Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling

Journal of Biochemistry

Volumn 144, Issue 5, 2008, Pages 599-607

  Ruddock, Mark W ^a   Stein, Andrew ^a   Landaker, Edwin ^a   Park, Jun ^a   Cooksey, Robert C ^a   McClain, Donald ^a   Patti, Mary Elizabeth ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

oxidation; Insulin resistance; Insulin signalling; Liver; Palmitate

Indexed keywords

BROMOPALMITIC ACID; CPT 1 INHIBITOR; ETOMOXIR; FATTY ACID COENZYME A SYNTHETASE INHIBITOR; GLUTATHIONE SYNTHASE; GLUTATHIONE SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; OCTANOIC ACID; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P70; S6 KINASE; SATURATED FATTY ACID; TRANSCRIPTION FACTOR FKHR; TRIACSIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID METABOLISM; INHIBITION KINETICS; INSULIN METABOLISM; INSULIN RESISTANCE; LIVER CELL; NONHUMAN; OXIDATION KINETICS; PROTEIN EXPRESSION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; EPOXY COMPOUNDS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; FORKHEAD TRANSCRIPTION FACTORS; GLYCOGEN SYNTHASE KINASE 3; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; LIVER; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITIC ACID; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, INSULIN; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; TRIAZENES;

MUS;

EID: 55349100928     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn105     Document Type: Article

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