7,8-dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of alzheimer disease-like neuronal loss

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Castello, Nicholas A ^a   Nguyen, Michael H ^a   Tran, Jenny D ^a   Cheng, David ^a   Green, Kim N ^a   LaFerla, Frank M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDROXYFLAVONE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NEURON SPECIFIC NUCLEAR PROTEIN; 6,7-DIHYDROXYFLAVONE; CALMODULIN; FLAVONE DERIVATIVE; GREEN FLUORESCENT PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; DENDRITIC SPINE; DENDRITIC SPINE DENSITY; DENTATE GYRUS; ELEVATED PLUS MAZE TEST; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; MALE; MOUSE; MOUSE MODEL; NEURONAL LOSS; NONHUMAN; PYRAMIDAL NERVE CELL; SPATIAL MEMORY; AGONISTS; ANIMAL; DISEASE MODEL; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY;

ALZHEIMER DISEASE; ANIMALS; CALMODULIN; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; FLAVONES; GREEN FLUORESCENT PROTEINS; MICE; NEURONS; PYRAMIDAL CELLS; RECEPTOR, TRKB; SPATIAL MEMORY;

EID: 84897490760     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091453     Document Type: Article

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