TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice

Translational Psychiatry

Volumn 5, Issue , 2015, Pages

  Devi, L ^a   Ohno, M ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLYCOGEN SYNTHASE KINASE 3BETA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PROTEIN KINASE B; AMPA RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOGEN SYNTHASE KINASE 3; GSK3B PROTEIN, MOUSE; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NTRK2 PROTEIN, MOUSE; PEPTIDE FRAGMENT; PROTEIN TYROSINE KINASE;

5XFAD MOUSE; ALZHEIMER DISEASE; AMNESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBRAL PLAQUE; CONTROLLED STUDY; DISEASE EXACERBATION; HETEROZYGOTE; HIPPOCAMPUS; KNOCKOUT MOUSE; MOLECULAR PATHOLOGY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENILE PLAQUE; Y-MAZE TEST; AMYLOID PLAQUE; ANIMAL; BRAIN; DISEASE MODEL; GENETICS; MEMORY; MEMORY DISORDER; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HETEROZYGOTE; MEMBRANE GLYCOPROTEINS; MEMORY; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION;

EID: 84928893073     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2015.55     Document Type: Article

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