Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes

Metabolism: Clinical and Experimental

Volumn 63, Issue 2, 2014, Pages 283-295

  Egnatchik, Robert A ^a   Leamy, Alexandra K ^a   Noguchi, Yasushi ^b   Shiota, Masakazu ^c   Young, Jamey D ^a,c  

^a VANDERBILT UNIVERSITY   (United States)

^b AJINOMOTO CO INC   (Japan)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

Isotopomer modeling; Lipotoxicity; Mass spectrometry; Metabolic flux analysis; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CARBON 13; FATTY ACID; GLUTAMINE; PALMITIC ACID; PHENFORMIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

AEROBIC METABOLISM; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEPATOMA CELL; LIPOTOXICITY; LIVER CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

2′-7′-DICHLORODIHYDROFLUORESCEIN DIACETATE; BOVINE SERUM ALBUMIN; BSA; CAC; CITRIC ACID CYCLE; ETO; ETOMOXIR; FFA; FREE FATTY ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GC-MS; H(2)DCFDA; ISOTOPOMER MODELING; LIPOTOXICITY; MASS SPECTROMETRY; METABOLIC FLUX ANALYSIS; MFA; MONOUNSATURATED FATTY ACID; MUFA; N-ACETYL CYSTEINE; NAC; NAFLD; NASH; NON-ALCOHOLIC FATTY LIVER DISEASE; NON-ALCOHOLIC STEATOHEPATITIS; OA; OLEATE; PA; PALMITATE; PHEN; PHENFORMIN; PI; PROPIDIUM IODIDE; REACTIVE OXYGEN SPECIES; ROS; SATURATED FATTY ACID.; SFA;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARBON ISOTOPES; CARCINOMA, HEPATOCELLULAR; CASPASES, EFFECTOR; CELL LINE, TUMOR; ENZYME ACTIVATION; HEPATOCYTES; LIVER NEOPLASMS; METABOLIC FLUX ANALYSIS; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; PALMITATES; RATS; REACTIVE OXYGEN SPECIES;

EID: 84892673575     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.10.009     Document Type: Article

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