. Torrents D, Mykkanen J, Pineda M, Feliubadalo L, Estevez R, de Cid R, Sanjurjo P, Zorzano A, Nunes V, Huoponen K, Reinikainen A, Simell O, Savontaus ML, Aula P, Palacin M (1999) Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene. Nat Genet 21:293-296
64. Verrey F, Jack DL, Paulsen IT, Saier MH Jr, Pfeiffer R (1999) New glycoprotein-associated amino acid transporters. J Membr Biol 172:181-192
65. Verrey F, Meier C, Rossier G, Kuhn LC (2000) Glycoprotein-associated amino acid exchangers: Broadening the range of transport specificity. Pflugers Arch 440:503-512
66. Wagner CA, Lang F, Broer S (2001) Function and structure of heterodimeric amino acid transporters. Am J Physiol 281:C1077-C1093
67. Watzke N, Rauen T, Bamberg E, Grewer C (2000) On the mechanism of proton transport by the neuronal excitatory amino acid carrier 1. J Gen Physiol 116:609-622
68. Wolfersberger MG (2000) Amino acid transport in insects. Annu Rev Entomol 45:111-120
69. +/neutral amino acid cotransport. J Biol Chem 275:22790-22797
70. Zerangue N, Kavanaugh MP (1996) ASCT-1 is a neutral amino acid exchanger with chloride channel activity. J Biol Chem 271:27991-27994
71. Zerangue N, Kavanaugh MP (1996) Flux coupling in a neuronal glutamate transporter. Nature 383:634-637
72. +)-coupled rat brain glutamate transporter. Proc Natl Acad Sci USA 95:751-755