-
1
-
-
77956213410
-
Insulin induces swelling-dependent activation of the epidermal growth factor receptor in rat liver
-
Reinehr, R., Sommerfeld, A., and Häussinger, D. (2010) Insulin induces swelling-dependent activation of the epidermal growth factor receptor in rat liver. J. Biol. Chem. 285, 25904-25912
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 25904-25912
-
-
Reinehr, R.1
Sommerfeld, A.2
Häussinger, D.3
-
2
-
-
33744948514
-
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
-
Malhi, H., Bronk, S. F., Werneburg, N. W., and Gores G. J. (2006) Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 281, 12093-12101
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12093-12101
-
-
Malhi, H.1
Bronk, S.F.2
Werneburg, N.W.3
Gores, G.J.4
-
3
-
-
0030077331
-
Liver regeneration: Regulation of signal transduction during liver regeneration
-
Diehl, A. M., and Rai, R. M. (1996) Liver regeneration: Regulation of signal transduction during liver regeneration. FASEB J. 10, 215-227
-
(1996)
FASEB J.
, vol.10
, pp. 215-227
-
-
Diehl, A.M.1
Rai, R.M.2
-
4
-
-
0030933277
-
Oncoprotein networks
-
Hunter, T. (1997) Oncoprotein networks. Cell 88, 333-346
-
(1997)
Cell
, vol.88
, pp. 333-346
-
-
Hunter, T.1
-
5
-
-
0031919552
-
Insulin signal transduction through protein kinase cascades
-
Avruch, J. (1998) Insulin signal transduction through protein kinase cascades. Mol. Cell Biochem. 182, 31-48
-
(1998)
Mol. Cell Biochem.
, vol.182
, pp. 31-48
-
-
Avruch, J.1
-
6
-
-
0032987220
-
Insulin signaling: Metabolic pathways and mechanisms for specificity
-
Nystrom, F. H., and Quon, M. J. (1999) Insulin signaling: metabolic pathways and mechanisms for specificity. Cell Signal 11, 563-574
-
(1999)
Cell Signal
, vol.11
, pp. 563-574
-
-
Nystrom, F.H.1
Quon, M.J.2
-
7
-
-
0032898857
-
The insulin signaling pathway
-
Taha, C., and Klip, A. (1999) The insulin signaling pathway. J. Membr. Biol. 169, 1-12
-
(1999)
J. Membr. Biol.
, vol.169
, pp. 1-12
-
-
Taha, C.1
Klip, A.2
-
8
-
-
3042594002
-
Involvement of integrins and Src in tauroursodeoxy-cholate- induced and swelling-induced choleresis
-
Häussinger, D., Kurz, A. K., Wettstein, M., Graf, D., vom Dahl, S., and Schliess, F. (2003) Involvement of integrins and Src in tauroursodeoxy-cholate- induced and swelling-induced choleresis. Gastroenterology 124, 1476-1487
-
(2003)
Gastroenterology
, vol.124
, pp. 1476-1487
-
-
Häussinger, D.1
Kurz, A.K.2
Wettstein, M.3
Graf, D.4
Vom Dahl, S.5
Schliess, F.6
-
9
-
-
0038711645
-
Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver
-
Vom Dahl, S., Schliess, F., Reissmann, R., Görg, B., Weiergräber, O., Kocalkova, M., Dombrowski, F., and Häussinger, D. (2003) Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 278, 27088-27095
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27088-27095
-
-
Vom Dahl, S.1
Schliess, F.2
Reissmann, R.3
Görg, B.4
Weiergräber, O.5
Kocalkova, M.6
Dombrowski, F.7
Häussinger, D.8
-
10
-
-
2442674271
-
Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver
-
Schliess, F., Reissmann, R., Reinehr, R., vom Dahl, S., and Häussinger, D. (2004) Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 279, 21294-21301
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 21294-21301
-
-
Schliess, F.1
Reissmann, R.2
Reinehr, R.3
Vom Dahl, S.4
Häussinger, D.5
-
11
-
-
33644813043
-
JNK1 but not JNK2 promotes the development of steatohepatitis in mice
-
Schattenberg, J. M., Singh, R., Wang, Y., Lefkowitch, J. H., Rigoli, R. M., Scherer, P. E., and Czaja, M. J. (2006) JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 43, 163-172
-
(2006)
Hepatology
, vol.43
, pp. 163-172
-
-
Schattenberg, J.M.1
Singh, R.2
Wang, Y.3
Lefkowitch, J.H.4
Rigoli, R.M.5
Scherer, P.E.6
Czaja, M.J.7
-
12
-
-
54749148763
-
Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax
-
Wang, Y., Ausman, L. M., Russell, R. M., Greenberg, A. S., and Wang, X. D. (2008) Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. J. Nutr. 138, 1866-1871
-
(2008)
J. Nutr.
, vol.138
, pp. 1866-1871
-
-
Wang, Y.1
Ausman, L.M.2
Russell, R.M.3
Greenberg, A.S.4
Wang, X.D.5
-
13
-
-
38649124615
-
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
-
Puri, P., Mirshahi, F., Cheung, O., Natarajan, R., Maher, J. W., Kellum, J. M., and Sanyal, A. J. (2008) Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134, 568-576
-
(2008)
Gastroenterology
, vol.134
, pp. 568-576
-
-
Puri, P.1
Mirshahi, F.2
Cheung, O.3
Natarajan, R.4
Maher, J.W.5
Kellum, J.M.6
Sanyal, A.J.7
-
14
-
-
70350418854
-
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
-
Cazanave, S. C., Mott, J. L., Elmi, N. A., Bronk, S. F., Werneburg, N. W., Akazawa, Y., Kahraman, A., Garrison, S. P., Zambetti, G. P., Charlton, M. R., and Gores, G. J. (2009) JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J. Biol. Chem. 284, 26591-26602
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26591-26602
-
-
Cazanave, S.C.1
Mott, J.L.2
Elmi, N.A.3
Bronk, S.F.4
Werneburg, N.W.5
Akazawa, Y.6
Kahraman, A.7
Garrison, S.P.8
Zambetti, G.P.9
Charlton, M.R.10
Gores, G.J.11
-
15
-
-
34547193134
-
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
-
Malhi, H., Barreyro, F. J., Isomoto, H., Bronk, S. F., and Gores, G. J. (2007) Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut. 56, 1124-1131
-
(2007)
Gut.
, vol.56
, pp. 1124-1131
-
-
Malhi, H.1
Barreyro, F.J.2
Isomoto, H.3
Bronk, S.F.4
Gores, G.J.5
-
16
-
-
36348941705
-
Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver
-
Volkmann, X., Fischer, U., Bahr, M. J., Ott, M., Lehner, F., Macfarlane, M., Cohen, G. M., Manns, M. P., Schulze-Osthoff, K., and Bantel, H. (2007) Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 46, 1498-1508
-
(2007)
Hepatology
, vol.46
, pp. 1498-1508
-
-
Volkmann, X.1
Fischer, U.2
Bahr, M.J.3
Ott, M.4
Lehner, F.5
Macfarlane, M.6
Cohen, G.M.7
Manns, M.P.8
Schulze-Osthoff, K.9
Bantel, H.10
-
17
-
-
0042165989
-
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
-
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., and Gores, G. J. (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenter- ology 125, 437-443
-
(2003)
Gastroenterology
, vol.125
, pp. 437-443
-
-
Feldstein, A.E.1
Canbay, A.2
Angulo, P.3
Taniai, M.4
Burgart, L.J.5
Lindor, K.D.6
Gores, G.J.7
-
18
-
-
84856081407
-
CD95 death receptor and epidermal growth factor receptor (EGFR) in liver cell apoptosis and regeneration
-
Reinehr, R., and Häussinger, D. (2012) CD95 death receptor and epidermal growth factor receptor (EGFR) in liver cell apoptosis and regeneration. Arch. Biochem. Biophys. 518, 2-7
-
(2012)
Arch. Biochem. Biophys.
, vol.518
, pp. 2-7
-
-
Reinehr, R.1
Häussinger, D.2
-
19
-
-
0035084699
-
Non-alcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
-
Sanyal, A. J., Campbell-Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., and Clore, J. N. (2001) Non-alcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120, 1183-1192
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
Sterling, R.K.6
Luketic, V.A.7
Shiffman, M.L.8
Clore, J.N.9
-
21
-
-
30944469157
-
Non-alcoholic fatty liver disease and metabolic syndrome: What we know and what we don't know
-
Akbar, D. H., and Kawther, A. H. (2006) Non-alcoholic fatty liver disease and metabolic syndrome: what we know and what we don't know. Med. Sci. Monit. 12, RA23-R26
-
(2006)
Med. Sci. Monit.
, vol.12
, pp. RA23-R26
-
-
Akbar, D.H.1
Kawther, A.H.2
-
22
-
-
0035695238
-
Liver inflammatory cells, apoptosis, regeneration and stellate cell activation in non-alcoholic steatohepatitis
-
Susca, M., Grassi, A., Zauli, D., Volta, U., Lenzi, M., Marchesini, G., Bianchi, F. B., and Ballardini, G. (2001) Liver inflammatory cells, apoptosis, regeneration and stellate cell activation in non-alcoholic steatohepatitis. Dig. Liver Dis. 33, 768-777
-
(2001)
Dig. Liver Dis.
, vol.33
, pp. 768-777
-
-
Susca, M.1
Grassi, A.2
Zauli, D.3
Volta, U.4
Lenzi, M.5
Marchesini, G.6
Bianchi, F.B.7
Ballardini, G.8
-
23
-
-
4544335155
-
Hepatocyte apoptosis, expression of death receptors, and activation of NF-κB in the liver of nonalcoholic and alcoholic steatohepatitis patients
-
Ribeiro, P. S., Cortez-Pinto, H., Solá, S., Castro, R. E., Ramalho, R. M., Baptista, A., Moura, M. C., Camilo, M. E., and Rodrigues, C. M. (2004) Hepatocyte apoptosis, expression of death receptors, and activation of NF-κB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am. J. Gastroenterol. 99, 1708-1717
-
(2004)
Am. J. Gastroenterol.
, vol.99
, pp. 1708-1717
-
-
Ribeiro, P.S.1
Cortez-Pinto, H.2
Solá, S.3
Castro, R.E.4
Ramalho, R.M.5
Baptista, A.6
Moura, M.C.7
Camilo, M.E.8
Rodrigues, C.M.9
-
24
-
-
0033038672
-
Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
-
Matteoni, C. A., Younossi, Z. M., Gramlich, T., Boparai, N., Liu, Y. C., and McCullough, A. J. (1999) Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116, 1413-1419
-
(1999)
Gastroenterology
, vol.116
, pp. 1413-1419
-
-
Matteoni, C.A.1
Younossi, Z.M.2
Gramlich, T.3
Boparai, N.4
Liu, Y.C.5
McCullough, A.J.6
-
25
-
-
0038142845
-
Nonalcoholic fatty liver disease: An underrecognized cause of cryptogenic cirrhosis
-
Clark, J. M., and Diehl, A. (2003) Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 289, 3000-3004
-
(2003)
JAMA
, vol.289
, pp. 3000-3004
-
-
Clark, J.M.1
Diehl, A.2
-
26
-
-
1042277044
-
Non-alcoholic fatty liver disease: An emerging pathological spectrum
-
Zafrani, E. S. (2004) Non-alcoholic fatty liver disease: an emerging pathological spectrum. Virchows Arch. 444, 3-12
-
(2004)
Virchows Arch.
, vol.444
, pp. 3-12
-
-
Zafrani, E.S.1
-
27
-
-
0016792015
-
Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes
-
Meijer, A. J., Gimpel, J. A., Deleeuw, G. A., Tager, J. M., and Williamson, J. R. (1975) Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes. J. Biol. Chem. 250, 7728-7738
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 7728-7738
-
-
Meijer, A.J.1
Gimpel, J.A.2
Deleeuw, G.A.3
Tager, J.M.4
Williamson, J.R.5
-
28
-
-
28844486282
-
Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis
-
Boerner, J. L., Biscardi, J. S., Silva, C. M., and Parsons, S. J. (2005) Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis. Mol. Carcinog. 44, 262-273
-
(2005)
Mol. Carcinog.
, vol.44
, pp. 262-273
-
-
Boerner, J.L.1
Biscardi, J.S.2
Silva, C.M.3
Parsons, S.J.4
-
29
-
-
0033583220
-
c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function
-
Biscardi, J. S., Maa, M. C., Tice, D. A., Cox, M. E., Leu, T. H., and Parsons, S. J. (1999) c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J. Biol. Chem. 274, 8335-8343
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8335-8343
-
-
Biscardi, J.S.1
Maa, M.C.2
Tice, D.A.3
Cox, M.E.4
Leu, T.H.5
Parsons, S.J.6
-
30
-
-
0033558855
-
Modulation of the protein tyrosine kinase activity and autophosphorylation of the epidermal growth factor receptor by its juxtamembrane region
-
Poppleton, H. M., Wiepz, G. J., Bertics, P. J., and Patel, T. B. (1999) Modulation of the protein tyrosine kinase activity and autophosphorylation of the epidermal growth factor receptor by its juxtamembrane region. Arch. Biochem. Biophys. 363, 227-236
-
(1999)
Arch. Biochem. Biophys.
, vol.363
, pp. 227-236
-
-
Poppleton, H.M.1
Wiepz, G.J.2
Bertics, P.J.3
Patel, T.B.4
-
31
-
-
2542449195
-
T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
-
Hao, Z., Hampel, B., Yagita, H., and Rajewsky, K. (2004) T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J. Exp. Med. 199, 1355-1365
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1355-1365
-
-
Hao, Z.1
Hampel, B.2
Yagita, H.3
Rajewsky, K.4
-
32
-
-
12844269205
-
Fluorescence resonance energy transfer analysis of proapoptotic CD95/EGF receptor interactions in Huh7 cells
-
Eberle, A., Reinehr, R., Becker, S., and Häussinger, D. (2005) Fluorescence resonance energy transfer analysis of proapoptotic CD95/EGF receptor interactions in Huh7 cells. Hepatology 41, 715-726
-
(2005)
Hepatology
, vol.41
, pp. 715-726
-
-
Eberle, A.1
Reinehr, R.2
Becker, S.3
Häussinger, D.4
-
33
-
-
33745828301
-
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
-
Wei, Y., Wang, D., Topczewski, F., and Pagliassotti, M. J. (2006) Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 291, 275-281
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
, pp. 275-281
-
-
Wei, Y.1
Wang, D.2
Topczewski, F.3
Pagliassotti, M.J.4
-
34
-
-
67649304876
-
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria
-
Nakamura, S., Takamura, T., Matsuzawa-Nagata, N., Takayama, H., Misu, H., Noda, H., Nabemoto, S., Kurita, S., Ota, T., Ando, H., Miyamoto, K., and Kaneko, S. (2009) Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. J. Biol. Chem. 284, 14809-14818
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 14809-14818
-
-
Nakamura, S.1
Takamura, T.2
Matsuzawa-Nagata, N.3
Takayama, H.4
Misu, H.5
Noda, H.6
Nabemoto, S.7
Kurita, S.8
Ota, T.9
Ando, H.10
Miyamoto, K.11
Kaneko, S.12
-
35
-
-
84892673575
-
Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes
-
Egnatchik, R. A., Leamy, A. K., Noguchi, Y., Shiota, M., and Young, J. D. (2014) Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. Metabolism 63, 283-295
-
(2014)
Metabolism
, vol.63
, pp. 283-295
-
-
Egnatchik, R.A.1
Leamy, A.K.2
Noguchi, Y.3
Shiota, M.4
Young, J.D.5
-
36
-
-
77956921023
-
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
-
Gao, D., Nong, S., Huang, X., Lu, Y., Zhao, H., Lin, Y., Man, Y., Wang, S., Yang, J., and Li, J. (2010) The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J. Biol. Chem. 285, 29965-29973
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 29965-29973
-
-
Gao, D.1
Nong, S.2
Huang, X.3
Lu, Y.4
Zhao, H.5
Lin, Y.6
Man, Y.7
Wang, S.8
Yang, J.9
Li, J.10
-
37
-
-
84903627822
-
FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress
-
Pereira, S., Park, E., Mori, Y., Haber, C. A., Han, P., Uchida, T., Stavar, L., Oprescu, A. I., Koulajian, K., Ivovic, A., Yu, Z., Li, D., Bowman, T. A., Dewald, J., El-Benna, J., Brindley, D. N., Gutierrez-Juarez, R., Lam, T. K., Najjar, S. M., McKay, R. A., Bhanot, S., Fantus, I. G., and Giacca, A. (2014) FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress. Am. J. Physiol. Endocrinol. Metab. 307, E34-E46
-
(2014)
Am. J. Physiol. Endocrinol. Metab.
, vol.307
, pp. E34-E46
-
-
Pereira, S.1
Park, E.2
Mori, Y.3
Haber, C.A.4
Han, P.5
Uchida, T.6
Stavar, L.7
Oprescu, A.I.8
Koulajian, K.9
Ivovic, A.10
Yu, Z.11
Li, D.12
Bowman, T.A.13
Dewald, J.14
El-Benna, J.15
Brindley, D.N.16
Gutierrez-Juarez, R.17
Lam, T.K.18
Najjar, S.M.19
McKay, R.A.20
Bhanot, S.21
Fantus, I.G.22
Giacca, A.23
more..
-
39
-
-
33244464562
-
Critical nodes in signaling pathways: Insights into insulin action
-
Taniguchi, C. M., Emanuelli, B., and Kahn, C. R. (2006) Critical nodes in signaling pathways: insights into insulin action. Nat. Rev. Mol. Cell Biol. 7, 85-96
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
40
-
-
0034878320
-
Insulin resistence induced by loop diuretics and hyperosmolarity in perfused rat liver
-
Schliess, F., von Dahl, S., and Häussinger, D. (2001) Insulin resistence induced by loop diuretics and hyperosmolarity in perfused rat liver. Biol. Chem. 382, 1063-1069
-
(2001)
Biol. Chem.
, vol.382
, pp. 1063-1069
-
-
Schliess, F.1
Von Dahl, S.2
Häussinger, D.3
-
41
-
-
0037059330
-
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., and White, M. F. (2002) Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277, 1531-1537
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1531-1537
-
-
Aguirre, V.1
Werner, E.D.2
Giraud, J.3
Lee, Y.H.4
Shoelson, S.E.5
White, M.F.6
-
42
-
-
33750823407
-
Saturated fatty acids inhibit induction of insulin gene transcription by JNKmediated phosphorylation of insulin-receptor substrates
-
Solinas, G., Naugler, W., Galimi, F., Lee, M. S., and Karin, M. (2006) Saturated fatty acids inhibit induction of insulin gene transcription by JNKmediated phosphorylation of insulin-receptor substrates. Proc. Natl. Acad. Sci. U.S.A. 103, 16454-16459
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 16454-16459
-
-
Solinas, G.1
Naugler, W.2
Galimi, F.3
Lee, M.S.4
Karin, M.5
-
43
-
-
55349100928
-
Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signaling
-
Ruddock, M. W., Stein, A., Landaker, E., Park, J., Cooksey, R. C., McClain, D., and Patti, M. E. (2008) Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signaling. J. Biochem. 144, 599-607
-
(2008)
J. Biochem.
, vol.144
, pp. 599-607
-
-
Ruddock, M.W.1
Stein, A.2
Landaker, E.3
Park, J.4
Cooksey, R.C.5
McClain, D.6
Patti, M.E.7
-
44
-
-
80053554640
-
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
-
Holzer, R. G., Park, E. J., Li, N., Tran, H., Chen, M., Choi, C., Solinas, G., and Karin, M. (2011) Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 141, 173-184
-
(2011)
Cell
, vol.141
, pp. 173-184
-
-
Holzer, R.G.1
Park, E.J.2
Li, N.3
Tran, H.4
Chen, M.5
Choi, C.6
Solinas, G.7
Karin, M.8
-
45
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
Shimabukuro, M., Zhou, Y. T., Levi, M., and Unger, R. H. (1998) Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. U.S.A. 95, 2498-2502
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
46
-
-
0034612153
-
Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: Prevention by cyclosporin A
-
Kong, J. Y., and Rabkin, S. W. (2000) Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A. Biochim. Biophys. Acta 1485, 45-55
-
(2000)
Biochim. Biophys. Acta
, vol.1485
, pp. 45-55
-
-
Kong, J.Y.1
Rabkin, S.W.2
-
47
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway
-
Feldstein, A. E., Werneburg, N. W., Canbay, A., Guicciardi, M. E., Bronk, S. F., Rydzewski, R., Burgart, L. J., and Gores, G. J. (2004) Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway. Hepatology 40, 185-194
-
(2004)
Hepatology
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
Guicciardi, M.E.4
Bronk, S.F.5
Rydzewski, R.6
Burgart, L.J.7
Gores, G.J.8
-
48
-
-
2442476459
-
Lysosomes in cell death
-
Guicciardi, M. E., Leist, M., and Gores, G. J. (2004) Lysosomes in cell death. Oncogene 23, 2881-2890
-
(2004)
Oncogene
, vol.23
, pp. 2881-2890
-
-
Guicciardi, M.E.1
Leist, M.2
Gores, G.J.3
-
49
-
-
56649094325
-
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
-
Malhi, H., and Gores, G. J. (2008) Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin. Liver Dis. 28, 360-369
-
(2008)
Semin. Liver Dis.
, vol.28
, pp. 360-369
-
-
Malhi, H.1
Gores, G.J.2
-
50
-
-
83755225852
-
Osmotic regulation of bile acid transport, apoptosis and proliferation in rat liver
-
Häussinger, D., and Reinehr, R. (2011) Osmotic regulation of bile acid transport, apoptosis and proliferation in rat liver. Cell. Physiol. Biochem. 28, 1089-1098
-
(2011)
Cell. Physiol. Biochem.
, vol.28
, pp. 1089-1098
-
-
Häussinger, D.1
Reinehr, R.2
-
51
-
-
33751539470
-
+ hepatic stellate cells are progenitor cells
-
+ hepatic stellate cells are progenitor cells. Biochem. Biophys. Res. Commun. 352, 410-417
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.352
, pp. 410-417
-
-
Kordes, C.1
Sawitza, I.2
Müller-Marbach, A.3
Ale-Agha, N.4
Keitel, V.5
Klonowski-Stumpe, H.6
Häussinger, D.7
-
52
-
-
84915755718
-
Hepatic stellate cells can contribute to liver regeneration via progenitor cell formation
-
Kordes, C., Sawitza, I., Götze, S., Herebian, D., and Häussinger, D. (2014) Hepatic stellate cells can contribute to liver regeneration via progenitor cell formation. J. Clin. Invest. 124, 5503-5515
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 5503-5515
-
-
Kordes, C.1
Sawitza, I.2
Götze, S.3
Herebian, D.4
Häussinger, D.5
-
53
-
-
42949177536
-
CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells
-
Reinehr, R., Sommerfeld, A., and Häussinger, D. (2008) CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells. Gastroenterology 134, 1494-1506
-
(2008)
Gastroenterology
, vol.134
, pp. 1494-1506
-
-
Reinehr, R.1
Sommerfeld, A.2
Häussinger, D.3
-
54
-
-
1642409200
-
CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes
-
Reinehr, R., Görg, B., Höngen, A., and Häussinger, D. (2004) CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes. J. Biol. Chem. 279, 10364-10373
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10364-10373
-
-
Reinehr, R.1
Görg, B.2
Höngen, A.3
Häussinger, D.4
-
55
-
-
69249141789
-
Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis
-
Sommerfeld, A., Reinehr, R., and Häussinger, D. (2009) Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. J. Biol. Chem. 284, 22173-22183
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 22173-22183
-
-
Sommerfeld, A.1
Reinehr, R.2
Häussinger, D.3
-
56
-
-
0031021356
-
RAIDD is a new 'death' adapter molecule
-
Duan, H., and Dixit, V. M. (1997) RAIDD is a new 'death' adapter molecule. Nature 385, 86-89
-
(1997)
Nature
, vol.385
, pp. 86-89
-
-
Duan, H.1
Dixit, V.M.2
-
57
-
-
79959517565
-
Human fatty liver disease: Old questions and new insights
-
Cohen, J. C., Horton, J. D., and Hobbs, H. H. (2011) Human fatty liver disease: old questions and new insights. Science 332, 1519-1523
-
(2011)
Science
, vol.332
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
|