Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

Nature Communications

Volumn 6, Issue , 2015, Pages

  Ip, W K Eddie ^a   Medzhitov, Ruslan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; APOPTOSIS REGULATORY PROTEIN; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; INTERLEUKIN 1BETA; IPAF PROTEIN, MOUSE; NLRP3 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; SALT INTAKE;

ADAPTATION; ENVIRONMENTAL STRESS; HOMEOSTASIS; IMMUNE RESPONSE; OSMOREGULATION; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL PERITONITIS; FEMALE; HYPEROSMOLALITY; HYPEROSMOTIC STRESS; IMMUNIZATION; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; SALT INTAKE; SENSOR; ANIMAL; C57BL MOUSE; ENZYME ACTIVATION; IMMUNOLOGY; METABOLISM; MITOCHONDRION; MITOPHAGY; OSMOLARITY; OSMOTIC PRESSURE; PATHOLOGY; SECRETION (PROCESS); TH17 CELL;

MAMMALIA; MUS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CASPASE 1; ENZYME ACTIVATION; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; MACROPHAGES; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OSMOLAR CONCENTRATION; OSMOTIC PRESSURE; REACTIVE OXYGEN SPECIES; SODIUM CHLORIDE, DIETARY; TH17 CELLS;

EID: 84929145248     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7931     Document Type: Article

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