Disrupted spermine homeostasis: A novel mechanism in polyglutamine-mediated aggregation and cell death

Journal of Neuroscience

Volumn 24, Issue 32, 2004, Pages 7118-7127

  Colton, C A ^a   Xu, Q ^a   Burke, J R ^a   Bae, S Y ^a   Wakefield, J K ^b   Nair, A ^b   Strittmatter, W J ^a   Vitek, M P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Tranzyme Inc   (United States)

Author keywords

Difluoromethylornithine; Huntington's disease; Nitric oxide; Polyglutamine; Protein aggregation; Spermine

Indexed keywords

ARGINASE; ARGININE; EFLORNITHINE; ORNITHINE DECARBOXYLASE; POLYAMINE; POLYGLUTAMINE; SPERMINE; YELLOW FLUORESCENT PROTEIN;

AMINO ACID TRANSPORT; ARTICLE; CELL AGGREGATION; CELL DEATH; CELL LINE; CHEMICAL MODIFICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HOMEOSTASIS; HUNTINGTON CHOREA; NERVE CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TURBIDITY;

ACETYLTRANSFERASES; ANIMALS; ARGINASE; ARGININE; BIOLOGICAL TRANSPORT; CELL DEATH; CELL LINE; GLUTAMINE; HOMEOSTASIS; LUMINESCENT PROTEINS; NEPHELOMETRY AND TURBIDIMETRY; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORNITHINE DECARBOXYLASE; PEPTIDES; RATS; RECOMBINANT FUSION PROTEINS; SPERMINE; TYROSINE 3-MONOOXYGENASE; UP-REGULATION;

EID: 4143102615     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1233-04.2004     Document Type: Article

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